keyword
https://read.qxmd.com/read/37996362/pretreatment-mri-based-radiomics-for-prediction-of-rectal-cancer-outcome-a-discovery-and-validation-study
#21
JOURNAL ARTICLE
Hongyan Huang, Lujun Han, Jianbo Guo, Yanyu Zhang, Shiwei Lin, Shengli Chen, Xiaoshan Lin, Caixue Cheng, Zheng Guo, Yingwei Qiu
RATIONALE AND OBJECTIVES: Accurate prediction of local recurrence or distant metastasis is critical for developing individualized therapies for locally advanced rectal cancer (LARC) patients after standard therapy. This study aims to develop and validate a multiparameter MRI-based radiomics signature (RS) for prognostic prediction in LARC patients receiving neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) and to explore the ability of RS for personalized survival risk stratification...
November 22, 2023: Academic Radiology
https://read.qxmd.com/read/37993062/comparison-of-adenoma-miss-rate-and-adenoma-detection-rate-between-conventional-colonoscopy-and-colonoscopy-with-second-generation-distal-attachment-cuff-a-multicenter-randomized-back-to-back-trial
#22
JOURNAL ARTICLE
Kelly E van Keulen, Ioannis S Papanikolaou, Tony W C Mak, Periklis Apostolopoulos, Helmut Neumann, Gabriele Delconte, Manuele Furnari, Yonne Peters, James Y W Lau, Dimitrios Polymeros, Ruud W N Schrauwen, Federica Cavalcoli, Eleni Koukoulioti, Konstantinos Triantafyllou, Joseph C Anderson, Heiko Pohl, D K Rex, P D Siersema
BACKGROUND AND AIMS: Endocuff VisionTM has been designed to enhance mucosal visualization thereby improving detection of (pre-)malignant colorectal lesions. This multicenter, international, back-to-back, randomized colonoscopy trial compared adenoma detection rate (ADR) and adenoma miss rate (AMR) between Endocuff Vision-assisted colonoscopy (EVC) and conventional colonoscopy (CC). METHODS: Patients aged 40-75 years referred for non-immunochemical fecal occult blood test-based screening, surveillance, or diagnostic colonoscopy were included at ten hospitals and randomized into four groups: Group 1; 2xCC, Group 2; CC followed by EVC, Group 3; EVC followed CC and Group 4; 2xEVC...
November 20, 2023: Gastrointestinal Endoscopy
https://read.qxmd.com/read/37986131/allocating-mental-effort-in-cognitive-tasks-a-model-of-motivation-in-the-act-r-cognitive-architecture
#23
JOURNAL ARTICLE
Yuxue C Yang, Andrea Stocco
Motivation is the driving force that influences people's behaviors and interacts with many cognitive functions. Computationally, motivation is represented as a cost-benefit analysis that weighs efforts and rewards in order to choose the optimal actions. Shenhav and colleagues proposed an elegant theory, the Expected Value of Control (EVC), which describes the relationship between cognitive efforts, costs, and rewards. In this paper, we propose a more fine-grained and detailed motivation framework that incorporates the principles of EVC into the ACT-R cognitive architecture...
November 20, 2023: Topics in Cognitive Science
https://read.qxmd.com/read/37918399/hierarchical-organization-of-social-action-features-along-the-lateral-visual-pathway
#24
JOURNAL ARTICLE
Emalie McMahon, Michael F Bonner, Leyla Isik
Recent theoretical work has argued that in addition to the classical ventral (what) and dorsal (where/how) visual streams, there is a third visual stream on the lateral surface of the brain specialized for processing social information. Like visual representations in the ventral and dorsal streams, representations in the lateral stream are thought to be hierarchically organized. However, no prior studies have comprehensively investigated the organization of naturalistic, social visual content in the lateral stream...
October 25, 2023: Current Biology: CB
https://read.qxmd.com/read/37918284/operationalisation-of-the-forenseq%C3%A2-kintelligence-kit-for-australian-unidentified-and-missing-persons-casework
#25
JOURNAL ARTICLE
Jessica Watson, Dennis McNevin, Kelly Grisedale, Michelle Spiden, Shelley Seddon, Jodie Ward
Single nucleotide polymorphism (SNP) genotyping technologies can generate investigative leads for human remains identification, including estimation of biological sex, biogeographical ancestry (BGA), externally visible characteristics (EVCs), identity, uniparental lineage and extended kinship. The ForenSeq® Kintelligence Kit provides forensic laboratories with the ability to apply this suite of genetic tools to forensic samples using one panel targeting 10,230 SNPs (including 56 ancestry-informative, 24 phenotype-informative, 94 identity-informative, 106 X chromosome, 85 Y chromosome and 9867 kinship-informative SNPs) sequenced on the MiSeq FGx® Sequencing System...
