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Detrusor overactivity

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https://www.readbyqxmd.com/read/27924790/can-the-lower-urinary-tract-storage-symptoms-be-completely-resolved-after-plasmakinetic-enucleation-of-the-prostate
#1
Bing-Kun Li, Bin-Shen Chen, Yu-Hong Xin, Chun-Xiao Liu, Shao-Bo Zheng, Ya-Wen Xu, Hu-Lin Li, Yong Zou, Li-Ping Li
The aim of this study was to determine whether the lower urinary tract storage symptoms of benign prostatic obstruction (BPO) could be completely resolved after plasmakinetic enucleation of the prostate (PKEP) and the possible predictors of persistent symptoms. Two hundred and sixty-seven cases of BPO performed PKEP from July 2008 to June 2009 were retrospectively analyzed. Five-year postoperative data were collected and compared with the preoperative data. According to the urodynamic results, the patients were divided into involuntary detrusor contraction (IDC) group (n = 95) and no IDC group (n = 172) preoperatively; the patients with IDC were divided into IDC-persistent group (n = 33) and IDC-resolved group (n = 62) after PKEP...
December 2, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27891636/effects-of-pulsed-radiofrequency-neuromodulation-on-the-rat-with-overactive-bladder
#2
En Jen, Tsung-Hsun Hsieh, Tsung-Che Lu, Meng-Chao Chen, Fu-Jung Lee, Chih-Ting Lin, Shih-Ching Chen, Pei-Yi Chu, Chih-Wei Peng, Chii-Wann Lin
AIM: To quantify the effects of pulsed radiofrequency (PRF) electrical stimulations of the pudendal and pelvic nerves on the bladder function of rats with detrusor overactivity. METHODS: All rats were pretreated with a continuous transvesical infusion of 0.5% acetic acid (AA) for inducing detrusor overactivity. Intravesical pressure was recorded using cysometrography (CMG) during the continuous transvesical infusion to examine the effects of PRF electrical stimulation of the pudendal and pelvic nerves individually...
November 28, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27891403/efficacy-of-transcutaneous-electrical-nerve-stimulation-in-the-treatment-of-overactive-bladder
#3
Nidhi Sharma, Kaja Rekha, Krishnamurthy Jayashree Srinivasan
INTRODUCTION: Overactive Bladder (OAB) accounts for 40-70% cases of incontinence. The etiology is unknown though detrusor instability is found in urodynamic evaluation of almost all cases. Detrusor instability or hyperreflexia can be inhibited by direct inhibition of impulses in the pre-ganglionic afferent neuron or by inhibition of bladder pre-ganglionic neurons of the efferent limb of micturition reflex. Transcutaneous Electrical Nerve Stimulation (TENS) is based on the gate control theory of abolishing the local micturition reflex arc...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889830/urinary-retention-in-female-oab-after-intravesical-botox-injection-who-is-really-at-risk
#4
Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut-Miotla, Konrad Futyma, Tomasz Rechberger
INTRODUCTION AND HYPOTHESIS: Intravesical onabotulinumtoxinA (Botox) injections are effective for the treatment of idiopathic overactive bladder (OAB) symptoms. The aim of our study was to assess the predisposing factors for urinary retention in women with OAB after intravesical Botox injection. METHODS: All participants were women of European descent with idiopathic OAB. OnabotulinumtoxinA (100 U) was administered in 20 intra-detrusor injections. Analysis was performed based on the results of safety assessments made during follow-up (FU) visits on weeks 2, 4 and 12, in 208 women who were treated with Botox injections for refractory OAB and who completed all FU visits...
November 26, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27867329/caffeine-as-a-probable-factor-for-increased-risk-of-oab-development-in-elderly-people
#5
Kirill V Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova
OBJECTIVE: This study was conducted to compare overactive bladder (OAB) prevalence among people greater than 60 years of age who intake various doses of caffeine, as well as those who abstain from caffeine. PATIENTS AND METHODS: A randomized observational study was carried out in Vladivostok Gerontological Hospital. A total of 1,098 retired people greater than 60 years of age (659 women and 439 men, average age 67.1 years) took part in the study. They were admitted to the in-patient department with the purpose of annual physical examination performed in accordance with the order of the Ministry of Public Health of the Russian Federation...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27865667/lower-urinary-tract-symptoms-in-parkinson-s-disease-prevalence-aetiology-and-management
#6
REVIEW
Claire McDonald, Kristian Winge, David J Burn
Lower urinary tract symptoms (LUTS) are common in Parkinson's disease (PD), effecting 27-85% of patients with PD. Irritative symptoms predominate and urodynamic studies confirm high prevalence of detrusor overactivity in PD. LUTS are present early in PD and are more common in PD than in age matched controls. The assessment of LUTS in PD is complicated by coexisting bradykinesia and cognitive impairment. Although LUTS become more troublesome as PD progresses it remains unclear if LUTS severity correlates with motor symptoms and/or duration of PD...
