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Detrusor overactivity

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https://www.readbyqxmd.com/read/28208214/pathogenesis-of-enuresis-towards-a-new-understanding
#1
REVIEW
Tryggve Nevéus
Enuresis was historically viewed as a primarily psychiatric disorder, but this understanding has changed dramatically since the end of the last century, when it became clear that somatic factors, such as nocturnal polyuria as a result of vasopressin deficiency, nocturnal detrusor overactivity and high arousal thresholds, all play a crucial role in enuresis pathogenesis. It has also become clear that enuresis is inherited in the majority of cases, although the correlation between genotype and enuretic phenotype is not straightforward...
February 16, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28198657/genital-nerve-stimulation-increases-bladder-capacity-after-sci-a-meta-analysis
#2
Dennis J Bourbeau, Graham H Creasey, Steven Sidik, Steven W Brose, Kenneth J Gustafson
BACKGROUND: Neurogenic detrusor overactivity (NDO) often results in decreased bladder capacity, urinary incontinence, and vesico-ureteral reflux. NDO can trigger autonomic dysreflexia and can impair quality of life. Electrical stimulation of the genital nerves (GNS) acutely inhibits reflex bladder contractions and can increase bladder capacity. Quantifying the effect of GNS on bladder capacity and determining what study factors and subject factors influence bladder capacity improvements will inform the design of clinical GNS interventions...
February 15, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28197002/an-exploratory-study-for-bladder-dysfunction-in-atypical-antipsychotic-emergent-urinary-incontinence
#3
Preeti Sinha, Anupam Gupta, V Senthil Kumar Reddi, Chittaranjan Andrade
INTRODUCTION: This is an exploratory study, which aimed to analyze urodynamic findings in patients who are on atypical antipsychotics and present with urinary incontinence (UI) in order to understand the mechanisms of antipsychotic-emergent UI. PATIENTS AND METHODS: Eight patients (34 ± 7.6 years; five males and three females) diagnosed with schizophrenia or other psychotic disorders, who were on risperidone, olanzapine, or clozapine monotherapy and having UI were recruited...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28195356/efficacy-of-onabotulinum-toxin-a-injection-in-pediatric-patients-with-non-neurogenic-detrusor-overactivity
#4
Omer Bayrak, Erkan Sadioglu, Haluk Sen, Kazim Dogan, Sakip Erturhan, Ilker Seckiner
AIMS: To evaluate the effectiveness and reliability of onabotulinum toxin A (onaBoNT-A) injections in pediatric patients with non-neurogenic detrusor overactivity (NNDO). METHODS: Between January 2010 and February 2016, 39 patients underwent onaBoNT-A injections for NNDO, and were evaluated retrospectively. Three-day voiding diary was filled at baseline, and at the postoperative 9th month. The voiding frequency, incontinence episodes, and the cystometric capacity were noted...
February 14, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28194560/a-comparative-study-of-electroacupuncture-at-zhongliao-bl33-and-other-acupoints-for-overactive-bladder-symptoms
#5
Likun Yang, Yang Wang, Qian Mo, Zhishun Liu
Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detecting urodynamics in eight groups: no intervention group, D-BL33 group (deep needling at BL33), S-BL33 group (shallow needling at BL33), non-acupoint group (needling at the non-acupoint next to BL33), Weizhong (BL40) group, Sanyinjiao (SP6) group, Tongtian (BL7) group, and Hegu (LI4) group...
February 14, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28185483/genital-nerve-stimulation-is-tolerable-and-effective-for-bladder-inhibition-in-sensate-individuals-with-incomplete-sci
#6
Steven W Brose, Dennis J Bourbeau, Kenneth J Gustafson
BACKGROUND: Neurogenic detrusor overactivity after spinal cord injury (SCI) causes urinary incontinence and reduces bladder capacity. Surface electrical genital nerve stimulation (GNS) acutely inhibits reflex bladder contractions. The stimulation amplitude selected for GNS is typically twice the amplitude that is required to evoke the pudendal-anal reflex. There is concern about the ability of persons with sensation to comfortably tolerate effective levels of GNS. The objective of this work is to determine if persons with incomplete SCI are able to tolerate acute GNS for bladder inhibition...
February 10, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28176494/ultrasound-bladder-wall-thickness-and-detrusor-overactivity-a-multicentre-test-accuracy-study
#7
P Latthe, L Middleton, S Rachaneni, S McCooty, J Daniels, A Coomarasamy, M Balogun, J Duckett, R Thakar, I Goranitis, T Roberts, J Deeks
OBJECTIVE: Women with overactive bladder (OAB) often undergo urodynamics before invasive treatments are considered. Ultrasound measurement of bladder wall thickness (BWT) is a less invasive, less expensive and widely available test. It has the potential to diagnose the presence of detrusor overactivity (DO). We aimed to evaluate the accuracy of BWT in the diagnosis of DO. DESIGN: Prospective cohort study. SETTING: Twenty-two UK clinics (university and district general hospitals)...
