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https://www.readbyqxmd.com/read/29046443/prion-protein-devoid-of-the-octapeptide-repeat-region-delays-bse-pathogenesis-in-mice
#1
Hideyuki Hara, Hironori Miyata, Nandita Rani Das, Junji Chida, Tatenobu Yoshimochi, Keiji Uchiyama, Hitomi Watanabe, Gen Kondoh, Takashi Yokoyama, Suehiro Sakaguchi
Conformational conversion of the cellular isoform of prion protein PrP(C), into the abnormally folded, amyloidogenic isoform, PrP(Sc), is a key pathogenic event in prion diseases including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. We previously reported that the octapeptide repeat (OR) region could be dispensable for converting PrP(C) into PrP(Sc) after infection with RML prions. We demonstrated that mice transgenically expressing mouse PrP with deletion of the OR region on the PrP-knockout background, designated Tg(PrPΔOR)/Prnp(0/0) mice, did not reduce susceptibility to RML scrapie prions, with abundant accumulation of PrP(Sc)ΔOR in their brains...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29039494/internal-driving-factors-leading-to-extrahepatic-manifestation-of-the-hepatitis%C3%A2-c-virus-infection
#2
Zhou-Yi Wu, Jian-Rui Li, Meng-Hao Huang, Jun-Jun Cheng, Hu Li, Jin-Hua Chen, Xiao-Qin Lv, Zong-Gen Peng, Jian-Dong Jiang
The hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, which are correlated with poor outcomes, and thus increase the morbidity and mortality of chronic hepatitis C (CHC). Therefore, understanding the internal linkages between systemic manifestations and HCV infection is helpful for treatment of CHC. Yet, the mechanism by which the virus evokes the systemic diseases remains to be elucidated. In the present study, using gene set enrichment analysis (GSEA) and signaling pathway impact analysis (SPIA), a comprehensive analysis of microarray data of mRNAs was conducted in HCV-infected and -uninfected Huh7...
October 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038059/first-isolation-and-characterization-of-the-pathogenic-aeromonas-veronii-bv-veronii-associated-with-ulcerative-syndrome-in-the-indigenous-pelophylax-ridibundus-of-al-ahsaa-saudi-arabia
#3
Ashraf Y Z Khalifa, Gamal Bekhet
Virulent microbial pathogen infections are the main cause for amphibian decline worldwide. In the present study, a bacterial strain named RDL-2, which was isolated from the skin of infected Pelophylax ridibundus larvae, was cultured and then phenotypically and biochemically characterized using scanning electron microscopic observations and the API20E strip and Biolog Gen III MicroPlate system. The 16S rRNA gene sequence of this strain was also obtained and used in strain identification and phylogenetic analysis...
October 13, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28990692/functional-results-of-free-tissue-transfer-for-complex-heel-calcaneal-defects
#4
Chang-Yi Chou, Hao-Yu Chiao, Chi-Yu Wang, Yu-Shan Sun, Chin-Ta Lin, Niann-Tzyy Dai, Shyi-Gen Chen, Shun-Cheng Chang
BACKGROUND: Loss of soft tissue in heel-calcaneal region is frequently caused by trauma, infection, or tumors. Limited availability of similar tissue becomes challenging, therefore, the use of free tissue transfer offers a solution. Our aim is to describe long term functional outcome of different free tissue transfers for these defects. PATIENTS AND METHODS: We retrospectively reviewed 24 consecutive cases of the heel-calcaneal defect between January 2009 and December 2014...
October 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28970818/evolutionary-trends-of-perkinsozoa-alveolata-characters-based-on-observations-of-two-new-genera-of-parasitoids-of-dinoflagellates-dinovorax-gen-nov-and-snorkelia-gen-nov
#5
Albert Reñé, Elisabet Alacid, Isabel Ferrera, Esther Garcés
Parasites are one of the ecologically most relevant groups of marine food webs, but their taxonomic and biological complexity hampers the assessment of their diversity and evolutionary trends. Moreover, the within-host processes that govern parasitoid infection, development and reproduction are often unknown. In this study, we describe a new species of a perkinsozoan endoparasitoid that infects the toxic dinoflagellate Dinophysis sacculus, by including observations of its morphology, ultrastructure, life-cycle development and phylogeny...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28957692/4-3h-quinazolone-regulates-innate-immune-signaling-upon-respiratory-syncytial-virus-infection-by-moderately-inhibiting-the-rig-1-pathway-in-raw264-7-cell
#6
Liwei He, Fangtian Fan, Xianbang Hou, Hongyan Wu, Juan Wang, Huiqin Xu, Yun Sun
The root of Isatis indigotica, also known as Ban-Lan-Gen (BLG), is commonly used for prevention and early treatment of respiratory virus infection, but the underlying mechanisms of action remain unclear. In the early stage of infection, the innate immune system is activated by virus, and related immune cells such as macrophages secrete large amounts of cytokines including IFNs and ILs. On the one hand, these cytokines can remove virus. On the other hand, they dominantly mediate the inflammatory injury caused by viral infection...
