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https://www.readbyqxmd.com/read/28167046/aranciocystis-muskarensis-n-gen-n-sp-a-neogregarine-pathogen-of-the-anisoplia-segetum-herbst-coleoptera-scarabaeidae
#1
Çağrı Bekircan, Mustafa Cüce, Hilal Baki, Onur Tosun
In this study, a new genus and species of neogregarine which is a pathogen of Anisoplia segetum Herbst (Coleoptera: Scarabaeidae), is described. The adult beetles of A. segetum were collected from Nevşehir, Turkey and neogregarine infection rates were determined as 18.52%. The Giemsa-stained mature oocysts are lemon-shaped and measured 9.34±0.82μm in length and 5.77±0.77μm in width. The oocyst wall surface of the mature oocysts is similar to an osage orange (tuberculate). Morphological, ultrastructural and molecular features indicate that the previously undescribed neogregarine is dissimilar to all known neogregarine taxa and represents the first record from Anisoplia segetum and is named here as Aranciocystis muskarensis n...
February 3, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28143791/kidney-and-innate-immunity
#2
REVIEW
Ying-Hui Wang, Yu-Gen Zhang
Innate immune system is an important modulator of the inflammatory response during infection and tissue injury/repair. The kidney as a vital organ with high energy demand plays a key role in regulating the disease related metabolic process. Increasing research interest has focused on the immune pathogenesis of many kidney diseases. However, innate immune cells such as dendritic cells, macrophages, NK cells and a few innate lymphocytes, as well as the complement system are essential for renal immune homeostasis and ensure a coordinated balance between tissue injury and regeneration...
January 28, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28119097/aurantiamide-acetate-from-baphicacanthus-cusia-root-exhibits-anti-inflammatory-and-anti-viral-effects-via-inhibition-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-influenza-a-virus-infected-cells
#3
Beixian Zhou, Zifeng Yang, Qitong Feng, Xiaoli Liang, Jing Li, Mark Zanin, Zhihong Jiang, Nanshan Zhong
ETHNOPHARMACOLOGICAL RELEVANCE: Baphicacanthus cusia root also names "Nan Ban Lan Gen" has been traditionally used to prevent and treat influenza A virus infections. Here, we identified a peptide derivative, aurantiamide acetate (compound E17), as an active compound in extracts of B. cusia root. Although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism by which it functions as an anti-viral or as an anti-inflammatory during influenza virus infection are poorly defined...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28096855/helminth-infections-of-meriones-persicus-persian-jird-mus-musculus-house-mice-and-cricetulus-migratorius-grey-hamster-a-cross-sectional-study-in-meshkin-shahr-district-northwest-iran
#4
Zabiholah Zarei, Mehdi Mohebali, Zahra Heidari, Jaber Davoodi, Afshin Shabestari, Afsaneh Motevalli Haghi, Khadijeh Khanaliha, Eshrat Beigom Kia
BACKGROUND: Rodents have important role as reservoirs of different parasites. The aim of this study was to determine helminth parasites of abundant rodents in Meshkin-Shahr, Ardabil Province northwest Iran. METHODS: From April 2014 to March 2015; 205 rodents including 118 Meriones persicus, 63 Mus musculus and 24 Cricetulus migratorius were collected, using live traps. All rodents were dissected and their different tissues examined for infectivity with helminth parasites...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28089813/parasciadicleithrum-octofasciatum-n-gen-n-sp-monogenoidea-dactylogyridae-parasite-of-rocio-octofasciata-regan-cichlidae-perciformes-from-mexico-characterised-by-morphological-and-molecular-evidence
#5
Carlos A Mendoza-Palmero, Isabel Blasco-Costa, David Hernández-Mena, Gerardo Pérez-Ponce de León
Based on an integrative taxonomic approach, combining morphological characters and partial sequences of the 28S rRNA gene, a new genus and species, Parasciadicleithrum octofasciatum, is proposed to accommodate dactylogyrids infecting the gills of Rocio octofasciata (Cichlidae) from a tributary of the Lacantún River basin, Chiapas State, southern Mexico. Morphologically, the new genus resembles members of Sciadicleithrum (Dactylogyridae) in the presence of membranes on the anterior margins of both ventral and dorsal haptoral bars...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/28087492/multi-antibiotic-resistant-and-putative-virulence-gene-signatures-in-enterococcus-species-isolated-from-pig-farms-environment
#6
Abeni Beshiru, Isoken H Igbinosa, Faith I Omeje, Abraham G Ogofure, Martin M Eyong, Etinosa O Igbinosa
The continuous misuse of antimicrobials in food animals both orally and subcutaneously as therapeutic and prophylactic agents to bacterial infections could be detrimental and contribute to the dissemination of resistant clones in livestock production. The present study was carried out to determine the antibiogram and virulence gene characteristics of Enterococcus species from pig farms. A total of 300 faecal samples were obtained from two pig farms in Benin City between February and July 2016. Standard culture-based and polymerase chain reaction (PCR) assay were adopted in the detection and characterization of the Enterococcus species...
