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Kang An, Hang Yin, Ju Mei, Jiaquan Zhu, Min Tang
OBJECTIVES: We retrospectively analysed data from non-valvular atrial fibrillation (AF) patients who underwent minimally invasive surgical AF ablation at our centre. Our purpose was to explore the atrial endocardial expression of von Willebrand factor (vWF) and thrombomodulin (TM) and their association with rhythm results after the procedure. METHODS: From January 2014 to May 2015, 60 patients underwent minimally invasive surgical AF ablation at our centre. Left atrial appendage samples were obtained during the procedure and immunohistochemistry for endocardial markers including vWF and TM was performed and semi-quantitatively graded...
March 14, 2018: Interactive Cardiovascular and Thoracic Surgery
Andleeb Z Naqvi, Kabir-Ud-Din
Phase separation in amphiphilic systems is an important phenomenon. The temperature at which an amphiphilic solution phase separates is known as Cloud Point (CP). This article reviews in detail the process of phase separation in various amphiphiles (surfactants, polymers and drugs) and effect of different classes of additives on the CP of these amphiphilic systems. Ions affect the CP of drugs in a different way: kosmotropes and hard bases decrease while chaotropes and soft bases increase the CP of nonionic and cationic surfactants...
February 3, 2018: Colloids and Surfaces. B, Biointerfaces
Aniko Krumbholz, Martin Schönfelder, Hande Hofmann, Detlef Thieme
BACKGROUND: The endogenous glucocorticosteroid cortisol (F) and its metabolite cortisone (E) are known to be involved in stress adaption and anti-inflammatory and immune regulatory effects. The ratios of F to E in the matrices serum, hair and saliva are different. The shift of this ratio by the enzyme activity of 11β-hydroxysteroid-dehydrogenase, which inactivates cortisol, was often discussed. The aim of our study was to calculate the contribution of the plasma protein binding (PPB) to this shift...
February 26, 2018: Forensic Science International
Osnat Israelsohn-Azulay, Yigal Zidon, Tsadok Tsach
A shooting event involved several types of ammunition that were all shot from a single firearm. GSR analysis of samples taken from the suspect's hands, hair and from his clothes was carried out. Mixed compositions particles were found among other GSR particles, attributed to the weapon memory effect. SEM/EDX analysis of these particles highlighted a particle with defined domains containing distinct groups of elements. Some of these elements were absent in the primers mixtures of the ammunition used in the shooting event...
March 6, 2018: Forensic Science International
Alberto Perez, Florian Sittel, Gerhard Stock, Ken A Dill
The molecular actions of proteins occur along reaction coordinates. Current computer methods have limited ability to explore them. We describe a fast protocol called MELD-path that: (1) efficiently samples relevant conformational states via MELD, an accelerator of Molecular Dynamics (MD), (2) seeds multiple short MD trajectories from MELD states, then (3) constructs Markov State Models (MSM) that give the routes and kinetics. We tested the method against extensive (multi μs) MD simulations of the right-handed- to left-handed-helix transition of a 9-mer peptide of AIB, the symmetry of which allows us to establish convergence...
March 16, 2018: Journal of Chemical Theory and Computation
David Kavaler, Vladimir Filkov
Stack Overflow is a popular crowdsourced question and answer website for programming-related issues. It is an invaluable resource for software developers; on average, questions posted there get answered in minutes to an hour. Questions about well established topics, e.g., the coercion operator in C++, or the difference between canonical and class names in Java, get asked often in one form or another, and answered very quickly. On the other hand, questions on previously unseen or niche topics take a while to get a good answer...
2018: PloS One
Sara Montserrat-Sangrà, Laura Ordeix, Pamela Martínez-Orellana, Laia Solano-Gallego
Canine leishmaniosis has a wide range of disease severity from mild (stage I), to severe (stages II-III), or very severe disease (stage IV). The objective of the study was to evaluate and compare serum antibody levels, Leishmania infantum specific IFN-γ production and TLR2 and TLR4 transcripts in non-stimulated blood from dogs with different clinical stages at the time of diagnosis as well as blood parasitemia. Enzyme-Linked ImmunoSorbent Assay (ELISAs) were performed to determine serum antibody levels and IFN-γ production and quantitative polymerase chain reaction ( q PCRs) in order to determine blood parasite load and TLR2 and TLR4 transcripts...
