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Detrusor overactivity

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https://www.readbyqxmd.com/read/29231593/-impacts-on-urodynamic-parameters-and-the-protein-expressions-of-m2-and-m3-receptors-of-detrusor-in-the-rats-of-detrusor-hyperreflexia-treated-with-ginger-salt-isolated-moxibustion-at-shenque-cv-8
#1
Yi Liu, Xuerui Wang, Tianran Li, Liting Lin, Guangxia Shi, Yuanbo Fu, Cunzhi Liu
OBJECTIVE: To discuss the effects on detrusor hyperreflexia treated with ginger-salt-isolated moxibustion at "Shenque" (CV 8) and its mechanism. METHODS: Thirty female adult SD rats were selected. The model of detrusor hyperreflexia was prepared with complete spinal transection at T9, of which, 20 rats were randomized into a model group (10 rats) and a moxibustion group (10 rats). A sham-operation group (10 rats) was set up for sham-spinal transection. In the moxibustion group, when urine incontinence occurred (about in 2 weeks of modeling), the ginger-salt-isolated moxibustion at "Shenque" (CV 8) was given, 3 moxa cones each time, once a day, continuously for 7 days...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29229221/intravesical-electromotive-botulinum-toxin-type-a-administration-for-management-of-urinary-incontinence-secondary-to-neuropathic-detrusor-overactivity-in-children-long-term-follow-up
#2
Seyedeh-Sanam Ladi-Seyedian, Lida Sharifi-Rad, Abdol-Mohammad Kajbafzadeh
OBJECTIVES: To investigate the long-term efficacy and success rate of intravesical electromotive botulinum toxin type A (BoNTA) "Dysport®" administration in myelomeningocele (MMC) patients who had urinary incontinence due to neuropathic detrusor overactivity (NDO). METHODS: Twenty four MMC patients (mean age: 9± 3.6 years, range: 3-16) were included in the study and followed up for six years. Using an electrode bladder catheter, 10 IU/kg of Dysport® (BoNTA) was inserted into the bladder for electromotive drug administration (EMDA) without anesthesia on outpatient basis...
December 8, 2017: Urology
https://www.readbyqxmd.com/read/29221474/increased-expression-of-neuregulin-1-in-the-urothelium-of-rat-bladder-with-partial-bladder-outlet-obstruction
#3
Seung Woo Yang, Seong Woo Jeong, Ki Hak Song
BACKGROUND: This study determined whether changes in the expression of neuregulin (NRG) 1, erbB2 tyrosine kinase (ErbB2) and the M2 muscarinic receptor in the urothelium and detrusor muscle of the rat bladder were associated with partial bladder outlet obstruction (PBOO). METHODS: Male Sprague-Dawley rats (body weight 250-300 g) were used and subdivided into control (n = 10) and PBOO groups (n = 20). PBOO was induced for 21 days, and the expression of NRG1, ErbB2 and M2 muscarinic receptor mRNA and protein was evaluated using reverse transcriptase-polymerase chain reaction (RT-PCR) and western blotting, respectively...
December 8, 2017: BMC Urology
https://www.readbyqxmd.com/read/29211399/oab-score-a-clinical-model-that-predicts-the-probability-of-presenting-overactive-detrusor-in-the-urodynamic-study
#4
Leandro Cristian Arribillaga, Marta Ledesma, Ariel Montedoro, Florencia Pisano, Rubén Guillermo Bengió
PURPOSE: To create a predictive model of involuntary detrusor contraction (IDC) to improve the diagnostic accuracy of overactive detrusor (OAD), associating overactive bladder (OAB) symptoms with other clinical parameters in the female population. MATERIALS AND METHODS: A total of 727 women were studied retrospectively. In all of them, urodynamic study was conducted for urogynecological causes. Demographics information, personal history, symptoms, physical exam, a 3-day frequency/volume chart and urinary culture, were collected in all patients and they subsequently underwent uroflowmetry and urodynamic studies...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29211350/the-angiotensin-ii-receptors-type-1-blockage-affects-the-urinary-bladder-activity-in-hyperosmolar-induced-detrusor-overactivity-in-rats-preliminary-results
#5
Kajetan Juszczak, Piotr Maciukiewicz
BACKGROUND: Angiotensin II receptors play a role in the pathogenesis of urinary bladder dysfunction, especially in the case of bladder outlet obstruction. The function of these receptors in the detrusor overactivity (DO) still remains unclear. OBJECTIVES: The study aims to investigate some of the mechanisms through which hyperosmolarity induces urinary bladder overactivity. The effect of angiotensin II receptor type 1 - AT1 (telmisartan) on urinary bladder function in physiological state and in hyperosmolar-induced DO in rat model was explored...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29179012/reproducibility-of-the-transvaginal-sonographic-assessment-of-bladder-wall-thickness
#6
Suneetha Rachaneni, Lee Middleton, Anuradha Sajja, Moji Balogun, Jane Daniels, Pallavi Latthe, Jonathan Deeks
OBJECTIVE: To assess whether transvaginal sonographic measurements of bladder wall thickness (BWT) have adequate reproducibility to detect differences in BWT potentially indicative of detrusor overactivity in women with overactive bladder. STUDY DESIGN: Three reproducibility studies were undertaken to assess (A) total measurement error, (B) intra-observer variability and (C) inter-observer measurement in the interpretation of scans. Women recruited to the Bladder Ultrasound Study underwent a transvaginal ultrasound scan to obtain a measurement of BWT...
