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https://www.readbyqxmd.com/read/28261153/non-invasive-respiratory-impedance-enhances-cerebral-perfusion-in-healthy-adults
#1
Christopher G Favilla, Ashwin B Parthasarathy, John A Detre, Arjun G Yodh, Michael T Mullen, Scott E Kasner, Kimberly Gannon, Steven R Messé
Optimization of cerebral blood flow (CBF) is the cornerstone of clinical management in a number of neurologic diseases, most notably ischemic stroke. Intrathoracic pressure influences cardiac output and has the potential to impact CBF. Here, we aim to quantify cerebral hemodynamic changes in response to increased respiratory impedance (RI) using a non-invasive respiratory device. We measured cerebral perfusion under varying levels of RI (6 cm H2O, 9 cm H2O, and 12 cm H2O) in 20 healthy volunteers. Simultaneous measurements of microvascular CBF and middle cerebral artery mean flow velocity (MFV), respectively, were performed with optical diffuse correlation spectroscopy and transcranial Doppler ultrasound...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28238711/efficacy-and-safety-of-ticagrelor-versus-aspirin-in-acute-stroke-or-transient-ischaemic-attack-of-atherosclerotic-origin-a-subgroup-analysis-of-socrates-a-randomised-double-blind-controlled-trial
#2
Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Michael D Hill, Jenny Jonasson, Scott E Kasner, Per Ladenvall, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong, S Claiborne Johnston
BACKGROUND: Ticagrelor is an effective antiplatelet therapy for patients with coronary atherosclerotic disease and might be more effective than aspirin in preventing recurrent stroke and cardiovascular events in patients with acute cerebral ischaemia of atherosclerotic origin. Our aim was to test for a treatment-by-ipsilateral atherosclerotic stenosis interaction in a subgroup analysis of patients in the Acute Stroke or Transient Ischaemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial...
April 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28102428/plasma-adamts13-activity-and-von-willebrand-factor-antigen-and-activity-in-patients-with-subarachnoid-haemorrhage
#3
Monisha Kumar, Wenjing Cao, Jenny K McDaniel, Huy P Pham, Dheeraj Raju, Kelsey Nawalinski, Suzanne Frangos, David Kung, Eric Zager, Scott E Kasner, Joshua M Levine, X Long Zheng
Increased von Willebrand factor (VWF) and reduced ADAMTS13 activity are associated with arterial thrombosis. This may also be the culprit mechanism implicated in delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). It was our objective to determine plasma VWF and ADAMTS13 in patients with SAH and healthy subjects; and to explore the levels of those markers and outcome after SAH. Forty consecutive patients were enrolled between September 2007 and April 2014 in a pilot study. Plasma samples were collected from SAH patients on post-bleed day (PBD) 0, 1, 3, 5, 7 and 10 and healthy controls...
April 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28077455/symptomatic-carotid-occlusion-is-frequently-associated-with-microembolization
#4
Ava L Liberman, Ali Zandieh, Caitlin Loomis, Jonathan M Raser-Schramm, Christina A Wilson, Jose Torres, Koto Ishida, Swaroop Pawar, Rebecca Davis, Michael T Mullen, Steven R Messé, Scott E Kasner, Brett L Cucchiara
BACKGROUND AND PURPOSE: Symptomatic carotid artery disease is associated with significant morbidity and mortality. The pathophysiologic mechanisms of cerebral ischemia among patients with carotid occlusion remain underexplored. METHODS: We conducted a prospective observational cohort study of patients hospitalized within 7 days of ischemic stroke or transient ischemic attack because of ≥50% carotid artery stenosis or occlusion. Transcranial Doppler emboli detection was performed in the middle cerebral artery ipsilateral to the symptomatic carotid...
February 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28029608/higher-stroke-risk-with-lower-blood-pressure-in-hemodynamic-vertebrobasilar-disease-analysis-from-the-veritas-study
#5
MULTICENTER STUDY
Sepideh Amin-Hanjani, Tanya N Turan, Xinjian Du, Dilip K Pandey, Linda Rose-Finnell, DeJuran Richardson, Mitchell S V Elkind, Gregory J Zipfel, David S Liebeskind, Frank L Silver, Scott E Kasner, Philip B Gorelick, Fady T Charbel, Colin P Derdeyn
BACKGROUND: Despite concerns regarding hypoperfusion in patients with large-artery occlusive disease, strict blood pressure (BP) control has become adopted as a safe strategy for risk reduction of stroke. We examined the relationship between BP control, blood flow, and risk of subsequent stroke in the prospective Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) study. METHODS: The VERiTAS study enrolled patients with recent vertebrobasilar (VB) transient ischemic attack or stroke and ≥50% atherosclerotic stenosis or occlusion of vertebral or basilar arteries...
