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https://www.readbyqxmd.com/read/29449171/changes-in-antimicrobial-susceptibility-of-commonly-clinically-significant-isolates-before-and-after-the-interventions-on-surgical-prophylactic-antibiotics-spas-in-shanghai
#1
Su Wang, Li-Zhong Han, Yu-Xing Ni, Yi-Bo Zhang, Qun Wang, Da-Ke Shi, Wen-Hui Li, Yi-Chen Wang, Chen-Rong Mi
Surveillances and interventions on antibiotics use have been suggested to improve serious drug-resistance worldwide. Since 2007, our hospital have proposed many measures for regulating surgical prophylactic antibiotics (carbapenems, third gen. cephalosporins, vancomycin, etc.) prescribing practices, like formulary restriction or replacement for surgical prophylactic antibiotics and timely feedback. To assess the impacts on drug-resistance after interventions, we enrolled infected patients in 2006 (pre-intervention period) and 2014 (post-intervention period) in a tertiary hospital in Shanghai...
February 12, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29444284/gentamicin-intercalated-smectite-as-a-new-therapeutic-option-for-helicobacter-pylori-eradication
#2
Su Jin Jeong, Jie-Hyun Kim, Da Hyun Jung, Kyoung Hwa Lee, Soon Young Park, Yungoo Song, Il-Mo Kang, Young Goo Song
Objectives: Novel antibacterial strategies against Helicobacter pylori are needed because H. pylori strains are acquiring resistance to antibiotics. We evaluated the efficacy of gentamicin-intercalated smectite hybrid (S-GEN)-based treatment regimens in a murine model of H. pylori infection. Methods: Two groups of 10 rats were administered either smectite or S-GEN to measure coverage of the gastric mucosa. To evaluate anti-H. pylori efficacy, mice were divided into eight groups of 10 mice each given different treatments, and H...
February 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29433688/synergism-of-prenylflavonoids-from-morus-alba-root-bark-against-clinical-mrsa-isolates
#3
Guo-Ying Zuo, Cui-Xian Yang, Jun Han, Yu-Qing Li, Gen-Chun Wang
BACKGROUND: Clinical methicillin-resistant Staphylococcus aureus (MRSA) is a thorny problem in current anti-infective therapeutics and a challenge of new drug development. Plant prenylflavonoids possess anti-MRSA activity, but few of the prenylflavonoids have been reported the synergistic anti-MRSA effect when they are used in combination with conventional antibacterial agents. PURPOSE: This study deals with anti-MRSA activity of four prenylflavonoids from the root bark of Morus alba and their synergism with 11 conventional antibacterial agents...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29424149/-inversive-liss-plate-in-treating-intertrochanteric-and-subtrochanteric-fractures-combined-with-femoral-shaft-fractures
#4
Lei Han, Yun-Gen Hu, Wei-Li Fang, Bo Jin, Shi-Chao Xu
OBJECTIVE: To study clinical effects of inversive LISS(less invasive stabilization system, LISS) plate for the treatment of intertrochanteric and subtrochanteric fractures combined with femoral shaft fractures. METHODS: From January 2012 to January 2015, 24 patients with intertrochanteric and subtrochanteric fractures combined with femoral shaft fractures were treated with inversive LISS plate, included 16 males and 8 females with an average age of 62.5 years old ranged from 35 to 81 years old...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29422897/fowl-adenovirus-serotype-4-sd0828-infections-causes-high-mortality-rate-and-cytokine-levels-in-specific-pathogen-free-chickens-compared-to-ducks
#5
Rong Li, Gen Li, Jing Lin, Shaojie Han, Xiaolan Hou, Hongyu Weng, Mengjiao Guo, Zhong Lu, Ning Li, Yingli Shang, Tongjie Chai, Liangmeng Wei
Hydropericardium syndrome and inclusion body hepatitis, together called hydropericardium-hepatitis syndrome, are acute infectious diseases found in chickens. These diseases are caused primarily by fowl adenovirus serotype 4 (FAdV-4) strains. In this study, we isolated a FAdV-4 strain (SD0828) from clinically diseased chickens and phylogenetically analyzed the L1 loops of the hexon protein sequences in 3-week-old specific pathogen-free chickens and ducks infected intramuscularly and orally, determining differences in the pathogenicity by observing clinical signs and gross and histological lesions...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29399925/molecular-phylogenetic-positions-and-ultrastructure-of-marine-gregarines-apicomplexa-cuspisella-ishikariensis-n-gen-n-sp-and-loxomorpha-cf-harmothoe-from-western-pacific-scaleworms-polynoidae
#6
Davis Iritani, Takeo Horiguchi, Kevin C Wakeman
Marine gregarines are unicellular parasites of invertebrates commonly found infecting the intestine and coelomic spaces of their hosts. Situated at the base of the apicomplexan tree, marine gregarines offer an opportunity to explore the earliest stages of apicomplexan evolution. Classification of marine gregarines is often based on the morphological traits of the conspicuous feeding stages (trophozoites) in combination with host affiliation and molecular phylogenetic data. Morphological characters of other life stages such as the spore are also used to inform taxonomy when such stages can be found...
