Isma'il Kadam, Mudar Dalloul, Jeanette Hausser, Doron Vaday, Ella Gilboa, Liang Wang, Joan Hittelman, Lori Hoepner, Lawrence Fordjour, Pavani Chitamanni, Anjana Saxena, Xinyin Jiang
BACKGROUND & AIMS: Both maternal metabolic dysregulation, e.g., gestational diabetes mellitus (GDM), and maternal supply of nutrients that participate in one-carbon (1C) metabolism, e.g., folate, choline, betaine, and vitamin B12 , have been demonstrated to influence epigenetic modification such as DNA methylation, thereby exerting long-lasting impacts on growth and development of offspring. This study aimed to determine how maternal 1C nutrient intake was associated with DNA methylation and further, development of children, as well as whether maternal GDM status modified the association in a prospective cohort...
April 12, 2024: Clinical Nutrition