keyword
MENU ▼
Read by QxMD icon Read
search

Hyperactive detrusor

keyword
https://www.readbyqxmd.com/read/28916252/decreased-monoamine-oxidase-a-expression-and-activity-in-the-bladders-of-rats-with-partial-outlet-obstruction
#1
Mai Michishita, Kazuo Yano, Ken-Ichi Tomita, Satoru Yoshikawa, Osamu Matsuzaki, Ken-Ichi Kasahara
OBJECTIVE To investigate changes in expression and activity of monoamine oxidase A (MAO-A) in rats with partial bladder outlet obstruction (pBOO). Previous studies suggested that monoamines, such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (NA), are involved in bladder hyperactivity secondary to pBOO. However, little is known about the role of MAO-A, an enzyme oxidizing 5-HT and NA, in the pathogenesis. METHODS Female Sprague Dawley rats were subjected to sham or pBOO operations for 7 days, then their bladders were isolated...
September 12, 2017: Urology
https://www.readbyqxmd.com/read/28891795/-intravesical-botulinum-toxin-under-local-anestesia-as-ambulatory-procedure
#2
José Javier Fabuel Alcañiz, Laura Martínez Arcos, Miguel Jimenez Cidre, Francisco Javier Burgos Revilla
Bladder hyperactivity is described as the presence of "voiding urgency, generally associated with increased daytime frequency and nocturia, with or without urinary incontinence, in the absence of urinary tract infection or other obvious pathology". Onabotulinum toxin A (BTA) is a recommendable therapeutic option in case of failure, contraindication or refusal of the conservative therapy or other non-pharmacological therapies. The injection of BTA in the detrusor has been performed under local, regional or general anesthesia either in the conventional or major ambulatory surgery operative room or in the cystoscopy room...
September 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28770419/urinary-biomarkers-in-patients-with-detrusor-underactivity-with-and-without-bladder-function-recovery
#3
Sheng-Fu Chen, Yuan-Hong Jiang, Hann-Chorng Kuo
PURPOSE: Detrusor underactivity (DU) is frequently encountered in elderly patients. Part of patients with DU might have bladder function recovery after treatment. This study investigated urinary proteins in these DU patients with and without bladder function recovery. METHODS: A total of 37 patients with chronic urinary retention and urodynamically proven DU were enrolled. After treatment, 24 DU patients had bladder function recovery whereas 13 had not, after 1-year follow-up...
August 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28754926/videourodynamic-studies-of-women-with-voiding-dysfunction
#4
Sheng-Mou Hsiao, Ho-Hsiung Lin, Hann-Chorng Kuo
This retrospective study is aimed to present videourodynamic findings of women with symptoms of voiding dysfunction in a medical center. Of 1914 women, the diagnoses included bladder outlet obstruction (BOO, n = 810, 42.3%), bladder dysfunction (n = 1,048, 54.8%) and normal tracings (n = 56, 2.9%). Anatomic BOO (n = 49) included cystocele (n = 19) and urethral stricture (n = 30). Common functional BOOs included dysfunctional voiding (n = 325, 17.0%) and poor relaxation of the external sphincter (n = 336, 17...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428632/cyclophosphamide-induced-hcn1-channel-upregulation-in-interstitial-cajal-like-cells-leads-to-bladder-hyperactivity-in-mice
#5
Qian Liu, Zhou Long, Xingyou Dong, Teng Zhang, Jiang Zhao, Bishao Sun, Jingzhen Zhu, Jia Li, Qingqing Wang, Zhenxing Yang, Xiaoyan Hu, Longkun Li
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are confirmed to be expressed in bladder interstitial Cajal-like cells (ICC-LCs), but little is known about their possible role in cystitis-associated bladder dysfunction. The present study aimed to determine the functional role of HCN channels in regulating bladder function under inflammatory conditions. Sixty female wild-type C57BL/6J mice and sixty female HCN1-knockout mice were randomly assigned to experimental and control groups, respectively...