October 30, 2023: Forensic Science International. Genetics
https://read.qxmd.com/read/37915337/antioxidant-skincare-treatment-for-hyperpigmented-and-photodamaged-skin-multi-center-open-label-cross-seasonal-case-study
#26
JOURNAL ARTICLE
Deirdre Hooper, Ruth Tedaldi, Sofia Iglesia, Morgann B Young, Tatiana Kononov, Alisar S Zahr
OBJECTIVE: The objective of this study is three-fold. Firstly, to evaluate an enhanced vitamin C serum (eVCS) and its' combination with a retinol-bakuchiol serum (RBS) on pigmentation in vitro . Secondly, to evaluate the effect of the eVCS on skin function ex vivo . Lastly, to evaluate eVCS and RSB in the treatment of facial hyperpigmentation and overall photodamage across a range of opposing environments. METHODS: MelanoDerm™ tissues were topically treated with the eVCS, and a eVCS and RSB blend for 14 days, and then a melanin assay was performed...
October 2023: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/37893398/compound-control-of-trajectory-errors-in-a-non-resonant-piezo-actuated-elliptical-vibration-cutting-device
#27
JOURNAL ARTICLE
Chen Zhang, Zeliang Shu, Yanjie Yuan, Xiaoming Gan, Fuhang Yu
To improve the machining quality of the non-resonant elliptical vibration cutting (EVC) device, a compound control method for trajectory error compensation is proposed in this paper. Firstly, by analyzing the working principle of non-resonant EVC device and considering the elliptical trajectory error caused by piezoelectric hysteresis, a dynamic PI (Prandtl-Ishlinskii) model relating to voltage change rate and acceleration was established to describe the piezoelectric hysteresis characteristics of EVC devices...
October 21, 2023: Micromachines
https://read.qxmd.com/read/37878223/architecture-and-topologies-of-gene-regulatory-networks-associated-with-breast-cancer-adjacent-normal-and-normal-tissues
#28
JOURNAL ARTICLE
Swapnil Kumar, Vaibhav Vindal
Most cancer studies employ adjacent normal tissues to tumors (ANTs) as controls, which are not completely normal and represent a pre-cancerous state. However, the regulatory landscape of ANTs compared to tumor and non-tumor-bearing normal tissues is largely unexplored. Among cancers, breast cancer is the most commonly diagnosed cancer and a leading cause of death in women worldwide, with a lack of sufficient treatment regimens for various reasons. Hence, we aimed to gain deeper insights into normal, pre-cancerous, and cancerous regulatory systems of breast tissues towards identifying ANT and subtype-specific candidate genes...
October 25, 2023: Functional & Integrative Genomics
https://read.qxmd.com/read/37871963/rapid-processing-of-observed-touch-through-social-perceptual-brain-regions-an-eeg-fmri-fusion-study
#29
JOURNAL ARTICLE
Haemy Lee Masson, Leyla Isik
Seeing social touch triggers a strong social-affective response that involves multiple brain networks, including visual, social perceptual, and somatosensory systems. Previous studies have identified the specific functional role of each system, but little is known about the speed and directionality of the information flow. Is this information extracted via the social perceptual system or from simulation from somatosensory cortex? To address this, we examined the spatiotemporal neural processing of observed touch...
October 23, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37859012/cutting-depth-oriented-ductile-machining-of-infrared-micro-lens-arrays-by-elliptical-vibration-cutting
#30
JOURNAL ARTICLE
Zhengding Zheng, Kai Huang, Chuangting Lin, Weiqi Huang, Jianguo Zhang, Xiao Chen, Junfeng Xiao, Jianfeng Xu
Infrared micro-lens arrays (MLAs) are widely used in advanced optical systems due to their advantages such as low focusing depth and high sensitivity. Elliptical vibration cutting (EVC) is a promising approach for the fabrication of MLAs on infrared brittle materials. However, the mechanism of ductile machining of MLAs prepared by EVC has not been fully elucidated so far. In this paper, based on the vibration intermittent cutting characteristics and the transient material removal state, a ductile machining model of MLAs on brittle material by EVC was established...