March 16, 2018: Veterinary Sciences
Robert W Irwin, Jeffrey Smith, S Barry Issenberg
The Accreditation Council for Graduate Medical Education (ACGME) and the American Board of Physical Medicine and Rehabilitation (ABPMR) developed milestones for evaluation of resident physicians that include proper musculoskeletal ultrasound (MSUS) examination of major joints. To date, there have been no published data demonstrating acquisition and retention of these skills and correlation with the milestone evaluation. The investigators developed and implemented a curriculum in musculoskeletal ultrasound examination for Physical Medicine and Rehabilitation (PM&R) residents at a large academic medical center...
March 15, 2018: American Journal of Physical Medicine & Rehabilitation
Mursel Bicer, Saltuk Bugra Baltaci, Suleyman Patlar, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Aim The present study aimed to examine the effects of melatonin supplementation on lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise. Methods The study was conducted on 80 Sprague-Dawley type adult male rats which were equally allocated to eight groups: group 1, general control; group 2, melatonin-supplemented control; group 3, melatonin-supplemented diabetic control; group 4, swimming control; group 5, melatonin-supplemented swimming; group 6, melatonin-supplemented diabetic swimming; group 7, diabetic swimming; group 8, diabetic control...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
Nadia Lombardi, Stefania Vitale, David Turrà, Massimo Reverberi, Corrado Fanelli, Francesco Vinale, Roberta Marra, Michelina Ruocco, Alberto Pascale, Giada d'Errico, Sheridan Lois Woo, Matteo Lorito
Plant roots release complex mixtures of bioactive molecules including compounds that affect the activity and modify the composition of the rhizosphere microbiome. In this work, we investigated the initial phase of the interaction between tomato and an effective biocontrol strain of Trichoderma harzianum (T22). We found that root exudates (RE), obtained from plants grown in a split root system and exposed to a choice of biotic and abiotic stress factors (wounding, salt, pathogen attack), stimulate the growth and act as chemoattractants of the biocontrol fungus...
March 16, 2018: Molecular Plant-microbe Interactions: MPMI
Paul Seli, Jonathan S A Carriere, Jeffrey D Wammes, Evan F Risko, Daniel L Schacter, Daniel Smilek
We examined the hypothesis that people can modulate their mind wandering on the basis of their expectations of upcoming challenges in a task. To this end, we developed a novel paradigm in which participants were presented with an analog clock, via a computer monitor, and asked to push a button every time the clock's hand was pointed at 12:00. Importantly, the time at which the clock's hand was pointed at 12:00 was completely predictable and occurred at 20-s intervals. During some of the 20-s intervals, we presented thought probes to index participants' rates of mind wandering...
March 1, 2018: Psychological Science
Sakshi Chopra, Harsimarpreet Kaur, Ravindra M Pandey, Ashima Nehra
Background: Due to the paucity of quick, cognitive screening tools available in India that are independent of cultural and educational influences, a 6-item paper and pencil test, covering areas of memory, executive functioning, attention, and visuospatial ability domains - the Neuropsychological Evaluation Screening Tool (NEST) was developed. Aim and Method: NEST was administered to 84 healthy controls to analyze, revise, and review items. In the second phase, 408 patients, above 16 years of age, with their educational level ranging from being illiterate to having greater than 25 years of education, with various neurological and psychiatric conditions were independently administered NEST, Hindi Mental State Examination (HMSE), and a detailed cognitive evaluation using PGI Memory Scale (PGIMS)...
March 2018: Neurology India
Laurent Mathieu, Michel Levadoux, Emmanuel Soucany de Landevoisin, Tarun J McBride Windsor, Sylvain Rigal
INTRODUCTION: Noncombat-related hand injuries are common in current theatres of operations. Crushing is one of the most frequent mechanisms that may cause traumatic amputations of digits. In the military setting, management of these digital amputations is challenging regarding limitation in microsurgical means in medical treatment facilities and aeromedical evacuation delays out of the combat zone. METHODS: Two cases of digital replantation performed in French forward surgical units are described...
2018: SICOT-J
Hesham Mostafa Zakaria, Peter Joseph Massa, Richard L Smith, Tarek Hazem Moharram, John Corrigan, Ian Lee, Lonni Schultz, Jianhui Hu, Suresh Patel, Brent Griffith
Preoperative identification of the eloquent brain is important for neurosurgical planning. One common method of finding the motor cortex is by localizing "the Omega sign." No studies have tested the reliability of imaging to identify the Omega sign. We identified 40 recent and consecutive patients who had undergone preoperative functional magnetic resonance imaging for identification of the hand motor area prior to tumor resection. We recruited 11 neurosurgical residents of various levels of training and one board-certified neurosurgeon to identify the hand motor cortex Omega...