November 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29176310/urinary-disorders-and-marfan-syndrome-a-series-of-4-cases
#7
Claire Hentzen, Nicolas Turmel, Camille Chesnel, Frederique Le Breton, Samer Sheikh Ismael, Gérard Amarenco
Marfan syndrome is a genetic disease responsible for causing cardiovascular, eye and musculoskeletal damages. Urinary disorders are not common. We present 4 cases of chronic urinary tract symptoms, with 2 different pathophysiological processes. Three patients presented with spinal cord infarct following aortic dissection surgery. They were affected by an overactive bladder with detrusor overactivity and detrusor-sphincter dyssynergia. One patient complained of voiding dysfunction, possibly related to dural ectasia...
November 24, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29164680/effects-of-tadalafil-on-storage-and-voiding-function-in-patients-with-male-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-a-urodynamic-based-study
#8
Yoshihisa Matsukawa, Tsuyoshi Majima, Kazuna Matsuo, Yasuhito Funahashi, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
OBJECTIVE: To investigate the effects of tadalafil on storage and voiding function in treatment-naïve patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia, based on a urodynamic study. METHODS: This was an open-labeled, single-center, prospective study. A total of 80 untreated outpatients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia received tadalafil 5 mg/day for 12 weeks. Subjective symptoms and objective findings on voiding and storage function obtained through urodynamic studies, including cystometry and pressure flow study, were evaluated before and after treatment...
November 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29163833/a-systematic-review-and-meta-analysis-of-effectiveness-and-safety-of-therapy-for-overactive-bladder-using-botulinum-toxin-a-at-different-dosages
#9
Hui-Yun Gu, Ju-Kun Song, Wen-Jun Zhang, Jin Xie, Qi-Sheng Yao, Wen-Jing Zeng, Chao Zhang, Yu-Ming Niu
Purpose: To assess the effectiveness and safety of botulinum toxin A (BTX-A) at different dosages for overactive bladder (OAB). Materials and Methods: The MEDLINE, EMBASE, and Cochrane Controlled Trials Register databases were searched through November 3, 2016 to identify relevant randomized controlled trials (RCTs). Results: Eleven studies were identified in this meta-analysis. Compared with placebo, the urinary incontinence (UI) episodes per week as the primary outcomes, urodynamic parameters including maximum cystometric capacity (MCC), and maximum detrusor pressure (MDP) for neurogenic detrusor overactivity (NDO) at 6 weeks, and for idiopathic detrusor overactivity (IDO) at 36 weeks were evaluated...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135810/can-urodynamic-parameters-predict-sling-revision-for-voiding-dysfunction-in-women-undergoing-synthetic-midurethral-sling-placement
#10
Brian J Linder, Emanuel C Trabuco, John B Gebhart, Christopher J Klingele, John A Occhino, Daniel S Elliott, Deborah J Lightner
OBJECTIVE: The objective of the study was to evaluate the utility of urodynamic studies performed before primary midurethral sling placement for stress urinary incontinence in predicting the need for subsequent sling release for voiding dysfunction. METHODS: The health records of women managed with primary synthetic midurethral sling placement at Mayo Clinic (Rochester, MN) from January 1, 2002, to December 31, 2012, were reviewed. The primary outcome was surgical sling release for postoperative voiding dysfunction (ie, prolonged retention, elevated postvoid residual volumes with new voiding symptoms, or de novo onset or worsening of overactive bladder symptoms)...
