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https://www.readbyqxmd.com/read/28941391/chlorinated-paraffins-leaking-from-hand-blenders-can-lead-to-significant-human-exposures
#1
Bo Yuan, Anna Strid, Per Ola Darnerud, Cynthia A de Wit, Jessica Nyström, Åke Bergman
BACKGROUND: Chlorinated paraffins (CPs, polychlorinated n-alkanes) are versatile, high-production-volume chemicals. A previous study indicated that hand blenders leak CPs into prepared food. OBJECTIVES: (1) to estimate exposure to CPs from hand blender use compared to background CP exposure from diet; (2) to assess the risk from human dietary exposure to CPs from hand blender use; (3) to investigate how hand blenders leak out CPs. METHODS: CPs were analyzed in food market baskets, in cooking oil/water samples (1g oil/100mL water) mixed using 16 different hand blenders, and in dismantled components of the hand blenders...
September 20, 2017: Environment International
https://www.readbyqxmd.com/read/28938784/immunocastration-as-an-alternative-to-caponization-evaluation-of-its-effect-on-body-and-bone-development-and-on-meat-color-and-composition
#2
M A G Quaresma, I C Antunes, M F Ribeiro, S Prazeres, R J B Bessa, P Martins da Costa
Caponization is associated with some morbidity and mortality, which contributes to important economic losses. This practice is executed without any pain relief (neither anesthesia nor analgesia) and can be painful and without consideration of animal welfare. On the other hand, immunocastration accomplished by Improvac and Bovipriva in pigs and cattle represents a noninvasive procedure, and for that reason is regarded as an alternative with improved animal welfare. This study includes 4 experimental groups consisting of capons, slips, roosters, and birds submitted to the Improvac treatment...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938736/deep-sequencing-shows-that-oocytes-are-not-prone-to-accumulate-mtdna-heteroplasmic-mutations-during-ovarian-ageing
#3
L Boucret, C Bris, V Seegers, D Goudenège, V Desquiret-Dumas, M Domin-Bernhard, V Ferré-L'Hotellier, P E Bouet, P Descamps, P Reynier, V Procaccio, P May-Panloup
STUDY QUESTION: Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER: Our results suggest that oocytes are not subject to the accumulation of mtDNA point mutations during ovarian ageing. WHAT IS KNOWN ALREADY: Ageing is associated with the alteration of mtDNA integrity in various tissues. Primary oocytes, present in the ovary since embryonic life, may accumulate mtDNA mutations during the process of ovarian ageing...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938663/transcatheter-hepatic-arterial-chemoembolization-and-sorafenib-for-hepatocellular-carcinoma-a-meta-analysis-of-randomized-double-blind-controlled-trials
#4
Jun Li, Wenhui Liu, Wenhua Zhu, Yinqiao Wu, Benyan Wu
We performed a meta-analysis of transcatheter hepatic arterial chemoembolization (TACE) combined with sorafenib for hepatocellular carcinoma (HCC), which included 4 double-blind, randomized controlled trials (RCTs) that investigated the effects of TACE combined with sorafenib (experimental groups) on time to disease progression (TTP), overall survival (OS), and various sorafenib-related adverse events, compared to those in the placebo (control) groups. A total of 877 HCC cases from 14 countries, including China and the USA, were included in our meta-analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938213/combination-of-aquifer-thermal-energy-storage-and-enhanced-bioremediation-biological-and-chemical-clogging
#5
Zhuobiao Ni, Pauline van Gaans, Huub Rijnaarts, Tim Grotenhuis
Interest in the combination concept of aquifer thermal energy storage (ATES) and enhanced bioremediation has recently risen due to the demand for both renewable energy technology and sustainable groundwater management in urban areas. However, the impact of enhanced bioremediation on ATES is not yet clear. Of main concern is the potential for biological clogging which might be enhanced and hamper the proper functioning of ATES. On the other hand, more reduced conditions in the subsurface by enhanced bioremediation might lower the chance of chemical clogging, which is normally caused by Fe(III) precipitate...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938198/differentiation-of-black-writing-ink-on-paper-using-luminescence-lifetime-by-time-resolved-luminescence-spectroscopy
#6
Mototsugu Suzuki, Norimitsu Akiba, Kenji Kurosawa, Yoshinori Akao, Yoshiyasu Higashikawa
The time-resolved luminescence spectra and the lifetimes of eighteen black writing inks were measured to differentiate pen ink on altered documents. The spectra and lifetimes depended on the samples. About half of the samples only exhibited short-lived luminescence components on the nanosecond time scale. On the other hand, the other samples exhibited short- and long-lived components on the microsecond time scale. The samples could be classified into fifteen groups based on the luminescence spectra and dynamics...
