keyword
https://read.qxmd.com/read/38321133/a-genome-wide-association-study-for-survival-from-a-multi-centre-european-study-identified-variants-associated-with-covid-19-risk-of-death
#21
MULTICENTER STUDY
Francesca Minnai, Filippo Biscarini, Martina Esposito, Tommaso A Dragani, Luis Bujanda, Souad Rahmouni, Marta E Alarcón-Riquelme, David Bernardo, Elena Carnero-Montoro, Maria Buti, Hugo Zeberg, Rosanna Asselta, Manuel Romero-Gómez, Israel Fernandez-Cadenas, Chiara Fallerini, Kristina Zguro, Susanna Croci, Margherita Baldassarri, Mirella Bruttini, Simone Furini, Alessandra Renieri, Francesca Colombo
The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Genetics Initiative (HGI), which identified sixteen loci associated with COVID-19 severity. Herein, we investigated the genetic determinants of COVID-19 mortality, by performing a case-only genome-wide survival analysis, 60 days after infection, of 3904 COVID-19 patients from the GEN-COVID and other European series (EGAS00001005304 study of the COVID-19 HGI)...
February 6, 2024: Scientific Reports
https://read.qxmd.com/read/38316902/dual-color-live-imaging-unveils-stepwise-organization-of-multiple-basal-body-arrays-by-cytoskeletons
#22
JOURNAL ARTICLE
Gen Shiratsuchi, Satoshi Konishi, Tomoki Yano, Yuichi Yanagihashi, Shogo Nakayama, Tatsuya Katsuno, Hiroka Kashihara, Hiroo Tanaka, Kazuto Tsukita, Koya Suzuki, Elisa Herawati, Hitomi Watanabe, Toyohiro Hirai, Takeshi Yagi, Gen Kondoh, Shimpei Gotoh, Atsushi Tamura, Sachiko Tsukita
For mucociliary clearance of pathogens, tracheal multiciliated epithelial cells (MCCs) organize coordinated beating of cilia, which originate from basal bodies (BBs) with basal feet (BFs) on one side. To clarify the self-organizing mechanism of coordinated intracellular BB-arrays composed of a well-ordered BB-alignment and unidirectional BB-orientation, determined by the direction of BB to BF, we generated double transgenic mice with GFP-centrin2-labeled BBs and mRuby3-Cep128-labeled BFs for long-term, high-resolution, dual-color live-cell imaging in primary-cultured tracheal MCCs...
February 5, 2024: EMBO Reports
https://read.qxmd.com/read/38311322/g1-the-common-echinococcus-granulosus-genotype-infected-domestic-cat-felis-catus-in-iraq
#23
JOURNAL ARTICLE
Musafer H Al-Ardi
BACKGROUND: Infections of cats with Echinococcus granulosus is uncommon because the cat is not part of the parasite life cycle that a carnivorous and another herbivore represent. Nevertheless, it occurs incidentally when eating food or drinking water contaminated with the worm's larva, especially with the presence of the definitive host (dogs), in this case, the infections are concentrated in stray or outside cats. For this reason, this study examined the possibility of cat infection with E...
January 2024: Journal of Veterinary Science
https://read.qxmd.com/read/38305703/implications-of-two-component-systems-envz-ompr-and-baes-baer-in-in-vitro-temocillin-resistance-in-escherichia-coli
#24
JOURNAL ARTICLE
Patricia Pérez-Palacios, José Luis Rodríguez-Ochoa, Ana Velázquez-Escudero, Jesús Rodríguez-Baño, José Manuel Rodríguez-Martínez, Álvaro Pascual, Fernando Docobo-Pérez
BACKGROUND: BaeS/BaeR is a two-component system of Escherichia coli that controls the expression of porins and efflux pumps. Its role in beta-lactam resistance is limited. OBJECTIVES: To study the role of baeS/baeR two-component system in temocillin resistance in E. coli. METHODS: E. coli strain BW25113 and single-gene deletion mutants related to two-component systems were collected from the KEIO collection. Double-gen deletion mutants were generated...
February 2, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38300979/fever-clinic-construction-and-management-targeted-to-prevention-and-control-of-healthcare-associated-respiratory-viral-infections-in-jiangsu-china-a-cross-sectional-observational-study
#25
JOURNAL ARTICLE
Yue Yang, Bo Liu, Ya-Jun Wen, Zhan-Jie Li, Yong-Xiang Zhang, Gen-Ming Zhao, Bi-Jie Hu, Wen-Sen Chen, Wei-Hong Zhang
To analyze the post-COVID-19 construction and management of fever clinics targeted to prevention and control of healthcare-associated respiratory viral infections in medical institutions at all levels in China, and to provide a basis for promoting their standardized construction, we conducted this survey on the construction of fever clinics in 429 medical institutions of Jiangsu Province from July to December 2020. Contents of the questionnaire included the general situation of medical institutions, the construction status and future construction plans of fever clinics...
