keyword
MENU ▼
Read by QxMD icon Read
search

hyperintensities dementia

keyword
https://www.readbyqxmd.com/read/28596452/effect-of-long-term-vascular-care-on-progression-of-cerebrovascular-lesions-magnetic-resonance-imaging-substudy-of-the-prediva-trial-prevention-of-dementia-by-intensive-vascular-care
#1
Jan Willem van Dalen, Eric P Moll van Charante, Matthan W A Caan, Philip Scheltens, Charles B L M Majoie, Aart J Nederveen, Willem A van Gool, Edo Richard
BACKGROUND AND PURPOSE: This study aimed to evaluate the effect of a nurse-led multidomain cardiovascular intervention on white matter hyperintensity (WMH) progression and incident lacunar infarcts in community-dwelling elderly with hypertension. METHODS: The preDIVA trial (Prevention of Dementia by Intensive Vascular Care) was an open-label, cluster-randomized controlled trial in community-dwelling individuals aged 70 to 78 years. General practices were assigned by computer-generated randomization to 6-year nurse-led, multidomain intensive vascular care or standard care...
June 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28588075/cerebral-perfusion-and-the-risk-of-dementia-a-population-based-study
#2
Frank J Wolters, Hazel I Zonneveld, Albert Hofman, Aad van der Lugt, Peter J Koudstaal, Meike W Vernooij, M Arfan Ikram
Background -Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown. We prospectively determined the association of cerebral perfusion with subsequent cognitive decline and development of dementia. Methods -Between 2005 and 2012, we measured cerebral blood flow by 2D phase-contrast magnetic resonance imaging (MRI) in non-demented participants of the population-based Rotterdam Study...
June 6, 2017: Circulation
https://www.readbyqxmd.com/read/28566448/disease-progression-and-regression-in-sporadic-small-vessel-disease-insights-from-neuroimaging
#3
REVIEW
Esther M C van Leijsen, Frank-Erik de Leeuw, Anil M Tuladhar
Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of dementia. Comprehensive characterization of the time course of disease progression will result in better understanding of aetiology and clinical consequences of SVD. SVD progression has been studied extensively over the years, usually describing change in SVD markers over time using neuroimaging at two time points. As a consequence, SVD is usually seen as a rather linear, continuously progressive process...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28559496/magnetic-resonance-imaging-of-cardiovascular-function-and-the-brain-is-dementia-a-cardiovascular-driven-disease
#4
REVIEW
Albert de Roos, Jeroen van der Grond, Gary Mitchell, Jos Westenberg
The proximal aorta acts as a coupling device between heart and brain perfusion, modulating the amount of pressure and flow pulsatility transmitted into the cerebral microcirculation. Stiffening of the proximal aorta is strongly associated with age and hypertension. The detrimental effects of aortic stiffening may result in brain damage as well as heart failure. The resulting cerebral small vessel disease and heart failure may contribute to early cognitive decline and (vascular) dementia. This pathophysiological sequence of events underscores the role of cardiovascular disease as a contributory mechanism in causing cognitive decline and dementia and potentially may provide a starting point for prevention and treatment...
May 30, 2017: Circulation
https://www.readbyqxmd.com/read/28555103/blood-pressure-control-in-aging-predicts-cerebral-atrophy-related-to-small-vessel-white-matter-lesions
#5
Kyle C Kern, Clinton B Wright, Kaitlin L Bergfield, Megan C Fitzhugh, Kewei Chen, James R Moeller, Nooshin Nabizadeh, Mitchell S V Elkind, Ralph L Sacco, Yaakov Stern, Charles S DeCarli, Gene E Alexander
Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28536518/mri-visual-ratings-of-brain-atrophy-and-white-matter-hyperintensities-across-the-spectrum-of-cognitive-decline-are-differently-affected-by-age-and-diagnosis
#6
Hanneke F M Rhodius-Meester, Marije R Benedictus, Mike P Wattjes, Frederik Barkhof, Philip Scheltens, Majon Muller, Wiesje M van der Flier
Aim: To assess the associations of age and diagnosis with visual ratings of medial temporal lobe atrophy (MTA), parietal atrophy (PA), global cortical atrophy (GCA), and white matter hyperintensities (WMH) and to investigate their clinical value in a large memory clinic cohort. Methods: We included 2,934 patients (age 67 ± 9 years; 1,391 [47%] female; MMSE 24 ± 5) from the Amsterdam Dementia Cohort (1,347 dementia due to Alzheimer's disease [AD]; 681 mild cognitive impairment [MCI]; 906 controls with subjective cognitive decline)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28529873/white-matter-hyperintensities-are-seen-only-in-grn-mutation-carriers-in-the-genfi-cohort
