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Detrusor overactivity

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https://www.readbyqxmd.com/read/29665997/lower-urinary-tract-symptoms-what-s-new-in-medical-treatment
#1
REVIEW
Benoit Peyronnet, Benjamin M Brucker, Martin C Michel
CONTEXT: Pharmacological treatment is a cornerstone in the management of patients with lower urinary tract symptoms (LUTS). OBJECTIVE: To review emerging evidence in the medical treatment of LUTS. EVIDENCE ACQUISITION: An Embase/Pubmed-based literature search was conducted in December 2017, screening for randomized controlled trials (RCTs), prospective and retrospective series, animal model studies, and reviews on medical treatment of LUTS...
April 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29653162/inconsistency-in-the-definition-of-urinary-tract-infection-after-intravesical-botulinum-toxin-a-injection-a-systematic-review
#2
Andrew W Stamm, Sarah A Adelstein, Andrew Chen, Alvaro Lucioni, Kathleen C Kobashi, Una J Lee
PURPOSE: In order to more accurately examine the rate of urinary tract infection following onabotulinumtoxinA injection of the bladder, we systematically reviewed the literature for definitions of urinary tract infection utilized in series that reported on onabotulinumtoxinA injections and assessed them for consistency with guideline statements defining urinary tract infections. MATERIALS AND METHODS: A systematic review of the literature was performed via query using MEDLINE and EMBASE...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29650001/prediction-of-autonomic-dysreflexia-during-urodynamics-a-prospective-cohort-study
#3
Matthias Walter, Stephanie C Knüpfer, Jacquelyn J Cragg, Lorenz Leitner, Marc P Schneider, Ulrich Mehnert, Andrei V Krassioukov, Martin Schubert, Armin Curt, Thomas M Kessler
BACKGROUND: Autonomic dysreflexia is a severe and potentially life-threatening condition in patients with spinal cord injury, as it can lead to myocardial ischemia, brain hemorrhage, or even death. Urodynamic investigation is the gold standard to assess neurogenic lower urinary tract dysfunction due to spinal cord injury and reveal crucial pathological findings, such as neurogenic detrusor overactivity. However, neurogenic detrusor overactivity and urodynamic investigation are known to be leading triggers of autonomic dysreflexia...
April 13, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29643467/potential-orphan-drug-therapy-of-intravesical-liposomal-onabotulinumtoxin-a-for-ketamine-induced-cystitis-by-mucosal-protection-and-anti-inflammation-in-a-rat-model
#4
Wei-Chia Lee, Chia-Hao Su, You-Lin Tain, Cheng-Nan Tsai, Chun-Chieh Yu, Yao-Chi Chuang
Ketamine abusers may develop ulcerative cystitis and severe lower urinary tract symptoms, which is a medical dilemma. Recently, researchers have found the endemic of ketamine-induced cystitis worldwide. The intravesical administration of liposome-encapsulated onabotulinumtoxinA (Lipotoxin) might facilitate the healing of the damaged urothelium from liposomes, and reduce the urinary symptoms by onabotulinumtoxinA-induced chemo-denervation. Using female Sprague-Dawley rats, we investigated the effects of Lipotoxin on ketamine-induced cystitis...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642368/re-effectiveness-of-btx-a-and-neuromodulation-in-treating-oab-with-or-without-detrusor-overactivity-a-systematic-review
#5
Alan J Wein
No abstract text is available yet for this article.
April 2018: Journal of Urology
https://www.readbyqxmd.com/read/29617074/evaluation-of-urodynamic-parameters-after-sling-surgery-in-men-with-post-prostatectomy-urinary-incontinence
#6
Odair Gomes Paiva, João Paulo Cunha Lima, Carlos Alberto Bezerra
OBJECTIVE: To evaluate urodynamic alterations after sub-urethral sling surgery (SSU) in patients with post-prostatectomy urinary incontinence (PPUI). MATERIALS AND METHODS: We evaluated data of 22 patients submitted to radical prostatectomy (RP) or transurethral resection of prostate (TURP) that presented post-surgical urinary incontinence and were treated with SSU implant in a pilot study previously performed in our institution. METHODS: Those patients with PPUI were evaluated by urodynamic exam (UD) before and after surgery, and the parameters were compared, including uroflow, cystometry and micturition study...