January 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28073612/gonorrhea-and-chlamydia-in-the-emergency-department-continued-need-for-more-focused-treatment-for-men-women-and-pregnant-women
#7
Sean P Wilson, Taher Vohra, McKenna Knych, Jared Goldberg, Christopher Price, Sean Calo, Meredith Mahan, Joseph Miller
INTRODUCTION: Delay in current nucleic acid amplification testing for Neisseria gonorrhoeae and Chlamydia trachomatis has led to recommendations for presumptive treatment in patients with concern for infection and unreliable follow-up. In the urban setting, it is assumed that many patients have unreliable follow-up, therefore presumptive therapy is thought to be used frequently. We sought to measure the frequency of disease and accuracy of presumptive treatment for these infections. METHODS: This was an observational cohort study performed at an urban academic Level 1 trauma center ED with an annual census of 95,000 visits per year...
January 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28065818/growth-retardation-induced-by-avian-leukosis-virus-subgroup-j-associated-with-down-regulated-wnt-%C3%AE-catenin-pathway
#8
Weiguo Feng, Defang Zhou, Wei Meng, Gen Li, Pingping Zhuang, Zhifang Pan, Guihua Wang, Ziqiang Cheng
Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces growth retardation and neoplasia in chickens, leading to enormous economic losses in poultry industry. Increasing evidences showed several signal pathways involved in ALV-J infection. However, what signaling pathway involved in growth retardation is largely unknown. To explore the possible signaling pathway, we tested the cell proliferation and associated miRNAs in ALV-J infected CEF cells by CCK-8 and Hiseq, respectively. The results showed that cell proliferation was significantly inhibited by ALV-J and three associated miRNAs were identified to target Wnt/β-catenin pathway...
January 5, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28039902/long-term-safety-and-efficacy-of-telbivudine-in-infants-born-to-mothers-treated-during-the-second-or-third-trimesters-of-pregnancy
#9
G-R Han, H-X Jiang, C-M Wang, Y Ding, G-J Wang, X Yue, L Zhou, W Zhao
Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis B virus (HBV) perinatal transmission with no safety concerns in infants aged up to 1 year. This study evaluated the long-term efficacy and safety of telbivudine in 214 infants born to 210 pregnant women with chronic hepatitis B infection who were treated with telbivudine during pregnancy (weeks 20-32 of gestation). The infants were followed for up to 5 years after birth. The efficacy endpoint was the rate of perinatal transmission, which was established by HBsAg and HBV DNA levels at 7 and 12 months...
December 31, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28034667/adjunctive-hyperbaric-oxygen-therapy-in-severe-burns-experience-in-taiwan-formosa-water-park-dust-explosion-disaster
#10
I-Han Chiang, Shyi-Gen Chen, Kun-Lun Huang, Yu-Ching Chou, Niann-Tzyy Dai, Chung-Kan Peng
BACKGROUND: Despite major advances in therapeutic strategies for the management of patients with severe burns, significant morbidity and mortality is observed. Hyperbaric oxygen therapy (HBOT) increases the supply of oxygen to burn areas. The aim of this study was to determine whether HBOT is effective in the treatment of major thermal burns. METHODS: On June 27, 2015 in New Taipei, Taiwan, a mass casualty disaster occurred as fire erupted over a large crowd, injuring 499 people...
