keyword
MENU ▼
Read by QxMD icon Read
search

Adult traumatic brain injury

keyword
https://www.readbyqxmd.com/read/29150595/notch1-signaling-activation-contributes-to-adult-hippocampal-neurogenesis-following-traumatic-brain-injury
#1
Ming Tu, Penglei Zhu, Shaobo Hu, Wei Wang, Zhipeng Su, Jiaqing Guan, Chongran Sun, Weiming Zheng
BACKGROUND Neural stem cells are reported to exist in the hippocampus of adult mammals and are important sources of neurons for repair. The Notch1 signaling pathway is considered as one of the important regulators of neural stem cells, but its role in adult brains is unclear. We aimed to describe the role of Notch1 signaling in the adult rat hippocampus after traumatic brain injury. MATERIAL AND METHODS The model rats were randomly divided into 4 groups as follows: sham, sham-TBI, sham-Ad-TBI, and NICD-Ad-TBI...
November 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29142381/nursing-management-of-adults-with-severe-traumatic-brain-injury-a-narrative-review
#2
REVIEW
Roseminu Varghese, Jyothi Chakrabarty, Girish Menon
Effective nursing management strategies for adults with severe traumatic brain injury (STBI) are still a remarkable issue and a difficult task for neurologists, neurosurgeons, and neuronurses. A list of justified indications and scientific rationale for nursing management of these patients are continuously evolving. The objectives of the study are to analyze the pertinently available research and clinical studies that demonstrate the nursing management strategies for adults with STBI and to synthesize the available evidence based on the review...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29139337/do-people-with-severe-traumatic-brain-injury-benefit-from-making-errors-a-randomized-controlled-trial-of-error-based-and-errorless-learning
#3
Tamara Ownsworth, Jennifer Fleming, Robyn Tate, Elizabeth Beadle, Janelle Griffin, Melissa Kendall, Julia Schmidt, Amanda Lane-Brown, Mathilde Chevignard, David H K Shum
BACKGROUND: Errorless learning (ELL) and error-based learning (EBL) are commonly used approaches to rehabilitation for people with traumatic brain injury (TBI). However, it is unknown whether making errors is beneficial in the learning process to promote skills generalization after severe TBI. OBJECTIVE: To compare the efficacy of ELL and EBL for improving skills generalization, self-awareness, behavioral competency, and psychosocial functioning after severe TBI...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29137197/effect-of-age-on-glasgow-coma-scale-in-patients-with-moderate-and-severe-traumatic-brain-injury-an-approach-with-propensity-score-matched-population
#4
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: The most widely used methods of describing traumatic brain injury (TBI) are the Glasgow Coma Scale (GCS) and the Abbreviated Injury Scale (AIS). Recent evidence suggests that presenting GCS in older patients may be higher than that in younger patients for an equivalent anatomical severity of TBI. This study aimed to assess these observations with a propensity-score matching approach using the data from Trauma Registry System in a Level I trauma center. Methods: We included all adult patients (aged ≥20 years old) with moderate to severe TBI from 1 January 2009 to 31 December 2016...