September 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28938167/a-method-for-measuring-manual-position-control
#7
Cory Adam Potts, Alexander A Brown, Stanislaw Solnik, David A Rosenbaum
There is no generally accepted method for measuring manual position control. We developed a method for doing so. We asked university students to hold a handle that had one rotational degree of freedom. The angular position of the handle depended on the degree of pronation-supination of the forearm. The subjects' task was to hold the handle as steadily as possible to keep a needle positioned in a pie-shaped target zone on a computer screen. If the needle remained in the zone for 0.5s, the gain of the feedback loop increased; otherwise the gain decreased or remained at the starting value of 1...
September 19, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28938156/removal-of-intra-and-extracellular-microcystin-by-submerged-ultrafiltration-uf-membrane-combined-with-coagulation-flocculation-and-powdered-activated-carbon-pac-adsorption
#8
Ayşe Büşra Şengül, Gamze Ersan, Neşe Tüfekçi
In this study, we investigated the performance of conventional (coagulation/flocculation→powdered activated carbon [PAC] adsorption) and advanced treatment (coagulation/flocculation→PAC adsorption→submerged ultrafiltration [UF] membrane) processes separately and sequentially for the removal of total (intra- and extracellular) microcystin. Results of the conventional treatment process demonstrated that coagulation/flocculation alone was not effective (up to 70%) for the removal of total microcystin, while the uptake of total microcystin was achieved up to 84% by PAC adsorption (PAC dose of 20mg/L)...
September 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28938152/comparison-of-manual-and-automated-ampliseq%C3%A2-workflows-in-the-typing-of-a-somali-population-with-the-precision-id-identity-panel
#9
Suzanne van der Heijden, Susanne Juel de Oliveira, Marie-Louise Kampmann, Claus Børsting, Niels Morling
The Precision ID Identity Panel was used to type 109 Somali individuals in order to obtain allele frequencies for the Somali population. These frequencies were used to establish a Somali HID-SNP database, which will be used for the biostatistic calculations in family and immigration cases. Genotypes obtained with the Precision ID Identity Panel were found to be almost in complete concordance with genotypes obtained with the SNPforID PCR-SBE-CE assay. In seven SNP loci, silent alleles were identified, of which most were previously described in the literature...
September 14, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28938100/exposure-to-phthalates-in-patients-with-diabetes-and-its-association-with-oxidative-stress-adiponectin-and-inflammatory-cytokines
#10
Yishuang Duan, Lei Wang, Liping Han, Bin Wang, Hongwen Sun, Liming Chen, Lingyan Zhu, Yi Luo
Epidemiologic studies have revealed higher concentrations of the metabolites of phthalic acid esters (mPAEs) in patients with type 2 diabetes. On the other hand, oxidative stress, adiponectin, and inflammatory cytokines play important roles in the pathogenesis of diabetes and its complications. However, little information is known about the association between exposure to PAEs and these physiological parameters. Hence, paired urine and blood samples were collected from a total of 329 volunteers, and 11 main mPAEs and malondialdehyde (MDA), as a biomarker of oxidative stress, were measured in the urine samples...
