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Diagrams and Visualization

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https://www.readbyqxmd.com/read/28412452/enhancement-of-dissolution-rate-through-eutectic-mixture-and-solid-solution-of-posaconazole-and-benznidazole
#1
Camila Bezerra Melo Figueirêdo, Daniela Nadvorny, Amanda Carla Quintas de Medeiros Vieira, José Lamartine Soares Sobrinho, Pedro José Rolim Neto, Ping I Lee, Monica Felts de La Roca Soares
Benznidazole (BNZ), the only commercialized antichagasic drug, and the antifungal compound posaconazole (PCZ) have shown synergistic action in the therapy of Chagas disease, however both active pharmaceutical ingredients (APIs) exhibit low aqueous solubility potentially limiting their bioavailability and therapeutic efficacy. In this paper, we report for the first time the formation of a eutectic mixture as well as an amorphous solid solution of PCZ and BNZ (at the same characteristic ratio of 80:20wt%), which provided enhanced solubility and dissolution rate for both APIs...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28401430/bilateral-effects-of-excipients-on-protein-stability-preferential-interaction-type-of-excipient-and-surface-aromatic-hydrophobicity-of-protein
#2
Lili Wen, Xianxian Zheng, Xinyue Wang, Hairong Lan, Zongning Yin
PURPOSE: Understanding the mechanism of protein-excipient interaction and illuminating the influencing factors on protein stability are key steps in the rational design of protein formulations. The objective of this study was to assess effects of preferential interaction type of excipient and surface aromatic hydrophobicity of protein on protein solution stability. METHODS: The preferential interaction between excipient and aromatic hydrophobic area of protein was investigated by solubility and fluorescence studies of amino acid derivatives in excipient solutions...
April 11, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28381292/reproducibility-and-repeatability-of-same-day-two-sequential-fdg-pet-mr-and-pet-ct
#3
David Groshar, Hanna Bernstine, Natalia Goldberg, Meital Nidam, Dan Stein, Ifat Abadi-Korek, Liran Domachevsky
BACKGROUND: To determine PET/CT and PET/MR reproducibility and PET/MR repeatability of fluorine 18 fluorodeoxyglucose (FDG) uptake measurements in tumors in cancer patients. METHODS: This IRB approved prospective study was performed between October 2015 and February 2016 in consecutive patients who performed same day PET/CT and two sequential PET/MR. Thirty three patients with visible tumors (N = 63) were included. SUV for body weight (SUV) and lean body mass (SUL) were obtained...
April 5, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28334343/pathwaymapper-a-collaborative-visual-web-editor-for-cancer-pathways-and-genomic-data
#4
Istemi Bahceci, Ugur Dogrusoz, Konnor C La, Özgün Babur, Jianjiong Gao, Nikolaus Schultz
Motivation: While existing network visualization tools enable the exploration of cancer genomics data, most biologists prefer simplified, curated pathway diagrams, such as those featured in many manuscripts from The Cancer Genome Atlas (TCGA). These pathway diagrams typically summarize how a pathway is altered in individual cancer types, including alteration frequencies for each gene. Results: To address this need, we developed the web-based tool PathwayMapper, which runs in most common web browsers...
March 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334310/different-from-trees-more-than-metaphors-branching-silhouettes-corals-cacti-and-the-oaks
#5
János Podani
There has long been ambiguity in the use of the term tree in phylogenetic systematics, which is a continuous source of misinterpretation of evolutionary relationships. The basic problem is that while many trees with phylogenetic or evolutionary relevance, such as cladograms, are consistent with graph theory, tree-like visualization of phylogeny may also be done via other types of graphics, especially botanical (or literal) tree drawings. As a consequence, the meaning of such diagrams is not always clear: a given picture may have multiple interpretations in its different parts and two figures that look similar may actually carry quite different information...
March 11, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28334105/biojava-modfinder-identification-of-protein-modifications-in-3d-structures-from-the-protein-data-bank
#6
Jianjiong Gao, Andreas Prlic, Chunxiao Bi, Wolfgang F Bluhm, Dimitris Dimitropoulos, Dong Xu, Philip E Bourne, Peter W Rose
Summary: We developed a new software tool, BioJava-ModFinder, for identifying protein modifications observed in 3D structures archived in the Protein Data Bank (PDB). Information on more than 400 types of protein modifications were collected and curated from annotations in PDB, RESID, and PSI-MOD. We divided these modifications into three categories: modified residues, attachment modifications, and cross-links. We have developed a systematic method to identify these modifications in 3D protein structures...