February 5, 2018: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/29398033/preoperative-biliary-colonization-infection-caused-by-multidrug-resistant-mdr-pathogens-in-patients-undergoing-major-hepatectomy-with-extrahepatic-bile-duct-resection
#7
Gen Sugawara, Yukihiro Yokoyama, Tomoki Ebata, Tsuyoshi Igami, Junpei Yamaguchi, Takashi Mizuno, Tetsuya Yagi, Masato Nagino
BACKGROUND: The aim of this study was to review the surgical outcomes of patients who underwent major hepatectomy with extrahepatic bile duct resection after preoperative biliary drainage with a particular focus on the impact of preoperative biliary colonization/infection caused by multidrug-resistant pathogens. METHODS: Medical records of patients who underwent hepatobiliary resection after preoperative external biliary drainage between 2001 and 2015 were reviewed retrospectively...
February 1, 2018: Surgery
https://www.readbyqxmd.com/read/29355977/helicobacter-pylori-infection-is-associated-with-favorable-outcome-in-advanced-gastric-cancer-patients-treated-with-s-1-adjuvant-chemotherapy
#8
Satoshi S Nishizuka, Gen Tamura, Masahiro Nakatochi, Norimasa Fukushima, Yukimi Ohmori, Chihiro Sumida, Takeshi Iwaya, Takashi Takahashi, Keisuke Koeda
BACKGROUND AND OBJECTIVES: Limited information exists regarding beneficial effects of Helicobacter pylori. To examine the effect in advanced gastric cancer, we compared survival for patients treated with surgery-only or adjuvant chemotherapy on the basis of H. pylori infection status. METHODS: A cohort of 491 patients who underwent R0 resection for locally advanced gastric cancer between 2000 and 2009 at 12 institutions in northern Japan was included. H. pylori infection status, was assessed from paraffin-embedded formalin-fixed samples...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29349966/-a-medium-term-therapeutic-effects-of-anatomic-locking-plate-for-femoral-intertrochanteric-with-lateral-femoral-wall-fractures
#9
Jin-Wei Xu, Lei Han, Yun-Gen Hu, Wei-Li Fang, Bo Ji
OBJECTIVE: To retrospectively study medium term follow-up outcomes of the femoral intertrochanteric with lateral femoral wall fractures using anatomic locking plate fixation. METHODS: From June 2010 to January 2013, 18 cases of the unstable femoral intertrochanteric with lateral femoral wall fractures were treated with the anatomic locking plate, included 8 males and 10 females with an average age of 75.5 years ranging from 19 to 83 years old. There were 8 cases of traffic accident injuries, 6 cases of falls injuries, and 4 cases of falling from high place...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349956/-therapeutic-observation-of-subcutaneous-pedicle-screw-rod-system-with-modified-placement-for-tile-b-pelvic-fractures
#10
Xiao-Tian Wu, Nong Chen, Fu-Gen Pan, Zuo-Qing Liu, Xiao-Jian He
OBJECTIVE: To investigate the feasibility and therapeutic effect of subcutaneous pedicle screw-rod system with modified placement in treatment of Tile B pelvic fractures. METHODS: From June 2014 to August 2015, 14 patients with Tile B pelvic fractures were treated by subcutaneous pedicle screw-rod system with modified placement in the anterior inferior iliac spine and pubic tubercle. There were 8 males and 6 females, aged from 23 to 65 years with an average of 42 years...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29320984/prevalence-and-antibiotic-susceptibility-of-uropathogens-from-cases-of-urinary-tract-infections-uti-in-shashemene-referral-hospital-ethiopia
#11
Wubalem Desta Seifu, Alemayehu Desalegn Gebissa
BACKGROUND: Urinary tract infection (UTI) remains to be one of the most common infectious diseases diagnosed in developing countries. And a widespread use of antibiotics against uropathogens has led to the emergence of antibiotic resistant species. A laboratory based cross-sectional survey was conducted in Shashemene referral hospital to determine the prevalence and antibiotic susceptibility of uropathogens. METHODS: We have collected 384 clean catch mid-stream urine samples from all suspected UTI outpatients using sterile screw capped container...