September 19, 2017: Environment International
https://www.readbyqxmd.com/read/28938035/guided-bone-regeneration-with-collagen-membranes-and-particulate-graft-materials-a-systematic-review-and-meta-analysis
#11
Bastian Wessing, Stefan Lettner, Werner Zechner
PURPOSE: The aim of this meta-analysis was to evaluate different methods for guided bone regeneration using collagen membranes and particulate grafting materials in implant dentistry. MATERIALS AND METHODS: An electronic database search and hand search were performed for all relevant articles dealing with guided bone regeneration in implant dentistry published between 1980 and 2014. Only randomized clinical trials and prospective controlled studies were included...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28938017/a-highly-conserved-amino-acid-in-vp1-regulates-maturation-of-enterovirus-71
#12
Yong-Xin Zhang, Yu-Ming Huang, Quan-Jie Li, Xiao-Yu Li, Yong-Dong Zhou, Fei Guo, Jin-Ming Zhou, Shan Cen
Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in children, causing severe clinical outcomes and even death. Here, we report an important role of the highly conserved alanine residue at position 107 in the capsid protein VP1 (VP1A107) in the efficient replication of EV71. Substitutional mutations of VP1A107 significantly diminish viral growth kinetics without significant effect on viral entry, expression of viral genes and viral production. The results of mechanistic studies reveal that VP1A107 regulates the efficient cleavage of the VP0 precursor during EV71 assembly, which is required, in the next round of infection, for the transformation of the mature virion (160S) into an intermediate or A-particle (135S), a key step of virus uncoating...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28937951/effect-of-stress-level-on-different-forms-of-self-touch-in-pre-and-postadolescent-girls
#13
Kyra Densing, Hippokrates Konstantinidis, Melanie Seiler
Self-touch serves for regulation of both hyper- and hypoarousal. It remains unclear if different forms of self-touch occur in different contexts, and if the regulatory mechanisms are learned or innate. The authors describe forms and context of self-touch, and explore age differences in stress processing. They analyzed hand movements of 10 pre- and 10 postadolescent girls in low-stress and high-stress settings and found 3 forms of self-touch. In postadolescent participants, self-touch 2 (irregular structure, rhythmical, medium intensity) and 3 (phasic structure, single accent, medium intensity) were used for self-regulation, whereas self-touch 1 (irregular structure, single accent, low intensity) had conversational reasons...
September 22, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28937919/neurosurgical-management-of-a-rare-congenital-supratentorial-neurenteric-cyst-with-associated-nasal-dermal-sinus-case-report
#14
Paul MacMahon, Stanca Iacob, Sarah E Bach, Eric T Elwood, Julian J Lin, Anthony M Avellino
The authors describe the case of a patient with the classic clinical presentation and radiographic features of a nasal dermal sinus with an associated intracranial cyst; however, histopathology revealed that the intracranial cyst was neurenteric instead of the typical epidermoid or dermoid cyst. Preoperative assessment included CT and MRI, which revealed a direct communication between the patient's nasal polypoid lesion and the anterior skull base via the foramen cecum. At the hands of a multidisciplinary plastic surgery and neurosurgery team, the patient underwent concurrent gross-total resection of the nasal polypoid lesion, the intracranial intradural cystic lesion, and their interconnecting tract...
