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https://www.readbyqxmd.com/read/28322774/development-and-reliability-of-the-new-endoscopic-virtual-chromoendoscopy-score-the-picasso-score-paddington-international-virtual-chromoendoscopy-score-in-ulcerative-colitis
#1
Marietta Iacucci, Marco Daperno, Mark Lazarev, Razvan Arsenascu, Gian Eugenio Tontini, Oluseyi Akinola, Xianyong Sean Gui, Vincenzo Villanacci, Martin Goetz, Mark Lowerison, Brendan Cord Lethebe, Maurizio Vecchi, Helmut Neumann, Subrata Ghosh, Raf Bisschops, Ralf Kiesslich
INTRODUCTION: Endoscopic inflammation and healing are important therapeutic endpoints in ulcerative colitis (UC). We developed and validated a new electronic virtual chromoendoscopy (EVC) score that could reflect the full spectrum of mucosal and vascular changes including mucosal healing in UC. METHODS: Eight participants reviewed a 60-minute training module outlining the three different i-SCAN modes demonstrating the entire spectrum of inflammatory mucosal and vascular changes in UC...
March 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28314239/likelihood-ratio-and-posterior-odds-in-forensic-genetics-two-sides-of-the-same-coin
#2
Amke Caliebe, Susan Walsh, Fan Liu, Manfred Kayser, Michael Krawczak
It has become widely accepted in forensics that, owing to a lack of sensible priors, the evidential value of matching DNA profiles in trace donor identification or kinship analysis is most sensibly communicated in the form of a likelihood ratio (LR). This restraint does not abate the fact that the posterior odds (PO) would be the preferred basis for returning a verdict. A completely different situation holds for Forensic DNA Phenotyping (FDP), which is aimed at predicting externally visible characteristics (EVCs) of a trace donor from DNA left behind at the crime scene...
March 6, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28130474/design-and-validation-of-the-gi-nec-score-to-prognosticate-overall-survival-in-patients-with-high-grade-gastrointestinal-neuroendocrine-carcinomas
#3
Angela Lamarca, Thomas Walter, Marianne Pavel, Ivan Borbath, Patricia Freis, Barbara Nuñez, Alexa Childs, Mairéad G McNamara, Richard A Hubner, Rocio Garcia-Carbonero, Tim Meyer, Juan W Valle, Jorge Barriuso
BACKGROUND: Prognostic markers for risk stratification of patients with gastrointestinal high-grade neuroendocrine carcinomas (GI-NECs) are lacking; we designed and validated a prognostic score for overall survival (OS). METHODS: Consecutive patients diagnosed in five neuroendocrine specialist European centers were included. Patients were divided into three cohorts: a training cohort (TC), an external validation cohort (EVC), and a prospective validation cohort (PVC)...
January 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28081373/loss-of-function-of-evc2-in-dental-mesenchyme-leads-to-hypomorphic-enamel
#4
H Zhang, H Takeda, T Tsuji, N Kamiya, T Kunieda, Y Mochida, Y Mishina
Ellis-van Creveld (EvC) syndrome is an autosomal-recessive skeletal dysplasia, characterized by short stature and postaxial polydactyly. A series of dental abnormalities, including hypomorphic enamel formation, has been reported in patients with EvC. Despite previous studies that attempted to uncover the mechanism leading to abnormal tooth development, little is known regarding how hypomorphic enamel is formed in patients with EvC. In the current study, using Evc2/ Limbin mutant mice we recently generated, we analyzed enamel formation in the mouse incisor...
April 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28027321/elevated-fibroblast-growth-factor-signaling-is-critical-for-the-pathogenesis-of-the-dwarfism-in-evc2-limbin-mutant-mice
#5
Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Haruko Takeda, Greg Scott, Sudha Rajderkar, Manas K Ray, Yoshiyuki Mochida, Benjamin Allen, Veronique Lefebvre, Irene H Hung, David M Ornitz, Tetsuo Kunieda, Yuji Mishina
Ellis-van Creveld (EvC) syndrome is a skeletal dysplasia, characterized by short limbs, postaxial polydactyly, and dental abnormalities. EvC syndrome is also categorized as a ciliopathy because of ciliary localization of proteins encoded by the two causative genes, EVC and EVC2 (aka LIMBIN). While recent studies demonstrated important roles for EVC/EVC2 in Hedgehog signaling, there is still little known about the pathophysiological mechanisms underlying the skeletal dysplasia features of EvC patients, and in particular why limb development is affected, but not other aspects of organogenesis that also require Hedgehog signaling...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27995319/prediction-of-biogeographical-ancestry-from-genotype-a-comparison-of-classifiers
#6
Elaine Y Y Cheung, Michelle Elizabeth Gahan, Dennis McNevin
DNA can provide forensic intelligence regarding a donor's biogeographical ancestry (BGA) and other externally visible characteristics (EVCs). A number of algorithms have been proposed to assign individual human genotypes to a BGA using ancestry informative marker (AIM) panels. This study compares the BGA assignment accuracy of the population clustering program STRUCTURE and three generic classification approaches including a Bayesian algorithm, genetic distance, and multinomial logistic regression (MLR). A selection of 142 ancestry informative single nucleotide polymorphisms (SNPs) were chosen from existing marker panels (SNPforID 34-plex, Eurasiaplex, Seldin, and Kidd's AIM panels) to assess BGA classification at the continental level for Africans, Europeans, East Asians, and Amerindians...