November 1, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27846033/brush-cells-the-newly-identified-gatekeepers-of-the-urinary-tract
#7
Wolfgang Kummer, Klaus Deckmann
PURPOSE OF REVIEW: A specialized epithelial cell with chemosensory properties of taste cells known from the mouth has been newly identified in the urethra and linked to pathogen recognition. We here describe its properties and its link to defence mechanisms, showing parallels to similar sentinel cells in the respiratory and gastrointestinal tract. RECENT FINDINGS: In the urethra, slender epithelial cells with apical microvilli ('brush cells') express bitter and umami taste receptors and the downstream signalling cascade known from oropharyngeal gustation, utilizing it to monitor for bacterial products and bacterial growth facilitating conditions...
November 14, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27844406/partial-bladder-outlet-obstruction-is-associated-with-decreased-expression-and-function-of-the-small-conductance-ca-2-activated-k-channel-in-guinea-pig-detrusor-smooth-muscle
#8
Ning Li, Xiaoning He, Zizheng Li, Yili Liu, Ping Wang
PURPOSE: Partial bladder outlet obstruction (PBOO) usually induces overactive bladder (OAB) associated with detrusor overactivity (DO) which is related to the increased contractility of detrusor smooth muscle (DSM). The pharmacological activation of small-conductance Ca(2+)-activated K(+) (SK) channels dramatically attenuates DSM contractility. However, the role of SK channels in the PBOO DSM is less clear. Here, we tested the hypothesis that PBOO is associated with decreased expression and function of SK channels in DSM and that the activation of SK channels is a potential target to regulate DO...
November 14, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27824068/sulforaphane-improves-ischemia-induced-detrusor-overactivity-by-downregulating-the-enhancement-of-associated-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-rat-bladder
#9
Huai-Ching Tai, Shiu-Dong Chung, Chiang-Ting Chien, Hong-Jeng Yu
Atherosclerosis-associated pelvic ischemia has been reported to be a risk factor for bladder dysfunction and subsequent lower urinary tract symptoms (LUTS) in the elderly population. However, the molecular mechanisms of this association remain unclear. We hypothesized that stress-induced cellular responses might play a role in the pathogenesis of ischemia-induced bladder dysfunction. In the present study, the animal model of bladder ischemia was induced by bilateral partial arterial occlusion (BPAO) in rats...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819757/urethral-pressure-variation-a-neglected-contributing-factor-in-patients-with-overactive-bladder-syndrome
#10
Kirschner-Hermanns Ruth, Anding Ralf, Gadzhiev Nariman, Campbell Adele, Goping Ing, Huppertz Nadine
OBJECTIVE: To study urethral pressure variations during the whole filling phase among different groups of patients. MATERIAL AND METHODS: We investigated 79 consecutive patients from January 2011 to June 2012. All patients were recruited within our routine practice in our continence clinic and were evaluated with urodynamic exam according to the standards of the International Continence Society (ICS) with an additional continuous measurement of the urethral pressure profile (cUPP) that was done in a supine position...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27816615/nocturnal-urinary-disorders-in-multiple-sclerosis-clinical-and-urodynamic-study-of-309-patients
#11
Elsa Mauruc, Amandine Guinet-Lacoste, Lætitia Falcou, Philippe Manceau, Delphine Verollet, Frédérique Le Breton, Gérard Amarenco
PURPOSE: The aim of this study was to describe nocturia with or without leakage in a population of patients with multiple sclerosis. MATERIALS AND METHODS: This is a retrospective, single center study of 309 patients with multiple sclerosis who were followed at an experienced neurourology center between 2011 and 2013. All patients had daytime urinary symptoms associated with this disorder. Among the patients with nocturia 2 groups were defined, including those with isolated nocturia but without nocturnal urinary incontinence and patients with nocturia associated with nocturnal urinary incontinence...
November 2, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27816462/-lower-urinary-tract-dysfunction-in-normal-pressure-hydrocephalus-review-of-the-literature
#12
E Bey, B Nicot, O Casez, L Le Normand
INTRODUCTION: Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. The aim of this review article was to discuss diagnostic and therapeutic options for these patients. SOURCES: A literature review of MedLine publications on urinary incontinence in normal pressure hydrocephalus was conducted. The following keywords were used: "hydrocephalus, normal pressure" and "bladder dysfunction" or "urinary incontinence" or "overactive bladder" or "urinary bladder, neurogenic"...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27813141/renal-deterioration-after-spinal-cord-injury-is-associated-with-length-of-detrusor-contractions-during-cystometry-a-study-with-a-median-of-41-years-follow-up
#13
Marlene Elmelund, Niels Klarskov, Per Bagi, Peter S Oturai, Fin Biering-Sørensen
AIMS: To investigate which urodynamic parameters are associated with renal deterioration over a median of 41 years follow-up after traumatic spinal cord injury. METHODS: Medical records of patients with a traumatic spinal cord injury sustained 1944-1975 were reviewed from time of injury until 2012. Patients who attended regular renography and/or renal clearance examinations and had minimum one cystometry and pressure-flow study were included. Renal deterioration was diagnosed as split renal function ≤30% in one kidney or relative glomerular filtration rate ≤51% of expected according to age and gender...
