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https://www.readbyqxmd.com/read/29427214/pharmacotherapy-for-nocturia
#1
REVIEW
Karl-Erik Andersson, Philip Van Kerrebroeck
PURPOSE OF REVIEW: To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria. RECENT FINDINGS: The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria. The multifactorial pathophysiology not only implies several possible targets for therapeutic intervention but also means that it is unlikely that one treatment modality including drugs will be successful in all patients...
February 9, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29414759/proteomic-analysis-of-urothelium-of-rats-with-detrusor-overactivity-induced-by-bladder-outlet-obstruction
#2
Edmond Chankgyun Park, Jae Sung Lim, Seung Il Kim, Sang-Yeop Lee, Yu-Kyung Tak, Chi-Won Choi, Sung-Ho Yun, Joohyun Park, Minji Lee, Hyo Kyun Chung, Koon Soon Kim, Yong Gil Na, Ju Hyun Shin, Gun-Hwa Kim
Overactive bladder (OAB) syndrome is a condition that has four symptoms: urgency, urinary frequency, nocturia, and urge incontinence and negatively affects a patient's life. Recently, it is considered that the urinary bladder urothelium is closely linked to pathogenesis of OAB. However, the mechanisms of pathogenesis of OAB at the molecular level remain poorly understood, mainly as a result of lack of modern molecular analysis. The goal of this study is to identify a potential target protein that could act as a predictive factor for effective diagnosis and aid in the development of therapeutic strategies for the treatment of OAB syndrome...
February 1, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29406911/anti-cholinergic-medications-for-bladder-dysfunction-worsen-cognition-in-persons-with-multiple-sclerosis
#3
Sarah A Morrow, Heather Rosehart, Alp Sener, Blayne Welk
Bladder dysfunction is common in persons with MS (PwMS), often due to detrusor muscle overactivity. Anticholinergic medications are considered the first line treatment for bladder dysfunction and are known to worsen cognition in healthy older adults and in persons with dementia. Yet, it is not known if these medications have the same effect on PwMS. Thus, the Objective of this prospective matched-cohort study was to determine if anticholinergic medications affect objective measures of cognition in PwMS. We recruited PwMS starting either oxybutynin or tolterodine (cases)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29401598/muscarinic-receptors-2-and-5-regulate-bitter-response-of-urethral-brush-cells-via-negative-feedback
#4
Klaus Deckmann, Amir Rafiq, Christian Erdmann, Christian Illig, Melanie Durschnabel, Jürgen Wess, Wolfgang Weidner, Thomas Bschleipfer, Wolfgang Kummer
We have recently identified a cholinergic chemosensory cell in the urethral epithelium, urethral brush cell (UBC), that, upon stimulation with bitter or bacterial substances, initiates a reflex detrusor activation. Here, we elucidated cholinergic mechanisms that modulate UBC responsiveness. We analyzed muscarinic acetylcholine receptor (M1-5 mAChR) expression by using RT-PCR in UBCs, recorded [Ca2+]i responses to a bitter stimulus in isolated UBCs of wild-type and mAChR-deficient mice, and performed cystometry in all involved strains...
January 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29379662/a-comparison-of-normal-and-high-post-void-residual-urine-and-urodynamic-parameters-in-women-with-overactive-bladder
#5
Hediye Dağdeviren, Hüseyin Cengiz, Çağlar Helvacıoğlu, Ulkar Heydarova, Cihan Kaya, Murat Ekin
Objective: To investigate voiding functions and assess the relationships of voiding parameters to overactive bladder symptoms and postvoiding residue volumes. Materials and Methods: This is a retrospective study analyzing urodynamic parameters in patients who were diagnosed as having overactive in our urogynecology clinic between April 2014 and April 2016. A total of 290 women who met the selection criteria were included in the study. The patients were divided into two groups according to postvoiding residue volumes: group 1, postvoiding residue volumes <100 mL (n=135); group 2, postvoiding residue volumes ≥100 mL (n=155)...
December 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29367168/does-vaginal-estriol-make-urodynamic-changes-in-women-with-overactive-bladder-syndrome-and-genitourinary-syndrome-of-menopause
#6
Maria Grazia Matarazzo, Salvatore Caruso, Giuliana Giunta, Gaetano Valenti, Giuseppe Sarpietro, Antonio Cianci
OBJECTIVES: OAB is a common finding in postmenopausal women. Hypoestrogenism is the root cause of many signs and symptoms of Genitourinary Syndrome of Menopause (vaginal dryness, atrophy, dyspareunia, urinary disorders, etc.). As such the aim of this study was to evaluate the urodynamic effects of ultralowdose estriol vaginal gel formulation to treat women with Genitourinary Syndrome of Menopause and Overactive Bladder Syndrome. STUDY DESIGN: This open-labeled, single center, prospective study involved 37 women with OAB recruited in our Urogynecological Unit between January and July 2016...