April 21, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28413135/a-systematic-review-of-the-diagnosis-and-treatment-of-patients-with-neurogenic-hyperactivity-of-the-detrusor-muscle
#6
A Borau, J M Adot, M Allué, S Arlandis, D Castro, M Esteban, J Salinas
BACKGROUND: Neurogenic detrusor hyperactivity (NDH) is a urodynamic observation characterised by involuntary detrusor contractions during the filling phase that are caused by an underlying neurological disease. The common and severe complications that can result from NDH warrant the preparation of healthcare protocols for the proper management of patients with NDH. OBJECTIVE: The aim of this study is to standardise the criteria for the decision-making process in the management of patients with diagnosed or suspected NDH, providing personalised medical care...
April 13, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28345779/sacral-neuromodulation-for-detrusor-hyperactivity-with-impaired-contractility
#7
Derek B Hennessey, Nathan Hoag, Johan Gani
INTRODUCTION: Detrusor hyperactivity with impaired contractility (DHIC) is a challenging condition to manage. Sacral neuromodulation (SNM) is a proven treatment modality for both the individual aspects of DHIC. To date, data reporting the outcome of SNM for DHIC are lacking. MATERIALS AND METHODS: Consecutive patients undergoing SNM for DHIC were followed prospectively, from April 2013 to October 2016. Patient demographics, bladder diaries, subjective response rates, ICIQ-OAB, and PGI-I scores were recorded...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28325529/transcutaneous-stimulation-of-the-posterior-tibial-nerve-for-treating-refractory-urge-incontinence-of-idiopathic-and-neurogenic-origin
#8
C Valles-Antuña, M L Pérez-Haro, C González-Ruiz de L, A Quintás-Blanco, E M Tamargo-Diaz, J García-Rodríguez, A San Martín-Blanco, J M Fernandez-Gomez
OBJECTIVE: To assess the efficacy of treatment with transcutaneous posterior tibial nerve stimulation (TPTNS) in patients with urge urinary incontinence, of neurogenic or nonneurogenic origin, refractory to first-line therapeutic options. MATERIAL AND METHODS: We included 65 patients with urge urinary incontinence refractory to medical treatment. A case history review, a urodynamic study and a somatosensory evoked potentials (SEP) study were conducted before the TPTNS, studying the functional urological condition by means of a voiding diary...
March 18, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28265323/bladder-and-bowel-dysfunction-in-children-an-update-on-the-diagnosis-and-treatment-of-a-common-but-underdiagnosed-pediatric-problem
#9
REVIEW
Joana Dos Santos, Roberto I Lopes, Martin A Koyle
Bladder and bowel dysfunction (BBD) describes a spectrum of lower urinary symptoms (LUTS) accompanied by fecal elimination issues that manifest primarily by constipation and/or encopresis. This increasingly common entity is a potential cause of significant physical and psychosocial burden for children and families. BBD is commonly associated with vesicoureteral reflux (VUR) and recurrent urinary tract infections (UTIs), which at its extreme may lead to renal scarring and kidney failure. Additionally, BBD is frequently seen in children diagnosed with behavioural and neuropsychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28131828/ep3-activation-facilitates-bladder-excitability-via-hcn-channels-on-iccs
#10
Chao Wu, Xingyou Dong, Qian Liu, Jingzhen Zhu, Teng Zhang, Qingqing Wang, Xiaoyang Hu, Zhenxing Yang, Longkun Li
EP3 is a receptor for prostaglandin E2 (PGE2), and although its effect on bladder excitability has attracted considerable attention, the underlying mechanism remains unclear. To investigate whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the interstitial cells of Cajal (ICCs) of the bladder are involved in the effect of EP3 activation on bladder excitability, wild-type mice, HCN1 knockout (HCN1(-/-)) mice and rats were used in our study. Double immunofluorescence staining and immunoprecipitation assays demonstrated the interaction between EP3 and the HCN channels...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27676764/botulinum-toxin-therapy-for-neurogenic-detrusor-hyperactivity-versus-augmentation-enterocystoplasty-impact-on-the-quality-of-life-of-patients-with-sci