2024: PloS One
https://read.qxmd.com/read/38290230/atranorin-inhibits-zika-virus-infection-in-human-glioblastoma-cell-line-snb-19-via-targeting-zika-virus-envelope-protein
#26
JOURNAL ARTICLE
Guan-Gen Huang, Hao-Yu Wang, Xiao-Han Wang, Tao Yang, Xiao-Meng Zhang, Chun-Lan Feng, Wei-Min Zhao, Wei Tang
BACKGROUND: Zika virus (ZIKV) is a single-stranded RNA flavivirus transmitted by mosquitoes. Its infection is associated with neurological complications such as neonatal microcephaly and adult Guillain-Barré syndrome, posing a serious threat to the health of people worldwide. Therefore, there is an urgent need to develop effective anti-ZIKV drugs. Atranorin is a lichen secondary metabolite with a wide range of biological activities, including anti-inflammatory, antibacterial and antioxidant, etc...
January 8, 2024: Phytomedicine
https://read.qxmd.com/read/38286451/-short-term-clinical-efficacy-observation-of-lesion-removal-bone-graft-fusion-and-external-brace-treatment-for-late-stage-wrist-tuberculosis
#27
JOURNAL ARTICLE
Yi-Bin Hu, Jun Fei, De-Xin Hu, Gen-Jun Chen, Jin-Ping Hu
OBJECTIVE: To observe the clinical efficacy of lesion removal, bone grafting, fusion, and external fixation in the treatment of late-stage wrist tuberculosis. METHODS: From October 2015 to May 2019, 25 patients with late-stage wrist tuberculosis were treated using lesion removal, bone grafting, fusion, and external fixation. Among these patients, there were 14 males and 11 females, aged from 40 to 74 years old, with an average age of (60.72±8.45) years old...
January 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/38286450/-retrospective-analysis-and-comparison-of-total-internal-disability-preservation-technique-and-standardized-reconstruction-technique
#28
JOURNAL ARTICLE
Wen-Ming Jin, Bao Li, Gen Zhao, Han Li, Xin-Wei Liu
OBJECTIVE: To investigate the efficacy and clinical results of total internal protection technique in anterior cruciate ligament reconstruction. METHODS: A total of 56 patients undergoing anterior cruciate ligament reconstruction treated from January 2018 to December 2019 were selected. According to the different surgical methods, they were divided into total internal reconstruction group and standard bone tunnel group. There were 21 patients in the total internal reconstruction group, including 15 males and 6 females, aged from 20 to 48 with an average of (35...
January 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/38258766/sulbactam-durlobactam-a-novel-drug-for-the-treatment-of-multidrug-resistant-acinetobacter-baumannii-infections-a-systematic-review
#29
JOURNAL ARTICLE
Hemasri Velmurugan, Sajitha Venkatesan, Hadush Negash Meles, Pugazhenthan Thangaraju, Krishnapriya Neelambaram
BACKGROUND: Sulbactam-durlobactam (SUL-DUR) has been tested in vitro for its ability to gen- erate resistance in clinical isolates of Acinetobacter species. According to prior studies, combining durlobac- tam with sulbactam causes sulbactam-resistant isolates to become more active and revert to susceptibility. We aimed to conduct a systematic review of the in vitro activity of SUL-DUR on A. baumannii (Ab) iso- lates, including carbapenem-resistant A. baumannii (CRAb), to provide an overview for physicians dealing with Ab infections...
January 22, 2024: Infectious Disorders Drug Targets
https://read.qxmd.com/read/38257890/research-advances-on-the-role-of-lipids-in-the-life-cycle-of-human-coronaviruses
#30
REVIEW
Cuiling Ding, Yibo Chen, Gen Miao, Zhongtian Qi
Coronaviruses (CoVs) are emerging pathogens with a significant potential to cause life-threatening harm to human health. Since the beginning of the 21st century, three highly pathogenic and transmissible human CoVs have emerged, triggering epidemics and posing major threats to global public health. CoVs are enveloped viruses encased in a lipid bilayer. As fundamental components of cells, lipids can play an integral role in many physiological processes, which have been reported to play important roles in the life cycle of CoVs, including viral entry, uncoating, replication, assembly, and release...
