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https://www.readbyqxmd.com/read/28214921/vitamin-d-administration-during-pregnancy-as-prevention-for-pregnancy-neonatal-and-postnatal-complications
#1
REVIEW
Carol L Wagner, Bruce W Hollis, Kalliopi Kotsa, Hana Fakhoury, Spyridon N Karras
Pregnancy represents a time of rapid bodily change, which includes physical proportions, physiology and responsibility. At this context, maternal vitamin D stores have been the objective of extensive scientific research during the last decades, focusing on their potential effects on maternal an neonatal health. A growing body of observational studies indicated that maternal hypovitaminosis D (as defined by maternal 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml or <50 nmol/l) is a significant risk factor for adverse neonatal outcomes including asthma, multiple sclerosis and other neurological disorders...
February 18, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28213594/brighter-children-the-association-between-seasonality-of-birth-and-child-iq-in-a-population-based-birth-cohort
#2
Nina H Grootendorst-van Mil, Régine P M Steegers-Theunissen, Albert Hofman, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
OBJECTIVE: Season of birth has repeatedly been found to be a risk indicator for adverse neurodevelopmental outcomes. Several explanations for this finding have been put forward but no conclusion has been reached. In the current study, we explored the role of sociodemographic and biological factors in the association between season of birth and child IQ. DESIGN: In a prenatally recruited birth cohort (born in 2002-2006), we examined the association between season of birth and non-verbal IQ at age 6 years among 6034 children...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28206812/is-diabetes-associated-with-lower-vitamin-c-status-in-pregnant-women-a-prospective-study
#3
Bente Juhl, Finn Friis Lauszus, Jens Lykkesfeldt
Few studies have examined how vitamin C status is affected in diabetic pregnancy and no comparison between normal and diabetic pregnancies has been found. This study evaluated vitamin C status prospectively during pregnancy in women with type 1 diabetes mellitus (n=76), in non-diabetic women (n=60), and in their respective neonates. Vitamin C was lower in diabetic women throughout all trimesters compared to controls (p<0.01). Repeated measurements analysis showed significant differences between diabetic and non-diabetic women; also when adjusted for birth weight ratio and age...
February 16, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28202290/effect-of-psychotropic-drug-treatment-on-sterol-metabolism
#4
Željka Korade, Wei Liu, Emily B Warren, Kristan Armstrong, Ned A Porter, Christine Konradi
Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol (7DHC), a molecule that gives rise to oxysterols, vitamin D, and atypical neurosteroids. We examined levels of cholesterol and the cholesterol precursors desmosterol, lanosterol, 7DHC and its isomer 8-dehydrocholesterol (8DHC), in blood samples of 123 psychiatric patients on various antipsychotic and antidepressant drugs, and 85 healthy controls, to see if the observations in cell lines hold true for patients as well...
February 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28188842/vitamin-d-supplementation-during-pregnancy-improvements-in-birth-outcomes-and-complications-through-direct-genomic-alteration
#5
REVIEW
Bruce W Hollis, Carol L Wagner
Pregnancy represents a time of rapid change, including dramatic shifts in vitamin D metabolism. Circulating concentrations of the active form of vitamin D-1,25(OH)2D skyrocket early in pregnancy to levels that would be toxic to a nonpregnant adult, signaling a decoupling of vitamin D from the classic endocrine calcium metabolic pathway, likely serving an immunomodulatory function in the mother and her developing fetus. In this review, we summarize the unique aspects of vitamin D metabolism and the data surrounding vitamin D requirements during this important period...
February 7, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28178022/the-impact-of-essential-fatty-acid-b-vitamins-vitamin-c-magnesium-and-zinc-supplementation-on-stress-levels-in-women-a-systematic-review
#6
Delia McCabe, Karolina Lisy, Craig Lockwood, Marc Colbeck
BACKGROUND: Women juggling multiple roles in our complex society are increasingly experiencing psychological stress. Dietary supplementation to manage stress is widespread despite limited supporting evidence. A systematic review of the available literature was undertaken to investigate the efficacy of specific dietary supplements in managing female stress and anxiety. OBJECTIVES: To identify the impact of essential fatty acids (EFAs), B vitamins, vitamin C, magnesium and/or zinc, consumed as dietary supplements to the daily diet, on female stress and anxiety levels...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28176445/the-screening-emperor-has-no-clothes-on-primary-prevention-will-always-trump-testing-for-preterm-birth
#7
Khalid Khan, Donald Dudley
When a woman planning a pregnancy seeks advice, say regarding neural tube defects, we do not tell her, "we have a great screening test that we will use to see if your baby has risk of a serious defects of the brain, spine, or spinal cord and as soon as we know that the test is positive we will try to do something about it." In fact we say, "her are some vitamin pills called folate that you should start taking right now so that we can reduce the risk of these defects developing in the first place". This is a primary prevention strategy that we know that works well, and we determined this by performing trials of sufficient sample size with the right design to address this question...
