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Ceruloplasmin

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https://www.readbyqxmd.com/read/27909964/oxidative-stress-and-biochemical-markers-of-endothelial-dysfunction-and-organ-damage-under-conditions-of-experimental-nonferrous-metal-intoxication
#1
F S Dzugkoeva, I V Mozhaeva, S G Dzugkoev, O I Margieva, A I Tedtoeva, M A Otiev
Chronic nickel intoxication caused by parenteral nickel chloride administration (0.5 mg/kg of body weight) to Wistar rats led to ROS generation inducing LPO in erythrocyte membranes and homogenates of renal, liver, and myocardial tissue. Superoxide dismutase (SOD) activity was inhibited, while catalase activity and ceruloplasmin concentration increased. LPO and its products disrupted nitric oxide production and reduced its bioavailability, which led to the development of endothelial dysfunction and impaired microcirculatory hemodynamics...
December 2, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27908399/serum-copper-concentrations-in-hospitalized-newborns
#2
Ricardo González-Tarancón, Luisa Calvo-Ruata, Maite Aramendía, Carmen Ortega, Elena García-González, Luis Rello
BACKGROUND: Low serum Cu and ceruloplasmin (Cp) concentrations in newborns can be the first indication of a severe Cu deficient intake or, alternatively, of genetic diseases affecting Cu metabolism. However, Cu and Cp concentrations can also be influenced by other variables that render their quantitative results difficult to interpret. Therefore, it is necessary to identify these variables and stratify Cu and Cp concentrations according to these altering factors. METHODS: Serum Cu and Cp concentrations for 564 hospitalized newborns (0-12days of life) are stratified according to their age, prematurity (birth weight or gestational age), type of feeding and inflammatory state (assessed by the serum high sensitivity C-reactive protein (hs-CRP) level) to identify potential correlations...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27903408/correlations-between-ceruloplasmin-lactoferrin-and-myeloperoxidase-in-meconium
#3
Ewa Skarżyńska, Joanna Żytyńska-Daniluk, Barbara Lisowska-Myjak
BACKGROUND AND AIMS: Oxidative stress and the generation of reactive oxygen/nitrogen species has a known significant impact on intrauterine fetal growth and the risk of metabolic diseases in adulthood. Compounds accumulated in fetal meconium may be a source of information about the oxidoreductive status during the intrauterine development. Three metal-containing proteins ceruloplasmin (CP), lactoferrin (LF) and myeloperoxidase (MPO) constitute the complementary panel modulating oxidative stress...
November 23, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27892863/nutrigenomic-activity-of-plant-derived-compounds-in-health-and-disease-results-of-a-dietary-intervention-study-in-dog
#4
Sandy Sgorlon, Bruno Stefanon, Misa Sandri, Monica Colitti
The study was conducted to investigate the effects of dietary administrations of four nutraceuticals in dogs. Seventy four dogs were enrolled in the trials, 24 healthy dogs were fed with a control diet (CT) and the experimental groups received for 60days the same diet supplemented with nutraceuticals, namely Echinacea angustifolia (EA, 0.10mg/kg live weight as echinacoside; 14 dogs), Vaccinium myrtillus (VM, 0.20mg/kg live weight as anthocyanidin, 13 dogs), Curcuma longa (CL, 6.60mg/kg live weight as curcumin, 18 dogs with arthrosis), and Sylibum marianum (SM, 1...
October 13, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27881232/serum-copper-zinc-and-iron-levels-and-markers-of-carbohydrate-metabolism-in-postmenopausal-women-with-prediabetes-and-type-2-diabetes-mellitus
#5
Margarita G Skalnaya, Anatoly V Skalny, Alexey A Tinkov
The objective of the present study was to evaluate serum level of copper, zinc, iron and metabolic parameters in postmenopausal women with diabetes. A total of 413 postmenopausal women were enrolled in the current study. Women were divided into 4 groups with equal age and body mass index according to glycated hemoglobin (HbA1c) levels (≤5.5; 5.5-6.0; 6.0-6.5; >6.5%). Serum Fe, Cu, and Zn levels were assessed using inductively-coupled plasma mass-spectrometry. Blood HbA1c, serum glucose, insulin, C-reactive protein (CRP), ferritin, and ceruloplasmin (Cp) were assessed using commercial kits...
November 16, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27869428/-hemolytic-anemia-as-the-first-clinical-presentation-of-wilson-disease-a-pediatric-case
#6
José A Henao C, Kathia Valverde Muñoz, María L Ávila A
: Wilson disease is an autosomal recessive disorder of the copper's hepatic metabolism; it results in toxicity due to accumulation of the mineral. The hemolytic anemia is present in 17% at some point of the disease, although it is a rare initial clinical presentation. CASE REPORT: 11 years old boy who presented with negative Coombs hemolytic anemia and elevation of liver enzymes. The possibility of Wilson disease was considered, which was confirmed with the finding of a Kayser-Fleischer ring in the eye exam...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27862254/hk2-proximal-tubule-epithelial-cells-synthesize-and-secrete-plasma-proteins-predominantly-through-the-apical-surface
#7
Ke-Wei Zhao, Elsa J Brochmann Murray, Samuel S Murray
Renal proximal tubule epithelial cells (PTECs) are known to reabsorb salts and small plasma proteins filtered through Bowman's capsule. Following acute kidney injury, PTECs assume some characteristics of hepatocytes in producing various plasma proteins. We now demonstrate that even at a resting state, a PTEC cell line, HK2 expresses mRNAs for and synthesizes and secretes plasma proteins in a complex with complement C3, an α2 -macroglobulin family chaperone, including albumin, transferrin, α1 -antitrypsin, α1 -antichymotrypsin, α2 -HS-glycoprotein, ceruloplasmin, haptoglobin, C1-inhibitor, secreted phosphoprotein-24, and insulin-like growth factor-1...