December 28, 2023: Microorganisms
https://read.qxmd.com/read/38254324/first-report-of-leaf-spot-of-pineapple-ananas-comosus-l-merr-caused-by-neoscytalidium-dimidiatum-in-malaysia
#31
JOURNAL ARTICLE
Mohamad Afifah, Zaiton Sapak, Nuraini Mohd Noor, Mohd Zafri Ab Wahab, Intan Sakinah Mohd Anuar, Nurul Wahida Ramli, Abdul Rahman Saili, Noor Hasniza Md Zin
In June 2017, severe leaf spots symptoms were observed by growers on pineapple leaves of Josapine variety in in Alor Pongsu (5°01'60.00" N, 100°34' 59.99" E), Perak, northwest of Peninsular Malaysia. The early infection stage shows that several brown spots could be observed, which then would merge to form large brown to creamy white lesions that cover all the leaf surface. This infection finally caused the plant to die after a while. Disease observations conducted from 2018 - 2023 showed that 10-15% incidences of the disease were observed in several pineapple farms located in Johor, Kedah, and Sarawak...
January 22, 2024: Plant Disease
https://read.qxmd.com/read/38188209/multiple-sparganosis-spinal-infections-mainly-in-the-thoracic-region-a-case-report
#32
Gan-Jun Wen, Jian Chen, Shi-Fei Zhang, Zhi-Sen Zhou, Gen-Long Jiao
BACKGROUND: Spinal infection with sparganosis is rarely seen, and multiple spinal infections with sparganosis in the thoracic spine have not been reported. CASE SUMMARY: In this case report, a 56-year old male patient suffered from back pain for 3 mo. Computed tomography examination of the thoracic spine showed bone destruction of the T4-5 vertebral body, as well as the right pedicle and lamina of T5. Magnetic resonance imaging showed high signals on T2W1 images and fat-suppressed images in the right vertebral body of T4-5 and the right pedicle and lamina of T5, a high signal in the vertebral canal, and similar high signals in the paravertebral and subcutaneous regions of the whole spine...
December 26, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/38180443/notch2-with-retinoic-acid-license-il-23-expression-by-intestinal-epcam-dcir2-cdc2s-in-mice
#33
JOURNAL ARTICLE
Daiya Ohara, Yusuke Takeuchi, Hitomi Watanabe, Yoonha Lee, Hiroki Mukoyama, Toshiaki Ohteki, Gen Kondoh, Keiji Hirota
Despite the importance of IL-23 in mucosal host defense and disease pathogenesis, the mechanisms regulating the development of IL-23-producing mononuclear phagocytes remain poorly understood. Here, we employed an Il23aVenus reporter strain to investigate the developmental identity and functional regulation of IL-23-producing cells. We showed that flagellin stimulation or Citrobacter rodentium infection led to robust induction of IL-23-producing EpCAM+ DCIR2+ CD103- cDC2s, termed cDCIL23, which was confined to gut-associated lymphoid tissues, including the mesenteric lymph nodes, cryptopatches, and isolated lymphoid follicles...
February 5, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38176301/postoperative-mediastinitis-and-sternal-osteitis-after-cardiac-surgery-caused-by-mycoplasma-hominis-a-case-report
#34
Gen Li, Wanjun Yu, Yangqin Ye, Peng Han, Liqiong Chen, Wenyan Zhang, Chi Xu, Lieying Fan
BACKGROUND: Mediastinitis and sternal osteitis are critical complications in cardiac surgery. Cases of these complications caused by Mycoplasma hominis are extremely rare. CASE PRESENTATION: We present a case of mediastinitis and sternal osteitis caused by M. hominis infection following ascending aortic replacement surgery. Whole gene sequencing analysis suggested the genitourinary tract as the most likely source of this M. hominis infection. Successful infection control was achieved through a regimen of moxifloxacin treatment...
March 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38135108/indocyanine-green-loaded-platelet-activated-by-photodynamic-and-photothermal-effects-for-selective-control-of-wound-repair
#35
JOURNAL ARTICLE
Tian-Qi Ma, Nan-Nan Chen, Rong-Cheng Xiao, Qi-Rui Li, Meng-Yi Zhan, Chang-Long Gou, Jun Hu, Fan Leng, Liu-Gen Li, Ning Han, Hai-Tao Li, Xing-Chun Peng, Si-Yuan Chen, Xian-Yu Li, Tong-Fei Li
OBJECTIVE: Prompt and effective wound repair is an essential strategy to promote recovery and prevent infection in patients with various types of trauma. Platelets can release a variety of growth factors upon activation to facilitate revascularization and tissue repair, provided that their activation is uncontrollable. The present study is designed to explore the selective activation of platelets by photodynamic and photothermal effects (PDE/PTE) as well as the trauma repair mediated by PDE/PTE...