November 4, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27808489/the-role-of-detrusor-overactivity-in-urinary-incontinence-after-radical-prostatectomy-a-systematic-review
#14
Antonio L Pastore, Giovanni Palleschi, Ester Illiano, Alessandro Zucchi, Antonio Carbone, Elisabetta Costantini
INTRODUCTION: The purpose of this review was to assess the evidence provided by Literature regarding the role of detrusor overactivity (DO) in determining urinary incontinence in patients submitted to radical prostatectomy. EVIDENCE ACQUISITION: The research was based on the online PubMed database spanning the period from November 1997 to May 2016.The review was conducted in accordance with the systematic review guidelines provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
November 3, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27794199/long-term-treatment-with-the-beta-3-adrenoceptor-agonist-mirabegron-ameliorates-detrusor-overactivity-and-restores-cyclic-adenosine-monophosphate-camp-levels-in-obese-mice
#15
Fabiano B Calmasini, Mariana G de Oliveira, Eduardo C Alexandre, Fábio H da Silva, Carmem P V da Silva, Tuany Z Candido, Edson Antunes, Fabíola Z Mónica
AIMS: To evaluate the effects of the beta-3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity. METHODS: C57BL/6 male mice were fed with standard chow or high-fat diet for 12 weeks. Lean and obese mice were treated orally with mirabegron (10 mg/kg/day) from the last 2 weeks of diet. Cystometric evaluations, functional assays, protein expression for phosphodiesterase type 4 (PDE4), and cyclic adenosine monophosphate (cAMP) measurement were carried out...
October 29, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27790301/the-use-of-intra-detrusor-onabotulinumtoxina-in-patients-with-myasthenia-gravis
#16
Ian Wright, Andrea Civitarese, Richard Baverstock
The use of intra-detrusor onabotulinumtoxinA (Botox(®)) in patients with myasthenia gravis has not been reported, and little evidence exists to substantiate a complete contraindication of Botox use in this population. Here, we present two cases of comorbid overactive bladder (OAB) and myasthenia gravis successfully treated with intra-detrusor Botox.
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27787187/overactive-bladder-in-women
#17
Julie C Jenks
Overactive bladder in women is a common chronic condition of urinary storage, affecting a significant proportion of the population. It is defined as a symptom diagnosis that indicates lower urinary tract dysfunction, in which patients experience urinary urgency, with or without urge incontinence, usually accompanied by frequency and nocturia. The diagnosis and treatment of overactive bladder are straightforward and systematic in line with national and international guidelines. However, women are required to disclose their bladder symptoms, and be motivated to make changes to their lifestyle to see improvements...
October 26, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27778388/detrusor-overactivity-increases-bladder-wall-thickness-in-male-patients-a-urodynamic-multicenter-cohort-study
#18
Cosimo De Nunzio, Fabrizio Presicce, Riccardo Lombardo, Simon Carter, Carlo Vicentini, Andrea Tubaro
AIMS: To evaluate the role of Bladder wall thickness (BWT) as a predictor of Detrusor overactivity (DO) in patients with Lower urinary tract symptoms (LUTS)/Benign prostatic enlargement without Bladder Outlet Obstruction. METHODS: From January 1996 to December 2000, each new patient, aged 45 years or older with LUTS, underwent standard diagnostic assessment, urodynamic studies (cystometry and pressure flow studies), and ultrasound measurements of the bladder wall thickness (BWT) in two centers...
October 24, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27778361/are-voiding-parameters-a-marker-for-the-severity-of-quality-of-life-impairment-in-women-with-overactive-bladder-symptoms
#19
Maya Basu, Stergios K Doumouchtsis
AIMS: There is evidence of an association between voiding parameters and the presence of overactive bladder symptoms. The aim of this study was to evaluate whether there is any association between pressure flow study parameters and the degree of health related quality of life impairment in women with OAB symptoms. The null hypothesis is that there is no significant correlation between quality of life domain scores and pressure flow study parameters. METHODS: One hundred and sixty-seven consecutive women with overactive bladder symptoms underwent evaluation with a quality of life assessment plus filling and voiding cystometry...
October 24, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27765580/comparison-of-different-antibiotic-protocols-for-asymptomatic-bacteriuria-in-patients-with-neurogenic-bladder-treated-with-botulinum-toxin-a
#20
Ana Claudia Paradella, André Ferraz de Arruda Musegante, Carlos Brites
Intravesical botulinum toxin A (BoNTA) injection has been widely used for the treatment of detrusor overactivity in patients with neurogenic bladder due to spinal cord injury who do not respond to conventional treatment. There is no consensus about antibiotic prophylaxis for this procedure. We conducted a retrospective analysis of medical records of adult patients with spinal cord injury who underwent detrusor BoNTA injection between January of 2007 and December of 2013 in a rehabilitation hospital. Occurrence of symptomatic urinary tract infection (UTI) was assessed in 3 groups in accordance with their use of antibiotics (prophylactic dosage, 3 days, more than 3 days) for the treatment of asymptomatic bacteriuria...
October 18, 2016: Brazilian Journal of Infectious Diseases
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