September 25, 2023: Optics Express
https://read.qxmd.com/read/37852113/embryo-maternal-communication-mediated-by-extracellular-vesicles-in-the-early-stages-of-embryonic-development-is-modified-by-in-vitro-conditions
#31
JOURNAL ARTICLE
C Aguilera, Y S Wong, M A Gutierrez-Reinoso, A E Velásquez, B Melo-Báez, J Cabezas, D Caamaño, F Navarrete, F O Castro, L L Rodriguez-Alvarez
Extracellular vesicles (EVs) have become important in embryo-maternal communication during early development. The aim of this study was to evaluate the effect of an in vitro system on early bidirectional embryo-maternal communication mediated by EVs. For this purpose, two experiments were performed: one to evaluate the effect of embryonic EVs on maternal cells and the second to determine the effect of maternal EVs on early embryonic development. For the first in vitro (IVP) and in vivo (IVV) experiments, bovine blastocysts were selected and individually cultured for 48 h to collect embryonic EVs secreted during days 7-9 of embryonic development...
October 12, 2023: Theriogenology
https://read.qxmd.com/read/37804988/how-electric-vehicles-benefit-urban-air-quality-improvement-a-study-in-wuhan
#32
JOURNAL ARTICLE
Dong Xie, Zhonghua Gou, Xuechen Gui
Urban air quality is a global concern, and while numerous studies have examined the impact of geography, climate, and urban development on air quality, few have considered the role of electric vehicles (EVs) in predictive models. Furthermore, little attention has been paid to the spatial heterogeneity of EVs. Given the rapid growth of the EV industry, it is crucial to understand the increasing significance of EVs and electric vehicle charging stations (EVCS) on air quality. This study focuses on Wuhan, a representative polycentric city, to investigate the combined effects of EVs and EVCS on air quality, alongside other urban factors...
October 5, 2023: Science of the Total Environment
https://read.qxmd.com/read/37783506/decoding-reach-direction-in-early-visual-cortex-of-congenitally-blind-individuals
#33
JOURNAL ARTICLE
Łukasz Bola, Petra Vetter, Mohr Wenger, Amir Amedi
Motor actions, such as reaching or grasping, can be decoded from fMRI activity of early visual cortex in sighted humans. This effect can depend on vision or visual imagery, or alternatively, could be driven by mechanisms independent of visual experience. Here, we show that the actions of reaching in different directions can be reliably decoded from fMRI activity of early visual cortex in congenitally blind humans (both sexes). Thus, neither visual experience nor visual imagery is necessary for early visual cortex to represent action-related information...
October 2, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37741281/parietal-driven-visual-working-memory-representation-in-occipito-temporal-cortex
#34
JOURNAL ARTICLE
Yaoda Xu
Human fMRI studies have documented extensively that the content of visual working memory (VWM) can be reliably decoded from fMRI voxel response patterns during the delay period in both the occipito-temporal cortex (OTC), including early visual areas (EVC), and the posterior parietal cortex (PPC).1 , 2 , 3 , 4 Further work has revealed that VWM signal in OTC is largely sustained by feedback from associative areas such as prefrontal cortex (PFC) and PPC.4 , 5 , 6 , 7 , 8 , 9 It is unclear, however, if feedback during VWM simply restores sensory representations initially formed in OTC or if it can reshape the representational content of OTC during VWM delay...
September 15, 2023: Current Biology: CB
https://read.qxmd.com/read/37734486/a-genome-wide-association-scan-reveals-novel-loci-for-facial-traits-of-koreans
#35
JOURNAL ARTICLE
Hye-Won Cho, Hyo-Jeong Ban, Hyun-Seok Jin, Seongwon Cha, Yong-Bin Eom
DNA-based prediction of externally visible characteristics (EVC) with SNPs is one of the research areas of interest in the forensic field. Based on a previous study performing GWAS on facial traits in a Korean population, herein, we present results stemming from GWA analysis with KoreanChip and novel genetic loci satisfying genome-wide significant level. We discovered a total of 20 signals and 12 loci were found to have novel associations with facial traits, including six loci located in intergenic regions and six loci located at UBE2O, HECTD2, CCDC108, TPK1, FCN2, and FRMPD1...
September 19, 2023: Genomics
https://read.qxmd.com/read/37684519/variants-in-efcab7-underlie-nonsyndromic-postaxial-polydactyly
#36
JOURNAL ARTICLE
Muhammad Bilal, Hammal Khan, Muhammad Javed Khan, Tobias B Haack, Rebecca Buchert, Khurram Liaqat, Kifayat Ullah, Sohail Ahmed, Thashi Bharadwaj, Anushree Acharya, Susana Peralta, Najumuddin, Hamid Ali, Muhammad Sharif Hasni, Isabelle Schrauwen, Asmat Ullah, Wasim Ahmad, Suzanne M Leal
Polydactyly is the most common limb malformation that occurs in 1.6-10.6 per one thousand live births, with incidence varying with ancestry. The underlying gene has been identified for many of the ~100 syndromes that include polydactyly. While for the more common form, nonsydromic polydactyly, eleven candidate genes have been reported. We investigated the underlying genetic cause of autosomal recessive nonsyndromic postaxial polydactyly in four consanguineous Pakistani families. Some family members with postaxial polydactyly also present with syndactyly, camptodactyly, or clinodactyly...
