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https://www.readbyqxmd.com/read/29329480/direct-endoscopy-and-diagnosis-of-adenocarcinoma-following-metal-stent-based-drainage-of-a-pancreatic-cyst
#1
Sebastian Zeissig, Renate Schmelz, Stefan Brückner, Daniela E Aust, Gustavo B Baretton, Jochen Hampe
No abstract text is available yet for this article.
January 12, 2018: Endoscopy
https://www.readbyqxmd.com/read/29242622/assessment-of-disturbed-glucose-metabolism-and-surrogate-measures-of-insulin-sensitivity-in-obese-children-and-adolescents
#2
Christian L Roth, Clinton Elfers, Christiane S Hampe
BACKGROUND: With the rising prevalence of obesity and type 2 diabetes (T2D) in obese children, it is becoming imperative to detect disturbed glucose metabolism as early as possible in order to prevent T2D development. SUBJECTS/METHODS: Cross-sectional study of 92 obese children (median age 11.7 years, 51% female) and 7 lean children (median age 11.4 years, 57% female) who underwent an oral glucose tolerance test (OGTT) in a tertiary pediatric care center. Glucose tolerance was assessed and different indices for β-cell function, insulin sensitivity and insulin secretion were calculated...
December 14, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29235098/hepcidin-and-dna-promoter-methylation-in-hepatocellular-carcinoma
#3
Silvia Udali, Annalisa Castagna, Michela Corbella, Andrea Ruzzenente, Sara Moruzzi, Filippo Mazzi, Tommaso Campagnaro, Domenica De Santis, Antonia Franceschi, Patrizia Pattini, Rossella Gottardo, Oliviero Olivieri, Luigi Perbellini, Alfredo Guglielmi, Sang-Woon Choi, Domenico Girelli, Simonetta Friso
BACKGROUND: The liver hormone hepcidin regulates iron homeostasis that is often altered in hepatocellular carcinoma (HCC). Epigenetic phenomena control gene expression through a dynamic fashion, therefore, considering the plasticity of both iron homeostasis and epigenetic mechanisms and their role in liver carcinogenesis, we investigated whether hepcidin gene (HAMP) expression is modulated by DNA methylation thus affecting iron status in human HCC. MATERIALS AND METHODS: Thirty-two patients affected by non-viral HCC were enrolled and their main clinical and biochemical characteristics obtained...
December 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29230833/causes-of-iron-overload-in-blood-donors-a-clinical-study
#4
A H Laursen, O W Bjerrum, L Friis-Hansen, T O Hansen, J L Marott, K Magnussen
BACKGROUND AND OBJECTIVES: Despite the obligate iron loss from blood donation, some donors present with hyperferritinaemia that can result from a wide range of acute and chronic conditions including hereditary haemochromatosis (HH). The objective of our study was to investigate the causes of hyperferritinaemia in the blood donor population and explore the value of extensive HH mutational analyses. MATERIALS AND METHODS: Forty-nine consecutive donors (f = 6, m = 43) were included prospectively from the Capital Regional Blood Center...
December 12, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29229700/flexible-hinges-in-bacterial-chemoreceptors
#5
Narahari Akkaladevi, Filiz Bunyak, David Stalla, Tommi A White, Gerald L Hazelbauer
Transmembrane bacterial chemoreceptors are extended, rod-shaped homodimers with ligand-binding sites at one end and interaction sites for formation of signaling complexes and histidine kinase control at the other. There are atomic-resolution structures of chemoreceptor fragments but not of intact, membrane-inserted receptors. Electron tomography of in vivo signaling complex arrays lack distinct densities for chemoreceptor rods away from the well-ordered base plate region, implying structural heterogeneity. We investigated using negative staining, transmission electron microscopy and image analysis to characterize molecular shapes of intact homodimers of Escherichia coli aspartate receptor Tar rendered functional by insertion into Nanodisc-provided E...
December 11, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29228995/correcting-the-predictive-validity-of-a-selection-test-for-the-effect-of-indirect-range-restriction
#6
Stefan Zimmermann, Dietrich Klusmann, Wolfgang Hampe
BACKGROUND: The validity of selection tests is underestimated if it is determined by simply calculating the predictor-outcome correlation found in the admitted group. This correlation is usually attenuated by two factors: (1) the combination of selection variables which can compensate for each other and (2) range restriction in predictor and outcome due to the absence of outcome measures for rejected applicants. METHODS: Here we demonstrate the logic of these artifacts in a situation typical for student selection tests and compare four different methods for their correction: two formulas for the correction of direct and indirect range restriction, expectation maximization algorithm (EM) and multiple imputation by chained equations (MICE)...