December 26, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28011210/synergistic-antibacterial-effect-of-bi2s3-nanospheres-combined-with-ineffective-antibiotic-gentamicin-against-methicillin-resistant-staphylococcus-aureus
#11
Lulu Ma, Jie Wu, Shilei Wang, Hao Yang, Donghui Liang, Zhong Lu
In this paper, Bi2S3 nanospheres with size of 212nm were prepared by a simple hydrothermal process. The selectively enhanced antibacterial effects of Bi2S3 nanospheres with three classes of ineffective antibiotics, β-lactam (cefuroxime, CXM; cefotaxime, CTX and piperacillin, PIP), quinolone (ciprofloxacin, CIP) and aminoglycoside (gentamicin, GEN) against clinical isolated methicillin-resistant Staphylococcus aureus (MRSA) were investigated for the first time. GEN shows significantly synergistic growth inhibition against MRSA when combined with Bi2S3 nanospheres, while CXM, CTX, PIP and CIP do not...
December 10, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27995869/evaluation-of-xpert-mrsa-gen-3-and-bd-max-mrsa-xt-for-meticillin-resistant-staphylococcusaureus-screening-in-a-routine-diagnostic-setting-in-a-low-prevalence-area
#12
Xiaohui Chen Nielsen, Tina Vasehus Madsen, Jørgen Engberg
Screening and pre-emptive isolation of at-risk patients are important aspects of the Danish approach to the prevention of meticillin-resistant Staphylococcusaureus (MRSA) infection, but screening with conventional culture can take up to 3 days for results to become available with attendant costs and disadvantages of prolonged isolation. We sought to evaluate the accuracy, time to availability of results and potential economic benefits of two next-generation MRSA screening assays, Xpert MRSA Gen 3 (GX MRSA) and BD MAX MRSA XT, in a setting of a consolidated laboratory serving a number of hospitals with a low prevalence of MRSA and using enrichment culture as a reference method...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27993617/parahepatospora-carcini-n-gen-n-sp-a-parasite-of-invasive-carcinus-maenas-with-intermediate-features-of-sporogony-between-the-enterocytozoon-clade-and-other-microsporidia
#13
Jamie Bojko, Fraser Clark, David Bass, Alison M Dunn, Sarah Stewart-Clark, Paul D Stebbing, Grant D Stentiford
Parahepatospora carcini n. gen. n. sp., is a novel microsporidian parasite discovered infecting the cytoplasm of epithelial cells of the hepatopancreas of a single Carcinus maenas specimen. The crab was sampled from within its invasive range in Atlantic Canada (Nova Scotia). Histopathology and transmission electron microscopy were used to show the development of the parasite within a simple interfacial membrane, culminating in the formation of unikaryotic spores with 5-6 turns of an isofilar polar filament...
December 18, 2016: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/27990331/wongia-gen-nov-papulosaceae-sordariomycetes-a-new-generic-name-for-two-root-infecting-fungi-from-australia
#14
Wanporn Khemmuk, Andrew D W Geering, Roger G Shivas
The classification of two root-infecting fungi, Magnaporthe garrettii and M. griffinii, was examined by phylogenetic analysis of multiple gene sequences. This analysis demonstrated that M. garrettii and M. griffinii were sister species that formed a well-supported separate clade in Papulosaceae (Diaporthomycetidae, Sordariomycetes), which clusters outside of the Magnaporthales. Wongia gen. nov, is established to accommodate these two species which are not closely related to other species classified in Magnaporthe nor to other genera, including Nakataea, Magnaporthiopsis and Pyricularia, which all now contain other species once classified in Magnaporthe...