#11
Charles Fattal, Claire Anquetil, Samer Abdelhamid
OBJECTIVE: To compare quality of life (QoL) in patients with spinal cord injury who underwent overactive detrusor treatment by Botulinum Toxin (BT) versus augmentation cystoplasty (AC). MATERIALS/PATIENTS AND METHODS: Prospective and descriptive study. Patients with refractory overactive bladder due to SCI were treated by at least 2 successive injections of BT or by AC. QoL was assessed using Qualiveen-30 (Q30). Clinical data and urodynamic parameters were collected and compared...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27494539/mucosal-modulation-of-contractility-in-bladder-strips-from-normal-and-overactive-rat-models-and-the-effect-of-botulinum-toxin-a-on-overactive-bladder-strips
#12
Patrick C Campbell, Bronagh McDonnell, Kevin P Monaghan, Lauren Baysting, Oonagh Little, Karen D McCloskey
AIMS: To investigate the local, regulatory role of the mucosa on bladder strip contractility from normal and overactive bladders and to examine the effect of botulinum toxin A (BoNT-A). METHODS: Bladder strips from spontaneously hyperactive rat (SHR) or normal rats (Sprague Dawley, SD) were dissected for myography as intact or mucosa-free preparations. Spontaneous, neurogenic and agonist-evoked contractions were investigated. SHR strips were incubated in BoNT-A (3 h) to assess effects on contractility...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27328304/-how-does-lower-urinary-tract-dysfunction-affekt-female-sexuality
#13
R Anding, R Kirschner-Hermanns, A Rantell, A Wiedemann
With increasing age many women suffer from lower urinary tract dysfunction (LUTD) and female sexual dysfunction. An increasing body of evidence supports an association between the 2 conditions. Especially women with urodynamically proved detrusor hyperactivity suffer from sexual dysfunction and there is some evidence that in patients with stress incontinence sexual health improves after successful surgery.
2016: Aktuelle Urologie
https://www.readbyqxmd.com/read/27225054/-usefulness-of-urodynamics-in-the-treatment-of-mixed-urinary-incontinence-in-women-with-suburethral-slings
#14
Jesús Salinas-Casado, Santiago Méndez-Rubio, Laura Pesquera-Ortega, Miguel Vírseda-Chamorro, Pablo Gutiérrez-Martín, Luis Resel-Folkersma, Manuel Esteban-Fuertes, Jesús Moreno-Sierra
OBJECTIVE: The urodynamic results in suburethral slings (SS), are contradictory. We evaluate a series on patients with stress urinary incontinence (associated or not with bladder hyperactivity) that underwent suburethral slings (SS) operations. METHODS: 42 women (age 62±12 years) with urinary incontinence underwent suburethral slings (86% TOT, 12% TVT, 2% others), 36% of them with simultaneous pelvic organ prolapse correction. Medical history and a pre and postsurgery urodynamic studies (according to ICS instructions, except when specified) were performed...
May 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27222131/a-ventral-root-avulsion-injury-model-for-neurogenic-underactive-bladder-studies
#15
REVIEW
Huiyi H Chang, Leif A Havton
Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration during bladder emptying and results in incomplete and prolonged bladder emptying. The clinical diagnosis of DU is challenging when present alone or in association with other bladder conditions such as detrusor overactivity, urinary retention, detrusor hyperactivity with impaired contractility, aging, and neurological injuries. Several etiologies may be responsible for DU or the development of an underactive bladder (UAB), but the pathobiology of DU or UAB is not well understood...
