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Roy hamilton

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August 13, 2016: Restorative Neurology and Neuroscience
Felix Gervits, Sharon Ash, H Branch Coslett, Katya Rascovsky, Murray Grossman, Roy Hamilton
Primary progressive aphasia (PPA) is a neurodegenerative condition characterized by gradual deterioration of language function. We investigated whether two weeks of daily transcranial direct current stimulation (tDCS) treatment would improve language abilities in six people with a non-fluent form of PPA. tDCS was applied in an unblinded trial at an intensity of 1.5mA for 20min/day over 10days. At the time of stimulation, patients were engaged in narrating one of several children's wordless picture stories. A battery of neuropsychological assessments was administered four times: at baseline, immediately following the 2-week stimulation period, and then 6-weeks and 12-weeks following the end of stimulation...
August 11, 2016: Brain and Language
Roy H Hamilton
No abstract text is available yet for this article.
July 25, 2016: Restorative Neurology and Neuroscience
Franz Geiger, Francis Pope, Rob MacKenzie, William Brune, Paul S Monks, William Bloss, Gary Fuller, Nicolas Moussiopoulos, Matthew Hort, Alison Tomlin, Albert Presto, Dominik van Pinxteren, Athanasia Vlachou, Dwayne Heard, C N Hewitt, Urs Baltensperger, Alastair Lewis, Xavier Querol, Saewung Kim, Jacqueline Hamilton, Roberto Sommariva, Gordon McFiggans, Roy Harrison, Jose L Jimenez, Eben Cross, John Wenger, Spyros Pandis, Astrid Kiendler-Scharr, Neil M Donahue, Lisa Whalley, Brian McDonald, Simone Pieber, André Prévôt, Mohammed Salim Alam, Nivedita Krishna Kumar, Andreas Wahner, Andreas Skouloudis, Markus Kalberer, Timothy Wallington, Rachel Dunmore
No abstract text is available yet for this article.
July 18, 2016: Faraday Discussions
Marom Bikson, Pnina Grossman, Chris Thomas, Adantchede Louis Zannou, Jimmy Jiang, Tatheer Adnan, Antonios P Mourdoukoutas, Greg Kronberg, Dennis Truong, Paulo Boggio, André R Brunoni, Leigh Charvet, Felipe Fregni, Brita Fritsch, Bernadette Gillick, Roy H Hamilton, Benjamin M Hampstead, Ryan Jankord, Adam Kirton, Helena Knotkova, David Liebetanz, Anli Liu, Colleen Loo, Michael A Nitsche, Janine Reis, Jessica D Richardson, Alexander Rotenberg, Peter E Turkeltaub, Adam J Woods
This review updates and consolidates evidence on the safety of transcranial Direct Current Stimulation (tDCS). Safety is here operationally defined by, and limited to, the absence of evidence for a Serious Adverse Effect, the criteria for which are rigorously defined. This review adopts an evidence-based approach, based on an aggregation of experience from human trials, taking care not to confuse speculation on potential hazards or lack of data to refute such speculation with evidence for risk. Safety data from animal tests for tissue damage are reviewed with systematic consideration of translation to humans...
September 2016: Brain Stimulation
Viviane Kovess-Masfety, Mathilde M Husky, Katherine Keyes, Ava Hamilton, Ondine Pez, Adina Bitfoi, Mauro Giovanni Carta, Dietmar Goelitz, Rowella Kuijpers, Roy Otten, Ceren Koç, Sigita Lesinskiene, Zlatka Mihova
BACKGROUND: Worldwide, approximately one in eight children or adolescents suffer from a mental disorder. The present study was designed to determine the cross-national prevalence of mental health problems in children aged 6-11 across seven European countries including Italy, Germany, the Netherlands, Lithuania, Bulgaria, Romania, and Turkey. METHODS: Data were collected on 7682 children for whom either parent- or teacher SDQ were completed. RESULTS: The present study provides country-specific normative banding for both parent- and teacher SDQ scores...