February 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28169608/vitamin-d-deficiency-in-pregnant-ukrainian-women-effects-of-alcohol-consumption-on-vitamin-d-status
#8
Charles R Carlson, Janet Y Uriu-Adams, Christina D Chambers, Lyubov Yevtushok, Natalya Zymak-Zakutnya, Priscilla H Chan, Jordan J Schafer, Wladimir Wertelecki, Carl L Keen
OBJECTIVE: Heavy alcohol consumption can alter vitamin D status; however, the relationships between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied. The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180) and low/unexposed control (N = 179) Ukrainian pregnant women. METHODS: Women who attended prenatal care facilities in 2 regions of Ukraine (Rivne and Khmelnytsky) for a routine prenatal visit were screened for the study...
January 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28168179/nutrient-intake-according-to-weight-gain-during-pregnancy-job-status-and-household-income
#9
You-Mi Jung, Mi-Ja Choi
The objective of this study was to investigate the association of nutrient intake and pregnancy outcome mediated by weight gain during pregnancy, job status, and household income. Maternal age, educational level, self-reported pre-pregnancy weights, educational level, and household income were collected from the women at 2 months postpartum. For each offspring, weight at birth, length at birth, and gestational age were collected. Participants were asked to report the frequency of consumption of foods between 28-42 weeks into the pregnancy...
January 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28166924/-lifestyle-recommendations-for-prevention-of-spontaneous-preterm-birth-in-asymptomatic-pregnant-women
#10
E Maisonneuve
OBJECTIVES: To establish recommendations for lifestyle of pregnant women and its impact on spontaneous preterm births. MATERIAL AND METHODS: We searched Pubmed and Cochrane databases and checked reference lists of retrieved studies. This review of the literature concerns only women who have no symptoms for the ongoing pregnancy. RESULTS: Concerning maternal occupation during pregnancy, there is a mild increase of the risk of preterm birth only for women who work more than 40hours a week or who have hard working conditions according to a fatigue score (LE2)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28161177/influence-of-conjugated-linoleic-acid-and-vitamin-e-on-performance-energy-metabolism-and-change-of-fat-depot-mass-in-transitional-dairy-cows
#11
S Schäfers, D von Soosten, U Meyer, C Drong, J Frahm, J Kluess, C Raschka, J Rehage, A Tröscher, W Pelletier, S Dänicke
The objective of this experiment was to determine the effects of conjugated linoleic acid (CLA) and vitamin E as well as their interaction on performance variables and lipomobilization during late pregnancy and early lactation (wk 6 antepartum until wk 10 postpartum). For this purpose, 59 pluriparous German Holstein cows were assigned to 4 dietary groups in a 2 × 2 design with the factors CLA and vitamin E at 2 levels. For this trial, we selected cows with a high body condition score because they are more likely to mobilize fat and consequently are at a higher risk of developing ketosis...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28161065/placental-genetic-variations-in-vitamin-d-metabolism-and-birthweight
#12
Tsegaselassie Workalemahu, Sylvia E Badon, Michal Dishi-Galitzky, Chunfang Qiu, Michelle A Williams, Tanya Sorensen, Daniel A Enquobahrie
INTRODUCTION: Vitamin D has pleiotropic functions that regulate fetal growth and development. We investigated associations of common placental genetic variations in vitamin D metabolism with birthweight. METHODS: The study was conducted among participants (506 maternal-infant pairs) of a pregnancy cohort study. Data were collected using interviewer-administered questionnaires and post-delivery medical record abstraction. DNA, extracted from placental samples collected at delivery, was genotyped for eight single nucleotide polymorphisms (SNPs) in five vitamin D metabolism genes (CUBN, LRP2, VDR, GC, and CYP2R1)...
February 2017: Placenta
https://www.readbyqxmd.com/read/28161064/dysregulation-of-maternal-and-placental-vitamin-d-metabolism-in-preeclampsia
#13
J A Tamblyn, R Susarla, C Jenkinson, L E Jeffery, O Ohizua, R F Chun, S Y Chan, M D Kilby, M Hewison
INTRODUCTION: Epidemiology has linked preeclampsia (PET) to decreased maternal serum 25-hydroxyvitamin D3 (25(OH)D3). However, alterations in systemic and placental/decidual transport and metabolism of 25(OH)D3 during pregnancy suggest that other forms of vitamin D may also contribute to the pathophysiology of PET. METHODS: In a cross sectional analysis of normal pregnant women at 1st (n = 25) and 3rd trimester (n = 21), pregnant women with PET (n = 22), and non-pregnant female controls (n = 20) vitamin D metabolites were quantified in paired maternal serum, placental, and decidual tissue...
February 2017: Placenta
https://www.readbyqxmd.com/read/28150405/vitamin-d-and-risk-of-preterm-birth-up-to-date-meta-analysis-of-randomized-controlled-trials-and-observational-studies
#14
REVIEW
Shan-Shan Zhou, Yong-Hao Tao, Kun Huang, Bei-Bei Zhu, Fang-Biao Tao
AIM: We performed a meta-analysis of randomized controlled trials (RCT) and observational studies to answer the two following questions: (i) whether low maternal circulating 25 hydroxyvitamin D (25-OHD) is associated with an increased risk of preterm birth (PTB) or spontaneous PTB (sPTB); and (ii) whether vitamin D supplementation alone during pregnancy can reduce the risk of PTB. METHODS: Literature search was carried out using Pubmed, Web of Science and Embase databases up to June 2016...
