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M Majumder, R S Manna, G Simutis, J C Orain, T Dey, F Freund, A Jesche, R Khasanov, P K Biswas, E Bykova, N Dubrovinskaia, L S Dubrovinsky, R Yadav, L Hozoi, S Nishimoto, A A Tsirlin, P Gegenwart
Temperature-pressure phase diagram of the Kitaev hyperhoneycomb iridate β-Li_{2}IrO_{3} is explored using magnetization, thermal expansion, magnetostriction, and muon spin rotation measurements, as well as single-crystal x-ray diffraction under pressure and ab initio calculations. The Néel temperature of β-Li_{2}IrO_{3} increases with the slope of 0.9  K/GPa upon initial compression, but the reduction in the polarization field H_{c} reflects a growing instability of the incommensurate order. At 1.4 GPa, the ordered state breaks down upon a first-order transition, giving way to a new ground state marked by the coexistence of dynamically correlated and frozen spins...
June 8, 2018: Physical Review Letters
Ed Madeley, Brett Duane
Data sourcesPubMed, EMBASE, Web of Science, Cochrane library, China Biology Medicine Disc (CBM), China National Knowledge infrastructure (CNKI).Study SelectionThis study included only human randomised controlled trials (RCTs) and clinical controlled trials (CCTs). To be included studies had to include patients prescribed oral anticoagulant therapy (OAT) requiring dental extraction(s). Comparison was made between patients discontinuing OAT for the dental extraction(s) and those continuing with their OAT. The outcome measured was post-operative bleeding identified by clinician or patient...
June 2018: Evidence-based Dentistry
Christine Marquez, Alekhya Mascarenhas Johnson, Sabrina Jassemi, Jamie Park, Julia E Moore, Caroline Blaine, Gertrude Bourdon, Mark Chignell, Moriah E Ellen, Jacques Fortin, Ian D Graham, Anne Hayes, Jemila Hamid, Brenda Hemmelgarn, Michael Hillmer, Bev Holmes, Jayna Holroyd-Leduc, Linda Hubert, Brian Hutton, Monika Kastner, John N Lavis, Karen Michell, David Moher, Mathieu Ouimet, Laure Perrier, Andrea Proctor, Thomas Noseworthy, Victoria Schuckel, Sharlene Stayberg, Marcello Tonelli, Andrea C Tricco, Sharon E Straus
BACKGROUND: Systematic reviews are infrequently used by health care managers (HCMs) and policy-makers (PMs) in decision-making. HCMs and PMs co-developed and tested novel systematic review of effects formats to increase their use. METHODS: A three-phased approach was used to evaluate the determinants to uptake of systematic reviews of effects and the usability of an innovative and a traditional systematic review of effects format. In phase 1, survey and interviews were conducted with HCMs and PMs in four Canadian provinces to determine perceptions of a traditional systematic review format...
June 22, 2018: Implementation Science: IS
James P Corsetti, Tanzy M Love, Charles E Sparks, Stephan J L Bakker, Robin P F Dullaart
OBJECTIVE: Familial dysbetalipoproteinemia (FD) or Type III hyperlipoproteinemia is closely associated with the ε2ε2 genotype of the common APOE polymorphism although not all ε2 homozygotes develop FD indicating that additional factors play a role including insulin resistance (IR). The current study was undertaken to explore relationships and influences among factors, especially IR, that might elucidate FD progression pathways. METHODS: Bayesian network (BN) modeling, a probabilistic graphical exploratory data analysis tool that portrays relationships and influences among variables as simple diagrams, was applied to 52 e2e2 subjects...
June 18, 2018: Clinical Biochemistry
Catarina Florindo, Lucas G Celia-Silva, Luís F G Martins, Luís C Branco, Isabel M Marrucho
A supramolecular hydrogel based on a metal-containing deep eutectic solvent (DES) is presented here for the first time. The phase diagram of the DES-based hydrogel was drawn and its rheological properties were determined.
June 21, 2018: Chemical Communications: Chem Comm
Hiroyasu Koizumi, Takaya Ishii, Tomoyo Okazaki, Masahiro Kaketani, Hideo Matsumura, Takayuki Yoneyama
The castability, mechanical properties, and fracture characteristics of Ti-15Mo-5Zr-3Al alloy were compared with those of Ti-6Al-7Nb alloy and pure titanium (CP Ti) for application of this β-type titanium alloy in cast dental prostheses. Cast specimens were prepared with a centrifugal casting machine. A tensile test was performed according to ISO standard 22674. The castability index for Ti-15Mo-5Zr-3Al was lower than those for Ti-6Al-7Nb and CP Ti. The tensile strength of Ti-15Mo-5Zr-3Al was 852 MPa, which was lower than that of Ti-6Al-7Nb and higher than that of CP Ti...