November 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29133706/a-randomized-placebo-controlled-trial-of-progesterone-with-or-without-hypothermia-in-patients-with-acute-severe-traumatic-brain-injury
#5
Sumit Sinha, Amol Raheja, Neha Samson, Keshav Goyal, Sanjeev Bhoi, Arul Selvi, Pushpa Sharma, Bhawani Shankar Sharma
OBJECTIVE: Among newer neuroprotectant modalities, hypothermia and progesterone have shown a beneficial role in preliminary studies enrolling patients with severe traumatic brain injury (sTBI). The primary objective of this study was to evaluate the efficacy of progesterone with or without prophylactic hypothermia in acute sTBI patients. MATERIALS AND METHODS: This is a prospective, outcome assessor, statistician blinded, randomized, and placebo-controlled phase II trial of progesterone with or without hypothermia (factorial design)...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133177/region-specific-alterations-in-astrocyte-and-microglia-morphology-following-exposure-to-blasts-in-the-mouse-hippocampus
#6
Gloria J DeWalt, Biraaj Mahajan, Andrea R Foster, Lauren D E Thompson, Andrew A Marttini, Eric V Schmidt, Sara Mansuri, Dwayne D'Souza, Shama Patel, Madeline Tenenbaum, Karla I Brandao-Viruet, Dominique Thompson, Bryan Duong, Danica H Smith, Todd A Blute, William D Eldred
Traumatic brain injury (TBI) is a serious public health concern, especially injuries from repetitive insults. The main objective of this study was to immunocytochemically examine morphological alterations in astrocytes and microglia in the hippocampus 48hours following a single blast versus multiple blasts in adult C57BL/6 mice. The effects of ketamine and xylazine (KX), two common anesthetic agents used in TBI research, were also evaluated due to the confounding effect of anesthetics on injury outcome. Results showed a significant increase in hypertrophic microglia that was limited to the outer molecular layer of the dentate gyrus, but only in the absence of KX...
November 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29125015/factors-associated-with-return-to-work-in-patients-with-long-term-disabilities-due-to-neurological-and-neuropsychiatric-disorders
#7
Maura Mitrushina, Robert Tomaszewski
The current study explores factors predicting return to work in a sample of patients with neurological and neuropsychiatric disorders who have attended a prevocational readiness and social skills training programme many years after trauma. Participants were community-dwelling adults with long-term disabilities (N = 67). Results of univariate analyses followed by multivariate logistic regression analysis revealed that both pre-injury (prior) and post-injury (current) factors influenced the likelihood of employment in our sample: prior employment, current employment readiness, current cognitive competence (particularly memory and executive functioning) and emotional adjustment...
November 10, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29124763/neuronal-expression-of-brain-derived-neurotrophicfactor-in-the-injured-telencephalon-of-adult-zebrafish
#8
Pietro Cacialli, Livia D'Angelo, Olivier Kah, Pascal Coumailleau, Marie-Madeleine Gueguen, Elisabeth Pellegrini, Carla Lucini
The reparative ability of the central nervous system varies widely in the animal kingdom. In the mammalian brain, the regenerative mechanisms are very limited and newly formed neurons do not survive longer, probably due to a non-suitable local environment. On the opposite, fish can repair the brain after injury, with fast and complete recovery of damaged area. The brain of zebrafish, a teleost fish widely used as vertebrate model, also possesses high regenerative properties after injury. Taking advantage of this relevant model, the aim of the present study was to investigate the role of Brain-derived neurotrophic factor (BDNF) in the regenerative ability of adult brain, after stab wound telencephalic injury...
November 10, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29123841/post-traumatic-hypopituitarism-report-of-a-child-case
#9
Makoto Aoki, Shuichi Hagiwara, Masato Murata, Minoru Kaneko, Masahiko Kanbe, Jun Nakajima, Yusuke Sawada, Yoshio Ohyama, Jun'ichi Tamura, Kiyohiro Oshima
Case: We report a case of post-traumatic hypopituitarism in a 9-year-old boy who was injured in a car accident. Outcome: Post-traumatic hypopituitarism might be caused by moderate to severe head trauma, and while this possibility has recently drawn attention in adults, few reports are available regarding children. Our patient experienced head and facial injury, resulting in post-traumatic hypopituitarism. Six hours after injury he suffered from diabetes insipidus and hormone replacement therapy was started...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122642/evaluation-of-the-roche%C3%A2-elecsys-and-the-diasorin%C3%A2-liaison-s100-kits-in-the-management-of-mild-head-injury-in-the-emergency-room
#10
Quentin Delefortrie, François Lejeune, Benjamin Kerzmann, Raphaël Levy, Jean-François Adam, Thierry Sottiaux, Alexandre Grimmelprez, Patrick Vankerkhoven, Said Hachimi-Idrissi
INTRODUCTION: The aim of this single-center prospective study is to compare two commercially available S100ß kits (the Roche® Elecsys and the Diasorin® Liaison S100 kits) in terms of analytical and clinical performances in a population admitted in the emergency room for mild traumatic brain injury (mTBI). MATERIAL AND METHOD: 110 patients were enrolled from September 2014 to May 2015. Blood sample draws were performed within 3h after head trauma and the study population was split into pediatric and adult subpopulations (>18years of age)...