February 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27980126/prevention-of-stroke-in-patients-with-silent-cerebrovascular-disease-a-scientific-statement-for-healthcare-professionals-from-the-american-heart-association-american-stroke-association
#6
REVIEW
Eric E Smith, Gustavo Saposnik, Geert Jan Biessels, Fergus N Doubal, Myriam Fornage, Philip B Gorelick, Steven M Greenberg, Randall T Higashida, Scott E Kasner, Sudha Seshadri
Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to prevent stroke, the Stroke Council of the American Heart Association convened a writing committee to evaluate existing evidence, to discuss clinical considerations, and to offer suggestions for future research on stroke prevention in patients with 3 cardinal manifestations of silent cerebrovascular disease: silent brain infarcts, magnetic resonance imaging white matter hyperintensities of presumed vascular origin, and cerebral microbleeds...
February 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27900543/stroke-6th-edition-pathophysiology-diagnosis-and-management-by-james-c-grotta-gregory-w-albers-joseph-p-broderick-scott-e-kasner-eng-h-lo-a-david-mendelow-ralph-l-sacco-and-lawrence-k-s-wong-2016-1504-pages-us-405-00-hardcover-isbn-9780323295444-elsevier
#7
https://www.readbyqxmd.com/read/27893460/tgf-%C3%AE-1-modulates-microglial-phenotype-and-promotes-recovery-after-intracerebral-hemorrhage
#8
Roslyn A Taylor, Che-Feng Chang, Brittany A Goods, Matthew D Hammond, Brian Mac Grory, Youxi Ai, Arthur F Steinschneider, Stephen C Renfroe, Michael H Askenase, Louise D McCullough, Scott E Kasner, Michael T Mullen, David A Hafler, J Christopher Love, Lauren H Sansing
Intracerebral hemorrhage (ICH) is a devastating form of stroke that results from the rupture of a blood vessel in the brain, leading to a mass of blood within the brain parenchyma. The injury causes a rapid inflammatory reaction that includes activation of the tissue-resident microglia and recruitment of blood-derived macrophages and other leukocytes. In this work, we investigated the specific responses of microglia following ICH with the aim of identifying pathways that may aid in recovery after brain injury...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27530692/elevated-red-cell-distribution-width-is-associated-with-cerebral-infarction-in-aneurysmal-subarachnoid-hemorrhage
#9
James E Siegler, Christy Marcaccio, Kelsey Nawalinski, Francis Quattrone, Danielle K Sandsmark, Eileen Maloney-Wilensky, Suzanne Frangos, Joshua M Levine, Sherman C Stein, Scott E Kasner, Monisha A Kumar
BACKGROUND: Elevated red blood cell distribution width (RDW) has been associated with thrombotic disorders including myocardial infarction, venous thromboembolism, and ischemic stroke, independent of other inflammatory and coagulation biomarkers. The purpose of this study was to determine whether elevated RDW is associated with cerebral infarction and poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). METHODS: In this retrospective single-center cohort of aSAH patients (October 2009-September 2014), elevated RDW was defined as a mean RDW >14...