January 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29357569/re-bladder-wall-thickness-in-women-with-symptoms-of-overactive-bladder-and-detrusor-overactivity-results-from-the-randomised-placebo-controlled-shrink-study
#7
https://www.readbyqxmd.com/read/29354501/predicting-success-after-artificial-urinary-sphincter-which-preoperative-factors-drive-patient-satisfaction-postoperatively
#8
Nathan Chertack, Bradley C Gill, Kenneth W Angermeier, Drogo K Montague, Hadley M Wood
Background: To determine which preoperative factors drive patient-reported quality of life (QoL) after artificial urinary sphincter (AUS) implantation. Methods: Men receiving AUS after prostate cancer treatment were identified from a prospectively collected dataset. Preoperative factors were recorded during the initial incontinence consultation. Patients underwent urodynamic testing (UDS) preoperatively at surgeon discretion. Patients were surveyed by telephone postoperatively and given the EPIC Urinary Domain (EPIC-UD) and Urinary Distress Inventory (UDI-6) questionnaires...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29352989/detrusor-acontractility-after-acute-spinal-cord-injury-myth-or-reality
#9
Mirjam Bywater, Jure Tornic, Ulrich Mehnert, Thomas M Kessler
PURPOSE: We assessed urodynamic parameters within the first 40 days after spinal cord injury (SCI) investigating whether the detrusor is acontractile during the acute phase of SCI. PATIENTS AND METHODS: We performed a prospective cohort study including 54 patients with neurogenic lower urinary tract dysfunction (NLUTD) due to acute SCI undergoing urodynamic investigation (UDI) within the first 40 days after injury at a single university SCI center. RESULTS: and Limitations: Of the 54 patients, UDI revealed an acontractile detrusor in only 20 (37%) but unfavorable urodynamic parameters in a total of 34 (63%) patients...
January 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29341202/risk-factors-for-stress-urinary-incontinence-recurrence-after-single-incision-sling
#10
Stefania Palmieri, Matteo Frigerio, Federico Spelzini, Stefano Manodoro, Rodolfo Milani
AIMS: The aim of the study was to identify in a pure stress urinary incontinence (SUI) population risk factors for recurrence after single-incision slings (SIS). METHODS: This retrospective study analyzed women with complaints of SUI symptoms and urodynamically proven SUI. Exclusion criteria were recurrent SUI, overactive bladder syndrome/detrusor overactivity, preoperative postvoid residual >100 mL, reduced urethral mobility (<10° at the Q-tip test), concomitant anterior prolapse >I stage and previous history of radical pelvic surgery...
January 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29339638/a-nomogram-to-characterize-the-severity-of-detrusor-overactivity-during-the-ice-water-test-description-of-the-method-and-proof-of-concept
#11
André Reitz, Tanja Hüsch, Axel Haferkamp
AIMS: To develop a nomogram with severity categories for detrusor overactivity (DO). METHODS: By conducting ice water tests (IWT) in 55 patients with Parkinson's disease, we identified criteria to describe characteristics of the detrusor pressure curves: (1) a gradient of Δpdet over Δt at the maximum detrusor pressure and (2) the area under the curve. In a nomogram, 10 severity categories of DO were established: 1 and 2 were assigned to group A (mild), 3 and 4 to group B (moderate) and 5-10 to group C (severe)...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#12
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29299824/the-value-of-synchro-cystourethrometry-for-evaluating-the-relationship-between-urethral-instability-and-overactive-bladder
#13
Chaoyang Hua, Yibo Wen, Yan Zhang, Quande Feng, Xiangfei He, Yunlong Li, Junwei Wu, Jinjin Feng, Stuart B Bauer, Jianguo Wen
PURPOSE: To investigate the correlation between urethral instability (URI) and overactive bladder (OAB) in children. METHODS: We retrospectively investigated 126 children with OAB and 36 children without OAB using synchro-cystourethrometry. The prevalence of detrusor overactivity (DO) and URI, and the diagnostic sensitivity of DO alone and DO combined with URI, was compared. The OAB children with URI voluntarily received transcutaneous electrical pudendal nerve stimulation with anisodamine (stimulation group, SG) or anisodamine alone (non-stimulation group, NSG)...
