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Li-Juan Sun, De-Chao Duan, Cheng Peng, Jun-Yu He, Ji-Yan Shi
The biogeochemical cycle of sulfur can directly affect the speciation transformation of heavy metals in soils and their accumulation in plants. The toxicity of heavy metals in plants can be alleviated by their complexation with sulfur compounds like phytochelatins or metallothiones, consisting of the major mechanisms of phytodetoxification. Sulfur deficiency is becoming one of the limiting factors that influence Chinese agricultural production. Although the applications of sulfur fertilizer in soil have received much attention in recent years, the interaction mechanism of heavy metal with sulfur metabolism has not been studied extensively...
July 2014: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Qi Wei, Bi Juanjuan, Tian Longlong, Li Zhan, Liu Peng, Wu Wangsuo
The effects of oxidized multiwalled carbon nanotubes (oMWCNTs) on the behavior and hepatotoxicity of Cd(2+) in accumulated cadmium-metallothionein mice were investigated. The results indicated that, after exposure of oMWCNTs to normal mice, oMWCNTs could not induce the liver to produce metallothionein (MT). When exposing Cd-MT mouse to different doses of oMWCNTs oMWCNTs could cause Cd(2+) release from the accumulated Cd-MT; subsequently, one part of the free Cd(2+) was eliminated with blood circulation; the other part adsorbed by oMWCNTs would remain in the tissues together with oMWCNTs...
2014: BioMed Research International
Katarzyna A Wójcik, Janusz Błasiak, Anna Kamińska, Anna K Kurowska, Jerzy Szaflik, Jacek P Szaflik
Fuchs endothelial corneal dystrophy is a disease which occurs after the fourth decade of life. This disorder is characterized by the formation of excrescences growing from the Descemet membrane, called cormea guttata, and changes in the corneal en- dothelial cell density and morphology. The pathogenesis of Fuchs endothelial corneal dystrophy is not completely known. Auto- somal dominant mode of inheritance observed in some cases of Fuchs endothelial corneal dystrophy suggests possible genetic etiology of the disease...
2013: Klinika Oczna
Isabel María Quesada, Josep María Del Bas, Cinta Bladé, Anna Ardèvol, Mayte Blay, María Josepa Salvadó, Gerard Pujadas, Juan Fernández-Larrea, Lluis Arola
Procyanidins are the most abundant polyphenols in red wine and are also found in cereals, fruits, chocolate and tea. They exert many beneficial health effects, especially on the cardiovascular system (Bagchi et al. in Mutat Res 523-524:87-97, 2003; Williams et al. in Free Radic Biol Med 36:838-849, 2004; Dell'Agli et al. in Cardiovasc Res 63(4):593-602, 2004; Del Bas et al. FASEB J 19:479-480, 2005). Here, we show that oral administration of a grape seed procyanidins extract (GSPE) to healthy rats results, 5 h after treatment, in a 70% inhibition of metallothionein (MT) gene expression in the liver, as determined by oligonucleotide microarray hybridization...
October 2007: Genes & Nutrition
B Floriañczyk, L Grzybowska
Metallothioneins (MTs) protect the cell against reactive forms of oxygen, ionizing radiation, pharmacological agents and mutagens. Metallothioneins are also responsible for neoplastic cell resistance to cytostatic drugs. The aim of this study was to determine the MT level in cell fractions as well as to determine whether there is any change in the concentration of these proteins in a neoplastic cell, and in which cell fractions this change takes place. The neoplastic tissue examined was histopathologically ductal carcinoma invasive, and the control tissue was mastopathic tissue with proliferated connective and glandular tissue...
2000: Acta Oncologica
O M Colvin
The antineoplastic action and development of drug resistance are reviewed for chemotherapeutic agents used in the treatment of sarcoma, including alkylating agents (cyclophosphamide, ifosphamide, dacarbazine), platinum compounds (cisplatin, carboplatin), the anthracycline compound doxorubicin, the topoisomerase II inhibitor etoposide, and the taxanes (paclitaxel, taxotere). Drug resistance mechanisms discussed include changes in intracellular glutathione and metallothione levels, increased aldehyde dehydrogenase levels, enhanced DNA repair and protection from apoptosis (for alkylating agents); increased 0-6 alkyltranferase levels (for dacarbazine); multidrug resistance 1- and multidrug resistance associated protein-mediated drug export from cells (anthracyclines, taxanes); and structural alteration of microtubules (taxanes)...
October 1997: Seminars in Oncology
B Engström
Acute toxicity and organ distribution of cadmium was investigated in mice exposed to 1) single subcutaneous doses of 109Cd-labelled cadmium (3.2 mg (0.028 mmol)/kg b.wt.) alone or in combination with nitrilotriacetic acid, NTA (32 mg (0.167 mmol/kg b.wt.) or sodium tripolyphosphate, STPP (32 mg (0.087 mmol/kg b.wt.) and 2) single oral doses of cadmium (60 mg (0.53 mmol/kg b.wt.) alone or together with NTA (600 mg (3.14 mmol)/kg.b.wt.) or STPP (600 mg (1.63 mmol/kg b.wt.) Whole-body retention of radiolabelled cadmium as well as mortality was registered in all groups during 20-21 days...
February 1981: Acta Pharmacologica et Toxicologica
M D Maines
In biological systems oxidation of heme is carried out by two isozymes of the microsomal heme oxygenase, HO-1 and HO-2. HO-1 is the commonly known heme oxygenase, the activity of which can be induced by up to 100-fold in response to a wide variety of stimuli (metals, heme, hormones, etc.). HO-2 was only recently discovered, and the isozyme appears to be uninducible. The two forms are products of two different genes and differ in their tissue expression. The primary structure of HO-1 and an HO-2 fragment of 91 amino acid residues show only 58% homology, but share a region with 100% secondary structure homology...
July 1988: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
C Tohyama, Z A Shaikh
No abstract text is available yet for this article.
October 30, 1978: Biochemical and Biophysical Research Communications
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