January 25, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29608019/comparison-of-urodynamics-and-perineal-ultrasonography-for-the-diagnosis-of-mixed-urinary-incontinence-in-women
#7
Yang Hu, Yelin Lou, Limin Liao, Min Xu, Heng Zhang, Qing Yang, Haixiao Wu
OBJECTIVES: This study aimed to compare urodynamic studies (UDS) and perineal ultrasonography (US) for the assessment of mixed urinary incontinence (MUI) in women in China. METHODS: Adult women with MUI and healthy control participants were enrolled from 2 centers in China (Zhejiang and Beijing) between September 2010 and April 2017. Baseline clinical characteristics were recorded. The MUI type was categorized by the King's Health Questionnaire: stress-predominant, urge-predominant, or equal predominance...
April 2, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29603781/efficacy-and-safety-of-mirabegron-for-the-treatment-of-neurogenic-detrusor-overactivity-prospective-randomized-double-blind-placebo-controlled-study
#8
Jan Krhut, Vladimír Borovička, Karolína Bílková, Radek Sýkora, David Míka, Jan Mokriš, Roman Zachoval
AIMS: To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity. METHODS: This prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in three tertiary centers, and included 78 patients suffering from spinal cord injury or multiple sclerosis. Patients were randomized for Mirabegron 50 mg (Group A) or placebo (Group B). Urodynamic parameters, the 24 h pad-weight test, and patient-reported outcomes were assessed...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29603776/selective-bladder-denervation-for-overactive-bladder-oab-syndrome-from-concept-to-healing-outcomes-using-the-ovine-model
#9
James Fugett, Lynette Phillips, Emily Tobin, Eric Whitbrook, Haydon Bennett, Joshua Shrout, James E Coad
AIMS: We evaluated a Selective Bladder Denervation (SBD) device, which uses radiofrequency ablation, for the treatment of overactive bladder syndrome in terms of its nerve denervation, ablation characteristics, and post-treatment healing. METHODS: Using the SBD device, eight fresh extirpated ovine bladder trigones were treated (90°C set point for 60 s) and nitroblue tetrazolium viability stained to characterize the ablation. In addition, 12 trigones were treated in vivo with three adjacent ablations and divided into survival cohorts: Day 7, Day 30, and Day 90 to assess the ablations and their associated healing...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29580270/overactive-bladder-induces-transient-hypertension
#10
Kazumasa Torimoto, Yoshihiro Matsumoto, Daisuke Gotoh, Yosuke Morizawa, Makito Miyake, Shoji Samma, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto
OBJECTIVES: Several studies have shown the relationship between lower urinary tract symptoms and autonomic imbalance. We investigated the relationship between detrusor overactivity (DO) or urgency, and transient increase in blood pressure as a type of hypertension related to sympathetic hyperactivity. Study 1: we enrolled 14 male patients with DO and 10 without DO. We measured the overactive bladder symptom score (OABSS) and blood pressure during cystometry. Study 2: we enrolled 14 men patients with overactive bladder (OAB) and 8 without OAB...
March 27, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29528972/the-role-of-urodynamics-in-the-surgical-management-of-benign-prostatic-obstruction
#11
Matthew G Crockett, Marcus J Drake
PURPOSE OF REVIEW: Benign prostatic obstruction (BPO) is a common cause of lower urinary tract symptoms (LUTS) in elderly men. However, such symptoms are often caused by primary detrusor overactivity or underactivity. Surgical management where BPO is absent or merely incidental has a lower chance of success, and exposes the patient to the potential complications of surgery. This review discusses the diagnostic challenges facing this common presentation. RECENT FINDINGS: Most evidence comes from small, historical prospective cohort studies...
