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https://www.readbyqxmd.com/read/28437231/capsular-polysaccharide-types-and-virulence-related-traits-of-epidemic-kpc-producing-klebsiella-pneumoniae-isolates-in-a-chinese-university-hospital
#1
Yang Liu, Pan-Pan Liu, Lian-Hui Wang, Dan-Dan Wei, La-Gen Wan, Wei Zhang
Klebsiella pneumoniae is an important human pathogen associated with a variety of diseases and the prevalence of blaKPC carrying K. pneumoniae (KPC-Kp) is rapidly increasing. Capsule is an important virulence factor in K. pneumoniae. In this study, we determined to first systematically characterize capsular polysaccharide (CPS) and virulence traits in KPC-Kp strains. A total of 56 KPC-Kp isolates were recovered from clinical samples in a Chinese hospital, which were assigned to clonal lineages by multilocus sequence typing (MLST)...
February 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28427957/pcr-based-identification-of-trypanosoma-lewisi-and-trypanosoma-musculi-using-maxicircle-kinetoplast-dna
#2
Xiao-Kun Hong, Xuan Zhang, Octavio Alejandro Fusco, You-Gen Lan, Zhao-Rong Lun, De-Hua Lai
Trypanosoma lewisi, transmitted by rat fleas, is a widespread pathogen specific to rats with records of human infection cases. Its closely related species with global distribution, Trypanosoma musculi, is transmitted between mice by ingestion of infected fleas. These trypanosomes are of similar morphology, making it difficult to distinguish them by microscopy. In this study, we have developed a rapid, sensitive and reliable PCR method for the diagnosis of T. lewisi and T. musculi. The T. lewisi-specific amplicons were not produced by other Trypanosoma, such as T...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28426936/cholesterol-assisted-bacterial-cell-surface-engineering-for-photodynamic-inactivation-of-gram-positive-and-gram-negative-bacteria
#3
Hao-Ran Jia, Ya-Xuan Zhu, Zhan Chen, Fu-Gen Wu
Antibacterial photodynamic therapy (PDT) which enables effective killing of regular and multidrug-resistant (MDR) bacteria is a promising treatment modality for bacterial infection. However, because most photosensitizer (PS) molecules fail to strongly interact with the surface of Gram-negative bacteria, this technique is only suitable for treating Gram-positive bacterial infection, which largely hampers its practical applications. Herein, we revealed for the first time that cholesterol could significantly facilitate the hydrophobic binding of PSs to the bacterial surface, achieving the hydrophobic interaction-based bacterial cell surface engineering that could effectively photo-inactivate both Gram-negative and Gram-positive bacteria...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28420310/helminth-fauna-associated-with-three-neotropical-bat-species-chiroptera-mormoopidae-in-veracruz-mexico
#4
Emilio Clarke-Crespo, Gerardo Pérez-Ponce de León, Salvador Montiel-Ortega, Miguel Rubio-Godoy
Bats are recognized as potential hosts of pathogens exploiting the food chain to reach them as definitive hosts. However, very little is known about their endoparasites, especially for Neotropical bats. In this study, we assessed the helminth fauna associated with 3 insectivorous bat species roosting in the same single hot cave in central Veracruz, Mexico: the ghost-faced bat (Mormoops megalophylla), the naked-backed bat (Pteronotus davyi) and Wagner's mustached bat (Pteronotus personatus). During a period of 1 yr (April 2007-2008), a total of 135 mormoopid bats were collected and examined for helminths...