December 20, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27886158/recanalization-and-rupture-after-intracranial-aneurysm-treatment
#7
Emmanuel Costa, Geraldo R Vaz, Patrice Finet, Pierre Goffette, Marie A Docquier, Christian Raftopoulos
BACKGROUND: Treatment of intra cranial aneurysm (ICA) can sometimes required several procedures. The aim of this study is to analyze the risk of recanalization and rupture recurrence after ICA treatment by endovascular coiling (EVC) or surgical clipping (SC) on a very long follow-up. METHODS: Clinical data of 373 consecutive patients treated in our group between January 1996 and December 2006 as well by EVC as by SC for ruptured (RIA) or unruptured intracranial aneurysm (UIA), were reviewed...
November 25, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27751531/the-anatomy-of-non-conscious-recognition-memory
#8
Clive R Rosenthal, David Soto
Cortical regions as early as primary visual cortex have been implicated in recognition memory. Here, we outline the challenges that this presents for neurobiological accounts of recognition memory. We conclude that understanding the role of early visual cortex (EVC) in this process will require the use of protocols that mask stimuli from visual awareness.
October 14, 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27717584/parkinson-s-disease-snca-park2-and-lrrk2-targeting-micrornas-elevated-in-cingulate-gyrus
#9
Roman Tatura, Theo Kraus, Armin Giese, Thomas Arzberger, Malte Buchholz, Günter Höglinger, Ulrich Müller
INTRODUCTION: In order to better understand the role of epigenetic influences in the etiology of Parkinson's disease (PD), we studied the expression of microRNAs in gyri cinguli of patients and controls. METHODS: Expression profiling of 744 well-characterized microRNAs in gyri cinguli from patients and controls using TaqMan array microRNA cards. Verification of significantly dysregulated microRNAs by SYBR Green qRT-PCR. RESULTS: First screen by TaqMan array identified 43 microRNAs that were upregulated in gyri cinguli from patients...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27669989/dorsal-anterior-cingulate-cortex-and-the-value-of-control
#10
Amitai Shenhav, Jonathan D Cohen, Matthew M Botvinick
Debates over the function(s) of dorsal anterior cingulate cortex (dACC) have persisted for decades. So too have demonstrations of the region's association with cognitive control. Researchers have struggled to account for this association and, simultaneously, dACC's involvement in phenomena related to evaluation and motivation. We describe a recent integrative theory that achieves this goal. It proposes that dACC serves to specify the currently optimal allocation of control by determining the overall expected value of control (EVC), thereby licensing the associated cognitive effort...
September 27, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27630393/effects-of-lumbopelvic-sling-and-abdominal-drawing-in-exercises-on-lung-capacity-in-healthy-adults
#11
Myoung-Kwon Kim, Hyun-Gyu Cha, Young-Jun Shin
[Purpose] To examine the effects of lumbopelvic sling and abdominal drawing-in exercises on the lung capacities of healthy subjects. [Subjects and Methods] Twenty-nine healthy subjects with no orthopedic history of the back were recruited. Subjects were randomly assigned to a experimental group and control group. Subjects were allocated to one of two groups; an experimental group that underwent lumbopelvic sling and abdominal drawing-in exercises and a control group that underwent treadmill and abdominal drawing-in exercises...
August 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27623824/efficiency-of-lung-ventilation-for-people-performing-wind-instruments
#12
Anna Brzęk, Anna Famuła, Anna Kowalczyk, Ryszard Plinta
BACKGROUND: Wind instruments musicians are particularly prone to excessive respiratory efforts. Prolonged wind instruments performing may lead to changes in respiratory tracts and thus to respiratory muscles overload. It may result in decreasing lung tissue pliability and, as a consequence, in emphysema. Aim of the research has been to describe basic spirometric parameters for wind players and causes of potential changes. MATERIAL AND METHODS: Slow and forced spirometry with the use of Micro Lab Viasys (Micro Medical, Great Britain) was conducted on 31 wind musicians (group A)...
2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27605155/massively-parallel-sequencing-of-customised-forensically-informative-snp-panels-on-the-miseq
#13
Bhavik Mehta, Runa Daniel, Chris Phillips, Stephen Doyle, Gareth Elvidge, Dennis McNevin
Forensic DNA based intelligence, or Forensic DNA Phenotyping (FDP), utilises single nucleotide polymorphisms (SNPs) to infer the biogeographical ancestry (BGA) and externally visible characteristics (EVCs) of the donor of evidential material. SNaPshot(®) is a commonly employed forensic SNP genotyping technique which is limited to multiplexes of 30-40 SNPs in a single reaction and prone to PCR contamination. Massively parallel sequencing (MPS) has the ability to genotype hundreds of SNPs in multiple samples simultaneously by employing an oligonucleotide sample barcoding strategy...
