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Hyperactive detrusor

Charles Fattal, Claire Anquetil, Samer Abdelhamid
OBJECTIVE: To compare quality of life (QoL) in patients with spinal cord injury who underwent overactive detrusor treatment by Botulinum Toxin (BT) versus augmentation cystoplasty (AC). MATERIALS/PATIENTS AND METHODS: Prospective and descriptive study. Patients with refractory overactive bladder due to SCI were treated by at least 2 successive injections of BT or by AC. QoL was assessed using Qualiveen-30 (Q30). Clinical data and urodynamic parameters were collected and compared...
September 2016: Annals of Physical and Rehabilitation Medicine
Patrick C Campbell, Bronagh McDonnell, Kevin P Monaghan, Lauren Baysting, Oonagh Little, Karen D McCloskey
AIMS: To investigate the local, regulatory role of the mucosa on bladder strip contractility from normal and overactive bladders and to examine the effect of botulinum toxin A (BoNT-A). METHODS: Bladder strips from spontaneously hyperactive rat (SHR) or normal rats (Sprague Dawley, SD) were dissected for myography as intact or mucosa-free preparations. Spontaneous, neurogenic and agonist-evoked contractions were investigated. SHR strips were incubated in BoNT-A (3 h) to assess effects on contractility...
August 5, 2016: Neurourology and Urodynamics
R Anding, R Kirschner-Hermanns, A Rantell, A Wiedemann
With increasing age many women suffer from lower urinary tract dysfunction (LUTD) and female sexual dysfunction. An increasing body of evidence supports an association between the 2 conditions. Especially women with urodynamically proved detrusor hyperactivity suffer from sexual dysfunction and there is some evidence that in patients with stress incontinence sexual health improves after successful surgery.
August 2016: Aktuelle Urologie
Jesús Salinas-Casado, Santiago Méndez-Rubio, Laura Pesquera-Ortega, Miguel Vírseda-Chamorro, Pablo Gutiérrez-Martín, Luis Resel-Folkersma, Manuel Esteban-Fuertes, Jesús Moreno-Sierra
OBJECTIVE: The urodynamic results in suburethral slings (SS), are contradictory. We evaluate a series on patients with stress urinary incontinence (associated or not with bladder hyperactivity) that underwent suburethral slings (SS) operations. METHODS: 42 women (age 62±12 years) with urinary incontinence underwent suburethral slings (86% TOT, 12% TVT, 2% others), 36% of them with simultaneous pelvic organ prolapse correction. Medical history and a pre and postsurgery urodynamic studies (according to ICS instructions, except when specified) were performed...
May 2016: Archivos Españoles de Urología
Huiyi H Chang, Leif A Havton
Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration during bladder emptying and results in incomplete and prolonged bladder emptying. The clinical diagnosis of DU is challenging when present alone or in association with other bladder conditions such as detrusor overactivity, urinary retention, detrusor hyperactivity with impaired contractility, aging, and neurological injuries. Several etiologies may be responsible for DU or the development of an underactive bladder (UAB), but the pathobiology of DU or UAB is not well understood...
May 21, 2016: Experimental Neurology
C Anquetil, S Abdelhamid, A Gelis, C Fattal
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To compare quality of life (QoL) in patients with spinal cord injury (SCI) who underwent overactive detrusor treatment by botulinum toxin (BT) versus augmentation cystoplasty (AC). SETTING: France. METHODS: Prospective and descriptive study: Patients with a refractory overactive bladder due to SCI treated by at least two successive injections of BT or by AC. QoL was assessed using Qualiveen-30 (Q30)...
April 26, 2016: Spinal Cord
Chung-Cheng Wang, Cheng-Ling Lee, Hann-Chorng Kuo
We investigated the efficacy and safety of intravesical onabotulinumtoxinA injection in patients with detrusor hyperactivity and impaired contractility (DHIC). Twenty-one patients with urodynamically proven DHIC and 21 age-matched patients with overactive bladder (OAB) with urodynamic detrusor overactivity were treated with intravesical injections of 100 U of onabotulinumtoxinA. The overactive bladder symptom score, urgency severity score, patient perception of bladder condition, global response assessment, voiding diary, and procedure-related adverse events (AE) at baseline, two weeks, one, three, and six months after treatment were assessed...