April 18, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28403000/the-combined-use-of-a-neurocutaneous-flap-and-the-ilizarov-technique-for-reconstruction-of-large-soft-tissue-defects-and-bone-loss-in-the-tibia
#5
Jia Xu, Wan-Run Zhong, Liang Cheng, Chun-Yang Wang, Gen Wen, Pei Han, Yi-Min Chai
BACKGROUND: Management of posttraumatic large soft tissue defects and bone loss remains a therapeutic and surgical challenge for orthopedic surgeons. We assessed the use of a neurocutaneous flap and the Ilizarov technique in the reconstruction of severe composite defects in the tibia. METHODS: We retrospectively reviewed 18 consecutive patients with trauma-related soft tissue defects and bone loss. The size of the soft tissue defect ranges from 8 × 9 cm to 14 × 18 cm...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28373868/morin-attenuates-streptococcus-suis-pathogenicity-in-mice-by-neutralizing-suilysin-activity
#6
Gen Li, Gejin Lu, Zhimin Qi, Hongen Li, Lin Wang, Yanhui Wang, Bowen Liu, Xiaodi Niu, Xuming Deng, Jianfeng Wang
Streptococcus suis, a Gram-positive pathogen, is widely recognized as an important agent of swine infection, and it is also known to cause a variety of zoonoses, such as meningitis, polyarthritis and pneumonia. Suilysin (SLY), an extracellular pore-forming toxin that belongs to the cholesterol-dependent cytolysin family, is an essential virulence factor of S. suis capsular type 2 (SS2). Here, we found that morin hydrate (morin), a natural flavonoid that lacks anti-SS2 activity, inhibits the hemolytic activity of SLY, protects J774 cells from SS2-induced injury and protects mice from SS2 infection...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28361043/cleavage-of-grb2-associated-binding-protein-2-by-viral-proteinase-2a-during-coxsackievirus-infection
#7
Haoyu Deng, Gabriel Fung, Ye Qiu, Chen Wang, Jingchun Zhang, Zheng-Gen Jin, Honglin Luo
Coxsackievirus type B3 (CV-B3), an enterovirus associated with the pathogenesis of several human diseases, subverts, or employs the host intracellular signaling pathways to support effective viral infection. We have previously demonstrated that Grb2-associated binding protein 1 (GAB1), a signaling adaptor protein that serves as a platform for intracellular signaling assembly and transduction, is cleaved upon CV-B3 infection, resulting in a gain-of-pro-viral-function via the modification of GAB1-mediated ERK1/2 pathway...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28329211/therapeutic-vaccine-for-genital-herpes-simplex-virus-2-infection-findings-from-a-randomized-trial
#8
David I Bernstein, Anna Wald, Terri Warren, Kenneth Fife, Stephen Tyring, Patricia Lee, Nick Van Wagoner, Amalia Magaret, Jessica B Flechtner, Sybil Tasker, Jason Chan, Amy Morris, Seth Hetherington
Background.: Genital herpes simplex virus type 2 (HSV-2) infection causes recurrent lesions and frequent viral shedding. GEN-003 is a candidate therapeutic vaccine containing HSV-2 gD2ΔTMR and ICP4.2, and Matrix-M2 adjuvant. Methods.: Persons with genital herpes were randomized into three dose cohorts to receive three intramuscular doses 21 days apart of 10 µg, 30 µg, or 100 µg of GEN-003, antigens without adjuvant, or placebo. Participants obtained genital swabs twice-daily for HSV-2 detection and monitored genital lesions for 28-day periods at baseline and intervals after the last dose...
January 30, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28320712/efficacy-of-telavancin-alone-and-in-combination-with-ampicillin-in-a-rat-model-of-enterococcus-faecalis-endocarditis
#9
Truc T Tran, Vincent H Tam, Barbara E Murray, Cesar A Arias, Kavindra V Singh
We first assessed telavancin (TLV) pharmacokinetics after a single subcutaneous dose of 35 mg/kg. The pharmacokinetic data were used to predict a TLV dose that simulates human exposure and the efficacy of TLV was then evaluated using TLV 21 mg/kg Q 12 h against Enterococcus faecalis OG1RF (TLV MIC of 0.06 μg/ml) in a rat endocarditis model with an indwelling catheter. Therapy was given for 3 days with TLV, daptomycin (DAP) or ampicillin (AMP) monotherapy and with combinations of TLV plus AMP, AMP plus gentamicin (GEN), and AMP plus ceftriaxone (CRO); rats were sacrificed 24 h after the last dose...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28302561/ameliorative-effect-of-gossypin-against-gentamicin-induced-nephrotoxicity-in-rats
#10
Mohamed Katary, Ahmad Salahuddin
AIM: Gentamicin (GEN) is an aminoglycoside antibiotic employed in treatment of life-threatening gram-negative infections, but one of its major side effects is the induction of nephrotoxicity. Therefore, the aim of this work was to scrutinize the possible protective effect of gossypin against GEN-induced nephrotoxicity. METHOD: Rats were randomly divided into four groups. First group served as a control, second group was injected with gossypin (10mg/kg, orally) for 7days, third group was injected with GEN (80mg/kg, i...