January 1, 2018: Neuroradiology Journal
Tomas Madura, Kazuteru Doi, Yasunori Hattori, Sotetsu Sakamoto, Takashi Shimoe
The purpose of this study was to evaluate long-term outcomes of the free functioning gracilis transfer in children with traumatic total brachial plexus palsy. We used the free functioning gracilis transfer to reconstruct elbow flexion and prehension in 17 children with a mean age of 13.4 years (range 3-17) who were followed-up over a mean period of 6 years (range 2-16). The transferred gracilis delivered a stable elbow flexion with a useful power, as well as reconstructed active finger motion. In 3-11-year-old patients we noted a tendency towards developing a progressive flexion contracture of the elbow...
January 1, 2018: Journal of Hand Surgery, European Volume
Senda Sammoud, Alan Michael Nevill, Yassine Negra, Raja Bouguezzi, Helmi Chaabene, Younés Hachana
This study aimed to estimate the optimal body size, limb segment length, and girth or breadth ratios of 100-m breaststroke performance in youth swimmers. In total, 59 swimmers [male: n = 39, age = 11.5 (1.3) y; female: n = 20, age = 12.0 (1.0) y] participated in this study. To identify size/shape characteristics associated with 100-m breaststroke swimming performance, we computed a multiplicative allometric log-linear regression model, which was refined using backward elimination. Results showed that the 100-m breaststroke performance revealed a significant negative association with fat mass and a significant positive association with the segment length ratio (arm ratio = hand length/forearm length) and limb girth ratio (girth ratio = forearm girth/wrist girth)...
March 16, 2018: Pediatric Exercise Science
Robert T Keys, Anina N Rich, Regine Zopf
Tracking one's own body is essential for environmental interaction, and involves integrating multisensory cues with stored information about the body's typical features. Exactly how multisensory information is integrated in own-body perception is still unclear. For example, Ide and Hidaka (Exp Brain Res 228:43-50, 2013) found that participants made less precise visuo-tactile temporal order judgments (TOJ) when viewing hands in a plausible orientation (upright; typical for one's own hand) compared to an implausible orientation (rotated 180°)...
March 15, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Holger Muggenthaler, T X Trinh, S Heinke, C Rode, S Schenkl, M Hubig, G Mall
Forensic experts often have to assess injury and fatality risks in the context of violent blunt force trauma. Maximum striking velocities in one- and two-handed strikes with a rod-like implement can be of particular interest. Current literature lacks studies addressing this problem. The purpose of this study was therefore to measure and analyse maximum striking velocities in one-handed and two-handed strikes in female and male volunteers. We hypothesised higher striking velocities in two-handed strikes compared to one-handed strikes...
March 15, 2018: International Journal of Legal Medicine
Paul M Gittings, Dana A Hince, Benedict M Wand, Fiona M Wood, Dale W Edgar
External stabilization is reported to improve reliability of hand held dynamometry, yet this has not been tested in burns. We aimed to assess the reliability of dynamometry using an external system of stabilization in people with moderate burn injury and explore construct validity of strength assessment using dynamometry.Participants were assessed on muscle and grip strength three times on each side. Assessment occurred three times per week for up to four weeks. Within session reliability was assessed using intraclass correlations calculated for within session data grouped prior to surgery, immediately after surgery and in the sub-acute phase of injury...
March 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Ahmad Alobeid, Tarek El-Bialy, Susanne Reimann, Ludger Keilig, Dirk Cornelius, Andreas Jäger, Christoph Bourauel
Background/objective: The aim of this study was to evaluate the efficacy of tooth alignment with conventional and self-ligating labial and lingual orthodontic bracket systems. Materials/methods: We tested labial brackets (0.022″ slot size) and lingual brackets (0.018″ slot size). The labial brackets were: (i) regular twin brackets (GAC-Twin [Dentsply]), (ii) passive self-ligating brackets including (Damon-Q® [ORMCO]; Ortho classic H4™ [Orthoclassic]; FLI®SL [RMO]), and (iii) active self-ligating brackets (GAC In-Ovation®C [DENTSPLY] and SPEED™[Strite])...
March 13, 2018: European Journal of Orthodontics
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