2018: Journal of Oral Science
Ni Wu, Jun Yan, Tao Han, Jijun Zou, Weimin Shen
BACKGROUND: Orofacial clefts include cleft lip only (CLO), cleft palate only (CPO), and cleft lip with palate (CLP). Previously, we reported the expression profile of plasma microRNAs in CLO, CPO, and CLP, respectively. However, the interaction of each subtype remains poorly investigated. METHODS: In this study, we integrated the expression profiles of plasma miRNAs in these 3 subtypes, and assessed the distinct and overlapping dysregulated miRNAs using Venn diagrams...
June 2018: Medicine (Baltimore)
Arianne Teherani, Karen E Hauer, Alicia Fernandez, Talmadge E King, Catherine Lucey
While students entering medical schools are becoming more diverse, trainees in residency programs in competitive specialties and academic medicine faculty have not increased in diversity. As part of an educational continuous quality improvement (ECQI) process at the University of California, San Francisco, School of Medicine, the authors examined data for the classes of 2013-2016 to determine whether differences existed between underrepresented in medicine (UIM) and not-UIM students' clinical performance (clerkship director ratings and number of clerkship honors grades awarded) and honor society membership--all of which influence residency selection and academic career choices...
June 19, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
A Ciach
The low-T part of the phase diagram in self-assembling systems is correctly predicted by known versions of density functional theory (DFT). The high-T part obtained in DFT, however, does not agree with simulations even on the qualitative level. In this work, a new version of DFT for systems with spontaneous inhomogeneities on a mesoscopic length scale is developed. The contribution to the grand thermodynamic potential associated with mesoscopic fluctuations is explicitly taken into account. The expression for this contribution is obtained by methods known from the Brazovskii field theory...
June 20, 2018: Soft Matter
Rodrigo F O Pena, Michael A Zaks, Antonio C Roque
Spontaneous cortical population activity exhibits a multitude of oscillatory patterns, which often display synchrony during slow-wave sleep or under certain anesthetics and stay asynchronous during quiet wakefulness. The mechanisms behind these cortical states and transitions among them are not completely understood. Here we study spontaneous population activity patterns in random networks of spiking neurons of mixed types modeled by Izhikevich equations. Neurons are coupled by conductance-based synapses subject to synaptic noise...
June 19, 2018: Journal of Computational Neuroscience
Fan Tang, Hui Feng, Hang Zhao, Hongxia Dan, Yuqi Du, Yandi Xiao, Qianming Chen
Recently, supramolecular hydrogels have attracted increasing interest owing to their tunable stability and inherent biocompatibility. However, only few studies have been reported in the literature on self-healing supramolecular nucleoside hydrogels, compared to self-healing polymer hydrogels. In this work, we successfully developed a self-healing supramolecular nucleoside hydrogel obtained by simply mixing equimolar amounts of guanosine (G) and isoguanosine (isoG) in the presence of K+. The gelation properties have been studied systematically by comparing different alkali metal ions as well as mixtures with different ratios of G and isoG...
June 19, 2018: Chemistry, An Asian Journal
Michelle M Pang, Thomas R Clandinin
Retinotopic maps represent a fundamental organizing principle of visual system wiring. A recent study illustrates how careful coordination of developmental strategies can simultaneously create a diverse array of cell types and establish a complex wiring diagram.
June 18, 2018: Current Biology: CB
G-M Li, C-L Zhang, R-P Rui, B Sun, W Guo
OBJECTIVE: This paper aims at screening the common differential genes of coronary atherosclerotic heart disease (CAD) and ischemic cardiomyopathy (ICM), and to conduct pathway analysis and protein-protein interaction (PPI) network analysis for the differential genes. MATERIALS AND METHODS: The CAD and ICM datasets were collected from the Gene Expression Omnibus (GEO) database for human tumors to extract data components of peripheral blood RNA of patients and normal people in GSE71226 and GSE9128 chips; "limma" package of "R" software was used to screen the differential genes, and "pheatmap" package was applied to construct heat maps for the differential genes; Cytoscape, Database for Annotation, Visualization and Integration Discovery (DAVID) and String platforms were utilized for PPI network analysis, Genome Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the selected differential genes...