November 7, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29121826/treatment-of-traumatic-brain-injury-with-vepoloxamer-purified-poloxamer-188
#11
Yanlu Zhang, Michael Chopp, Martin Emanuele, Li Zhang, Zheng Gang Zhang, Mei Lu, Talan Zhang, Asim Mahmood, Ye Xiong
Vepoloxamer is an amphipathic polymer that has shown potent hemorrheologic, cytoprotective, and anti-inflammatory effects in both preclinical and clinical studies. This study was designed to investigate the therapeutic effects of vepoloxamer on sensorimotor and cognitive functional recovery in rats after traumatic brain injury (TBI) induced by controlled cortical impact. Young adult male Wistar rats were randomly divided into the following groups: 1) Sham; 2) Saline; or 3) Vepoloxamer. Vepoloxamer (300 mg/kg) or saline was intravenously administered over 60 min via intravenous infusion into tail veins starting at 2 h post injury...
November 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29117034/a-feasibility-randomized-controlled-crossover-trial-of-home-based-warm-footbath-to-improve-sleep-in-the-chronic-phase-of-traumatic-brain-injury
#12
Hsiao-Yean Chiu, En-Yuan Lin, Hsiao-Ting Chiu, Pin-Yuan Chen
INTRODUCTION: Sleep disturbance is a common complaint after traumatic brain injury (TBI). The aim of this study was to examine the effects of a home-based warm footbath intervention on sleep in patients with TBI. METHODS: This was a randomized controlled crossover study, and 23 adults with TBI were recruited and randomized to receive first a 30-minute, 41°C warm footbath and then a usual care, or vice versa, with each lasting 3 days and separated by a 3-day washout...
December 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29108471/intranasally-delivered-wnt3a-improves-functional-recovery-after-traumatic-brain-injury-by-modulating-autophagic-apoptotic-and-regenerative-pathways-in-the-mouse-brain
#13
James Ya Zhang, Jinhwan Lee, Xiaohuan Gu, Zheng Wei, Mallory Jessica Harris, Shan Ping P Yu, Ling Wei
Traumatic brain injury (TBI) is a prevalent disorder, but no effective therapies currently exist. An underlying pathophysiology of TBI includes the pathologic elevation of autophagy. β-Catenin, a downstream mediator of the canonical Wnt pathway, is a repressor of autophagy. The Wnt/β-catenin pathway plays a crucial role in cell proliferation and neuronal plasticity/repair in the adult brain. We hypothesized that activation of this pathway could promote neuroprotection and neural regeneration following TBI...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29099813/stress-induced-hyperglycemia-but-not-diabetic-hyperglycemia-is-associated-with-higher-mortality-in-patients-with-isolated-moderate-and-severe-traumatic-brain-injury-analysis-of-a-propensity-score-matched-population
#14
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: Admission hyperglycemia is associated with higher morbidity and mortality in patients with traumatic brain injury (TBI). Stress-induced hyperglycemia (SIH), a form of hyperglycemia induced by the stress response, is associated with increased patient mortality following TBI. However, admission hyperglycemia occurs not only in SIH but also in patients with diabetic hyperglycemia (DH). Current information regarding whether trauma patients with SIH represent a distinct group with differential outcomes compared to those with DH remains limited...