May 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29527818/vascular-fibrinoid-necrosis-in-the-urinary-bladder-of-ketamine-abusers-a-new-finding-that-may-provide-a-clue-to-the-pathogenesis-of-ketamine-induced-vesicopathy
#12
Yen-Chang Chen, Jia-Fong Jhang, Yung-Hsiang Hsu, Hann-Chorng Kuo
Two 31-year-old women who had abused ketamine, 1 for 8 years and 1 for 5 years, presented with ketamine-induced vesicopathy with urinary frequency, decreased bladder capacity, and detrusor overactivity. An enterocystoplasty was performed in both cases. The pathology of the urinary bladders in both women showed ulcerative cystitis and fibrinoid necrosis of vessels; the latter was confirmed by Masson trichrome staining. Fibrinoid necrosis of vessels is a kind of immune complex-mediated vasculitis that induces the release of inflammatory mediators, with subsequent thrombosis, ischemic injury, and eventual tissue necrosis in localized areas, the so-called Arthus reaction...
March 11, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29522865/intra-detrusor-injections-of-botulinum-toxin-type-a-in-children-with-spina-bifida-a-multicenter-study
#13
Juliette Hascoet, Benoit Peyronnet, Véronique Forin, Maximilien Baron, Grégoire Capon, Thomas Prudhomme, Clément Allenet, Simon Tournier, Charlotte Maurin, Jean-Nicolas Cornu, Ourdia Bouali, Matthieu Peycelon, Alexis Arnaud, Mariette Renaux-Petel, Agnès Liard, Gilles Karsenty, Andrea Manunta, Xavier Game
OBJECTIVE: To assess the effectiveness of Intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida. PATIENTS AND METHODS: All patients aged under 16 year-old who underwent IDBTX-A between 2002 and 2016 at six institutions were included in a retrospective study. Our primary endpoint was the success rate of IDBTX-A defined as both clinical improvement (no incontinence episodes between clean-intermittent catheterization (CIC), absence of urgency, less than 8 CIC per day)) and urodynamic improvement (resolution of derusor overactivity, normal bladder compliance for age) lasting ≥ 12 weeks...
March 6, 2018: Urology
https://www.readbyqxmd.com/read/29516546/the-effect-of-neutralization-of-nerve-growth-factor-ngf-on-bladder-and-urethral-dysfunction-in-mice-with-spinal-cord-injury
#14
Naoki Wada, Takahiro Shimizu, Nobutaka Shimizu, William C de Groat, Anthony J Kanai, Pradeep Tyagi, Hidehiro Kakizaki, Naoki Yoshimura
AIMS: To investigate the role of nerve growth factor (NGF) in lower urinary tract dysfunction in mice with spinal cord injury (SCI). METHODS: Using 4-week SCI mice, single-filling cystometry and external urethral sphincter (EUS)-electromyography were performed under an awake condition. In some SCI mice, anti-NGF antibodies (10 µg/kg/h) were administered for 1 or 2 weeks before the urodynamic study. NGF levels in the bladder and L6/S1 spinal cord were assayed by ELISA...
March 8, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29508446/predicting-a-successful-outcome-in-sacral-neuromodulation-testing-are-urodynamic-parameters-prognostic
#15
Richard P Nobrega, Eskinder Solomon, Julie Jenks, Tamsin Greenwell, Jeremy Ockrim
AIMS: To assess whether the urodynamic parameters of mean voided volume, peak detrusor overactivity (DO) pressure, bladder compliance, capacity, and volume at first detrusor overactivity during filling cystometry can predict a successful outcome at first stage tined lead placement (FSTLP). METHODS: Ninty-nine consecutive patients with urodynamically proven idiopathic detrusor overactivity (IDO) refractory to medical treatment and opting for Sacral Nerve Stimulation (SNS), were assessed pre and post FSTLP...