June 2018: European Review for Medical and Pharmacological Sciences
Pietro Apostoli, Giuseppe De Palma, Matteo Paganelli
OBJECTIVES: The correspondence between biomarkers and the complex interaction of toxics with the human organism has been fully described years ago by the American National Research Council which developed a precious diagram. METHODS: This model is still valid in describing the new methodologic agnostic or "omic" approaches to the science of exposure. RESULTS: Reference values and exposome share indeed the search for internal dose biomarkers; adduttomics may be seen as an evolution of the target dose markers while epigenetics itself is a new way of exploring the world of early effect biomarkers...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Xiaomei Wang, Guoxun Ji, Cen Shi, Juan Diwu, Lanhua Chen, Daxiang Gui, Jianmei Wan, Mark A Silver, Jianqiang Wang, Shuao Wang
Deferiprone (3-hydroxy-1,2-dimethyl-4(1H)-pyridone, DFP), which is a drug clinically used for removing heavy metals in vivo, was explored for its removal efficiency towards uranium. The reaction of uranyl nitrate hexahydrate with DFP at room temperature yielded the compound [(UO2)(H2O)(C7NO2H8)2]·4H2O (1), which crystallizes from a mixed solution of methanol and water (pH = 7.0). X-ray diffraction shows that the stable complexation of uranyl occurs from the coordination of two bidentate DFP ligands perpendicular to the O[double bond, length as m-dash]U[double bond, length as m-dash]O unit with a fifth coordinating oxygen atom coming from one water molecule, resulting in a pentagonal bipyramidal geometry...
June 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Wógenes N Oliveira, Lucas Amaral-Machado, Everton N Alencar, Henrique R Marcelino, Julieta Genre, Walicyranison P Silva-Rocha, Amanda D Gondim, Guilherme M Chaves, Matheus F Fernandes-Pedrosa, Eryvaldo Socrates T Egito
Amphotericin B (AmB), a potent antifungal drug, presents physicochemical characteristics that impair the development of suitable dosage forms. In order to overcome the AmB insolubility, several lipid carriers such as microemulsions have been developed. In this context, the bullfrog oil stands out as an eligible oily phase component, since its cholesterol composition may favor the AmB incorporation. Thus, the aim of this study was to develop a microemulsion based on bullfrog oil containing AmB. Moreover, its thermal stability, antifungal activity, and cytotoxicity in vitro were evaluated...
June 18, 2018: AAPS PharmSciTech
Gayani N Pallewela, Elizabeth A Ploetz, Paul E Smith
Triplet correlations play a central role in our understanding of fluids and their properties. Of particular interest is the relationship between the pair and triplet correlations. Here we use a combination of Fluctuation Solution Theory and experimental pair radial distribution functions to investigate the accuracy of the Kirkwood Superposition Approximation (KSA), as given by integrals over the relevant pair and triplet correlation functions, at a series of state points for pure water using only experimental quantities...
August 25, 2018: Fluid Phase Equilibria
Viktor Rozsa, Ding Pan, Federico Giberti, Giulia Galli
The phase diagram of water at extreme conditions plays a critical role in Earth and planetary science, yet remains poorly understood. Here we report a first-principles investigation of the liquid at high temperature, between 11 GPa and 20 GPa-a region where numerous controversial results have been reported over the past three decades. Our results are consistent with the recent estimates of the water melting line below 1,000 K and show that on the 1,000-K isotherm the liquid is rapidly dissociating and recombining through a bimolecular mechanism...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Charkarra Anderson-Lewis, Gabrielle Darville, Rebeccah Eve Mercado, Savannah Howell, Samantha Di Maggio
BACKGROUND: The proportion of people in the United States who are members of at least two ethnic groups is projected to increase to 10% by the year 2050. This makes addressing health disparities and health inequities in minority populations increasingly more difficult. Minority populations, including those who classify themselves as African American and Hispanic, are using mobile phones to access health information via the internet more frequently than those who classify themselves as white, providing unique opportunities for those in public health and health education to reach these traditionally underserved populations using mobile health (mHealth) interventions...
June 18, 2018: JMIR MHealth and UHealth
Karin Alvåsen, Ian Dohoo, Anki Roth, Ulf Emanuelson
BACKGROUND: Longevity is an important trait for increasing the profitability of dairy production. Long cow longevity is also essential to reduce the environmental impact of milk production, and to maintain positive consumer attitude. Genetic selection for increased longevity has been effective, but the phenotypic trend of longevity in Swedish dairy cows has not been improved. The objective of this study was to identify herd characteristics and management routines that are associated with the average cow longevity in a herd...
June 19, 2018: Acta Veterinaria Scandinavica
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