#7
Carole H Sudre, Martina Bocchetta, David Cash, David L Thomas, Ione Woollacott, Katrina M Dick, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Sébastien Ourselin, M Jorge Cardoso, Jonathan D Rohrer
Genetic frontotemporal dementia is most commonly caused by mutations in the progranulin (GRN), microtubule-associated protein tau (MAPT) and chromosome 9 open reading frame 72 (C9orf72) genes. Previous small studies have reported the presence of cerebral white matter hyperintensities (WMH) in genetic FTD but this has not been systematically studied across the different mutations. In this study WMH were assessed in 180 participants from the Genetic FTD Initiative (GENFI) with 3D T1- and T2-weighed magnetic resonance images: 43 symptomatic (7 GRN, 13 MAPT and 23 C9orf72), 61 presymptomatic mutation carriers (25 GRN, 8 MAPT and 28 C9orf72) and 76 mutation negative non-carrier family members...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28492093/higher-prevalence-of-cerebral-white-matter-hyperintensities-in-homozygous-apoe-%C3%A9-4-allele-carriers-aged-45-75-results-from-the-alfa-study
#8
Santiago Rojas, Anna Brugulat-Serrat, Nuria Bargalló, Carolina Minguillón, Alan Tucholka, Carles Falcon, Andreia Carvalho, Sebastian Morán, Manel Esteller, Nina Gramunt, Karine Fauria, Jordi Camí, José L Molinuevo, Juan D Gispert
Cerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ɛ4 allele of the APOE gene is the major factor accountable for Alzheimer's disease heritability. However, the relationship between white matter hyperintensities and APOE genotype in healthy subjects remains controversial. We investigated the association between APOE-ɛ4 and vascular risk factors with white matter hyperintensities, and explored their interactions, in a cohort of cognitively healthy adults (45-75 years)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28478812/migraine-white-matter-hyperintensities-and-cerebral-microinfarcts-are-silent-cryptogenic-strokes-and-relate-to-dementia
#9
Arnold E Eggers
No abstract text is available yet for this article.
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28448092/handgrip-strength-predicts-longitudinal-changes-in-clock-drawing-test-performance-an-observational-study-in-a-sample-of-older-non-demented-adults
#10
G Viscogliosi, M G Di Bernardo, E Ettorre, I M Chiriac
OBJECTIVE: Impairment of physical performance might identify older people at higher risk of dementia over time. The present study evaluated handgrip strength as independent predictor of cognitive decline. DESIGN: Observational, prospective. Follow-up duration: 11.2 ± 0.8 months. SETTING AND PARTICIPANTS: Geriatric outpatients center. 104 consecutive stroke- and dementia-free older adults (44% men, ages 80.2 ± 5.4 years). METHODS: The Clinical Dementia Rating scale and the Clock Drawing Test (CDT) were administered...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28428977/19th-workshop-of-the-international-stroke-genetics-consortium-april-28-29-2016-boston-massachusetts-usa-2016-001-mri-defined-cerebrovascular-genomics-the-charge-consortium
#11
S Debette, Y Saba, D Vojinovic, X Jian, H Adams, G Chauhan, M Sargurupremraj, S Kaffashian, J Ding, J C Bis, P Nyquist, K Mather, C Van Duijn, L J Launer, M A Ikram, H Schmidt, W T Longstreth, M Fornage, S Seshadri
The CHARGE consortium is an investigator-initiated collaboration to facilitate meta-analyses of genome-wide association studies (GWAS) and genomic analyses based on next generation sequencing (NGS), among multiple large and well-phenotyped population-based cohort studies around the world (http://www.chargeconsortium.com). Within the neuro-CHARGE working group, we are presenting an update of ongoing genomic studies on MRI-markers of cerebrovascular disease. Large population-based studies have shown that the burden of cerebrovascular disease extends far beyond that of clinical stroke...
March 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28382615/a-case-of-multiple-system-atrophy-with-preexisting-alzheimer-s-disease-and-predating-the-hot-cross-bun-sign
#12
Chi-Wei Lin, Chi-Yu Tseng, Chung-Ping Lo, Min-Chien Tu
PURPOSE: Synucleinopathy, tauopathy and amyloidopathy were classified as distinct clinical and pathological entities in traditional classification systems, and their interactions have been studied on neuropathology and molecular genetics recently. CASE REPORT: In this report, we present a 69-year-old male patient who had been diagnosed with probable Alzheimer's disease (AD) dementia due to progressive forgetfulness in February 2013. His Mini- Mental State Examination score was 21/30, and his Cognitive Abilities Screening Instrument score was 78/100, resulted from profound deficits in recent memory and abstract thinking domains...
