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https://www.readbyqxmd.com/read/27896038/focal-seizures-induced-by-intracranial-electroencephalogram-grids
#1
Eric Hudgins, Mesha-Gay Brown, Brian Litt, Kathryn Davis, Andrew G Richardson, Timothy Lucas
Here we present a unique, but important seizure variant directly related to placement of subdural grids. Two distinct epileptogenic zones were identified, one which correlated with the patient's baseline seizures and a separate zone associated with atypical semiology and localization. Inspection of this zone at surgery revealed cortical deformation from the grid itself. The patient underwent successful surgical resection of the primary epileptogenic zone, but not that of the atypical zone. She remains seizure free at two years following surgery...
October 15, 2016: Curēus
https://www.readbyqxmd.com/read/27883904/enabling-an-open-data-ecosystem-for-the-neurosciences
#2
Martin Wiener, Friedrich T Sommer, Zachary G Ives, Russell A Poldrack, Brian Litt
No abstract text is available yet for this article.
November 23, 2016: Neuron
https://www.readbyqxmd.com/read/27861321/laser-interstitial-thermal-therapy-technology-physics-of-magnetic-resonance-imaging-thermometry-and-technical-considerations-for-proper-catheter-placement-during-magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy
#3
Nitesh V Patel, Matthew Mian, R Jason Stafford, Brian V Nahed, Jon T Willie, Robert E Gross, Shabbar F Danish
: Laser-induced thermal therapy has become a powerful tool in the neurosurgical armamentarium. The physics of laser therapy are complex, but a sound understanding of this topic is clinically relevant, as many centers have incorporated it into their treatment algorithm, and educated patients are demanding consideration of its use for their disease. Laser ablation has been used for a wide array of intracranial lesions. Laser catheter placement is guided by stereotactic planning; however, as the procedure has popularized, the number of ways in which the catheter can be inserted has also increased...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27810004/enabling-an-open-data-ecosystem-for-the-neurosciences
#4
Martin Wiener, Friedrich T Sommer, Zachary G Ives, Russell A Poldrack, Brian Litt
As the pace and complexity of neuroscience data grow, an open data ecosystem must develop and grow with it to allow neuroscientists the ability to reach for new heights of discovery. However, the problems and complexities of neuroscience data sharing must first be addressed. Among the challenges facing data sharing in neuroscience, the problem of incentives, discoverability, and sustainability may be the most pressing. We here describe these problems and provide potential future solutions to help cultivate an ecosystem for data sharing...
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27807850/temporal-behavior-of-seizures-and-interictal-bursts-in-prolonged-intracranial-recordings-from-epileptic-canines
#5
Hoameng Ung, Kathryn A Davis, Drausin Wulsin, Joost Wagenaar, Emily Fox, John J McDonnell, Ned Patterson, Charles H Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic intracranial recordings in canine epilepsy. METHODS: Continuous, yearlong intracranial electroencephalography (iEEG) recordings from four dogs with naturally occurring epilepsy were analyzed for seizures and interictal bursts...
November 3, 2016: Epilepsia
https://www.readbyqxmd.com/read/27568515/virtual-cortical-resection-reveals-push-pull-network-control-preceding-seizure-evolution
#6
Ankit N Khambhati, Kathryn A Davis, Timothy H Lucas, Brian Litt, Danielle S Bassett
In ∼20 million people with drug-resistant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and spread to surrounding tissue, disrupting function in otherwise normal brain regions. To identify network control mechanisms that regulate seizure spread, we developed a novel tool for pinpointing brain regions that facilitate synchronization in the epileptic network. Our method measures the impact of virtually resecting putative control regions on synchronization in a validated model of the human epileptic network...
September 7, 2016: Neuron
https://www.readbyqxmd.com/read/27227650/correction-forecasting-seizures-using-bivariate-intracranial-eeg-measures-and-svm-in-naturally-occurring-canine-epilepsy
#7
Benjamin H Brinkmann, Edward E Patterson, Charles Vite, Vincent M Vasoli, Daniel Crepeau, Matt Stead, J Jeffry Howbert, Vladimir Cherkassky, Joost B Wagenaar, Brian Litt, Gregory A Worrell
[This corrects the article DOI: 10.1371/journal.pone.0133900.].
2016: PloS One
https://www.readbyqxmd.com/read/27147092/non-equilibrium-dynamics-and-floral-trait-interactions-shape-extant-angiosperm-diversity
#8
Brian C O'Meara, Stacey D Smith, W Scott Armbruster, Lawrence D Harder, Christopher R Hardy, Lena C Hileman, Larry Hufford, Amy Litt, Susana Magallón, Stephen A Smith, Peter F Stevens, Charles B Fenster, Pamela K Diggle
Why are some traits and trait combinations exceptionally common across the tree of life, whereas others are vanishingly rare? The distribution of trait diversity across a clade at any time depends on the ancestral state of the clade, the rate at which new phenotypes evolve, the differences in speciation and extinction rates across lineages, and whether an equilibrium has been reached. Here we examine the role of transition rates, differential diversification (speciation minus extinction) and non-equilibrium dynamics on the evolutionary history of angiosperms, a clade well known for the abundance of some trait combinations and the rarity of others...