February 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28143670/maternal-and-fetal-folate-vitamin-b12-and-homocysteine-concentrations-and-childhood-kidney-outcomes
#15
Kozeta Miliku, Anne Mesu, Oscar H Franco, Albert Hofman, Eric A P Steegers, Vincent W V Jaddoe
BACKGROUND: Folate, vitamin B12, and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring. We examined the associations of folate, vitamin B12, and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children. STUDY DESIGN: Population-based prospective cohort study from fetal life onward. SETTINGS & PARTICIPANTS: This study was performed among 4,226 pregnant women and their children...
January 28, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28137896/vitamin-d-deficiency-and-impaired-placental-function-potential-regulation-by-glucocorticoids
#16
Nathanael Yates, Rachael Christina Crew, Caitlin Wyrwoll
Maternal vitamin D deficiency has been implicated in a range of pregnancy complications including preeclampsia, preterm birth and intrauterine growth restriction. Some of these adverse outcomes arise from alterations in placental function. Indeed, vitamin D appears critical for implantation, inflammation, immune function and angiogenesis of the placenta. Despite these associations, absence of placental vitamin D receptor in mice provokes little effect. Thus, interactions between maternal and fetal compartments are likely crucial for instigating adverse placental changes...
January 30, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28134839/the-road-not-so-travelled-should-measurement-of-vitamin-d-epimers-during-pregnancy-affect-our-clinical-decisions
#17
Spyridon N Karras, Kalliopi Kotsa, Elena Angeloudi, Pantelis Zebekakis, Declan P Naughton
Observational studies suggest an adverse effect of maternal hypovitaminosis D during pregnancy. However, intervention studies failed to show convincing benefit from vitamin D supplementation during pregnancy. With analytical advances, vitamin D can now be measured in ten forms-including as epimers-which were thought to be biologically inactive, but can critically impair immunoassays. The aim of this commentary is to highlight the potential clinical and analytical significance of vitamin D epimers in the interpretation of vitamin D roles in pregnancy...
January 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28130996/association-of-maternal-and-index-child-s-diet-with-subsequent-leukemia-risk-a-systematic-review-and-meta-analysis
#18
REVIEW
Nick Dessypris, Maria A Karalexi, Evangelos Ntouvelis, Andreas-Antonios Diamantaras, Vassilios Papadakis, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Maria Moschovi, Sophia Polychronopoulou, Vasiliki Sidi, Eftichia Stiakaki, Eleni Th Petridou
BACKGROUND: Exploring the effect of maternal and/or childhood diet on offspring leukemogenesis is challenging, given differences in food group categories, their potentially variable impact depending on time window of exposure and the multiple leukemia subtypes. We opted to quantitatively synthesize published data on the association of maternal/child diet with leukemia risk. METHODS: Medline was searched until June 30th, 2016 for eligible articles on the association of childhood leukemia with consumption of (i) food groups, excluding alcoholic and non-alcoholic beverages, and (ii) specific dietary supplements before/during index pregnancy and childhood...
January 25, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28130504/early-life-nutritional-exposures-and-lifelong-health-immediate-and-long-lasting-impacts-of-probiotics-vitamin-d-and-breastfeeding
#19
Cristiana Berti, Carlo Agostoni, Riccardo Davanzo, Elina Hyppönen, Erika Isolauri, Helle M Meltzer, Régine P M Steegers-Theunissen, Irene Cetin
Pregnancy and infancy comprise the most critical stages for conditioning an individual's health, with a number of implications for subsequent risks of morbidity, mortality, and reproductive health. Nutrition may influence both the overall pregnancy outcome and the growth trajectory and immune system of the fetus and infant, with short- and long-term effects on the health of the offspring. Within this context, leading experts at Expo Milano 2015 in Milan, Italy, discussed up-to-date knowledge while providing suggestions and challenges before, during, and after pregnancy...
January 27, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28129773/investigation-of-the-vitamin-d-nutritional-status-in-women-with-gestational-diabetes-mellitus-in-beijing
#20
Yanping Liu, Qiaer Jin, Yuanyuan Bao, Shanshan Li, Jing Wang, Ling Qiu
BACKGROUND: Vitamin D deficiency is a common issue, which has relation with GDM, during the pregnant period. To study the Vitamin D nutritional status of pregnant women with gestational diabetes mellitus (GDM) in the middle and late pregnancy and analyze the different sources of Vitamin D intake. METHODS: A total of ninety-eight pregnant women with GDM were enrolled voluntarily in this study. The patients were divided into two groups, Vitamin D supplement intake and control group...
January 28, 2017: Lipids in Health and Disease
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