September 25, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28941182/enhanced-wound-healing-performance-of%C3%A2-a%C3%A2-phyto-polysaccharide-enriched-dressing%C3%A2-%C3%A2-a-preclinical-small-and-large-animal-study
#7
Chih-Hsin Wang, Shu-Jen Chang, Yuan-Sheng Tzeng, Yu-Jen Shih, Chang Adrienne, Shyi-Gen Chen, Tim-Mo Chen, Niann-Tzyy Dai, Juin-Hong Cherng
Alginate is a natural rich anionic polysaccharide (APS), commonly available as calcium alginate (CAPS). It can maintain a physiologically moist microenvironment, which minimises bacterial infection and facilitates wound healing at a wound site. Patients with burn injuries suffer from pain and an inflammatory response. In this study, we evaluated the CAPS dressing and traditional dressing containing carboxymethyl cellulose (CMC) for wound healing and scar tissue formation in a burn model of rat and swine. In our pilot study of a burn rat model to evaluate inflammatory response and wound healing, we found that the monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β were up-regulated in the CAPS treatment group...
September 21, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28904942/a-simple-but-accurate-method-for-evaluating-drug-resistance-in-infectious-hcvcc-system
#8
Jian-Rui Li, Wen-Jing Li, Jun-Jun Cheng, Meng-Hao Huang, Zhou-Yi Wu, Chen-Chen Jiang, Hu Li, Jin-Hua Chen, Xiao-Qin Lv, Biao Dong, Jian-Dong Jiang, Zong-Gen Peng
Use of direct-acting antivirals sometimes causes viral drug resistance, resulting in inefficiency in treated patients in real-world practice. Therefore, how to rapidly and accurately evaluate drug resistance is an urgent problem to be solved for rational use and development of antivirals in the future. Here, we aim to develop a new method by which we can evaluate easily but effectively whether a drug will still be efficient in the future treatment in infectious hepatitis C virus cell culture system. HCV-infected Huh7...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28900156/dual-roles-of-two-isoforms-of-autophagy-related-gene-atg10-in-hcv-subgenomic-replicon-mediated-autophagy-flux-and-innate-immunity
#9
Qiong Zhao, Zhan-Ying Hu, Jing-Pu Zhang, Jian-Dong Jiang, Yuan-Yuan Ma, Jian-Rui Li, Zong-Gen Peng, Jin-Hua Chen
Autophagy and immune response are two defense systems that human-body uses against viral infection. Previous studies documented that some viral mechanisms circumvented host immunity mechanisms and hijacked autophagy for its replication and survival. Here, we focus on interactions between autophagy mechanism and innate-immune-response in HCV-subgenomic replicon cells to find a mechanism linking the two pathways. We report distinct effects of two autophagy-related protein ATG10s on HCV-subgenomic replication...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898322/-new-mutation-in-atm-gen-in-patient-whith-ataxia-telangiectasia-clinical-case
#10
Felipe Ruiz-Botero, Juliet T Rodríguez-Guerrero
INTRODUCTION: The ataxia telangiectasia syndrome (AT) is a genetic disease with an autosomal recessive inheritance pattern, with multisystem involvement and a broad clinical spectrum. It is caused by the mutation of the ATM gene, causing reduction or absence of the ATM proteinkinase, altering processes in the cell cycle, DNA repair and apoptosis. The objective of this article is to report the case of a patient with ataxia telangiectasia syndrome, caused by a mutation not previously reported in the literature...