December 11, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29203869/trpm7-kinase-activity-is-essential-for-t-cell-colonization-and-alloreactivity-in-the-gut
#7
Andrea Romagnani, Valentina Vettore, Tanja Rezzonico-Jost, Sarah Hampe, Elsa Rottoli, Wiebke Nadolni, Michela Perotti, Melanie A Meier, Constanze Hermanns, Sheila Geiger, Gunther Wennemuth, Camilla Recordati, Masayuki Matsushita, Susanne Muehlich, Michele Proietti, Vladimir Chubanov, Thomas Gudermann, Fabio Grassi, Susanna Zierler
The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7 R/R ) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of intra-epithelial lymphocytes. Defective T cell gut colonization reduces MHCII expression in intestinal epithelial cells...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29203791/identification-of-insulin-sensitizing-molecules-acting-by-disrupting-the-interaction-between-the-insulin-receptor-and-grb14
#8
Anaïs Gondoin, Cornelia Hampe, Richard Eudes, Cyril Fayolle, Cécile Pierre-Eugène, Maria Miteva, Bruno O Villoutreix, Florence Charnay-Pouget, David J Aitken, Tarik Issad, Anne-Françoise Burnol
Metabolic diseases are characterized by a decreased action of insulin. During the course of the disease, usual treatments frequently fail and patients are finally submitted to insulinotherapy. There is thus a need for innovative therapeutic strategies to improve insulin action. Growth factor receptor-bound protein 14 (Grb14) is a molecular adapter that specifically binds to the activated insulin receptor (IR) and inhibits its tyrosine kinase activity. Molecules disrupting Grb14-IR binding are therefore potential insulin-sensitizing agents...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29175121/elevated-unmethylated-and-methylated-insulin-dna-are-unique-markers-of-a-%C3%AE-ketosis-prone-diabetes
#9
Surya N Mulukutla, Sarah A Tersey, Christiane S Hampe, Raghavendra G Mirmira, Ashok Balasubramanyam
A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD compared to all other KPD subgroups.
October 31, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29158088/interplay-of-adipocyte-and-hepatocyte-leptin-upregulates-hepcidin
#10
Kiyoko Yamamoto, Takahiro Kuragano, Tomoko Kimura, Masayoshi Nanami, Yukiko Hasuike, Takeshi Nakanishi
Conflicting evidence concerning leptin, an adipocyte-derived hormone, in atherogenesis and non-alcoholic fatty liver disease (NAFLD) has been reported. Iron metabolism and iron-mediated oxidative stress should be taken into consideration for the clarification of the pathogenesis of these diseases. In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice...
November 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29148036/function-and-mechanism-of-the-pyrin-inflammasome
#11
REVIEW
Rosalie Heilig, Petr Broz
Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene have been linked to autoinflammatory diseases such as Familial Mediterranean Fever (FMF) or pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). Recent insights have now revealed how pyrin is activated during infection, providing a molecular basis for the understanding of such disease-causing mutations in pyrin...
November 16, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29134618/the-mechanisms-of-systemic-iron-homeostasis-and-etiology-diagnosis-and-treatment-of-hereditary-hemochromatosis
#12
REVIEW
Hiroshi Kawabata
Hereditary hemochromatosis (HH) is a group of genetic iron overload disorders that manifest with various symptoms, including hepatic dysfunction, diabetes, and cardiomyopathy. Classic HH type 1, which is common in Caucasians, is caused by bi-allelic mutations of HFE. Severe types of HH are caused by either bi-allelic mutations of HFE2 that encodes hemojuvelin (type 2A) or HAMP that encodes hepcidin (type 2B). HH type 3, which is of intermediate severity, is caused by bi-allelic mutations of TFR2 that encodes transferrin receptor 2...
November 13, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29110513/ankaferd-influences-mrna-expression-of-iron-regulated-genes-during-iron-deficiency-anemia
#13
Afife Gulec, Sukru Gulec
Ankaferd Blood Stopper (ABS) comprises a mixture of plants and stops bleeding via forming a protein network by erythroid aggregation. Bleeding causes reduction of iron levels in body. It has been indicated that ABS contains significant amount of iron. Thus, we investigated the biological activity of ABS-derived iron on iron-regulated genes during iron-deficiency anemia (IDA). IDA We selected Caco-2 and HepG2 cell lines as in vitro models of human intestine and liver, respectively. Iron deficiency anemia was induced by deferoxamine...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29101207/ferroportin-disease-pathogenesis-diagnosis-and-treatment
#14
REVIEW
Antonello Pietrangelo
Ferroportin Disease (FD) is an autosomal dominant hereditary iron loading disorder associated with heterozygote mutations of the ferroportin-1 (FPN) gene. It represents one of the commonest causes of genetic hyperferritinemia, regardless of ethnicity. FPN1 transfers iron from the intestine, macrophages and placenta into the bloodstream. In FD, loss-of-function mutations of FPN1 limit but do not impair iron export in enterocytes, but they do severely affect iron transfer in macrophages. This leads to progressive and preferential iron trapping in tissue macrophages, reduced iron release to serum transferrin (i...