December 20, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38132730/insights-into-some-onygenalean-fungi-from-freshwater-sediments-in-spain-and-description-of-novel-taxa
#36
JOURNAL ARTICLE
Daniel Torres-Garcia, Josepa Gené, Dania García, Jose F Cano-Lira
During the course of a project investigating culturable Ascomycota diversity from freshwater sediments in Spain, we isolated 63 strains of cycloheximide-resistant fungi belonging to the order Onygenales . These well-known ascomycetes, able to infect both humans and animals, are commonly found in terrestrial habitats, colonizing keratin-rich soils or dung. Little is known about their diversity in aquatic environments. Combining morphological features and sequence analyses of the ITS and LSU regions of the nrDNA, we identified 14 species distributed in the genera Aphanoascus , Arachniotus , Arthroderma , Arthropsis , Emmonsiellopsis , Gymnoascoideus, Leucothecium, Malbranchea , and Myriodontium ...
November 22, 2023: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38117271/species-of-dactylogyridae-platyhelminthes-monogenoidea-infecting-marine-fishes-of-moreton-bay-queensland-australia-with-proposals-of-pleuronectitrema-n-gen-and-ecnomotrema-n-gen-and-descriptions-of-13-new-species
#37
JOURNAL ARTICLE
Delane C Kritsky
Twenty-nine dactylogyrid species were reported from teleosts collected during a survey of the parasites of fishes of Moreton Bay, Queensland, Australia, in 2016. Two new genera, Ecnomotrema n. gen. and Pleuronectitrema n. gen., were proposed, and 13 new species were illustrated and described: Atherinicus difficilis n. sp., Diversohamulus similis n. sp., and Ecnomotrema cetiosum n. sp. from Atherinomorus vaigiensis; Haliotrema apiculum n. sp. from Pempheris schwenkii; Haliotrema tugulduriforme n. sp. from Scarus ghobban; Lethrinitrema australiense n...
2023: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/38110897/pseudomonas-otitidis-bacteremia-in-an-immunocompromised-patient-with-cellulitis-case-report-and-literature-review
#38
REVIEW
Takeo Mori, Sadako Yoshizawa, Kageto Yamada, Takahiro Sato, Masakazu Sasaki, Yusuke Nakamura, Ukyo Gen, Hinako Murakami, Katsuhito Kashiwagi, Tadashi Maeda, Taito Miyazaki, Tetsuo Yamaguchi, Yoshihisa Urita, Yoshikazu Ishii, Kazuhiro Tateda
BACKGROUND: Pseudomonas otitidis belongs to the genus Pseudomonas and causes various infections, including ear, skin, and soft tissue infections. P. otitidis has a unique susceptibility profile, being susceptible to penicillins and cephalosporins but resistant to carbapenems, due to the production of the metallo-β-lactamase called POM-1. This revealed genetic similarities with Pseudomonas aeruginosa, which can sometimes lead to misidentification. CASE PRESENTATION: We report the case of a 70-year-old Japanese male who developed cellulitis and bacteremia during chemotherapy for multiple myeloma...
December 18, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/38096330/comparison-of-yeast-derived-commercial-feed-additives-on-salmonella-enteritidis-survival-and-microbiota-populations-in-rooster-cecal-in-vitro-incubations
#39
JOURNAL ARTICLE
Margaret Costello, Peter Rubinelli, Jessica Brown, Elena Olson, Dana Dittoe, Si Hong Park, Douglas Korver, Zachary Lawless, Dale Thompson, Steven Ricke
Yeast-derived products have become more of an interest in the poultry industry as of late because of their use in modulating the gastrointestinal tract (GIT) microbiome to both improve production parameters and prevent infection. This study aimed to evaluate the effects of various yeast-derived products on Salmonella enterica inoculation in un in vitro rooster cecal incubations and associated effects on the cecal microbiome. Cecal contents were obtained from 53-wk old White Leghorn H & N Nick Chick roosters (n = 3) fed a wheat-based, commercial-type basal diet...
2023: PloS One
https://read.qxmd.com/read/38070565/unveiling-the-underwater-threat-exploring-cadmium-s-adverse-effects-on-tilapia
#40
JOURNAL ARTICLE
Zituo Yang, Joey Wong, Le Wang, Fei Sun, May Lee, Gen Hua Yue
Prolonged exposure to environmentally relevant amounts of cadmium (Cd) in aquatic environments, even at small doses (0.1 and 1 μg/L), might endanger the health of underwater creatures. This research delved into the impacts of a four-month cadmium exposure on Mozambique tilapia (Oreochromis mossambicus), aiming to uncover the mechanisms behind it. Through close examination, we found that the 4-momth cadmium exposure led to harmful effects on the fish's gills, muscles, brain, and intestines. This exposure also triggered changes in gene expressions in the brain and liver, affected the respiratory system and weakened liver's ability to detoxify and defend against potential infections...
December 7, 2023: Science of the Total Environment
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