March 2016: Toxins
M Silva-Ramos, I Silva, M Faria, M T Magalhães-Cardoso, J Correia, F Ferreirinha, P Correia-de-Sá
This study was designed to investigate whether reduced adenosine formation linked to deficits in extracellular ATP hydrolysis by NTPDases contributes to detrusor neuromodulatory changes associated with bladder outlet obstruction in men with benign prostatic hyperplasia (BPH). The kinetics of ATP catabolism and adenosine formation as well as the role of P1 receptor agonists on muscle tension and nerve-evoked [(3)H]ACh release were evaluated in mucosal-denuded detrusor strips from BPH patients (n = 31) and control organ donors (n = 23)...
December 2015: Purinergic Signalling
T Hüsch, T Neuerburg, A Reitz, A Haferkamp
BACKGROUND: Urodynamic studies are utilised for identification and follow-up of functional disorders of the lower urinary tract. Provocation tests are used to determine disorders which could not be revealed in standard cystometry. The ice water test is a simple test to identify neurogenic bladder dysfunction and to screen the integrity of the upper motor neuron in neurogenic bladder dysfunction. OBJECTIVES: Development and significance of the ice water test is presented in this review against the background of physiology and pathophysiology of the lower urinary tract...
April 2016: Der Urologe. Ausg. A
Sevgi Ikbali Afsar, Banu Sarifakioglu, Şeniz Akcay Yalbuzdağ, Sacide Nur Saraçgil Coşar
OBJECTIVES: We aimed to investigate the relationship between the severity of the spinal lesion and urodynamic findings, bladder drainage method at discharge, and incidence of renal calculi in patients with spinal cord injury (SCI). STUDYDESIGN: Retrospective. SETTING: In-patient rehabilitation unit of a tertiary research hospital. METHODS: A total of 131 patients who were admitted to our clinic with a diagnosis of SCI and placed into a rehabilitation program were included in the study...
2016: Journal of Spinal Cord Medicine
M Rodríguez-Ruiz, I Somoza, N Curros-Mata
OBJECTIVES: Kidney failure is the main cause of morbidity and mortality in patients with myelodysplasia. We analysed the presence of renal lesions in these patients using dimercaptosuccinic acid scintigraphy and related their presence with the type of vesical function and the delay in receiving appropriate management. MATERIAL AND METHODS: We performed a retrospective study of patients with myelodysplasia treated in our hospital since 2004. We analysed the epidemiological and clinical data and the pattern of bladder function according to urodynamic studies...
January 2016: Actas Urologicas Españolas
I Alatas, H Demirci, Huseyin Canaz, O Akdemir, S Baydin, K Ozel
AIM: Spina bifida (SB) is a congenital deformity that is frequently seen in infancy. Surgical treatment and clinical follow-up of patients with the diagnosis of SB are important to provide education to the patients and their relatives, to increase patient survival, to ensure that they have a more comfortable life. Neuro-urological problems are highly important for the patients in terms of both social and medical. MATERIALS AND METHODS: The medical records of patients who underwent surgery for SB and tethered cord syndrome at our clinic in the past year were retrospectively evaluated...
April 2015: Asian Journal of Neurosurgery
Andrzej Wróbel, Mirosław Łańcut, Tomasz Rechberger
INTRODUCTION: A credible animal overactive bladder model used in basic research is an indispensable harbinger of safe and ethical clinical trials on human subjects. Our objective was to develop a new animal model of a hyperactive bladder that will be void of inflammatory urothelium lesions and display significant sensitivity to muscarinic receptor antagonists. METHODS: To examine the influence of 0.75% retinyl acetate solution on cystometric parameters, it was infused into the bladder for 5min...
July 2015: Journal of Pharmacological and Toxicological Methods
BoŻena Eberdt-Gołąbek, Krystyna Zmysłowska, MaŁgorzata Słowik, Dominika Gładysz, Kamil K Hozyasz
UNLABELLED: Primary monosymptomatic nocturnal enuresis (PMNE) is the most frequent (85%) type of enuresis in children. It remains a diagnostic and therapeutic challenge to establish its etiology and implement a proper treatment. AIM: The aim of the study was to establish the causes of PMNE in children on the basis of own investigations and assess factors having influence over PMNE etiology, which would enable the choice of effective therapy. MATERIALS AND METHODS: The study concerned 85 children with PMNE aged from 5 to 15 years...