November 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29130569/a-re-adjustable-sling-for-female-recurrent-stress-incontinence-and-intrinsic-sphincteric-deficiency-long-term-results-in-205-patients-using-the-remeex-sling-system
#11
Carlos Errando-Smet, Cristina Gutiérrez Ruiz, Pedro Arañó Bertrán, Humberto Villavicencio Mavrich
AIMS: To evaluate the outcomes and complications at long-term follow-up after a Remeex re-adjustable sling for recurrent stress urinary incontinence (rSUI) and intrinsic sphincteric deficiency (ISD) in women. METHODS: Two hundred thirty women with SUI were evaluated after undergoing a re-adjustable sling operation. Twenty-five patients were lost to follow-up, 205 were classified by Q-tip, urodynamic, and clinical criteria into ISD (109) and rSUI (96). Outcome measures included number of pads, 1 h pad-test, urodynamics and subjective satisfaction index with the procedure...
November 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29125525/early-postnatal-bladder-function-in-fetoscopic-myelomeningocele-repair-patients
#12
Gene O Huang, Michael A Belfort, William E Whitehead, Oluyinka O Olutoye, Jonathan Castillo, Heidi Castillo, Kathryn K Ostermaier, Chester J Koh, Duong D Tu
PURPOSE: Prenatal repair of myelomeningocele (MMC) via hysterotomy has demonstrated neurosurgical and motor benefits, when compared to postnatal repairs. Urologic benefits, however, remain to be seen. The purpose of this study was to review early postnatal bladder function in patients undergoing a novel endoscopic approach for MMC repair using an exteriorized uterus. METHODS: A prospective urologic assessment of patients undergoing fetoscopic MMC repair and receiving subsequent care at our facility, was performed...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29124347/the-effect-of-onabotulinumtoxina-according-to-site-of-injection-in-patients-with-overactive-bladder-a-systematic-review-and-meta-analysis
#13
Jung Ki Jo, Kyu Nam Kim, Dong Won Kim, Yong Tae Kim, Ji Yoon Kim, Ji Yeon Kim
PURPOSE: This study assessed the efficacy and safety of onabotulinumtoxinA according to injection site for treatment of overactive bladder. METHODS: A systematic literature review located randomized controlled trials of onabotulinumtoxinA treatment for neurogenic detrusor overactive bladder and idiopathic overactive bladder in adults. We searched MEDLINE, EMBASE, and the Cochrane Controlled Trials Register using the Ovid platform. Meta-analysis was based on Cochrane Review Methods...
November 9, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29118531/preliminary-report-on-the-effect-of-urethral-diverticulum-magnetic-resonance-imaging-configuration-on-the-incidence-of-new-onset-urodynamic-stress-urinary-incontinence-following-excision
#14
Sachin Malde, Sahar Naaseri, Rajesh Kavia, Mahreen Pakzad, Rizwan Hamid, Jeremy Ockrim, Tamsin J Greenwell
Context: Excision of urethral diverticulum in females has been reported to be associated with new onset urodynamic stress urinary incontinence (USUI) in up to 49%. Aims: We have assessed the incidence of new onset USUI in all patients having urethral diverticulum excision with Martius fat pad interposition under the care of a single surgeon between May 1, 2007, and December 1, 2011. The incidence of new onset USUI has been correlated with the preoperative magnetic resonance imaging (MRI) appearance of the urethral diverticulum...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29112292/a-kit-ligand-stem-cell-factor-as-a-possible-mediator-inducing-overactive-bladder
#15
Yasue Kubota, Takashi Hamakawa, Satoshi Osaga, Atsushi Okada, Shuzo Hamamoto, Noriyasu Kawai, Kenjiro Kohri, Takahiro Yasui
OBJECTIVE: To investigate whether c-kit ligand, stem cell factor (SCF) affects the biological behavior of overactive bladder (OAB) and discuss the role of SCF as a possible mediator inducing OAB. MATERIALS AND METHODS: First, we performed an immunohistochemical study to examine the localization of SCF in the guinea pig and human bladder. Next, urinary SCF levels were measured in patients with OAB and in control subjects to evaluate a potential biomarker for the diagnosis of OAB...