December 2017: Haematologica
https://www.readbyqxmd.com/read/29092861/effect-of-dietary-palmitic-and-stearic-acids-on-sucrose-motivation-and-hypothalamic-and-striatal-cell-signals-in-the-rat
#15
Dianne P Figlewicz, Jennifer Jay, Constance H West, Aryana Zavosh, Christiane S Hampe, Jared R Radtke, Murray A Raskind, Elaine R Peskind
e have reported that motivation for sucrose is increased in rats fed a moderate (31%) mixed-fat diet for 4-6 weeks. In this study, rats were fed diets containing 32% stearic (STEAR) or palmitic (PALM) acid, and behavior, metabolic profile, and cell signals were compared with those of rats fed a matched low fat (11% fat [LF]) diet. Rats fed STEAR or PALM increased sucrose motivation relative to LF rats (one-way ANOVA for lever presses, p=.03). Diet did not change fasting glucose, insulin, total cholesterol, triglycerides, intravenous glucose tolerance test glucose profile, percent body fat, or total kcal, although kcal as fat were increased (ANOVA p<0...
November 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29070017/postdiagnostic-physical-activity-sleep-duration-and-tv-watching-and-all-cause-mortality-among-long-term-colorectal-cancer-survivors-a-prospective-cohort-study
#16
Ilka Ratjen, Clemens Schafmayer, Romina di Giuseppe, Sabina Waniek, Sandra Plachta-Danielzik, Manja Koch, Greta Burmeister, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger, Wolfgang Lieb
BACKGROUND: Lifestyle recommendations for cancer survivors are warranted to improve survival. In this study, we aimed to examine the association of total physical activity, different types of physical activity, hours of sleeping at day and night, and hours spent watching television (TV) with all-cause mortality in long-term colorectal cancer (CRC) survivors. METHODS: We assessed physical activity in 1376 CRC survivors (44% women; median age, 69 years) at median 6 years after CRC diagnosis using a validated questionnaire...
October 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29066846/specific-neurophysiological-mechanisms-underlie-cognitive-inflexibility-in-inflammatory-bowel-disease
#17
Vanessa A Petruo, Sebastian Zeißig, Renate Schmelz, Jochen Hampe, Christian Beste
Inflammatory bowel disease (IBD) is highly prevalent. While the pathophysiological mechanisms of IBD are increasingly understood, there is a lack of knowledge concerning cognitive dysfunctions in IBD. This is all the more the case concerning the underlying neurophysiological mechanisms. In the current study we focus on possible dysfunctions of cognitive flexibility (task switching) processes in IBD patients using a system neurophysiological approach combining event-related potential (ERP) recordings with source localization analyses...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29055010/an-excitable-rho-gtpase-signaling-network-generates-dynamic-subcellular-contraction-patterns
#18
Melanie Graessl, Johannes Koch, Abram Calderon, Dominic Kamps, Soumya Banerjee, Tomáš Mazel, Nina Schulze, Jana Kathrin Jungkurth, Rutuja Patwardhan, Djamschid Solouk, Nico Hampe, Bernd Hoffmann, Leif Dehmelt, Perihan Nalbant
Rho GTPase-based signaling networks control cellular dynamics by coordinating protrusions and retractions in space and time. Here, we reveal a signaling network that generates pulses and propagating waves of cell contractions. These dynamic patterns emerge via self-organization from an activator-inhibitor network, in which the small GTPase Rho amplifies its activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1. Rho also inhibits itself by local recruitment of actomyosin and the associated RhoGAP Myo9b...
October 20, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29052181/probiotic-strains-and-mechanistic-insights-for-the-treatment-of-type-2-diabetes
#19
REVIEW
Christiane S Hampe, Christian L Roth
INTRODUCTION: The intestinal microbial composition appears to differ between healthy controls and individuals with Type 2 diabetes (T2D). This observation has led to the hypothesis that perturbations of the intestinal microbiota may contribute to the development of T2D. Manipulations of the intestinal microbiota may therefore provide a novel approach in the prevention and treatment of T2D. Indeed, fecal transplants have shown promising results in both animal models for obesity and T2D and in human clinical trials...
November 2017: Endocrine
https://www.readbyqxmd.com/read/29020610/neonatal-c57bl-6j-and-parkin-mice-respond-differently-following-developmental-manganese-exposure-result-of-a-high-dose-pilot-study
#20
Melanie L Foster, Thomas B Bartnikas, Hailey C Maresca-Fichter, Courtney Mercadante, Miriam Dash, Chelsea Miller, David C Dorman
It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to evaluate whether responses to neonatal manganese (Mn) exposure differ in mice with a Park2 gene defect (parkin mice) when compared with a wildtype strain (C57BL/6J). Neonatal parkin and C57BL/6J littermates were randomly assigned to 0, 11, or 25mg Mn/kg-day dose groups with oral exposures occurring from postnatal day (PND) 1 through PND 28...
October 8, 2017: Neurotoxicology
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