November 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27112841/botulinum-toxin-therapy-for-neurogenic-detrusor-hyperactivity-versus-augmentation-enterocystoplasty-impact-on-the-quality-of-life-of-patients-with-sci
#16
C Anquetil, S Abdelhamid, A Gelis, C Fattal
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To compare quality of life (QoL) in patients with spinal cord injury (SCI) who underwent overactive detrusor treatment by botulinum toxin (BT) versus augmentation cystoplasty (AC). SETTING: France. METHODS: Prospective and descriptive study: Patients with a refractory overactive bladder due to SCI treated by at least two successive injections of BT or by AC. QoL was assessed using Qualiveen-30 (Q30)...
November 2016: Spinal Cord
https://www.readbyqxmd.com/read/26999209/efficacy-and-safety-of-intravesical-onabotulinumtoxina-injection-in-patients-with-detrusor-hyperactivity-and-impaired-contractility
#17
Chung-Cheng Wang, Cheng-Ling Lee, Hann-Chorng Kuo
We investigated the efficacy and safety of intravesical onabotulinumtoxinA injection in patients with detrusor hyperactivity and impaired contractility (DHIC). Twenty-one patients with urodynamically proven DHIC and 21 age-matched patients with overactive bladder (OAB) with urodynamic detrusor overactivity were treated with intravesical injections of 100 U of onabotulinumtoxinA. The overactive bladder symptom score, urgency severity score, patient perception of bladder condition, global response assessment, voiding diary, and procedure-related adverse events (AE) at baseline, two weeks, one, three, and six months after treatment were assessed...
March 18, 2016: Toxins
https://www.readbyqxmd.com/read/26521170/impairment-of-atp-hydrolysis-decreases-adenosine-a1-receptor-tonus-favoring-cholinergic-nerve-hyperactivity-in-the-obstructed-human-urinary-bladder
#18
M Silva-Ramos, I Silva, M Faria, M T Magalhães-Cardoso, J Correia, F Ferreirinha, P Correia-de-Sá
This study was designed to investigate whether reduced adenosine formation linked to deficits in extracellular ATP hydrolysis by NTPDases contributes to detrusor neuromodulatory changes associated with bladder outlet obstruction in men with benign prostatic hyperplasia (BPH). The kinetics of ATP catabolism and adenosine formation as well as the role of P1 receptor agonists on muscle tension and nerve-evoked [(3)H]ACh release were evaluated in mucosal-denuded detrusor strips from BPH patients (n = 31) and control organ donors (n = 23)...
December 2015: Purinergic Signalling
https://www.readbyqxmd.com/read/26459574/-the-ice-water-test-and-bladder-cooling-reflex-physiology-pathophysiology-and-clinical-importance
#19
REVIEW
T Hüsch, T Neuerburg, A Reitz, A Haferkamp
BACKGROUND: Urodynamic studies are utilised for identification and follow-up of functional disorders of the lower urinary tract. Provocation tests are used to determine disorders which could not be revealed in standard cystometry. The ice water test is a simple test to identify neurogenic bladder dysfunction and to screen the integrity of the upper motor neuron in neurogenic bladder dysfunction. OBJECTIVES: Development and significance of the ice water test is presented in this review against the background of physiology and pathophysiology of the lower urinary tract...
April 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/26322550/an-unresolved-relationship-the-relationship-between-lesion-severity-and-neurogenic-bladder-in-patients-with-spinal-cord-injury
#20
Sevgi Ikbali Afsar, Banu Sarifakioglu, Şeniz Akcay Yalbuzdağ, Sacide Nur Saraçgil Coşar
OBJECTIVES: We aimed to investigate the relationship between the severity of the spinal lesion and urodynamic findings, bladder drainage method at discharge, and incidence of renal calculi in patients with spinal cord injury (SCI). STUDYDESIGN: Retrospective. SETTING: In-patient rehabilitation unit of a tertiary research hospital. METHODS: A total of 131 patients who were admitted to our clinic with a diagnosis of SCI and placed into a rehabilitation program were included in the study...
2016: Journal of Spinal Cord Medicine
keyword
keyword
68161
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"