May 11, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27114900/computational-analysis-in-epilepsy-neuroimaging-a-survey-of-features-and-methods
#9
REVIEW
Lohith G Kini, James C Gee, Brian Litt
Epilepsy affects 65 million people worldwide, a third of whom have seizures that are resistant to anti-epileptic medications. Some of these patients may be amenable to surgical therapy or treatment with implantable devices, but this usually requires delineation of discrete structural or functional lesion(s), which is challenging in a large percentage of these patients. Advances in neuroimaging and machine learning allow semi-automated detection of malformations of cortical development (MCDs), a common cause of drug resistant epilepsy...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27098152/a-novel-seizure-detection-algorithm-informed-by-hidden-markov-model-event-states
#10
Steven Baldassano, Drausin Wulsin, Hoameng Ung, Tyler Blevins, Mesha-Gay Brown, Emily Fox, Brian Litt
OBJECTIVE: Recently the FDA approved the first responsive, closed-loop intracranial device to treat epilepsy. Because these devices must respond within seconds of seizure onset and not miss events, they are tuned to have high sensitivity, leading to frequent false positive stimulations and decreased battery life. In this work, we propose a more robust seizure detection model. APPROACH: We use a Bayesian nonparametric Markov switching process to parse intracranial EEG (iEEG) data into distinct dynamic event states...
June 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27088236/bioresorbable-silicon-electronics-for-transient-spatiotemporal-mapping-of-electrical-activity-from%C3%A2-the-cerebral-cortex
#11
Ki Jun Yu, Duygu Kuzum, Suk-Won Hwang, Bong Hoon Kim, Halvor Juul, Nam Heon Kim, Sang Min Won, Ken Chiang, Michael Trumpis, Andrew G Richardson, Huanyu Cheng, Hui Fang, Marissa Thompson, Hank Bink, Delia Talos, Kyung Jin Seo, Hee Nam Lee, Seung-Kyun Kang, Jae-Hwan Kim, Jung Yup Lee, Younggang Huang, Frances E Jensen, Marc A Dichter, Timothy H Lucas, Jonathan Viventi, Brian Litt, John A Rogers
Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space...
July 2016: Nature Materials
https://www.readbyqxmd.com/read/27034258/crowdsourcing-reproducible-seizure-forecasting-in-human-and-canine-epilepsy
#12
Benjamin H Brinkmann, Joost Wagenaar, Drew Abbot, Phillip Adkins, Simone C Bosshard, Min Chen, Quang M Tieng, Jialune He, F J Muñoz-Almaraz, Paloma Botella-Rocamora, Juan Pardo, Francisco Zamora-Martinez, Michael Hills, Wei Wu, Iryna Korshunova, Will Cukierski, Charles Vite, Edward E Patterson, Brian Litt, Gregory A Worrell
SEE MORMANN AND ANDRZEJAK DOI101093/BRAIN/AWW091 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE  : Accurate forecasting of epileptic seizures has the potential to transform clinical epilepsy care. However, progress toward reliable seizure forecasting has been hampered by lack of open access to long duration recordings with an adequate number of seizures for investigators to rigorously compare algorithms and results. A seizure forecasting competition was conducted on kaggle.com using open access chronic ambulatory intracranial electroencephalography from five canines with naturally occurring epilepsy and two humans undergoing prolonged wide bandwidth intracranial electroencephalographic monitoring...
June 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26859260/millimeter-scale-epileptiform-spike-propagation-patterns-and-their-relationship-to-seizures
#13
Ann C Vanleer, Justin A Blanco, Joost B Wagenaar, Jonathan Viventi, Diego Contreras, Brian Litt
OBJECTIVE: Current mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale domains have a role in seizure generation that may be clinically significant. We use high-resolution, active, flexible surface electrode arrays with 500 μm inter-electrode spacing to explore epileptiform local field potential (LFP) spike propagation patterns in two dimensions recorded from subdural micro-electrocorticographic signals in vivo in cat...
April 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/26680762/dynamic-network-drivers-of-seizure-generation-propagation-and-termination-in-human-neocortical-epilepsy
#14
Ankit N Khambhati, Kathryn A Davis, Brian S Oommen, Stephanie H Chen, Timothy H Lucas, Brian Litt, Danielle S Bassett
The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. However, poor surgical outcome suggests a complex relationship between foci and the surrounding network that drives seizure dynamics. We developed a novel technique to objectively track seizure states from dynamic functional networks constructed from intracranial recordings. Each dynamical state captures unique patterns of network connections that indicate synchronized and desynchronized hubs of neural populations...