August 16, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27507860/global-survey-of-the-frequency-of-atrial-fibrillation-associated-stroke-embolic-stroke-of-undetermined-source-global-registry
#10
Kanjana S Perera, Thomas Vanassche, Jackie Bosch, Balakumar Swaminathan, Hardi Mundl, Mohana Giruparajah, Miguel A Barboza, Martin J O'Donnell, Maia Gomez-Schneider, Graeme J Hankey, Byung-Woo Yoon, Artemio Roxas, Philippa Lavallee, Joao Sargento-Freitas, Nikolay Shamalov, Raf Brouns, Rubens J Gagliardi, Scott E Kasner, Alessio Pieroni, Philipp Vermehren, Kazuo Kitagawa, Yongjun Wang, Keith Muir, Jonathan M Coutinho, Stuart J Connolly, Robert G Hart
BACKGROUND AND PURPOSE: Atrial fibrillation (AF) is increasingly recognized as the single most important cause of disabling ischemic stroke in the elderly. We undertook an international survey to characterize the frequency of AF-associated stroke, methods of AF detection, and patient features. METHODS: Consecutive patients hospitalized for ischemic stroke in 2013 to 2014 were surveyed from 19 stroke research centers in 19 different countries. Data were analyzed by global regions and World Bank income levels...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27466464/practice-advisory-recurrent-stroke-with-patent-foramen-ovale-update-of-practice-parameter-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#11
Steven R Messé, Gary Gronseth, David M Kent, Jorge R Kizer, Shunichi Homma, Lee Rosterman, Scott E Kasner
OBJECTIVE: To update the 2004 American Academy of Neurology guideline for patients with stroke and patent foramen ovale (PFO) by addressing whether (1) percutaneous closure of PFO is superior to medical therapy alone and (2) anticoagulation is superior to antiplatelet therapy for the prevention of recurrent stroke. METHODS: Systematic review of the literature and structured formulation of recommendations. CONCLUSIONS: Percutaneous PFO closure with the STARFlex device possibly does not provide a benefit in preventing stroke vs medical therapy alone (risk difference [RD] 0...
August 23, 2016: Neurology
https://www.readbyqxmd.com/read/27382005/pathogenesis-and-risk-factors-for-cerebral-infarct-after-surgical-aortic-valve-replacement
#12
Allie Massaro, Steven R Messé, Michael A Acker, Scott E Kasner, Jose Torres, Molly Fanning, Tania Giovannetti, Sarah J Ratcliffe, Michel Bilello, Wilson Y Szeto, Joseph E Bavaria, Emile R Mohler, Thomas F Floyd
BACKGROUND AND PURPOSE: Stroke is a potentially devastating complication of cardiac surgery. Identifying predictors of radiographic infarct may lead to improved stroke prevention for surgical patients. METHODS: We reviewed 129 postoperative brain magnetic resonance imagings from a prospective study of patients undergoing surgical aortic valve replacement. Acute infarcts were classified as watershed or embolic using prespecified criteria. RESULTS: Acute infarct on magnetic resonance imaging was seen in 79 of 129 patients (61%), and interrater reliability for stroke pathogenesis was high (κ=0...
August 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27289186/prophylactic-use-of-antiepileptic-drugs-in-patients-with-spontaneous-intracerebral-hemorrhage
#13
Ali Zandieh, Steven R Messé, Brett Cucchiara, Michael T Mullen, Scott E Kasner
BACKGROUND: The effect of prophylactic antiepileptic drugs (AEDs) on mortality and functional outcome in patients with intracerebral hemorrhage (ICH) is uncertain. METHODS: We used data from the Virtual International Stroke Trials Archive (VISTA) to evaluate the effect of prophylactic AEDs on ICH outcome. Univariate and multivariate logistic and Cox regression models were designed to determine the impact of prophylactic AEDs on mortality and disability, defined as a modified Rankin Scale (mRS) greater than 3 at 90 days following ICH...
September 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27256472/embolic-strokes-of-undetermined-source-prevalence-and-patient-features-in-the-esus-global-registry
#14
Kanjana S Perera, Thomas Vanassche, Jackie Bosch, Mohana Giruparajah, Balakumar Swaminathan, Katie R Mattina, Scott D Berkowitz, Antonio Arauz, Martin J O'Donnell, Sebastian F Ameriso, Graeme J Hankey, Byung-Woo Yoon, Philippa Lavallee, Luis Cunha, Nikolay Shamalov, Raf Brouns, Rubens J Gagliardi, Scott E Kasner, Alessio Pieroni, Philipp Vermehren, Kazuo Kitagawa, Yongjun Wang, Keith Muir, Jonathan Coutinho, Ildiko Vastagh, Stuart J Connolly, Robert G Hart
BACKGROUND: Recent evidence supports that most non-lacunar cryptogenic strokes are embolic. Accordingly, these strokes have been designated as embolic strokes of undetermined source (ESUS). AIMS: We undertook an international survey to characterize the frequency and clinical features of ESUS patients across global regions. METHODS: Consecutive patients hospitalized for ischemic stroke were retrospectively surveyed from 19 stroke research centers in 19 different countries to collect patients meeting criteria for ESUS...