September 8, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27518177/trauma-exposure-and-ptsd-symptoms-associate-with-violence-in-inner-city-civilians
#14
Cynthia Gillikin, Leah Habib, Mark Evces, Bekh Bradley, Kerry J Ressler, Jeff Sanders
Understanding whether a history of psychological trauma is associated with perpetrating aggressive and violent behavior is of critical importance to public health. This relationship is especially important to study within urban areas where violence is prevalent. In this paper we examined whether a history of trauma or Post Traumatic Stress Disorder (PTSD) in inner city civilians was associated with violent behavior. Data were collected from over 1900 primary care patients at Grady Memorial Hospital in Atlanta, Georgia...
December 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27390425/effects-of-stretching-the-scalene-muscles-on-slow-vital-capacity
#15
Juncheol Lee, Sehee Hwang, Seungim Han, Dongwook Han
[Purpose] The purpose of this study was to examine whether stretching of the scalene muscles would improve slow vital capacity (SVC). [Subjects and Methods] The subjects of this study were 20 healthy female students to whom the study's methods and purpose were explained and their agreement for participation was obtained. The SVC was measured using spirometry (Pony FX, COSMED Inc., Italy). The intervention used was stretching of the scalene muscles. Stretching was carried out for 15 min, 10 times at per each portion of scalene muscles: the anterior, middle, and posterior parts...
June 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27325544/oral-and-craniofacial-manifestations-of-ellis-van-creveld-syndrome-case-series
#16
Elif Bahar Tuna, Mine Koruyucu, Esma Kürklü, Muhsin Çifter, Koray Gençay, Figen Seymen, Beyhan Tüysüz
PURPOSE: The objective of this case series was to determine the oral, dental and craniofacial features of patients with EvC syndrome. MATERIAL AND METHODS: Eight patients with EvC syndrome were enrolled. A complete family history, pedigree analysis, detailed medical history were collected. Findings of clinical examination, including craniofacial and orodental manifestations, and radiological investigations were thoroughly studied. RESULTS: All eight patients had characteristic face, hypertrophic frenulum, conical and peg-shaped teeth, hypodontia of deciduous and/or permanent teeth and also skeletal dysplasia, small chest, short stature and hypoplastic nails...
August 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27242455/functional-mri-representational-similarity-analysis-reveals-a-dissociation-between-discriminative-and-relative-location-information-in-the-human-visual-system
#17
Zvi N Roth
Neural responses in visual cortex are governed by a topographic mapping from retinal locations to cortical responses. Moreover, at the voxel population level early visual cortex (EVC) activity enables accurate decoding of stimuli locations. However, in many cases information enabling one to discriminate between locations (i.e., discriminative information) may be less relevant than information regarding the relative location of two objects (i.e., relative information). For example, when planning to grab a cup, determining whether the cup is located at the same retinal location as the hand is hardly relevant, whereas the location of the cup relative to the hand is crucial for performing the action...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27222382/connectivity-reveals-sources-of-predictive-coding-signals-in-early-visual-cortex-during-processing-of-visual-optic-flow
#18
Andreas Schindler, Andreas Bartels
Superimposed on the visual feed-forward pathway, feedback connections convey higher level information to cortical areas lower in the hierarchy. A prominent framework for these connections is the theory of predictive coding where high-level areas send stimulus interpretations to lower level areas that compare them with sensory input. Along these lines, a growing body of neuroimaging studies shows that predictable stimuli lead to reduced blood oxygen level-dependent (BOLD) responses compared with matched nonpredictable counterparts, especially in early visual cortex (EVC) including areas V1-V3...
May 24, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27199711/more-than-meets-the-eye-the-merging-of-perceptual-and-conceptual-knowledge-in-the-anterior-temporal-face-area
#19
Jessica A Collins, Jessica E Koski, Ingrid R Olson
An emerging body of research has supported the existence of a small face sensitive region in the ventral anterior temporal lobe (ATL), referred to here as the "anterior temporal face area". The contribution of this region in the greater face-processing network remains poorly understood. The goal of the present study was to test the relative sensitivity of this region to perceptual as well as conceptual information about people and objects. We contrasted the sensitivity of this region to that of two highly-studied face-sensitive regions, the fusiform face area (FFA) and the occipital face area (OFA), as well as a control region in early visual cortex (EVC)...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27197107/-evolution-of-the-type-2-diabetes-mellitus-epidemia-in-insured-population-at-the-imss
#20
María Eugenia Velasco-Contreras
BACKGROUND: The global increase in type 2 diabetes mellitus (T2DM) is requiering higher demands in health institutions; It is a global emergency because of overspending that threaten social security, and kidney complications and cardiovascular damage, which affects millions enfermos.1 The aim of this work is to characterize the epidemic of T2DM with metabolic syndrome and define the institutional response containment-control universal educational interventions healthy lifestyles to prevent premature death and disability from ischemic heart disease (IHD), cerebrovascular disease (CVD), end stage renal disease ( IRT), blindness and amputations...
July 2016: Revista Médica del Instituto Mexicano del Seguro Social
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