August 2016: Social Psychiatry and Psychiatric Epidemiology
Denise Bockwoldt, Beth A Staffileno, Lola Coke, Rebekah Hamilton, Lou Fogg, Donna Calvin, Lauretta Quinn
African American (AA) adults are disproportionally affected by type 2 diabetes and are diagnosed at an earlier age, but are less adherent to diabetes medications compared with the general population. This qualitative study sought to describe the experiences of taking diabetes medications among midlife AA men and women with type 2 diabetes and to identify factors that influence these experiences. Fifteen AAs completed semistructured interviews. Using the Roy adaptation model, thematic analysis coded for both adaptive and ineffective experiences...
May 23, 2016: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
Priyanka P Shah-Basak, Rachel Wurzman, Juliann B Purcell, Felix Gervits, Roy Hamilton
PURPOSE: Aphasia-acquired loss of the ability to understand or express language-is a common and debilitating neurological consequence of stroke. Evidence suggests that transcranial magnetic (TMS) or direct current stimulation (tDCS) can significantly improve language outcomes in patients with aphasia (PWA). However, the relative efficacy between TMS and tDCS has not yet been explored. Mechanistic and methodological differences, patient inclusion/exclusion criteria and experimental designs may influence observed treatment benefits...
May 2, 2016: Restorative Neurology and Neuroscience
Brittany Hazard, Xiaoqin Zhang, Mahmoudreza Naemeh, M Kristina Hamilton, Bret Rust, Helen E Raybould, John W Newman, Roy Martin, Jorge Dubcovsky
Increased amylose in wheat (Triticum ssp.) starch is associated with increased resistant starch, a fermentable dietary fiber. Fermentation of resistant starch in the large intestine produces short-chain fatty acids that are associated with human health benefits. Since wheat foods are an important component of the human diet, increases in amylose and resistant starch in wheat grains have the potential to deliver health benefits to a large number of people. In three replicated field trials we found that mutations in starch branching enzyme II genes (SBEIIa and SBEIIb) in both A and B genomes (SBEIIa/b-AB) of durum wheat [T...
November 2015: Crop Science
Lauren E Mancuso, Irena P Ilieva, Roy H Hamilton, Martha J Farah
Transcranial direct current stimulation (tDCS) has been reported to improve working memory (WM) performance in healthy individuals, suggesting its value as a means of cognitive enhancement. However, recent meta-analyses concluded that tDCS has little or no effect on WM in healthy participants. In this article, we review reasons why these meta-analyses may have underestimated the effect of tDCS on WM and report a more comprehensive and arguably more sensitive meta-analysis. Consistent with our interest in enhancement, we focused on anodal stimulation...
August 2016: Journal of Cognitive Neuroscience
Amy Rose Price, Jonathan E Peelle, Michael F Bonner, Murray Grossman, Roy H Hamilton
UNLABELLED: A defining aspect of human cognition is the ability to integrate conceptual information into complex semantic combinations. For example, we can comprehend "plaid" and "jacket" as individual concepts, but we can also effortlessly combine these concepts to form the semantic representation of "plaid jacket." Many neuroanatomic models of semantic memory propose that heteromodal cortical hubs integrate distributed semantic features into coherent representations. However, little work has specifically examined these proposed integrative mechanisms and the causal role of these regions in semantic integration...
March 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
A M Barrett, Roy H Hamilton
No abstract text is available yet for this article.
April 26, 2016: Neurology
Joshua B Julian, Jack Ryan, Roy H Hamilton, Russell A Epstein
Thirty years of research suggests that environmental boundaries-e.g., the walls of an experimental chamber or room-exert powerful influence on navigational behavior, often to the exclusion of other cues [1-9]. Consistent with this behavioral work, neurons in brain structures that instantiate spatial memory often exhibit firing fields that are strongly controlled by environmental boundaries [10-15]. Despite the clear importance of environmental boundaries for spatial coding, however, a brain region that mediates the perception of boundary information has not yet been identified...
April 25, 2016: Current Biology: CB
Roy H Hamilton
Although recent years have seen a rapid increase in the diversity of patient populations and of society in general, individuals who belong to historically disadvantaged groups continue to struggle to achieve fuller representation and success in academic medicine. This is particularly true in academic neurology, where faculty from racial and ethnic minority groups are grossly underrepresented. Raising awareness of this problem in the field is an important first step to developing coordinated, strategic approaches to enhancing diversity in neurology...
