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Scott kasner

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https://www.readbyqxmd.com/read/27900543/stroke-6th-edition-pathophysiology-diagnosis-and-management-by-james-c-grotta-gregory-w-albers-joseph-p-broderick-scott-e-kasner-eng-h-lo-a-david-mendelow-ralph-l-sacco-and-lawrence-k-s-wong-2016-1504-pages-us-405-00-hardcover-isbn-9780323295444-elsevier
#1
https://www.readbyqxmd.com/read/27893460/tgf-%C3%AE-1-modulates-microglial-phenotype-and-promotes-recovery-after-intracerebral-hemorrhage
#2
Roslyn A Taylor, Che-Feng Chang, Brittany A Goods, Matthew D Hammond, Brian Mac Grory, Youxi Ai, Arthur F Steinschneider, Stephen C Renfroe, Michael H Askenase, Louise D McCullough, Scott E Kasner, Michael T Mullen, David A Hafler, J Christopher Love, Lauren H Sansing
Intracerebral hemorrhage (ICH) is a devastating form of stroke that results from the rupture of a blood vessel in the brain, leading to a mass of blood within the brain parenchyma. The injury causes a rapid inflammatory reaction that includes activation of the tissue-resident microglia and recruitment of blood-derived macrophages and other leukocytes. In this work, we investigated the specific responses of microglia following ICH with the aim of identifying pathways that may aid in recovery after brain injury...
November 28, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27530692/elevated-red-cell-distribution-width-is-associated-with-cerebral-infarction-in-aneurysmal-subarachnoid-hemorrhage
#3
James E Siegler, Christy Marcaccio, Kelsey Nawalinski, Francis Quattrone, Danielle K Sandsmark, Eileen Maloney-Wilensky, Suzanne Frangos, Joshua M Levine, Sherman C Stein, Scott E Kasner, Monisha A Kumar
BACKGROUND: Elevated red blood cell distribution width (RDW) has been associated with thrombotic disorders including myocardial infarction, venous thromboembolism, and ischemic stroke, independent of other inflammatory and coagulation biomarkers. The purpose of this study was to determine whether elevated RDW is associated with cerebral infarction and poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). METHODS: In this retrospective single-center cohort of aSAH patients (October 2009-September 2014), elevated RDW was defined as a mean RDW >14...
August 16, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27507860/global-survey-of-the-frequency-of-atrial-fibrillation-associated-stroke-embolic-stroke-of-undetermined-source-global-registry
#4
Kanjana S Perera, Thomas Vanassche, Jackie Bosch, Balakumar Swaminathan, Hardi Mundl, Mohana Giruparajah, Miguel A Barboza, Martin J O'Donnell, Maia Gomez-Schneider, Graeme J Hankey, Byung-Woo Yoon, Artemio Roxas, Philippa Lavallee, Joao Sargento-Freitas, Nikolay Shamalov, Raf Brouns, Rubens J Gagliardi, Scott E Kasner, Alessio Pieroni, Philipp Vermehren, Kazuo Kitagawa, Yongjun Wang, Keith Muir, Jonathan M Coutinho, Stuart J Connolly, Robert G Hart
BACKGROUND AND PURPOSE: Atrial fibrillation (AF) is increasingly recognized as the single most important cause of disabling ischemic stroke in the elderly. We undertook an international survey to characterize the frequency of AF-associated stroke, methods of AF detection, and patient features. METHODS: Consecutive patients hospitalized for ischemic stroke in 2013 to 2014 were surveyed from 19 stroke research centers in 19 different countries. Data were analyzed by global regions and World Bank income levels...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27466464/practice-advisory-recurrent-stroke-with-patent-foramen-ovale-update-of-practice-parameter-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#5
Steven R Messé, Gary Gronseth, David M Kent, Jorge R Kizer, Shunichi Homma, Lee Rosterman, Scott E Kasner
OBJECTIVE: To update the 2004 American Academy of Neurology guideline for patients with stroke and patent foramen ovale (PFO) by addressing whether (1) percutaneous closure of PFO is superior to medical therapy alone and (2) anticoagulation is superior to antiplatelet therapy for the prevention of recurrent stroke. METHODS: Systematic review of the literature and structured formulation of recommendations. CONCLUSIONS: Percutaneous PFO closure with the STARFlex device possibly does not provide a benefit in preventing stroke vs medical therapy alone (risk difference [RD] 0...