November 2023: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/37633159/a-pilot-study-to-investigate-the-efficacy-and-tolerability-of-lesion-network-guided-transcranial-electrical-stimulation-in-outpatients-with-psychosis-spectrum-illness
#37
JOURNAL ARTICLE
Nicolas Raymond, Robert M G Reinhart, Rebekah Trotti, David Parker, Shrey Grover, Bilge Turkozer, Dean Sabatinelli, Rachal Hegde, Deepthi Bannai, Dung Hoang, Swetha Gandu, Brett Clementz, Matcheri Keshavan, Paulo Lizano
BACKGROUND: Transcranial electrical stimulation (tES) may improve psychosis symptoms, but few investigations have targeted brain regions causally linked to psychosis symptoms. We implemented a novel montage targeting the extrastriate visual cortex (eVC) previously identified by lesion network mapping in the manifestation of visual hallucinations. OBJECTIVE: To determine if lesion network guided High Definition-tES (HD-tES) to the eVC is safe and efficacious in reducing symptoms related to psychosis...
August 22, 2023: Asian Journal of Psychiatry
https://read.qxmd.com/read/37576597/evc-evc2-complex-stability-and-ciliary-targeting-are-regulated-by-modification-with-ubiquitin-and-sumo
#38
JOURNAL ARTICLE
Pablo Barbeito, Raquel Martin-Morales, Adrian Palencia-Campos, Juan Cerrolaza, Celia Rivas-Santos, Leticia Gallego-Colastra, Jose Antonio Caparros-Martin, Carolina Martin-Bravo, Ana Martin-Hurtado, Laura Sánchez-Bellver, Gemma Marfany, Victor L Ruiz-Perez, Francesc R Garcia-Gonzalo
Ellis van Creveld syndrome and Weyers acrofacial dysostosis are two rare genetic diseases affecting skeletal development. They are both ciliopathies, as they are due to malfunction of primary cilia, microtubule-based plasma membrane protrusions that function as cellular antennae and are required for Hedgehog signaling, a key pathway during skeletal morphogenesis. These ciliopathies are caused by mutations affecting the EVC-EVC2 complex, a transmembrane protein heterodimer that regulates Hedgehog signaling from inside primary cilia...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37571500/cybersecurity-risk-analysis-of-electric-vehicles-charging-stations
#39
REVIEW
Safa Hamdare, Omprakash Kaiwartya, Mohammad Aljaidi, Manish Jugran, Yue Cao, Sushil Kumar, Mufti Mahmud, David Brown, Jaime Lloret
The increasing availability of Electric Vehicles (EVs) is driving a shift away from traditional gasoline-powered vehicles. Subsequently, the demand for Electric Vehicle Charging Systems (EVCS) is rising, leading to the significant growth of EVCS as public and private charging infrastructure. The cybersecurity-related risks in EVCS have significantly increased due to the growing network of EVCS. In this context, this paper presents a cybersecurity risk analysis of the network of EVCS. Firstly, the recent advancements in the EVCS network, recent EV adaptation trends, and charging use cases are described as a background of the research area...
July 27, 2023: Sensors
https://read.qxmd.com/read/37485807/prenatal-whole-exome-sequencing-identified-two-rare-compound-heterozygous-variants-in-evc2-causing-ellis-van-creveld-syndrome
#40
JOURNAL ARTICLE
Jianlong Zhuang, Shufen Liu, Junyu Wang, Yu'e Chen, Hegan Zhang, Yuying Jiang, Gaoxiong Wang, Chunnuan Chen
BACKGROUND: Pathogenic mutations in EVC or EVC2 gene can lead to Ellis-van Creveld (EvC) syndrome, which is a rare autosomal recessive skeletal dysplasia disorder. This study aimed to determine pathogenic gene variations associated with EvC syndrome in fetuses showing ultrasound anomalies. METHODS: A 32-year-old pregnant woman from Quanzhou, China was investigated. In her pregnancy examination, the fetus exhibited multiple fetal malformations, including a narrow thorax, short limbs, postaxial polydactyly, cardiac malformations, and separation of double renal pelvis...
July 23, 2023: Molecular Genetics & Genomic Medicine
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