November 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29105998/possible-role-of-hyposensitivity-of-c-fiber-afferents-at-the-proximal-urethra-in-the-development-of-urge-urinary-incontinence-in-patients-with-detrusor-overactivity
#16
Osamu Ichiyanagi, Akira Nagaoka, Sei Naito, Masaaki Tsukigi, Mayu Yagi, Tomoyuki Kato, Manabu Ishigooka, Norihiko Tsuchiya
OBJECTIVE: The aim of the present study was to investigate associations between urethral sensation and urge urinary incontinence (UUI) in patients with and without detrusor overactivity (DO). METHODS: The medical records of 80 consecutive patients who underwent filling cystometry and urethral current perception threshold (CPT) tests were examined retrospectively. Following the exclusion of 4 patients not eligible for analysis, patients were classified into neurogenic DO, idiopathic DO, or DO-negative groups based on neurological and cystometric findings (n = 30, 12, and 34, respectively)...
November 6, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29104793/increased-risk-of-erectile-dysfunction-in-men-with-multiple-sclerosis-an-italian-cross-sectional-study
#17
Raffaele Balsamo, Davide Arcaniolo, Marco Stizzo, Ester Illiano, Riccardo Autorino, Franca Natale, Elisabetta Costantini, Rocco Damiano, Marco De Sio
Introduction: Sexual dysfunctions (SDs) are common, but often underestimated symptoms in men with multiple sclerosis (MS). The most common sexual complaint in a multiple sclerosis male is erectile dysfunction (ED). The aim of this observational, cross-sectional study was to assess the prevalence of erectile dysfunction (ED) and its relationship with neurological disability, depression, urodynamic findings and lower urinary tract symptoms (LUTS) in these patients. Material and methods: From January 2014 to January 2016, there were 101 consecutive male patients with a diagnosis of Multiple Sclerosis according to the McDonald revised criteria and stable sexual relationships were included...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29098915/neuro-urological-sequelae-of-lumbar-spinal-stenosis
#18
Jason Gandhi, Janki Shah, Gargi Joshi, Sohrab Vatsia, Andrew DiMatteo, Gunjan Joshi, Noel L Smith, Sardar Ali Khan
PURPOSE: Lumbar spinal stenosis is characterized by the narrowing of the spinal canal, which subsequently induces impingement of neural elements in the lumbar spine. Thus, symptoms of lumbar spinal stenosis are typically associated with damage to those neural elements. Herewith, we target the genitourinary symptoms of lumbar spinal stenosis and the importance of differentiating these symptoms from other genitourinary pathologies, namely benign prostatic hyperplasia. MATERIALS AND METHODS: MeSH and keywords relevant to lumbar spinal stenosis and the organs of the urinary tract were used to a guide a literature search on MEDLINE...
December 4, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29076300/improvement-of-persistent-detrusor-overactivity-through-treatment-with-a-phytotherapeutic-agent-wsy-1075-after-relief-of-bladder-outlet-obstruction
#19
Su Jin Kim, Seung Hwan Jeon, Eun Bi Kwon, Hyun Cheol Jeong, Sae Woong Choi, Woong Jin Bae, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Sung Yeoun Hwang, Sae Woong Kim
PURPOSE: Many patients with benign prostatic hyperplasia need treatment for remaining storage symptoms after surgery. Therefore, we evaluated the effect of the phytotherapeutic agent WSY-1075 on persistent detrusor overactivity (DO) after the relief of bladder outlet obstruction (BOO). MATERIALS AND METHODS: Rats were assigned to 3 groups: control (n=6), persistent DO (n=6), and persistent DO treated with the phytotherapeutic agent WSY-1075 (n=6). Persistent DO after relief of partial BOO was generated in the rat model, and 6 of the rats with this condition were orally administered WSY-1075...
October 25, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29072046/diagnosis-and-clinical-evaluation-of-neurogenic-bladder
#20
Gerard Amarenco, Samer Sheikh Ismaël, Camille Chesnel, Audrey Charlanes, Frederique LE Breton
BACKGROUND: Neurologic diseases lead to urinary dysfunctions. AIM: The aim of this article is to present an overview of diagnosis and evaluation of neurogenic bladder with a special focus on urodynamic tests. CONCLUSION: Overactive bladder, with high detrusor pressure associated with detrusor sphincter dyssynergia, can lead to severe complications with renal failure, upper urinary tract dilatation and infectious complications. Underactive bladder with voiding dysfunction and urinary retention, is also a risk factor of urological alterations...
October 25, 2017: European Journal of Physical and Rehabilitation Medicine
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