August 23, 2016: Neurology
https://www.readbyqxmd.com/read/27382005/pathogenesis-and-risk-factors-for-cerebral-infarct-after-surgical-aortic-valve-replacement
#6
Allie Massaro, Steven R Messé, Michael A Acker, Scott E Kasner, Jose Torres, Molly Fanning, Tania Giovannetti, Sarah J Ratcliffe, Michel Bilello, Wilson Y Szeto, Joseph E Bavaria, Emile R Mohler, Thomas F Floyd
BACKGROUND AND PURPOSE: Stroke is a potentially devastating complication of cardiac surgery. Identifying predictors of radiographic infarct may lead to improved stroke prevention for surgical patients. METHODS: We reviewed 129 postoperative brain magnetic resonance imagings from a prospective study of patients undergoing surgical aortic valve replacement. Acute infarcts were classified as watershed or embolic using prespecified criteria. RESULTS: Acute infarct on magnetic resonance imaging was seen in 79 of 129 patients (61%), and interrater reliability for stroke pathogenesis was high (κ=0...
August 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27289186/prophylactic-use-of-antiepileptic-drugs-in-patients-with-spontaneous-intracerebral-hemorrhage
#7
Ali Zandieh, Steven R Messé, Brett Cucchiara, Michael T Mullen, Scott E Kasner
BACKGROUND: The effect of prophylactic antiepileptic drugs (AEDs) on mortality and functional outcome in patients with intracerebral hemorrhage (ICH) is uncertain. METHODS: We used data from the Virtual International Stroke Trials Archive (VISTA) to evaluate the effect of prophylactic AEDs on ICH outcome. Univariate and multivariate logistic and Cox regression models were designed to determine the impact of prophylactic AEDs on mortality and disability, defined as a modified Rankin Scale (mRS) greater than 3 at 90 days following ICH...
September 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27256472/embolic-strokes-of-undetermined-source-prevalence-and-patient-features-in-the-esus-global-registry
#8
Kanjana S Perera, Thomas Vanassche, Jackie Bosch, Mohana Giruparajah, Balakumar Swaminathan, Katie R Mattina, Scott D Berkowitz, Antonio Arauz, Martin J O'Donnell, Sebastian F Ameriso, Graeme J Hankey, Byung-Woo Yoon, Philippa Lavallee, Luis Cunha, Nikolay Shamalov, Raf Brouns, Rubens J Gagliardi, Scott E Kasner, Alessio Pieroni, Philipp Vermehren, Kazuo Kitagawa, Yongjun Wang, Keith Muir, Jonathan Coutinho, Ildiko Vastagh, Stuart J Connolly, Robert G Hart
BACKGROUND: Recent evidence supports that most non-lacunar cryptogenic strokes are embolic. Accordingly, these strokes have been designated as embolic strokes of undetermined source (ESUS). AIMS: We undertook an international survey to characterize the frequency and clinical features of ESUS patients across global regions. METHODS: Consecutive patients hospitalized for ischemic stroke were retrospectively surveyed from 19 stroke research centers in 19 different countries to collect patients meeting criteria for ESUS...
July 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27198480/real-world-use-of-prophylactic-antibiotics-in-insertable-cardiac-monitor-procedures
#9
Sean C Beinart, Andrea Natale, Atul Verma, Alpesh Amin, Scott Kasner, Hans-Christoph Diener, Erika Pouliot, Noreli Franco, Suneet Mittal
BACKGROUND: The use of prophylactic antibiotics during insertable cardiac monitor (ICM) procedures is a carryover of the common practice used with therapeutic cardiac implantable electronic devices. We sought to characterize the current practice of ICM insertion procedures to evaluate the influence of prophylactic antibiotic administration on the occurrence of infections. METHODS: We characterized insertion procedures and procedure-related infections from an ongoing multicenter registry (Reveal LINQ(TM) Registry)...