February 17, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28287524/a-web-tool-for-generating-high-quality-machine-readable-biological-pathways
#7
Miguel Ramirez-Gaona, Ana Marcu, Allison Pon, Jason Grant, Anthony Wu, David S Wishart
PathWhiz is a web server built to facilitate the creation of colorful, interactive, visually pleasing pathway diagrams that are rich in biological information. The pathways generated by this online application are machine-readable and fully compatible with essentially all web-browsers and computer operating systems. It uses a specially developed, web-enabled pathway drawing interface that permits the selection and placement of different combinations of pre-drawn biological or biochemical entities to depict reactions, interactions, transport processes and binding events...
February 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28260771/presentation-pattern-of-histology-and-illustrations-in-the-histology-text-books-commonly-used-by-the-medical-undergraduates-of-bangladesh
#8
N F Amin, K M Shamim
The teaching-learning and assessment of cell and histology have gone through remarkable changes in recent times. Histology text books recommended by renowned medical institutions should be good reflectors of these changes and the present trends. Cell and histology is categorically visual in nature. So, their presentation in text books is likely to show rational and meaningful use of illustrations. From July 2007 to June 2008, this descriptive observational study was done to analyze the presentation pattern of illustrations in two histology text books commonly recommended for the medical undergraduates of Bangladesh through: a) estimating the relative weights given to (i...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28253403/visualization-of-dietary-patterns-and-their-associations-with-age-related-macular-degeneration
#9
Chung-Jung Chiu, Min-Lee Chang, Tricia Li, Gary Gensler, Allen Taylor
Purpose: We aimed to visualize the relationship of predominant dietary patterns and their associations with AMD. Methods: A total of 8103 eyes from 4088 participants in the baseline Age-Related Eye Disease Study (AREDS) were classified into three groups: control (n = 2739), early AMD (n = 4599), and advanced AMD (n = 765). Using principle component analysis, two major dietary patterns and eight minor dietary patterns were characterized. Applying logistic regression in our analysis, we related dietary patterns to the prevalence of AMD...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28250343/evaluating-the-properties-of-poly-lactic-co-glycolic-acid-nanoparticle-formulations-encapsulating-a-hydrophobic-drug-by-using-the-quality-by-design-approach
#10
Masato Kozaki, Shin-Ichiro Kobayashi, Yukihiro Goda, Haruhiro Okuda, Kumiko Sakai-Kato
We applied the Quality by Design (QbD) approach to the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticle formulations encapsulating triamcinolone acetonide, and the critical process parameters (CPPs) were identified to clarify the correlations between critical quality attributes and CPPs. Quality risk management was performed by using an Ishikawa diagram and experiments with a fractional factorial design (ANOVA). The CPPs for particle size were PLGA concentration and rotation speed, and the CPP for relative drug loading efficiency was the poor solvent to good solvent volume ratio...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28196576/care-coordination-from-a-strengths-perspective-a-practice-based-evidence-evaluation-of-evidence-based-practice
#11
Karen A Monsen, Catherine E Vanderboom, Kirstie S Olson, Mary E Larson, Diane E Holland
BACKGROUND AND PURPOSE: It is critical to accurately represent strengths interventions to improve data and enable intervention effectiveness research from a strengths perspective. However, it is challenging to understand strengths interventions from the multiple perspectives of computerized knowledge representation, evidence-based practice guidelines, and practice-based evidence narratives. Intervention phrases abstracted from nurse care coordinator practice narratives described strengths interventions with community-dwelling elders...
February 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28186915/a-novel-variable-precision-reduction-approach-to-comprehensive-knowledge-systems
#12
Chao Yang, Hongbo Liu, Sean McLoone, C L Philip Chen, Xindong Wu
A comprehensive knowledge system reveals the intangible insights hidden in an information system by integrating information from multiple data sources in a synthetical manner. In this paper, we present a variable precision reduction theory, underpinned by two new concepts: 1) distribution tables and 2) genealogical binary trees. Sufficient and necessary conditions to extract comprehensive knowledge from a given information system are also presented and proven. A complete variable precision reduction algorithm is proposed, in which we introduce four important strategies, namely, distribution table abstracting, attribute rank dynamic updating, hierarchical binary classifying, and genealogical tree pruning...
February 8, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28173698/a-visual-language-for-protein-design
#13
Robert Sidney Cox, James Alastair McLaughlin, Raik Grünberg, Jacob Beal, Anil Wipat, Herbert M Sauro
As protein engineering becomes more sophisticated, practitioners increasingly need to share diagrams for communicating protein designs. To this end, we present a draft visual language, Protein Language, that describes the high-level architecture of an engineered protein with easy-to-draw glyphs, intended to be compatible with other biological diagram languages such as SBOL Visual and SBGN. Protein Language consists of glyphs for representing important features (e.g., globular domains, recognition and localization sequences, sites of covalent modification, cleavage and catalysis), rules for composing these glyphs to represent complex architectures, and rules constraining the scaling and styling of diagrams...