March 6, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29494684/neurogenic-bladder-findings-in-patients-with-congenital-zika-syndrome-a-novel-condition
#16
Lucia Maria Costa Monteiro, Glaura Nisya de Oliveira Cruz, Juliana Marin Fontes, Tania Regina Dias Saad Salles, Marcia Cristina Bastos Boechat, Ana Carolina Monteiro, Maria Elizabeth Lopes Moreira
INTRODUCTION: Congenital Zika Syndrome (CZS) has been associated with microcephaly and other central nervous system abnormalities including areas that have been implicated in the control of the lower urinary tract. As such, this descriptive case series has aimed to investigate whether CZS is linked with neurogenic bladder. Identifying such an association is paramount in the effort to recognize CZS complications that have putative treatment options that could mitigate the impact of CZS in infected children...
2018: PloS One
https://www.readbyqxmd.com/read/29489983/pelvic-floor-muscle-training-for-overactive-bladder-symptoms-a-prospective-study
#17
Fátima Fitz, Marair Sartori, Manoel João Girão, Rodrigo Castro
INTRODUCTION: Pelvic floor muscle training (PFMT) involves the contraction of the puborectal, anal sphincter and external urethral muscles, inhibiting the detrusor contraction, what justify its use in the treatment of overactive bladder (OAB) symptoms. OBJECTIVE: To verify the effects of isolated PFMT on the symptoms of OAB. METHOD: Prospective clinical trial with 27 women with mixed urinary incontinence (MUI), with predominance of OAB symptoms and loss ≥ 2 g in the pad test...
December 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29485034/the-use-of-urodynamic-studies-for-the-followup-of-neurogenic-bladders-treated-with-onabotulinumtoxina
#18
Michelle Bergeron, Genevieve Nadeau, Katherine Moore
INTRODUCTION: Intradetrusor injections of onabotulinumtoxinA (BoNTA) is well-established as treatment for patients with neurogenic bladders. Urodynamics (UDS) are used at regular intervals during followup to monitor intravesical pressure. With regards to the discomfort and risks associated with UDS, our objective was to assess if UDS done at regular intervals in the followup of neurogenic bladders treated with BoNTA had an impact on management. METHODS: We retrospectively analyzed the medical records of adult patients with neurologic disorders treated with BoNTA for either detrusor overactivity or low bladder compliance at the Institut de Réadaptation en Déficience Physique de Québec (IRDPQ)...
February 23, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29482913/single-onabotulinumtoxina-200u-dose-improved-clinical-symptoms-but-not-urothelial-dysfunction-in-neurogenic-detrusor-overactivity-due-to-spinal-cord-injury
#19
Sheng-Fu Chen, Yuan-Hong Jiang, Hann-Chorng Kuo
OBJECTIVE: To evaluate the changes in urothelial dysfunction protein expressions in bladder after onabotulinumtoxin injection and correlate that with clinical outcomes in spinal cord injury (SCI) patients. METHODS: Twenty-six patients with neurogenic detrusor overactivity (NDO) and urinary incontinence due to suprasacral SCI were treated with onabotulinumtoxinA 200U detrusor injection. Urodynamic studies and bladder biopsies were obtained at baseline, 3, and 6 months after treatment...
February 23, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29482891/early-experimental-results-of-using-a-novel-delivery-carrier-hyaluronan-phosphatidylethanolamine-ha-pe-which-may-allow-simple-bladder-instillation-of-botulinum-toxin-a-as-effectively-as-direct-detrusor-muscle-injection
#20
Mohamed Galal El Shatoury, Ling DeYoung, Eva Turley, Arjang Yazdani, Sumit Dave
INTRODUCTION: Botulinum toxin A (BTX-A) is a neurotoxin that inhibits acetylcholine release by cleaving cytosolic synaptosome-associated protein 25 (SNAP-25) and results in bladder relaxation. A BTX-A intravesical injection has been established as an effective option for treating detrusor overactivity. STUDY DESIGN: Sixty female Sprague Dawley rats were equally divided into control and experimental groups. Control Groups 1 to 3 received: BTX-A 10 units + saline instillation; hyaluronan-phosphatidylethanolamine (HA-PE) 0...
December 30, 2017: Journal of Pediatric Urology
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