2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28856207/a-new-sensitive-automated-assay-for-procalcitonin-detection-liaison-%C3%A2-brahms-pct-%C3%A2-ii-gen
#11
Antonio Fortunato
OBJECTIVES: To assess the performance of LIAISON(®) BRAHMS PCT(®) II GEN (DiaSorin, Saluggia, Italy) in procalcitonin (PCT) determination by comparing it to the assay reference method B·R·A·H·M·S PCT KRYPTOR (Thermo Fisher Scientific Clinical Diagnostics, Hennigsdorf, Germany) and assessing its ability to discriminate between healthy subjects and patients with suspected infection. METHODS: Diagnostic performance was evaluated on: a) 193 selected samples covering the assay range, whose procalcitonin levels were already evaluated with the B·R·A·H·M·S PCT(®) KRYPTOR; b) prospective samples: 150 apparently healthy specimens obtained from a blood bank, 161 hospitalized patients (not with specific pathologies), 243 apparently healthy children...
December 1, 2016: Pract Lab Med
https://www.readbyqxmd.com/read/28819664/antimicrobial-carbon-nanospheres
#12
Yao-Wen Jiang, Ge Gao, Xiaodong Zhang, Hao-Ran Jia, Fu-Gen Wu
Carbon nanomaterials have found numerous applications in various fields. However, their synthesis and functionalization usually require complicated procedures or tough experimental conditions. Herein, we report for the first time the synthesis of a new type of functional nanomaterial, quaternized carbon nanospheres (QCNSs), with superior antibacterial activity via a one-pot hydrothermal treatment of chitosan and hexadecylbetaine (abbreviated as BS-16). During the hydrothermal process, the direct reaction and carbonization between the amine-containing chitosan and the carboxyl-containing BS-16 were realized within only one step...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28812532/spontaneous-experimentally-induced-and-transmissible-aa-amyloidosis-in-japanese-quail-coturnix-japonica
#13
Yumi Nakayama, Junichi Kamiie, Gen Watanabe, Kazuhiko Suzuki, Tomoaki Murakami
The authors describe a spontaneous case of amyloid A (AA) amyloidosis in an adult female Japanese quail ( Coturnix japonica). The bird developed AA amyloidosis secondary to chronic peritonitis caused by a Gram-negative bacillus infection. Mild amyloid deposition was also identified in the intestinal tract of apparently healthy adult individuals, suggesting that quail may develop intestinal amyloidosis with age. Based on these observations, it was hypothesized that quail can develop AA amyloidosis following inflammatory stimulation with lipopolysaccharide (LPS)...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28774361/-value-of-combined-determination-of-neutrophil-cd64-and-procalcitonin-in-early-diagnosis-of-neonatal-bacterial-infection
#14
Dao-Jian Qin, Zong-Sheng Tang, Shu-Li Chen, Xue-Mei Xu, Shuang-Gen Mao, Shi-Fa Zhang
OBJECTIVE: To investigate the value of combined determination of neutrophil CD64 and procalcitonin (PCT) in the early diagnosis of neonatal bacterial infection. METHODS: According to discharge diagnosis, 37 neonates with bacterial infection were divided into sepsis (n=15) and ordinary infection (non-sepsis) groups (n=22). Twenty-one neonates without infection who were hospitalized during the same period of time were enrolled as the control group. Venous blood samples were collected immediately after admission...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28758635/cluster-distinguishing-genotypic-and-phenotypic-diversity-of-carbapenem-resistant-gram-negative-bacteria-in-solid-organ-transplantation-patients-a-comparative-study
#15
Theodoros Karampatakis, Anastasia Geladari, Lida Politi, Charalampos Antachopoulos, Elias Iosifidis, Olga Tsiatsiou, Aggeliki Karyoti, Vasileios Papanikolaou, Athanassios Tsakris, Emmanuel Roilides
PURPOSE: Solid-organ transplant recipients may display high rates of colonization and/or infection by multidrug-resistant bacteria. We analysed and compared the phenotypic and genotypic diversity of carbapenem-resistant (CR) strains of Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii isolated from patients in the Solid Organ Transplantation department of our hospital. METHODOLOGY: Between March 2012 and August 2013, 56 CR strains from various biological fluids underwent antimicrobial susceptibility testing with VITEK 2, molecular analysis by PCR amplification and genotypic analysis with pulsed-field gel electrophoresis (PFGE)...