July 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27198480/real-world-use-of-prophylactic-antibiotics-in-insertable-cardiac-monitor-procedures
#15
Sean C Beinart, Andrea Natale, Atul Verma, Alpesh Amin, Scott Kasner, Hans-Christoph Diener, Erika Pouliot, Noreli Franco, Suneet Mittal
BACKGROUND: The use of prophylactic antibiotics during insertable cardiac monitor (ICM) procedures is a carryover of the common practice used with therapeutic cardiac implantable electronic devices. We sought to characterize the current practice of ICM insertion procedures to evaluate the influence of prophylactic antibiotic administration on the occurrence of infections. METHODS: We characterized insertion procedures and procedure-related infections from an ongoing multicenter registry (Reveal LINQ(TM) Registry)...
August 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/26918178/diagnosis-prognosis-and-management-of-cryptogenic-stroke
#16
REVIEW
Cen Zhang, Scott Kasner
Despite many advances in our understanding of ischemic stroke, cryptogenic strokes (those that do not have a determined etiology) remain a diagnostic and therapeutic challenge. Previous classification approaches to cryptogenic stroke have led to inconsistent definitions, and evidence to determine optimal treatment is scarce. These limitations have prompted international efforts to redefine cryptogenic strokes, leading to more rigorous diagnostic criteria, outcome studies, and new clinical trials. Improvement in our ability to detect paroxysmal atrial fibrillation in patients with cryptogenic stroke has strengthened the idea that these strokes are embolic in nature...
2016: F1000Research
https://www.readbyqxmd.com/read/26891733/early-identification-of-cerebrovascular-events-in-patients-presenting-with-vertigo-or-dizziness
#17
EDITORIAL
Harrison X Bai, Yanqiao Xiao, Xin Zhao, Zhili Wang, Scott E Kasner, Li Yang
No abstract text is available yet for this article.
August 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26642907/warfarin-dosing-algorithms-and-the-need-for-human-intervention
#18
RANDOMIZED CONTROLLED TRIAL
Scott E Kasner, Le Wang, Benjamin French, Steven R Messé, Jonas Ellenberg, Stephen E Kimmel
BACKGROUND: Dosing algorithms for warfarin incorporate clinical and genetic factors, but human intervention to overrule algorithm-based dosing may occasionally be required. The frequency and reasons for varying from algorithmic warfarin management have not been well studied. METHODS: We analyzed a prospective cohort of 1015 participants from the Clarification of Optimal Anticoagulation through Genetics trial who were randomized to either pharmacogenetic- or clinically-guided warfarin dosing algorithms...
April 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/26540083/dalfampridine-in-chronic-sensorimotor-deficits-after-ischemic-stroke-a-proof-of-concept-study
#19
RANDOMIZED CONTROLLED TRIAL
David M Simpson, James Goldenberg, Scott Kasner, Marshall Nash, Michael J Reding, Richard M Zweifler, Gustavo Suarez, Ping Zhao, Herbert R Iii, Adrian L Rabinowicz, Enrique Carrazana
OBJECTIVE: To evaluate the safety and tolerability of dalfampridine extended release (D-ER) in participants with chronic post-ischemic stroke deficits, and to assess for potential drug activity on sensorimotor function. METHODS: Using a double-blind, placebo-controlled, cross-over design, participants were randomized to placebo/D-ER or D-ER/placebo sequences and given D-ER 10 mg or placebo twice daily. Key inclusion criteria were: ischemic stroke ≥ 6 months, Fugl-Meyer Assessment lower extremity motor score ≤ 28, ability to complete Timed 25-Foot Walk (T25FW)...
November 2015: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/26467999/racial-disparities-in-intravenous-recombinant-tissue-plasminogen-activator-use-persist-at-primary-stroke-centers
#20
COMPARATIVE STUDY
Hugo J Aparicio, Brendan G Carr, Scott E Kasner, Michael J Kallan, Karen C Albright, Dawn O Kleindorfer, Michael T Mullen
BACKGROUND: Primary stroke centers (PSCs) utilize more recombinant tissue plasminogen activator (rt-PA) than non-PSCs. The impact of PSCs on racial disparities in rt-PA use is unknown. METHODS AND RESULTS: We used data from the Nationwide Inpatient Sample from 2004 to 2010, limited to states that publicly reported hospital identity and race. Hospitals certified as PSCs by The Joint Commission were identified. Adults with a diagnosis of ischemic stroke were analyzed...
October 14, 2015: Journal of the American Heart Association
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