May 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28255815/effects-of-prion-protein-devoid-of-the-n-terminal-residues-25-50-on-prion-pathogenesis-in-mice
#11
Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
The N-terminal polybasic region of the normal prion protein, PrP(C), which encompasses residues 23-31, is important for prion pathogenesis by affecting conversion of PrP(C) into the pathogenic isoform, PrP(Sc). We previously reported transgenic mice expressing PrP with residues 25-50 deleted in the PrP-null background, designated as Tg(PrP∆preOR)/Prnp (0/0) mice. Here, we produced two new lines of Tg(PrP∆preOR)/Prnp (0/0) mice, each expressing the mutant protein, PrP∆preOR, 1.1 and 1.6 times more than PrP(C) in wild-type mice, and subsequently intracerebrally inoculated RML and 22L prions into them...
March 2, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28167046/aranciocystis-muskarensis-n-gen-n-sp-a-neogregarine-pathogen-of-the-anisoplia-segetum-herbst-coleoptera-scarabaeidae
#12
Çağrı Bekircan, Mustafa Cüce, Hilal Baki, Onur Tosun
In this study, a new genus and species of neogregarine which is a pathogen of Anisoplia segetum Herbst (Coleoptera: Scarabaeidae), is described. The adult beetles of A. segetum were collected from Nevşehir, Turkey and neogregarine infection rates were determined as 18.52%. The Giemsa-stained mature oocysts are lemon-shaped and measured 9.34±0.82μm in length and 5.77±0.77μm in width. The oocyst wall surface of the mature oocysts is similar to an osage orange (tuberculate). Morphological, ultrastructural and molecular features indicate that the previously undescribed neogregarine is dissimilar to all known neogregarine taxa and represents the first record from Anisoplia segetum and is named here as Aranciocystis muskarensis n...
March 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28143791/kidney-and-innate-immunity
#13
REVIEW
Ying-Hui Wang, Yu-Gen Zhang
Innate immune system is an important modulator of the inflammatory response during infection and tissue injury/repair. The kidney as a vital organ with high energy demand plays a key role in regulating the disease related metabolic process. Increasing research interest has focused on the immune pathogenesis of many kidney diseases. However, innate immune cells such as dendritic cells, macrophages, NK cells and a few innate lymphocytes, as well as the complement system are essential for renal immune homeostasis and ensure a coordinated balance between tissue injury and regeneration...
March 2017: Immunology Letters
https://www.readbyqxmd.com/read/28119097/aurantiamide-acetate-from-baphicacanthus-cusia-root-exhibits-anti-inflammatory-and-anti-viral-effects-via-inhibition-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-influenza-a-virus-infected-cells
#14
Beixian Zhou, Zifeng Yang, Qitong Feng, Xiaoli Liang, Jing Li, Mark Zanin, Zhihong Jiang, Nanshan Zhong
ETHNOPHARMACOLOGICAL RELEVANCE: Baphicacanthus cusia root also names "Nan Ban Lan Gen" has been traditionally used to prevent and treat influenza A virus infections. Here, we identified a peptide derivative, aurantiamide acetate (compound E17), as an active compound in extracts of B. cusia root. Although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism by which it functions as an anti-viral or as an anti-inflammatory during influenza virus infection are poorly defined...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28096855/helminth-infections-of-meriones-persicus-persian-jird-mus-musculus-house-mice-and-cricetulus-migratorius-grey-hamster-a-cross-sectional-study-in-meshkin-shahr-district-northwest-iran
#15
Zabiholah Zarei, Mehdi Mohebali, Zahra Heidari, Jaber Davoodi, Afshin Shabestari, Afsaneh Motevalli Haghi, Khadijeh Khanaliha, Eshrat Beigom Kia
BACKGROUND: Rodents have important role as reservoirs of different parasites. The aim of this study was to determine helminth parasites of abundant rodents in Meshkin-Shahr, Ardabil Province northwest Iran. METHODS: From April 2014 to March 2015; 205 rodents including 118 Meriones persicus, 63 Mus musculus and 24 Cricetulus migratorius were collected, using live traps. All rodents were dissected and their different tissues examined for infectivity with helminth parasites...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28089813/parasciadicleithrum-octofasciatum-n-gen-n-sp-monogenoidea-dactylogyridae-parasite-of-rocio-octofasciata-regan-cichlidae-perciformes-from-mexico-characterised-by-morphological-and-molecular-evidence