February 7, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28168811/transobturator-tape-operation-for-the-treatment-of-stress-urinary-incontinence-in-postmenopausal-women-aged-over-65%C3%A2-years
#8
Cenk Yasa, Funda Gungor Ugurlucan, Ozlem Dural, Harika Yumru, Cansu Gunaydin, Onay Yalcin
OBJECTIVE: We compared success rates and complication rates in women aged less then and equal to or more than 65 years who had undergone transobturator tape (TOT) surgery for stress urinary incontinence (SUI). METHODS: This was a retrospective cohort study that included patients who underwent surgery to treat SUI. We separated patients into two groups according to age: younger than 65 years and equal to or older than 65 years. Exclusion criteria were patients with history of incontinence surgery, history of radical pelvic surgery, concomitant pelvic organ prolapse repair, detrusor overactivity, and less than 1 year of postoperative follow-up...
February 6, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28159850/protocol-for-a-prospective-observational-study-of-cortical-lower-urinary-tract-control-changes-following-intradetrusor-injection-of-botulinum-toxin-a-in-patients-with-multiple-sclerosis
#9
Rodolfo A Elizondo, Christof Karmonik, Timothy B Boone, Rose Khavari
INTRODUCTION: Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor physical therapy are unsuccessful, intradetrusor injection of botulinum toxin-A (OnaBotA; Botox Allergan, Dublin, Ireland) is a highly effective option for these patients...
February 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28159527/cystometrogram-appearance-in-puv-is-reliably-quantified-by-the-shape-wall-reflux-and-diverticuli-swrd-score-and-presages-the-need-for-intervention
#10
A Niyogi, K Lumpkins, A Robb, L McCarthy
OBJECTIVE: Radiological bladder abnormalities in boys with posterior urethral valves (PUV) are well recognised; however, the assessment is subjective. The shape, wall, reflux and diverticuli (SWRD) score objectively assesses shape, wall, reflux and diverticuli in a simple way. This study was undertaken to demonstrate that the SWRD score is reliable, reproducible and correlates with bladder outcome and videourodynamic (VUD) assessment in boys with PUV. MATERIALS AND METHODS: Three blinded assessors determined the SWRD scores of PUV bladders from cystometrograms taken during VUD from September 2012 to October 2013...
January 12, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28149080/urodynamic-profile-in-acute-transverse-myelitis-patients-its-correlation-with-neurological-outcome
#11
Anupam Gupta, Sushruth Nagesh Kumar, Arun B Taly
OBJECTIVE: The objective of this study was to observe urodynamic profile of acute transverse myelitis (ATM) patients and its correlation with neurological outcome. PATIENTS AND METHODS: This prospective study was conducted in the neurorehabilitation unit of a tertiary university research hospital from July 2012 to June 2014. Forty-three patients (19 men) with ATM with bladder dysfunction, admitted in the rehabilitation unit, were included in this study. Urodynamic study (UDS) was performed in all the patients...
January 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28139104/-animated-biofeedback-for-the-dysfunctional-voiding-syndrome
#12
M Fernández Ibieta, M J Guirao Piñera, G Zambudio Carmona, J Rojas Ticona, I Martínez Castaño, V Villamil, A Sánchez Sánchez, A García López, P Reyes Ríos, J I Ruiz Jiménez
OBJECTIVES: To analyze clinical and electromyographic treatment outcome of dysfunctional voiding (DV) with animated Biofeedback (Bfb). Clinical or electromyographic variables associated with higher success rate were checked. PATIENTS AND METHODS: Cross-sectional study of patients with DV, that in 2010- 2015 followed animated Bfb program. Efficacy was measured with Uroflowmetry, Electromyography (EMG) and validated clinical questionnaire. Inclusion criteria: no myelodysplasia, no anatomical malformations and a minumin of 3 Bfb sessions...
April 10, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28139068/positive-outcomes-with-first-onabotulinumtoxina-treatment-persist-long-term-with-repeat-treatments-in-patients-with-neurogenic-detrusor-overactivity
#13
Pierre Denys, Roger Dmochowski, Philip Aliotta, David Castro-Diaz, Bertil Blok, Karen Ethans, Tamer Aboushwareb, Andrew Magyar, Michael Kennelly
OBJECTIVE: To examine whether response to first treatment with onabotulinumtoxinA is predictive of long-term treatment outcome in neurogenic detrusor overactivity (NDO) patients. PATIENTS AND METHODS: NDO patients in a 3-year extension study (following a 52-week phase 3 study) received onabotulinumtoxinA 'as needed' based on fulfilment of prespecified retreatment criteria. This post-hoc analysis included patients who received only the 200U dose during the phase 3 and extension studies...