December 2016: IMA Fungus
https://www.readbyqxmd.com/read/27989862/characterization-of-a-novel-disease-resistance-gene-rtp3-and-its-association-with-vnn-disease-resistance-in-asian-seabass
#15
Peng Liu, Le Wang, Bao Qing Ye, Shuqing Huang, Sek-Man Wong, Gen Hua Yue
Asian seabass, an important food fish in Southeast Asia, has suffered from nervous necrosis virus (NNV) infection, resulting in massive mortality of Asian seabass larvae and enormous economic losses. Identification and characterization of disease resistance genes is important. Previous transcriptome analysis of Asians seabass epithelial cells after NNV infection revealed a highly inducible gene, receptor-transporting protein 3 (rtp3), indicating it could play an important role in Asian seabass - NNV interaction...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27987055/description-and-phylogeny-of-a-new-microsporidium-from-the-elm-leaf-beetle-xanthogaleruca-luteola-muller-1766-coleoptera-chrysomelidae
#16
Çağrı Bekircan, Ufuk Bülbül, Halil I Güler, James J Becnel
This study describes a new genus and species of microsporidia which is a pathogen of the elm leaf beetle, Xanthogaleruca luteola Muller, 1776 (Coleoptera: Chrysomelidae). The beetles were collected from Istanbul in Turkey. All developmental stages are uninucleate and in direct contact with the host cell cytoplasm. Giemsa-stained mature spores are oval in shape and measured 3.40 ± 0.37 μm in length and 1.63 ± 0.20 μm in width. These uninucleate spores have an isofilar polar filament with 11 turns...
February 2017: Parasitology Research
https://www.readbyqxmd.com/read/27968847/bushenjianpi-formula-combined-with-entecavir-for-hbeag-negative-chronic-hepatitis-b-patients-a-multicentre-randomised-double-blind-placebo-controlled-trial
#17
Yue-Qiu Gao, Xin Zhang, Man Li, Zhen-Hua Zhou, Xue-Hua Sun, Xiao-Jun Zhu, Shu-Gen Jin
BACKGROUND: The treatment combination of traditional Chinese medicine with western medicine results in significant decrease of serum hepatitis B virus (HBV) DNA and increase of HBeAg loss in patients with HBeAg-positive chronic hepatitis B (CHB) without any serious adverse events. We aimed to assess whether the Bushenjianpi Formula combined with entecavir could increase the HBsAg loss rate in patients with HBeAg-negative CHB. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, we recruited patients with HBeAg-negative CHB from ten third-level grade-A hospital of Traditional Chinese Medicine...
October 2016: Lancet
https://www.readbyqxmd.com/read/27917361/il28b-genotype-is-associated-with-cirrhosis-or-transition-to-cirrhosis-in-treatment-naive-patients-with-chronic-hcv-genotype-1-infection-the-international-observational-gen-c-study
#18
Alessandra Mangia, Victor De Ledinghen, François Bailly, Javier Brahm, Jazeps Keiss, Jonas Valantinas, Nele Rasmann, Diethelm Messinger, Fernando Tatsch, Georgios Bakalos, Graham R Foster
BACKGROUND AND PURPOSE: Contradictory data exist on the association between host interleukin-28B (IL28B) rs12979860 genotype and liver fibrosis in patients with chronic hepatitis C (CHC). This large, international, observational study (NCT01675427/MV25600) investigated relationships between IL28B rs12979860 genotype and liver fibrosis stage in CHC patients. METHODS: A total of 3003 adult, treatment-naive CHC patients were enrolled into the study. Patients made one study visit to provide a blood sample for genotyping; other data were obtained from medical records...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27917194/a-network-approach-of-gene-co-expression-in-the-zea-mays-aspergillus-flavus-pathosystem-to-map-host-pathogen-interaction-pathways
#19
Bryan M Musungu, Deepak Bhatnagar, Robert L Brown, Gary A Payne, Greg OBrian, Ahmad M Fakhoury, Matt Geisler
A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). For the pathogen A. flavus, a link between aflatoxin production and vesicular transport was identified within the network...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27912884/synergism-of-coumarins-from-the-chinese-drug-zanthoxylum-nitidum-with-antibacterial-agents-against-methicillin-resistant-staphylococcus-aureus-mrsa
#20
Guo-Ying Zuo, Chun-Juan Wang, Jun Han, Yu-Qing Li, Gen-Chun Wang
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious therapeutic challenge in current clinic and new drug development. Natural coumarins have diverse bioactivities and the potential of resistance modifying effects. PURPOSE: This study is to present in-depth evaluations of in vitro antimicrobial activities of four natural coumarins 5-geranyloxy-7-methoxycoumarin (Gm, 1), (5,7-dimethoxy-8-prenyloxycoumarin (artanin, Ar, 2)), isopimpinellin (Is, 3) and phellopterin (Ph, 4) from Zanthoxylum nitidum (Roxb...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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