#16
Carlos A Mendoza-Palmero, Isabel Blasco-Costa, David Hernández-Mena, Gerardo Pérez-Ponce de León
Based on an integrative taxonomic approach, combining morphological characters and partial sequences of the 28S rRNA gene, a new genus and species, Parasciadicleithrum octofasciatum, is proposed to accommodate dactylogyrids infecting the gills of Rocio octofasciata (Cichlidae) from a tributary of the Lacantún River basin, Chiapas State, southern Mexico. Morphologically, the new genus resembles members of Sciadicleithrum (Dactylogyridae) in the presence of membranes on the anterior margins of both ventral and dorsal haptoral bars...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/28087492/multi-antibiotic-resistant-and-putative-virulence-gene-signatures-in-enterococcus-species-isolated-from-pig-farms-environment
#17
Abeni Beshiru, Isoken H Igbinosa, Faith I Omeje, Abraham G Ogofure, Martin M Eyong, Etinosa O Igbinosa
The continuous misuse of antimicrobials in food animals both orally and subcutaneously as therapeutic and prophylactic agents to bacterial infections could be detrimental and contribute to the dissemination of resistant clones in livestock production. The present study was carried out to determine the antibiogram and virulence gene characteristics of Enterococcus species from pig farms. A total of 300 faecal samples were obtained from two pig farms in Benin City between February and July 2016. Standard culture-based and polymerase chain reaction (PCR) assay were adopted in the detection and characterization of the Enterococcus species...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28073612/gonorrhea-and-chlamydia-in-the-emergency-department-continued-need-for-more-focused-treatment-for-men-women-and-pregnant-women
#18
Sean P Wilson, Taher Vohra, McKenna Knych, Jared Goldberg, Christopher Price, Sean Calo, Meredith Mahan, Joseph Miller
INTRODUCTION: Delay in current nucleic acid amplification testing for Neisseria gonorrhoeae and Chlamydia trachomatis has led to recommendations for presumptive treatment in patients with concern for infection and unreliable follow-up. In the urban setting, it is assumed that many patients have unreliable follow-up, therefore presumptive therapy is thought to be used frequently. We sought to measure the frequency of disease and accuracy of presumptive treatment for these infections. METHODS: This was an observational cohort study performed at an urban academic Level 1 trauma center ED with an annual census of 95,000 visits per year...
January 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28065818/growth-retardation-induced-by-avian-leukosis-virus-subgroup-j-associated-with-down-regulated-wnt-%C3%AE-catenin-pathway
#19
Weiguo Feng, Defang Zhou, Wei Meng, Gen Li, Pingping Zhuang, Zhifang Pan, Guihua Wang, Ziqiang Cheng
Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces growth retardation and neoplasia in chickens, leading to enormous economic losses in poultry industry. Increasing evidences showed several signal pathways involved in ALV-J infection. However, what signaling pathway involved in growth retardation is largely unknown. To explore the possible signaling pathway, we tested the cell proliferation and associated miRNAs in ALV-J infected CEF cells by CCK-8 and Hiseq, respectively. The results showed that cell proliferation was significantly inhibited by ALV-J and three associated miRNAs were identified to target Wnt/β-catenin pathway...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28039902/long-term-safety-and-efficacy-of-telbivudine-in-infants-born-to-mothers-treated-during-the-second-or-third-trimesters-of-pregnancy
#20
G-R Han, H-X Jiang, C-M Wang, Y Ding, G-J Wang, X Yue, L Zhou, W Zhao
Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis B virus (HBV) perinatal transmission with no safety concerns in infants aged up to 1 year. This study evaluated the long-term efficacy and safety of telbivudine in 214 infants born to 210 pregnant women with chronic hepatitis B infection who were treated with telbivudine during pregnancy (weeks 20-32 of gestation). The infants were followed for up to 5 years after birth. The efficacy endpoint was the rate of perinatal transmission, which was established by HBsAg and HBV DNA levels at 7 and 12 months...
December 31, 2016: Journal of Viral Hepatitis
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