March 11, 2016: Annals of Neurology
Viviane Kovess-Masfety, Katherine Keyes, Ava Hamilton, Gregory Hanson, Adina Bitfoi, Dietmar Golitz, Ceren Koç, Rowella Kuijpers, Sigita Lesinskiene, Zlatka Mihova, Roy Otten, Christophe Fermanian, Ondine Pez
BACKGROUND: Video games are one of the favourite leisure activities of children; the influence on child health is usually perceived to be negative. The present study assessed the association between the amount of time spent playing video games and children mental health as well as cognitive and social skills. METHODS: Data were drawn from the School Children Mental Health Europe project conducted in six European Union countries (youth ages 6-11, n = 3195). Child mental health was assessed by parents and teachers using the Strengths and Difficulties Questionnaire and by children themselves with the Dominic Interactive...
March 2016: Social Psychiatry and Psychiatric Epidemiology
Jared Medina, Daniel E Drebing, Roy H Hamilton, H Branch Coslett
Recent studies have found preferential responses for brief, transient visual stimuli near the hands, suggesting a link between magnocellular visual processing and peripersonal representations. We report an individual with a right hemisphere lesion whose illusory phantom percepts may be attributable to an impairment in the peripersonal system specific to transient visual stimuli. When presented with a single, brief (250 ms) visual stimulus to her ipsilesional side, she reported visual percepts on both sides - synchiria...
February 2016: Neuropsychologia
Marina N Nikiforova, Abigail I Wald, Melissa A Melan, Somak Roy, Shan Zhong, Ronald L Hamilton, Frank S Lieberman, Jan Drappatz, Nduka M Amankulor, Ian F Pollack, Yuri E Nikiforov, Craig Horbinski
BACKGROUND: Identification of genetic changes in CNS tumors is important for the appropriate clinical management of patients. Our objective was to develop a next-generation sequencing (NGS) assay for simultaneously detecting the various types of genetic alterations characteristic for adult and pediatric CNS tumors that can be applied to small brain biopsies. METHODS: We report an amplification-based targeted NGS assay (GlioSeq) that analyzes 30 genes for single nucleotide variants (SNVs) and indels, 24 genes for copy number variations (CNVs), and 14 types of structural alterations in BRAF, EGFR, and FGFR3 genes in a single workflow...
March 2016: Neuro-oncology
Payel Roy, Shivananda Manohar, Rajesh Raman, T S Sathyanarayana Rao, M S Darshan
BACKGROUND: Women's sexual dysfunction is found to be highly prevalent in western and Indian literature. Limited studies are available on drug naive depression in western literature and in Indian population. AIM: To determine the prevalence rate and symptom profile of female sexual dysfunctions in patients with untreated depression. DESIGN: A cross-sectional study in the psychiatry out-patient department of general hospital in South India...
July 2015: Indian Journal of Psychiatry
Pragyan Roy, Soumya P Panda, Arttatrana Pal, Sudhanshu S Mishra, P Jayasankar, Basanta K Das
The aims of this study were to identify alternative myxovirus (Mx) stimulatory compounds in Cirrhinus mrigala and to characterize the kinetics and intensity of their stimulated responses by semi-quantitative RT-PCR. Mx transcripts were measured in C. mrigala injected with Aeromonas OmpC (outer membrane protein) at a dose 0.4 mg/fish. At day 1, day 2, day 3, day 5, day 10, day 20 and day 30, samples were collected from kidney, spleen, liver, heart brain, gill, intestine and muscle for the study of Mx transcript and housekeeping gene β-actin...
February 2016: Applied Biochemistry and Biotechnology
Joshua Julian, Jack Ryan, Roy Hamilton, Russell Epstein
Previous work indicates that learning of spatial locations relative to environmental boundaries and the learning of spatial locations relative to discrete landmarks are dissociable processes supported by different neural systems (Wang & Spelke, 2002; Doeller & Burgess, 2008). However, the perceptual systems that provide the inputs to these learning mechanisms are not well understood. We hypothesized that the Occipital Place Area (OPA), a scene-selective region located near the transverse occipital sulcus, might play a critical role in boundary-based learning, by extracting boundary information from visual scenes during navigation...
2015: Journal of Vision
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