July 31, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28758171/qtl-mapping-for-resistance-to-iridovirus-in-asian-seabass-using-genotyping-by-sequencing
#16
Le Wang, Bin Bai, Shuqing Huang, Peng Liu, Zi Yi Wan, Baoqing Ye, Jinlu Wu, Gen Hua Yue
Identifying quantitative trait loci (QTL) for viral disease resistance is of particular importance in selective breeding programs of fish species. Genetic markers linked to QTL can be useful in marker-assisted selection (MAS) for elites resistant to specific pathogens. Here, we conducted a genome scan for QTL associated with Singapore grouper iridovirus (SGIV) resistance in an Asian seabass (Lates calcarifer) family, using a high-density linkage map generated with genotyping-by-sequencing. One genome-wide significant and three suggestive QTL were detected at LG21, LG6, LG13, and LG15, respectively...
July 31, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28754611/transdermal-delivery-of-gentamicin-using-dissolving-microneedle-arrays-for-potential-treatment-of-neonatal-sepsis
#17
Patricia González-Vázquez, Eneko Larrañeta, Maelíosa T C McCrudden, Courtney Jarrahian, Annie Rein-Weston, Manjari Quintanar-Solares, Darin Zehrung, Helen McCarthy, Aaron J Courtenay, Ryan F Donnelly
Neonatal infections are a leading cause of childhood mortality in low-resource settings. World Health Organization guidelines for outpatient treatment of possible serious bacterial infection (PSBI) in neonates and young infants when referral for hospital treatment is not feasible include intramuscular gentamicin (GEN) and oral amoxicillin. GEN is supplied as an aqueous solution of gentamicin sulphate in vials or ampoules and requires health care workers to be trained in dose calculation or selection of an appropriate dose based on the patient's weight band and to have access to safe injection supplies and appropriate sharps disposal...
July 25, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28744310/elevated-squamous-cell-carcinoma-antigen-cytokeratin-19-fragment-and-carcinoembryonic-antigen-levels-in-diabetic-nephropathy
#18
Jianzhong Chen, Feng Tao, Bin Zhang, Qingguang Chen, Yan Qiu, Qian Luo, Yanna Gen, Jiali Meng, Jue Zhang, Hao Lu
OBJECTIVE: We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabetic patients. METHODS: Nondialysis patients with diabetes (n = 261) and 90 healthy controls were enrolled. DN was defined as an UACR ≥ 30 mg/g in the absence of a urinary tract infection or other renal abnormalities...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28740347/chronic-hepatitis-b-nonalcoholic-steatohepatitis-and-physical-fitness-of-military-males-chief-study
#19
Yu-Jung Chen, Kai-Wen Chen, Yu-Leung Shih, Fang-Ying Su, Yen-Po Lin, Fan-Chun Meng, Felicia Lin, Yun-Shun Yu, Chih-Lu Han, Chih-Hung Wang, Jia-Wei Lin, Tsai-Yuan Hsieh, Yi-Hwei Li, Gen-Min Lin
AIM: To investigate the association of chronic hepatitis B and nonalcoholic steatohepatitis with physical fitness in a Taiwanese military male cohort. METHODS: We made a cross-sectional examination of this association using 3669 young adult military males according to cardiorespiratory fitness and hospitalization events recorded in the Taiwan Armed Forces study. Cases of chronic hepatitis B (n = 121) were defined by personal history and positive detection of hepatitis B surface antigen...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28731325/bioinspired-and-biomimetic-agnps-gentamicin-embedded-silk-fibroin-coatings-for-robust-antibacterial-and-osteogenetic-applications
#20
Wenhao Zhou, Zhaojun Jia, Pan Xiong, Jianglong Yan, Yangyang Li, Ming Li, Yan Cheng, Yufeng Zheng
With the progressively increasing demand for orthopedic Ti implants, the balance between two primary complications restricting implant applications is needed to be solved: the lack of bone tissue integration and biomedical device-associated infections (BAI), where emergence of multiresistance bacteria make it worse. Notably, a combination of silver nanoparticles (AgNPs) and a kind of antibiotic can synergistically inhibit bacterial growth, where a low concentration of AgNPs has been confirmed to promote the proliferation and osteogenesis of osteoblasts...
August 9, 2017: ACS Applied Materials & Interfaces
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