September 15, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28937867/coenzyme-q10-for-the-protection-of-lacrimal-gland-against-high-dose-radioiodine-therapy-associated-oxidative-damage-histopathologic-and-tissue-cytokine-level-assessments-in-an-animal-model
#15
Mehmet Yakin, Umit Eksioglu, Murat Sadic, Gokhan Koca, Guner Ozkan-Uney, Nihat Yumusak, Hande Husniye Telek, Ayten Demir, Nuray Yazihan, Firdevs Ornek, Meliha Korkmaz
PURPOSE: To evaluate protective effect of coenzyme Q10 (CoQ10) in lacrimal glands against high-dose radioactive iodine (RAI)-associated oxidative damage. MATERIALS AND METHODS: Thirty Wistar albino rats were randomly divided into three groups. Group 1 was the control group. Group 2 received 3 mCi/kg RAI via gastric gavage but no medication. Group 3 received 3 mCi/kg RAI via gastric gavage and 30 mg/kg/day CoQ10 intraperitoneally. CoQ10 was started at day one just before RAI administration and continued for five days...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937845/pharmacokinetics-of-beclomethasone-dipropionate-delivered-by-breath-actuated-inhaler-and-metered-dose-inhaler-in-healthy-subjects
#16
Calvin J Small, Michael Gillespie
BACKGROUND: Breath-actuated inhalers (BAIs) eliminate the need for hand-breath coordination required of pressurized metered-dose inhalers (MDIs). This pharmacokinetic study compared systemic exposure following beclomethasone dipropionate delivery through BAI versus MDI. METHODS: This open-label, three-period crossover, single-dose study randomized healthy subjects aged 18-45 years (N = 72) to 1 of 6 treatment sequences containing beclomethasone dipropionate BAI 160 mcg (40 mcg/inhalation, 4 inhalations), beclomethasone dipropionate BAI 320 mcg (80 mcg/inhalation, 4 inhalations), and beclomethasone dipropionate MDI 320 mcg (80 mcg/inhalation, 4 inhalations)...
September 22, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28937801/clinical-implications-of-hand-position-and-lower-limb-length-measurement-method-on-y-balance-test-scores-and-interpretation
#17
Kim Hébert-Losier
CONTEXT:   The Lower Quarter Y-Balance Test (LQ-YBT) was developed to provide an effective and efficient screen for injury risk in sports. Earlier protocol recommendations for the LQ-YBT involved the athlete placing the hands on the hips and the clinician normalizing scores to lower limb length measured from the anterior-superior iliac spine to the lateral malleolus. The updated LQ-YBT protocol recommends the athlete's hands be free moving and the clinician measure lower limb length to the medial malleolus...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937791/web-based-surveillance-of-illness-in-childcare-centers
#18
Natalie Schellpfeffer, Abaigeal Collins, David C Brousseau, Emily T Martin, Andrew Hashikawa
School absenteeism is an inefficient and unspecific metric for measuring community illness and does not provide surveillance during summertime. Web-based biosurveillance of childcare centers may represent a novel way to efficiently monitor illness outbreaks year-round. A web-based biosurveillance program ( sickchildcare.org ) was created and implemented in 4 childcare centers in a single Michigan county. Childcare providers were trained to report sick children who required exclusion or had parent-reported absences due to illness...
September 22, 2017: Health Security
https://www.readbyqxmd.com/read/28937658/extracellular-vesicle-associated-rna-as-a-carrier-of-epigenetic-information
#19
REVIEW
Carlo Maria Di Liegro, Gabriella Schiera, Italia Di Liegro
Post-transcriptional regulation of messenger RNA (mRNA) metabolism and subcellular localization is of the utmost importance both during development and in cell differentiation. Besides carrying genetic information, mRNAs contain cis-acting signals (zip codes), usually present in their 5'- and 3'-untranslated regions (UTRs). By binding to these signals, trans-acting factors, such as RNA-binding proteins (RBPs), and/or non-coding RNAs (ncRNAs), control mRNA localization, translation and stability. RBPs can also form complexes with non-coding RNAs of different sizes...
September 22, 2017: Genes
https://www.readbyqxmd.com/read/28937450/parenting-to-reduce-child-screen-time-a-feasibility-pilot-study
#20
Wesley Sanders, Justin Parent, Rex Forehand
OBJECTIVE: Excessive screen time has been associated with a multitude of child health problems. This pilot study examined the feasibility and preliminary outcome of a novel 1-session intervention designed to help parents reduce their child's screen time. METHODS: Thirty-nine parents of 5- to 12-year-old children were randomized to the intervention (a combined didactics and hands-on approach focused on technology-specific parenting) or waitlist control group. RESULTS: The findings suggested that a sample could be recruited in a reasonable time (6 wk) at a reasonable cost, randomized, and retained at 6 weeks postintervention...
September 19, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
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