December 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/28378939/medial-temporal-lobe-atrophy-as-a-predictor-of-poor-cognitive-outcomes-in-general-paresis
#13
Ben Chen, Haishan Shi, Le Hou, Xiaomei Zhong, Yanhua Wang, Zhangying Wu, Qi Peng, Dong Zheng, Yuefen Zhang, Yan Tan, Ziyan Fang, Xinru Chen, Xinni Luo, Sha Liu, Ning Yuping
BACKGROUND: The effect of penicillin therapy on clinical outcomes vary among patients with general paresis (GP). We sought to explore biomarkers that might serve as predictors of clinical outcomes in GP and identify patients requiring early intervention. METHODS: Thirty-five inpatients with GP were recruited. Each GP patient underwent comprehensive neuropsychological, neuroimaging and laboratory assessments before receiving penicillin therapy, and returned for follow-up evaluations after 6 months...
April 5, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28371474/muscle-mass-decline-arterial-stiffness-white-matter-hyperintensity-and-cognitive-impairment-japan-shimanami-health-promoting-program-study
#14
Katsuhiko Kohara, Yoko Okada, Masayuki Ochi, Maya Ohara, Tokihisa Nagai, Yasuharu Tabara, Michiya Igase
BACKGROUND: There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross-sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association. METHODS: Two sarcopenic indices were measured: thigh muscle cross-sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance)...
March 29, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28351960/pathogenesis-of-white-matter-changes-in-cerebral-small-vessel-diseases-beyond-vessel-intrinsic-mechanisms
#15
REVIEW
Anne Joutel, Hugues Chabriat
Cerebral small vessel diseases (SVDs) are a leading cause of age and hypertension-related stroke and dementia. The salient features of SVDs visible on conventional brain magnetic resonance images include white matter hyperintensities (WMHs) on T2-weighted images, small infarcts, macrohemorrhages, dilated perivascular spaces, microbleeds and brain atrophy. Among these, WMHs are the most common and often the earliest brain tissue changes. Moreover, over the past two decades, large population- and patient-based studies have established the clinical importance of WMHs, notably with respect to cognitive and motor disturbances...
April 25, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28341686/incidental-findings-on-brain-mri-of-cognitively-normal-first-degree-descendants-of-patients-with-alzheimer-s-disease-a-cross-sectional-analysis-from-the-alfa-alzheimer-and-families-project
#16
Anna Brugulat-Serrat, Santiago Rojas, Nuria Bargalló, Gerardo Conesa, Carolina Minguillón, Karine Fauria, Nina Gramunt, José Luis Molinuevo, Juan Domingo Gispert
OBJECTIVES: To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). DESIGN: Cross-sectional observational study. SETTING: All scans were obtained with a 3.0 T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if ≥2...
March 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28324763/interaction-of-apoe-e4-and-poor-glycemic-control-predicts-white-matter-hyperintensity-growth-from-73-to-76
#17
Simon R Cox, Stuart J Ritchie, David Alexander Dickie, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Sarah E Harris, Maria Valdés Hernández, Alan J Gow, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28322203/associations-between-amyloid-%C3%AE-and-white-matter-hyperintensities-a-systematic-review
#18
REVIEW
Austyn Roseborough, Joel Ramirez, Sandra E Black, Jodi D Edwards
INTRODUCTION: This systematic review synthesizes current evidence for associations between cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white matter hyperintensity (WMH) burden on magnetic resonance imaging in healthy elderly adults and individuals with cognitive impairment and dementia. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) systematic review guidelines, we systematically searched MEDLINE, Embase, Cochrane, and PsycINFO databases from January 2000 to September 2015...
March 16, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28318355/dementia-incidence-and-predictors-in-cerebral-amyloid-angiopathy-patients-without-intracerebral-hemorrhage
#19
Li Xiong, Gregoire Boulouis, Andreas Charidimou, Duangnapa Roongpiboonsopit, Michael J Jessel, Marco Pasi, Yael D Reijmer, Panagiotis Fotiadis, Alison Ayres, Emily Merrill, Kristin Schwab, Deborah Blacker, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
Cerebral amyloid angiopathy (CAA) is a common cause of cognitive impairment in older individuals. This study aimed to investigate predictors of dementia in CAA patients without intracerebral hemorrhage (ICH). A total of 158 non-demented patients from the Stroke Service or the Memory Clinic who met the modified Boston Criteria for probable CAA were included. At baseline, neuroimaging markers, including lobar microbleeds (cerebral microbleeds (CMBs)), white matter hyperintensities (WMH), cortical superficial siderosis (cSS), magnetic resonance imaging (MRI)-visible centrum semiovale perivascular spaces (CSO-PVS), lacunes, and medial temporal atrophy (MTA) were assessed...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28316994/multiple-factors-involved-in-the-pathogenesis-of-white-matter-lesions
#20
REVIEW
Jing Lin, Dilong Wang, Linfang Lan, Yuhua Fan
White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear...
2017: BioMed Research International
keyword
keyword
68158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"