August 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/26918178/diagnosis-prognosis-and-management-of-cryptogenic-stroke
#10
REVIEW
Cen Zhang, Scott Kasner
Despite many advances in our understanding of ischemic stroke, cryptogenic strokes (those that do not have a determined etiology) remain a diagnostic and therapeutic challenge. Previous classification approaches to cryptogenic stroke have led to inconsistent definitions, and evidence to determine optimal treatment is scarce. These limitations have prompted international efforts to redefine cryptogenic strokes, leading to more rigorous diagnostic criteria, outcome studies, and new clinical trials. Improvement in our ability to detect paroxysmal atrial fibrillation in patients with cryptogenic stroke has strengthened the idea that these strokes are embolic in nature...
2016: F1000Research
https://www.readbyqxmd.com/read/26891733/early-identification-of-cerebrovascular-events-in-patients-presenting-with-vertigo-or-dizziness
#11
EDITORIAL
Harrison X Bai, Yanqiao Xiao, Xin Zhao, Zhili Wang, Scott E Kasner, Li Yang
No abstract text is available yet for this article.
August 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26642907/warfarin-dosing-algorithms-and-the-need-for-human-intervention
#12
RANDOMIZED CONTROLLED TRIAL
Scott E Kasner, Le Wang, Benjamin French, Steven R Messé, Jonas Ellenberg, Stephen E Kimmel
BACKGROUND: Dosing algorithms for warfarin incorporate clinical and genetic factors, but human intervention to overrule algorithm-based dosing may occasionally be required. The frequency and reasons for varying from algorithmic warfarin management have not been well studied. METHODS: We analyzed a prospective cohort of 1015 participants from the Clarification of Optimal Anticoagulation through Genetics trial who were randomized to either pharmacogenetic- or clinically-guided warfarin dosing algorithms...
April 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/26540083/dalfampridine-in-chronic-sensorimotor-deficits-after-ischemic-stroke-a-proof-of-concept-study
#13
David M Simpson, James Goldenberg, Scott Kasner, Marshall Nash, Michael J Reding, Richard M Zweifler, Gustavo Suarez, Ping Zhao, Herbert R Iii, Adrian L Rabinowicz, Enrique Carrazana
OBJECTIVE: To evaluate the safety and tolerability of dalfampridine extended release (D-ER) in participants with chronic post-ischemic stroke deficits, and to assess for potential drug activity on sensorimotor function. METHODS: Using a double-blind, placebo-controlled, cross-over design, participants were randomized to placebo/D-ER or D-ER/placebo sequences and given D-ER 10 mg or placebo twice daily. Key inclusion criteria were: ischemic stroke ≥ 6 months, Fugl-Meyer Assessment lower extremity motor score ≤ 28, ability to complete Timed 25-Foot Walk (T25FW)...
November 2015: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/26467999/racial-disparities-in-intravenous-recombinant-tissue-plasminogen-activator-use-persist-at-primary-stroke-centers
#14
COMPARATIVE STUDY
Hugo J Aparicio, Brendan G Carr, Scott E Kasner, Michael J Kallan, Karen C Albright, Dawn O Kleindorfer, Michael T Mullen
BACKGROUND: Primary stroke centers (PSCs) utilize more recombinant tissue plasminogen activator (rt-PA) than non-PSCs. The impact of PSCs on racial disparities in rt-PA use is unknown. METHODS AND RESULTS: We used data from the Nationwide Inpatient Sample from 2004 to 2010, limited to states that publicly reported hospital identity and race. Hospitals certified as PSCs by The Joint Commission were identified. Adults with a diagnosis of ischemic stroke were analyzed...
October 14, 2015: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26463697/response-to-letter-regarding-article-proteinuria-but-not-egfr-predicts-stroke-risk-in-chronic-kidney-disease-chronic-renal-insufficiency-cohort-study
#15
LETTER
Danielle K Sandsmark, Scott E Kasner
No abstract text is available yet for this article.
November 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/26231276/transient-ischemic-attacks-presenting-with-dizziness-or-vertigo
#16
REVIEW
Christina A Blum, Scott E Kasner
Dizziness with or without associated neurologic symptoms is the most common symptom of posterior circulation transient ischemic attack (TIA) and can be more frequent before posterior circulation strokes. This entity carries a high risk of recurrent events and should be considered as a potential cause of spontaneous episodic vestibular syndrome. Diagnostic evaluation should include intracranial and extracranial imaging of the vertebral arteries and basilar artery. Aggressive medical management with antiplatelet therapy, statin use, and risk factor modification is the mainstay of treatment...