January 10, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29279480/salmonella-houtenae-induced-empyema-complicated-with-chronic-tuberculous-empyema
#12
Yuichi Mukai, Toshihiko Agatsuma, Gen Ideura
Salmonella spp. are food-borne pathogens that usually cause gastroenteritis, although bacteremia and subsequent focal metastatic infection can also occasionally occur. Of the known Salmonella spp., Salmonella houtenae is a rare subspecies, comprising less than 1% of all Salmonella strains. We herein report the first case of S. houtenae-induced empyema complicated with chronic tuberculous empyema, which was successfully treated by antibacterial agents alone. We wish to highlight the importance of being aware that Salmonella spp...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29277472/a-complex-of-the-blood-fluke-genus-psettarium-digenea-aporocotylidae-infecting-tetraodontiform-fishes-of-east-queensland-waters
#13
R Q-Y Yong, S C Cutmore, M K Jones, A R G Gauthier, T H Cribb
Seven species of Psettarium (Digenea: Aporocotylidae), including four new species, are reported from tetraodontiform fishes from off coastal east Queensland. Psettarium pandora n. sp. infects the yellow boxfish, Ostracion cubicus (Ostraciidae), the first known aporocotylid to infect this family of fishes. Three new species are reported from pufferfishes of the genus Arothron (Tetraodontidae): Psettarium yoshidai n. sp. infects the map puffer (Arothron mappa), Psettarium hustoni n. sp. infects the black-spotted puffer (A...
December 19, 2017: Parasitology International
https://www.readbyqxmd.com/read/29226330/transcutaneous-immunization-with-pneumococcal-surface-protein-a-in-mice
#14
Hiromi Nagano, Masaki Kawabata, Gen Sugita, Akitoshi Tsuruhara, Junichiro Ohori, Tomohiro Jimura, Keiichi Miyashita, Yuichi Kurono, Kazuhiro Tomonaga, David E Briles, Kohtaro Fujihashi
OBJECTIVE: Pneumococcal infection caused by Streptococcus pneumoniae is a major upper respiratory tract disease that causes severe illness and mortality. Therefore, it is important to develop safe and effective vaccines to prevent pneumococcal infections. The goal of the study was to investigate the effectiveness of transcutaneous immunization (TCI) for induction of pneumococcal surface protein A (PspA) responses in the upper respiratory tract. METHODS: C57BL/6 mice were transcutaneously immunized with 1 μg of PspA and 2 μg of cholera toxin (CT) six times at weekly intervals and compared with transcutaneously treated controls (PBS alone/PspA alone/CT alone)...
December 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29225477/molecular-evaluation-of-colistin-resistant-gene-expression-changes-in-acinetobacter-baumannii-with-real-time-polymerase-chain-reaction
#15
Shahriar Sepahvand, Mohammad Ali Davarpanah, Amir Roudgari, Abbas Bahador, Vajihe Karbasizade, Zahra Kargar Jahromi
Background: Acinetobacter baumannii is an important human pathogen which has recently gained increased attention due to the occurrence of drug-resistant nosocomial infections in patients suffering from immune system disorders, and those in hospital intensive care units. The aim of this research was to identify and isolate A. baumannii strains resistant to colistin, determine antibiotic resistance pattern of this bacteria, investigate the presence of colistin-resistant genes, and finally assess the effect of expression changes in pmrA and pmrB genes resistant to A...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29208560/multiplex-pcr-system-for-the-rapid-diagnosis-of-respiratory-virus-infection-a-systematic-review-and-meta-analysis
#16
REVIEW
Huai-Shiuan Huang, Chi-Lin Tsai, Jeffrey Chang, Tzu-Chun Hsu, Samuel Lin, Chien-Chang Lee
OBJECTIVES: We aim to provide a summary of evidence for the diagnostic accuracies of three multiplex PCR systems (mPCRs): BioFire Filmarray RP (Filmarray), Nanosphere Verigene RV+ test (Verigene) and Hologic Gen-Probe Prodesse assays on the detection of viral respiratory infections. METHODS: A comprehensive search up to July 1st, 2017 was conducted on Medline and Embase for studies that utilized Filmarray, Verigene and Prodesse for diagnosis of viral respiratory infections...