December 2015: PLoS Computational Biology
https://www.readbyqxmd.com/read/26608448/mining-continuous-intracranial-eeg-in-focal-canine-epilepsy-relating-interictal-bursts-to-seizure-onsets
#15
Kathryn A Davis, Hoameng Ung, Drausin Wulsin, Joost Wagenaar, Emily Fox, Ned Patterson, Charles Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Brain regions are localized for resection during epilepsy surgery based on rare seizures observed during a short period of intracranial electroencephalography (iEEG) monitoring. Interictal epileptiform bursts, which are more prevalent than seizures, may provide complementary information to aid in epilepsy evaluation. In this study, we leverage a long-term iEEG dataset from canines with naturally occurring epilepsy to investigate interictal bursts and their electrographic relationship to seizures...
January 2016: Epilepsia
https://www.readbyqxmd.com/read/26468323/glutamate-imaging-glucest-lateralizes-epileptic-foci-in-nonlesional-temporal-lobe-epilepsy
#16
Kathryn Adamiak Davis, Ravi Prakash Reddy Nanga, Sandhitsu Das, Stephanie H Chen, Peter N Hadar, John R Pollard, Timothy H Lucas, Russell T Shinohara, Brian Litt, Hari Hariharan, Mark A Elliott, John A Detre, Ravinder Reddy
When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients who have normal brain magnetic resonance imaging (MRI). We applied a glutamate imaging method, GluCEST (glutamate chemical exchange saturation transfer), to patients with nonlesional temporal lobe epilepsy based on conventional MRI. GluCEST correctly lateralized the temporal lobe seizure focus on visual and quantitative analyses in all patients...
October 14, 2015: Science Translational Medicine
https://www.readbyqxmd.com/read/26418017/lateral-transorbital-endoscopic-access-to-the-hippocampus-amygdala-and-entorhinal-cortex-initial-clinical-experience
#17
H Isaac Chen, Leif-Erik Bohman, Lyndsey Emery, Maria Martinez-Lage, Andrew G Richardson, Kathryn A Davis, John R Pollard, Brian Litt, Roberta E Gausas, Timothy H Lucas
BACKGROUND/AIMS: Transorbital approaches traditionally have focused on skull base and cavernous sinus lesions medial to the globe. Lateral orbital approaches to the temporal lobe have not been widely explored despite several theoretical advantages compared to open craniotomy. Recently, we demonstrated the feasibility of the lateral transorbital technique in cadaveric specimens with endoscopic visualization. We describe our initial clinical experience with the endoscope-assisted lateral transorbital approach to lesions in the temporal lobe...
2015: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/26241907/forecasting-seizures-using-intracranial-eeg-measures-and-svm-in-naturally-occurring-canine-epilepsy
#18
Benjamin H Brinkmann, Edward E Patterson, Charles Vite, Vincent M Vasoli, Daniel Crepeau, Matt Stead, J Jeffry Howbert, Vladimir Cherkassky, Joost B Wagenaar, Brian Litt, Gregory A Worrell
Management of drug resistant focal epilepsy would be greatly assisted by a reliable warning system capable of alerting patients prior to seizures to allow the patient to adjust activities or medication. Such a system requires successful identification of a preictal, or seizure-prone state. Identification of preictal states in continuous long- duration intracranial electroencephalographic (iEEG) recordings of dogs with naturally occurring epilepsy was investigated using a support vector machine (SVM) algorithm...
2015: PloS One
https://www.readbyqxmd.com/read/26035676/collaborating-and-sharing-data-in-epilepsy-research
#19
REVIEW
Joost B Wagenaar, Gregory A Worrell, Zachary Ives, Matthias Dümpelmann, Dümpelmann Matthias, Brian Litt, Andreas Schulze-Bonhage
Technological advances are dramatically advancing translational research in Epilepsy. Neurophysiology, imaging, and metadata are now recorded digitally in most centers, enabling quantitative analysis. Basic and translational research opportunities to use these data are exploding, but academic and funding cultures prevent this potential from being realized. Research on epileptogenic networks, antiepileptic devices, and biomarkers could progress rapidly if collaborative efforts to digest this "big neuro data" could be organized...
June 2015: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/25856480/engineering-the-next-generation-of-brain-scientists
#20
REVIEW
Brian Litt
New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technology requirements, cross-disciplinary education, open-source resources, and experiential learning are new ways we can efficiently equip future leaders to make the next disruptive discoveries.
April 8, 2015: Neuron
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