April 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
V I Kirpatovskii, I S Mudraya, K G Mkrtchyan, S V Revenko, G D Efremov, O N Nadtochii, I V Kabanova
Blood supply to the pelvic organs of outbred male rats was diminished by graduated constriction of the distal part of the inferior vena cava. Deficiency of intramural blood supply in prostate and urinary bladder was revealed by bioimpedance harmonic analysis according to the magnitude of first cardiac peak in the bioimpedance spectrogram. In 1-1.5 months, the histological examination revealed the glandular-stromal form of progressive benign prostatic hyperplasia in all ischemic rats. The development of hyperplasia was not accompanied by the changes in testosterone, dihydrotestosterone, or estradiol in blood and prostatic tissue...
April 2015: Bulletin of Experimental Biology and Medicine
B Henriet, T Roumeguère
BACKGROUND: OAB is common with a potential negative impact on quality of life. Anticholinergics and β3-mimetics are the first-line medical treatment. This treatment meets only 50% of patients given a lack of efficacy and adverse effects. Used in the treatment of neurogenic overactive bladder, botulinum toxin is now evaluated for the treatment of refractory non-neurogenic overactive bladder. The objective of this work is to review the literature data concerning the efficacy and safety of intradetrusor botulinum toxin injections to treat refractory idiopathic overactive bladder...
January 2015: Revue Médicale de Bruxelles
Johannes Weller, Manuela Pose, Chris Protzel, Felix Mader, Katrin Porath, Rüdiger Köhling, Oliver W Hakenberg, Timo Kirschstein
OBJECTIVES: To analyze the effect of adenosine on detrusor smooth muscle contraction and to assess age-related changes of adenosine function. METHODS: Sustained contractions were induced in young (10-30 days) and old (>60 days) rat detrusor muscle strips by application of 30 mmol/L K(+) and adenosine (0.1-400 µmol/L), which was either applied before raising the K(+) concentration or added to the precontracted muscle strip. Quantitative polymerase chain reaction analyses were used to study adenosine receptor expression in rat and human detrusor specimens...
March 2015: International Journal of Urology: Official Journal of the Japanese Urological Association
Bárbara Frias, João Santos, Marlene Morgado, Mónica Mendes Sousa, Susannah M Y Gray, Karen D McCloskey, Shelley Allen, Francisco Cruz, Célia Duarte Cruz
Neurogenic detrusor overactivity (NDO) is a well known consequence of spinal cord injury (SCI), recognizable after spinal shock, during which the bladder is areflexic. NDO emergence and maintenance depend on profound plastic changes of the spinal neuronal pathways regulating bladder function. It is well known that neurotrophins (NTs) are major regulators of such changes. NGF is the best-studied NT in the bladder and its role in NDO has already been established. Another very abundant neurotrophin is BDNF. Despite being shown that, acting at the spinal cord level, BDNF is a key mediator of bladder dysfunction and pain during cystitis, it is presently unclear if it is also important for NDO...
February 4, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
P Gutiérrez-Martín, M Vírseda-Chamorro, J Salinas Casado, A Gómez-Rodríguez, M Esteban-Fuertes
OBJECTIVES: To determine the urodynamic efficacy and factors that influence the urodynamic results of treatment of neurogenic detrusor hyperactivity with intradetrusor injection of botulinum toxin type A (BTX-A) in patients with spinal cord injury (SCI). MATERIAL AND METHODS: A retrospective study was conducted with a cohort of 70 patients composed of 40 men and 30 women with stable SCI (mean age, 39 ± 13.3 years) who underwent an intradetrusor injection of 300 IUs of BTX-A...
May 2015: Actas Urologicas Españolas
Takeshi Okinami, Masaaki Imamura, Nobuyuki Nishikawa, Hiromitsu Negoro, Yoshio Sugino, Koji Yoshimura, Akihiro Kanematsu, Hikaru Hashitani, Osamu Ogawa
Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder inflammation such as interstitial cystitis/bladder pain syndrome (IC/BPS). Gap junction, a key regulator of hyperactive conditions in the bladder, has been reported to be involved in pathological bladder inflammation. Here we report involvement of gap junction in the etiology of storage symptoms in bladder inflammation...
2014: PloS One
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