March 7, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28161336/dynamic-visualisation-of-municipal-waste-management-performance-in-the-eu-using-ternary-diagram-method
#14
R Pomberger, R Sarc, K E Lorber
This contribution describes the dynamic visualisation of European (EU 28) municipal waste management performance, using the Ternary Diagram Method. Municipal waste management performance depends primarily on three treatment categories: recycling & composting, incineration and landfilling. The framework of current municipal waste management including recycling targets, etc. is given by the Waste Framework Directive - 2008/98/EC. The proposed Circular Economy Package should stimulate Europe's transition towards more sustainable resources and energy oriented waste management...
February 1, 2017: Waste Management
https://www.readbyqxmd.com/read/28152841/evaluating-data-driven-breast-surgery-treatment-path-visualizations-from-registry-and-administrative-data
#15
Alexander S Taylor, Mia Alyce Levy
195 Background: Breast cancer patients face difficult decisions about their surgical care without a full understanding of their options. The learning health system goal is to use information from the care of prior patients to inform the care of future patients. We aim to apply this concept to generate data-driven surgical paths, develop interactive path visualizations to inform patients, and evaluate their impact. METHODS: We used cancer registry and administrative CPT codes for women diagnosed with stage 0-III breast cancer between FY2010-14 at a comprehensive cancer center...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28130697/blobel-and-sabatini-s-beautiful-idea-visual-representations-of-the-conception-and-refinement-of-the-signal-hypothesis
#16
Michelle Lynne LaBonte
In 1971, Günter Blobel and David Sabatini proposed a novel and quite speculative schematic model to describe how proteins might reach the proper cellular location. According to their proposal, proteins destined to be secreted from the cell contain a "signal" to direct their release. Despite the fact that Blobel and Sabatini presented their signal hypothesis as a "beautiful idea" not grounded in experimental evidence, they received criticism from other scientists who opposed such speculation. Following the publication of the 1971 model, Blobel persisted in conducting experiments and revising the model to incorporate new data...
January 27, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28113724/brain-modulyzer-interactive-visual-analysis-of-functional-brain-connectivity
#17
Sugeerth Murugesan, Kristofer Bouchard, Jesse A Brown, Bernd Hamann, William W Seeley, Andrew Trujillo, Gunther H Weber
We present Brain Modulyzer, an interactive visual exploration tool for functional magnetic resonance imaging (fMRI) brain scans, aimed at analyzing the correlation between different brain regions when resting or when performing mental tasks. Brain Modulyzer combines multiple coordinated views-such as heat maps, node link diagrams and anatomical views-using brushing and linking to provide an anatomical context for brain connectivity data. Integrating methods from graph theory and analysis, e.g., community detection and derived graph measures, makes it possible to explore the modular and hierarchical organization of functional brain networks...
May 9, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28100267/a-bibliometric-analysis-of-two-decades-of-aromatherapy-research
#18
Malcolm Koo
BACKGROUND: Quantitative data are lacking on the profile of published research in aromatherapy. The objective of the study was to investigate the profile of original and review articles under the topic aromatherapy using bibliometric analysis. METHODS: Articles on aromatherapy, published between 1995 and 2014, were retrieved from the Science Citation Index-Expanded database from the Web of Science. The records extracted were analyzed for citation characteristics, including the distribution of publication years, languages, countries or regions, journals, articles, and authors using HistCite 12...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28088457/preformulation-characterization-stabilization-and-formulation-design-for-the-acrylodan-labeled-glucose-binding-protein-sm4-ac
#19
Neha Sahni, Rajoshi Chaudhuri, John M Hickey, Prakash Manikwar, Ajit D'Souza, Andrew Metters, Sangeeta B Joshi, C Russell Middaugh, David B Volkin
This study describes the physicochemical characterization, stabilization, and formulation design of SM4-AC, an acrylodan-labeled glucose/galactose-binding protein for use in a continuous glucose monitoring device. The physical stability profile of SM4-AC as a function of pH and temperature was monitored using a combination of biophysical techniques and the resulting physical stability profile was visualized using an empirical phase diagram. Forced degradation chemical stability studies (Asn deamidation, Met oxidation) of SM4-AC were performed using a combination of capillary isoelectric focusing, peptide mapping, and reversed-phase HPLC...
January 11, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28078194/trauma-exposed-latina-immigrants-networks-a-social-network-analysis-approach
#20
Alejandra Hurtado-de-Mendoza, Adriana Serrano, Felisa A Gonzales, Nicole C Fernandez, Mark Cabling, Stacey Kaltman
OBJECTIVE: Trauma exposure among Latina immigrants is common. Social support networks can buffer the impact of trauma on mental health. This study characterizes the social networks of trauma-exposed Latina immigrants using a social network analysis perspective. METHODS: In 2011-2012 a convenience sample (n=28) of Latina immigrants with trauma exposure and presumptive depression or posttraumatic stress disorder was recruited from a community clinic in Washington DC...
November 2016: Journal of Latina/o Psychology
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