December 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29208030/experimental-therapeutic-assays-of-tephrosia-vogelii-against-leishmania-major-infection-in-murine-model-in-vitro-and-in-vivo
#17
Sylvia Naliaka Marango, Christopher Khayeka-Wandabwa, Judith Alice Makwali, Bernard Ngoitsi Jumba, Joseph K Choge, Eric Onyango Adino, Christopher O Anjili
BACKGROUND: Conventional targeted leishmanicidal chemotherapy has persistently remained prohibitive for most economically deprived communities due to costs, associated time to accessing health services and duration for successful treatment programme. Alternatives are bound to be incorporated in rational management of leishmaniasis by choice or default due to accessibility and cultural beliefs. Therefore, there is need to rigorously investigate and appraise the activity of medicinal compounds that may have anti-leishmanicidal activity especially in the context of products that are already being utilized by the populations for other ailments but have limited information on their therapeutic value and possible cytoxicity...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29193684/identification-of-a-novel-compound-targeting-the-nuclear-export-of-influenza-a-virus-nucleoprotein
#18
Feng Huang, Jingliang Chen, Junsong Zhang, Likai Tan, Gui Lu, Yongjie Luo, Ting Pan, Juanran Liang, Qianwen Li, Baohong Luo, Hui Zhang, Gen Lu
Although antiviral drugs are available for the treatment of influenza infection, it is an urgent requirement to develop new antiviral drugs regarding the emergence of drug-resistant viruses. The nucleoprotein (NP) is conserved among all influenza A viruses (IAVs) and has no cellular equivalent. Therefore, NP is an ideal target for the development of new IAV inhibitors. In this study, we identified a novel anti-influenza compound, ZBMD-1, from a library of 20,000 compounds using cell-based influenza A infection assays...
November 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29161485/aedes-albopictus-skuse-1894-infected-with-the-american-asian-genotype-of-dengue-type-2-virus-in-medell%C3%A3-n-suggests-its-possible-role-as-vector-of-dengue-fever-in-colombia
#19
Andrés Gómez-Palacio, Juan Suaza-Vasco, Sandra Castaño, Omar Triana, Sandra Uribe
INTRODUCTION: Aedes aegypti and Ae. albopictus are recognized vectors of dengue, yellow fever, chikungunya and Zika arboviruses in several countries worldwide. In Colombia, Ae. albopictus geographical distribution has increased to include highly populated cities such as Cali and Medellín. Although this species has been frequently found in urban and semi-urban zones in the country, its role as vector of the dengue fever is poorly known. OBJECTIVE: To identify the presence of Ae...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29158272/combination-antibiotic-exposure-selectively-alters-the-development-of-vancomycin-intermediate-resistance-in-staphylococcus-aureus
#20
Xuting Zheng, Andrew D Berti, Sue McCrone, Melanie Roch, Adriana E Rosato, Warren E Rose, Baiyi Chen
Invasive methicillin-resistant Staphylococcus aureus (MRSA) treated with vancomycin (VAN) is associated with reduced VAN susceptibility and treatment failure. VAN combination therapy is one strategy to improve response, but comprehensive assessments of combinations to prevent resistance are limited. This study identifies optimal combinations to prevent the emergence of VAN-intermediate Staphylococcus aureus (VISA). Two standard MRSA and two heterogeneous VISA (hVISA) strains were exposed for 28 days in vitro to VAN alone, VAN with cefazolin (CFZ), fosfomycin, gentamicin, meropenem, rifampin, piperacillin-tazobactam (TZP), or trimethoprim-sulfamethoxazole...
February 2018: Antimicrobial Agents and Chemotherapy
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