August 2015: Neurologic Clinics
https://www.readbyqxmd.com/read/26130097/proteinuria-but-not-egfr-predicts-stroke-risk-in-chronic-kidney-disease-chronic-renal-insufficiency-cohort-study
#17
MULTICENTER STUDY
Danielle K Sandsmark, Steven R Messé, Xiaoming Zhang, Jason Roy, Lisa Nessel, Lotuce Lee Hamm, Jiang He, Edward J Horwitz, Bernard G Jaar, Radhakrishna R Kallem, John W Kusek, Emile R Mohler, Anna Porter, Stephen L Seliger, Stephen M Sozio, Raymond R Townsend, Harold I Feldman, Scott E Kasner
BACKGROUND AND PURPOSE: Chronic kidney disease is associated with an increased risk of cardiovascular events. However, the impact of chronic kidney disease on cerebrovascular disease is less well understood. We hypothesized that renal function severity would be predictive of stroke risk, independent of other vascular risk factors. METHODS: The study population included 3939 subjects enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study, a prospective observational cohort...
August 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/26037731/the-impact-of-inpatient-versus-outpatient-initiation-on-early-warfarin-dosing
#18
RANDOMIZED CONTROLLED TRIAL
Scott E Kasner, Le Wang, Benjamin French, Steven R Messe, Richard Horenstein, Emile R Mohler, James A S Muldowney, Jonas Ellenberg, Stephen E Kimmel
BACKGROUND AND OBJECTIVES: Dosing algorithms for warfarin incorporate clinical and genetic factors but may not account for the numerous comorbidities affecting patients who start warfarin while hospitalized. We aimed to determine whether these algorithms perform differently when warfarin is initiated for inpatients compared with outpatients. PATIENTS AND METHODS: We analyzed a prospective cohort of 1015 participants from the Clarification of Optimal Anticoagulation through Genetics (COAG) trial who were randomized to either pharmacogenetically or clinically guided warfarin dosing algorithms...
August 2015: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/25977279/hemodynamic-features-of-symptomatic-vertebrobasilar-disease
#19
MULTICENTER STUDY
Sepideh Amin-Hanjani, Xinjian Du, Linda Rose-Finnell, Dilip K Pandey, DeJuran Richardson, Keith R Thulborn, Mitchell S V Elkind, Gregory J Zipfel, David S Liebeskind, Frank L Silver, Scott E Kasner, Victor A Aletich, Louis R Caplan, Colin P Derdeyn, Philip B Gorelick, Fady T Charbel
BACKGROUND AND PURPOSE: Atherosclerotic vertebrobasilar disease is an important cause of posterior circulation stroke. To examine the role of hemodynamic compromise, a prospective multicenter study, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS), was conducted. Here, we report clinical features and vessel flow measurements from the study cohort. METHODS: Patients with recent vertebrobasilar transient ischemic attack or stroke and ≥50% atherosclerotic stenosis or occlusion in vertebral or basilar arteries (BA) were enrolled...
July 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25851771/predictors-of-finding-occult-atrial-fibrillation-after-cryptogenic-stroke
#20
Christopher G Favilla, Erin Ingala, Jenny Jara, Emily Fessler, Brett Cucchiara, Steven R Messé, Michael T Mullen, Allyson Prasad, James Siegler, Mathew D Hutchinson, Scott E Kasner
BACKGROUND AND PURPOSE: Occult paroxysmal atrial fibrillation (AF) is found in a substantial minority of patients with cryptogenic stroke. Identifying reliable predictors of paroxysmal AF after cryptogenic stroke would allow clinicians to more effectively use outpatient cardiac monitoring and ultimately reduce secondary stroke burden. METHODS: We analyzed a retrospective cohort of consecutive patients who underwent 28-day mobile cardiac outpatient telemetry after cryptogenic stroke or transient ischemic stroke...
May 2015: Stroke; a Journal of Cerebral Circulation
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