January 3, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29298467/impact-of-preoperative-patient-characteristics-and-flow-rate-on-failure-early-complications-and-voiding-dysfunction-after-a-transobturator-tape-procedure-a-multicentre-study
#14
Andrea Cocci, Giovanni E Cacciamani, Giorgio Ivan Russo, Maria Angela Cerruto, Martina Milanesi, Luis G Medina, Sebastiano Cimino, Walter Artibani, Giuseppe Morgia, Marco Carini, Vincenzo Li Marzi
PURPOSE: To evaluate the impact of preoperative patient characteristics and flow rate on failure, early postoperative complications, and voiding in patients who underwent transvaginal tension-free vaginal tape-obturator (TVT-O) treatment for uncomplicated stress urinary incontinence (SUI). METHODS: We retrospectively reviewed patients who underwent TVT-O for SUI at 3 Italian centres. The exclusion criteria were predominant voiding and storage symptoms suggestive of detrusor overactivity, the presence of grade >1 urogenital prolapse, previous pelvic radiotherapy or other clinical contraindications for surgical procedures, neurogenic bladder dysfunction, and collagen diseases...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298465/near-normalized-gene-expression-profiles-in-bladder-with-detrusor-overactivity-in-rats-with-bladder-outlet-obstruction-after-deobstruction
#15
Tack Lee, U-Sung Lim, Dong Hyuk Kang, Hae-Do Jung, Hyunzu Kim, Bo-Hwa Choi, Ju-Hee Kang, Sang-Min Yoon, Chang-Shin Park
PURPOSE: The pathophysiological role of detrusor overactivity (DO) in the bladder, which is commonly observed in various bladder diseases, is not well understood. DO appears in bladder outlet obstruction (BOO), and may continue even after subsequent deobstruction. DO therefore provides an excellent opportunity to observe molecular biological changes. METHODS: In this study, to understand the molecular effects of persistent DO after BOO induction and deobstruction, we performed awake cystometry on female Sprague-Dawley rats divided into 4 groups: a sham group, a BOO group, a deobstructed group with DO after BOO (DDO), and a deobstructed group without DO after BOO (non-DDO)...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29291418/interrater-reliability-in-interpretation-of-neuropathic-pediatric-urodynamic-tracings-an-expanded-multi-center-study
#16
Anne G Dudley, Mark C Adams, John W Brock, Douglass B Clayton, David B Joseph, Chester J Koh, Paul A Merguerian, John C Pope, Jonathan C Routh, John C Thomas, Duong D Tu, M Chad Wallis, John S Wiener, Elizabeth B Yerkes, Chelsea J Lauderdale, Chevis N Shannon, Stacy T Tanaka
INTRODUCTION: and Objectives: Urodynamics often guide treatment of neuropathic bladder and are reported as objective data points in multi-institutional trials. Urodynamic interpretation, however, can be variable. In a pilot study, pediatric urologists interpreting videourodynamics (VUDS) showed only moderate agreement despite similar training and practice patterns. We hypothesized the pilot study variability would be replicated in a multi-institutional study. METHODS: We developed an anonymous electronic survey that contained twenty scenarios, each with a brief patient history, one urodynamic tracing and fluoroscopic image...
December 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29284441/expression-of-cannabinoid-1-and-2-receptors-and-the-effects-of-cannabinoid-1-and-2-receptor-agonists-on-detrusor-overactivity-associated-with-bladder-outlet-obstruction-in-rats
#17
Sung Dae Kim, Kang Jun Cho, Joon Chul Kim
BACKGROUND: This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats. METHODS: Male Sprague Dawley rats were randomly assigned to four groups (n = 10) in each group. The control group comprised sham-operated rats. A animals in the BOO, CB1 agonist and CB2 agonist groups all underwent BOO surgery. Three weeks postoperatively, cystometrography (CMG) was performed on all rats...
December 29, 2017: BMC Urology
https://www.readbyqxmd.com/read/29279877/definition-and-symptoms-of-underactive-bladder
#18
REVIEW
Alan D Uren, Marcus J Drake
Underactive bladder (UAB) is a symptom syndrome reflecting the urodynamic observation of detrusor underactivity (DU), a voiding contraction of reduced strength and/or duration, leading to prolonged or incomplete bladder emptying. An International Continence Society Working Group has described UAB as characterised by a slow urinary stream, hesitancy and straining to void, with or without a feeling of incomplete bladder emptying and dribbling, often with storage symptoms. Since DU often coexists with bladder outlet obstruction, or storage dysfunction (detrusor overactivity or incontinence), the exact contribution of the DU to the presenting complaints can be difficult to establish...
December 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29275144/case-presentation-botox-versus-nerve-stimulation
#19
R J A van Moorselaar, Jakko A Nieuwenhuijzen
A woman experiencing very strong urgency and associated frequency of micturition, but no incontinence, and deep dyspareunia was eventually diagnosed with idiopathic detrusor overactivity with symptoms of overactive bladder symptom complex and potentially bladder pain syndrome. A trial of neuromodulation was unsuccessful, but injections of onabotulinum toxin A have had a good effect.
December 20, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29273299/-self-intermittent-catheterization-and-urinary-retentions-in-parkinsonian-syndromes
#20
E Savard, A Declemy, V Coindreau, F Babany, C Chesnel, A Charlanes, F Le Breton, G Amarenco
INTRODUCTION: Lower urinary tract symptoms are common in Parkinson diseases, especially chronic urinary retention. In case of significant and symptomatic postvoid residual, a specific treatment is necessary in order to empty the bladder and nowadays the gold standard of such neurogenic bladder is based on self-intermittent-catheterizations, if possible at all. We carried out a retrospective study about feasibility and outcomes of self-intermittent-catheterizations in this population. METHODS: Retrospective study with qualitative and quantitative, clinical and instrumental (urodynamic) assessment, of lower urinary tract symptoms as urinary retention in extrapyramidal syndromes...
December 19, 2017: Progrès en Urologie
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