November 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29099343/feasibility-study-of-a-novel-high-flow-cold-air-cooling-protocol-of-the-porcine-brain-using-mri-temperature-mapping
#15
Jan Sedlacik, Åsmund Kjørstad, Zsuzsanna Nagy, Jan-Hendrik Buhk, Christoph R Behem, Constantin J Trepte, Jens Fiehler, Fabian Temme
Early, prehospital cooling seeks to reduce and control the body temperature as early as possible to protect the brain and improve patient outcome in cardiac arrest, stroke, and traumatic brain injury. In this study, we investigate the feasibility of localized cooling of the porcine brain by using a novel high-flow cold air protocol, which utilizes the close proximity between the nasal cavity and the brain. Five adult pigs were anesthetized and temperature change was mapped before, during, and after cooling by using the proton resonance frequency method on a 3 T Siemens Magnetom Skyra system...
November 3, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29097964/test-retest-reliability-of-a-measure-of-independence-in-everyday-activities-the-adl-profile
#16
Élisabeth Dutil, Carolina Bottari, Claudine Auger
Background: Very few performance-based measures used in occupational therapy have established test-retest reliability coefficients. Objectives of Study: This study presents the test-retest reliability of the task and operation scores of a performance-based measure of independence in everyday activities called the ADL Profile. Methods: 20 adults with severe traumatic brain injury (mean age 28.4 years; SD 9.9) were tested on two occasions with the 17 tasks (personal care, home, and community) of the ADL Profile...
2017: Occupational Therapy International
https://www.readbyqxmd.com/read/29095182/reducing-unnecessary-head-computed-tomography-in-mild-traumatic-brain-injury
#17
Nathaniel John Webster, Nathan Moore, Felicia Stewart
There is growing concern about the frequency of computed tomographic (CT) scans performed for evaluation of adults with suspected mild traumatic brain injury. The Canadian CT Head Rule and the New Orleans Criteria are the most studied head CT decision tools that aid providers in determining which patients do not require a CT scan. This article examines recent research to determine which of these tools has proven to be the most effective at safely reducing the use of head CT scans. The reviewed studies concluded that both the Canadian CT Head Rule and the New Orleans Criteria had similar sensitivities, but the Canadian CT Head Rule showed superior specificity in predicting the presence of a clinically significant brain injury...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29094067/comorbidities-confounding-the-outcomes-of-surgery-for-third-window-syndrome-outlier-analysis
#18
P Ashley Wackym, Heather T Mackay-Promitas, Shaban Demirel, Gerard J Gianoli, Martin S Gizzi, Dale M Carter, David A Siker
Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors. Study Design: Observational analytic case-control study in a tertiary referral center. Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29093643/labelling-facial-affect-in-context-in-adults-with-and-without-tbi
#19
Lyn S Turkstra, Sarah G Kraning, Sarah K Riedeman, Bilge Mutlu, Melissa Duff, Sara VanDenHeuvel
Recognition of facial affect has been studied extensively in adults with and without traumatic brain injury (TBI), mostly by asking examinees to match basic emotion words to isolated faces. This method may not capture affect labelling in everyday life when faces are in context and choices are open-ended. To examine effects of context and response format, we asked 148 undergraduate students to label emotions shown on faces either in isolation or in natural visual scenes. Responses were categorised as representing basic emotions, social emotions, cognitive state terms, or appraisals...
March 2017: Brain Impairment: a Multidisciplinary Journal of the Australian Society for the Study of Brain Impairment
https://www.readbyqxmd.com/read/29084102/lifetime-history-of-traumatic-brain-injury-and-current-disability-among-ohio-adults
#20
Honggang Yi, John D Corrigan, Bhavna Singichetti, Jennifer A Bogner, Kara Manchester, Jinhong Guo, Jingzhen Yang
OBJECTIVE: To examine the associations between lifetime history of traumatic brain injury (TBI) with loss of consciousness (LOC) and several types of current disability among adult, noninstitutionalized residents of Ohio. PARTICIPANTS: 2014 Ohio Behavioral Risk Factors Surveillance System participants (n = 6998). DESIGN: Statewide population-based survey. MAIN MEASURES: Lifetime history of TBI with LOC (number and severity of injury, age of first injury), and number and type of disability (vision, cognition, mobility, self-care, and/or independent living)...
October 27, 2017: Journal of Head Trauma Rehabilitation
keyword
keyword
68119
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"