January 31, 2017: BJU International
https://www.readbyqxmd.com/read/28120449/correlation-between-advanced-glycation-end-products-lower-urinary-tract-symptoms-and-bladder-dysfunctions-in-patients-with-type-2-diabetes-mellitus
#14
Alessandro Galì, Giuseppe Mucciardi, Salvatore Butticè, Enrica Subba, Carmela D'Amico, Francesco Lembo, Carlo Magno
OBJECTIVES: To explore whether serum and urinary advanced glycation end-products (AGEs) are related to urinary symptoms and bladder dysfunctions in diabetic patients. METHODS: Forty-seven patients with type 2 Diabetes mellitus (T2DM) and lower urinary tract symptoms (LUTS) were enrolled. LUTS evaluation was performed by IPSS (International Prostatic Symptoms Score), QoL (quality of life), OAB (overactive bladder). ICI-SF (International Consultation on Incontinence - short form) quaestionneires; ultrasound examination, evaluation of postvoid residual (PVR), uroflowmetry, cystometry with pressure-flow study (PFS) were performed to detect bladder dysfunctions...
January 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28119887/botulinum-toxin-in-spinal-cord-injury-patients-with-neurogenic-detrusor-overactivity
#15
Young Sam Cho, Khae Hawn Kim
Evidence for the efficacy and safety of intravesical onabotulinum toxin A (onabotA) injections has led to them being licensed in many countries, including Korea, for the treatment of patients with urinary incontinence due to neurogenic detrusor overactivity (NDO) resulting from spinal cord injury or multiple sclerosis who are refractory or intolerant to anticholinergic medications. OnabotA injections have an inhibitory effect on acetylcholine release for up to 10 months, with a recommended dose of 200 U. OnabotA treatment has a beneficial effect not only on urinary symptoms, but also on quality of life...
December 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28107730/systemic-atherosclerosis-and-voiding-symptom
#16
A Ozgur Yeniel, A Mete Ergenoglu, Reci Meseri, Anıl Ari, Ceren Sancar, Ismail Mete Itil
OBJECTIVE: To evaluate the effect of atherosclerosis on the storage and voiding symptoms of the bladder in women with overactive bladder (OAB). STUDY DESIGN: We retrospectively reviewed the charts of women with OAB who were evaluated between 2013 and 2015 in our urogynecology unit. Charts were assessed for history, examination findings, urinary diary, quality of life (QOL) questionnaires, urodynamic studies (UDSs), and four main risk factors for atherosclerosis: hypertension, diabetes mellitus, smoking, and hyperlipidemia...
January 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28097266/the-effect-of-posture-and-repetition-on-urodynamic-parameters-a-prospective-randomized-study
#17
Ho Joon Jeon, Min Soo Choo, Seung-June Oh
PURPOSE: To evaluate the effect of posture and repetition of filling cystometry on urodynamic parameters. MATERIALS AND METHODS: Seventy-one men with benign prostatic hyperplasia participated in a urodynamic study between September 2015 and August 2016 and were randomly assigned to a supine to supine (group SS, n=16), erect to erect (group EE, n=16), supine to erect (group SE, n=19) or erect to supine (group ES, n=20) group. The patients underwent filling cystometry twice...
January 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28090659/the-effect-of-intradetrusor-botulinum-neurotoxin-type-a-on-urinary-ngf-tgf-beta-1-timp-2-levels-in-children-with-neurogenic-detrusor-overactivity-due-to-myelodysplasia
#18
Tuncay Top, Cagri Akin Sekerci, Banu Isbilen-Basok, Yiloren Tanidir, Ilker Tinay, Ferruh Kemal Isman, Cem Akbal, Ferruh Simsek, Tufan Tarcan
AIMS: The aim of this study was to determine the value of urine nerve growth factor (NGF), transforming growth factor beta 1 (TGF-Beta-1), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) levels to predict the urodynamic profile before and after botulinum neurotoxin type A (BoNT-A) treatment in children with myelodysplasia. METHODS: This prospective study included 15 children with myelodysplasia who underwent intradetrusor BoNT-A injections due to neurogenic detrusor overactivity (NDOA)...
January 16, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28089606/parasacral-transcutaneous-electrical-neural-stimulation-ptens-once-a-week-for-the-treatment-of-overactive-bladder-in-children-a-randomized-controlled-trial
#19
Lidyanne Ilidia da Silva de Paula, Liliana Fajardo de Oliveira, Brysa Paiva Cruz, Dayana Maria de Oliveira, Laís Maini Miranda, Mauro de Moraes Ribeiro, Raphaela Ornellas Duque, André Avarese de Figueiredo, José de Bessa, José Murillo Bastos Netto
INTRODUCTION: Overactive bladder (OAB) is the most prevalent voiding disorder in childhood, and its main manifestation is urinary urgency. In general, urotherapy and anticholinergics are the first choices of treatment. Parasacral Transcutaneous Electrical Neural Stimulation (PTENS) was introduced as an alternative for the treatment of detrusor overactivity in children, but treatment protocols described to date require several sessions per week or long-lasting sessions, making it difficult for the child to adhere to the treatment...
December 21, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28070606/-neurogenic-detrusor-overactivity-and-onabotulinumtoxin-a-botox-%C3%A2-is-perioperative-antbiotic-prophylaxis-unnecessary
#20
A Kaufmann
No abstract text is available yet for this article.
February 2017: Der Urologe. Ausg. A
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