November 9, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27847413/determination-of-ceruloplasmin-some-other-acute-phase-proteins-and-biochemical-parameters-in-cows-with-endometritis
#8
S Kaya, O Merhan, C Kacar, A Colak, K Bozukluhan
AIM: The aim of this study is to determine serum ceruloplasmin levels in cows with endometritis of varying degrees of severity and to establish whether or not there is a correlation between acute phase protein (APP) levels and biochemical parameters. MATERIAL AND METHODS: The study was conducted with 100 Brown Swiss cows (3-8 years of age) on days 28-32 postpartum. Cows were divided into endometritis (mild, moderate, and severe endometriosis) and healthy groups based on ultrasonography, vaginoscopy, and cytological examination...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27836718/terminal-carbohydrates-abundance-immune-related-enzymes-bactericidal-activity-and-physico-chemical-parameters-of-the-senegalese-sole-solea-senegalensis-kaup-skin-mucus
#9
Francisco A Guardiola, María Cuartero, María Del Mar Collado-González, F Guillermo Díaz Baños, Alberto Cuesta, Miguel Ángel Moriñigo, M Ángeles Esteban
Recently, interest in mucosal surfaces, more specifically fish skin and its secreted mucus, has greatly increased among immunologists. The abundance of terminal carbohydrates, several enzymes (proteases, lysozyme, peroxidase, alkaline phosphatase, esterases and ceruloplasmin), bactericidal activity against fish pathogenic and non-pathogenic bacteria and several physico-chemical parameters (protein concentration, pH, conductivity, redox potential, osmolarity, density and viscosity) in the skin mucus of Senegalese sole (Solea senegalensis, Kaup) have been evaluated...
November 8, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27817091/is-aceruloplasminemia-treatable-combining-iron-chelation-and-fresh-frozen-plasma-treatment
#10
L Poli, A Alberici, P Buzzi, E Marchina, A Lanari, C Arosio, A Ciccone, F Semeraro, R Gasparotti, A Padovani, Barbara Borroni
We report the case of a patient with hereditary ceruloplasmin deficiency due to a novel gene mutation in ceruloplasmin gene (CP), treated with fresh frozen plasma (FFP) and iron chelation therapy. A 59-year-old man with a past history of diabetes was admitted to our department due to progressive gait difficulties and cognitive impairment. Neurological examination revealed a moderate cognitive decline, with mild extrapyramidal symptoms, ataxia, and myoclonus. Brain T2-weighted MR imaging showed bilateral basal ganglia hypointensity with diffuse iron deposition...
November 5, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27815605/peptide-serum-markers-in-islet-autoantibody-positive-children
#11
Christine von Toerne, Michael Laimighofer, Peter Achenbach, Andreas Beyerlein, Tonia de Las Heras Gala, Jan Krumsiek, Fabian J Theis, Anette G Ziegler, Stefanie M Hauck
AIMS/HYPOTHESIS: We sought to identify minimal sets of serum peptide signatures as markers for islet autoimmunity and predictors of progression rates to clinical type 1 diabetes in a case-control study. METHODS: A double cross-validation approach was applied to first prioritise peptides from a shotgun proteomic approach in 45 islet autoantibody-positive and -negative children from the BABYDIAB/BABYDIET birth cohorts. Targeted proteomics for 82 discriminating peptides were then applied to samples from another 140 children from these cohorts...
November 4, 2016: Diabetologia
https://www.readbyqxmd.com/read/27797330/-effect-of-iron-nanoparticles-on-free-radical-oxidation-process-in-blood-of-rats-with-pliss-lymphosarcoma
#12
P S Kachesova, I A Goroshinskaja, V B Borodulin, E V Shalashnaja, A V Chudilova, L A Nemashkalova
The use of metal nanoparticles (NPs) for cancer treatment requires careful examination of their biological effects. The aim of this study was to determine parameters of oxidative processes in the blood of tumor-bearing animals treated with metallic iron NPs only. The markers of antioxidant status and accumulation of lipid peroxidation products were measured in erythrocytes and blood plasma of rats with Pliss lymphosarcoma (PLS) and intact rats. PLS animals were treated eight times with iron NPs (at a dose of 1...
July 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27795469/impaired-thiol-disulphide-balance-in-acute-brucellosis
#13
Servet Kolgelier, Merve Ergin, Lutfi Saltuk Demir, Ahmet Cagkan Inkaya, Nazlim Aktug Demir, Murat Alisik, Ozcan Erel
The objective of this study was to examine a novel profile: thiol-disulphide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulphide profile tests were analysed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 ± 48.20 µmol/L in the acute brucellosis group and 461.13 ± 45.37 µmol/L in the healthy group, and total thiol levels were 298.58 ± 51.78 µmol/L in the acute brucellosis group and 504...
October 31, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27771984/the-effects-of-adding-ischemic-preconditioning-during-desflurane-inhalation-anesthesia-or-propofol-total-intravenous-anesthesia-on-pneumoperitoneum-induced-oxidative-stress
#14
Safinaz Karabayirli, Onder Surgit, Hulya Kasikara, Cemile Koca Bicer, Merve Ergin, Ruveyda Irem Demircioglu, Bunyamin Muslu
BACKGROUND: The aim of the study was to explore the differences in oxidative stress during anesthesia with desflurane/N2O or propofol/remifentanil in patients undergoing laparoscopic cholecystectomy and additionally to evaluate the differential effects of desflurane and propofol on ischemic preconditioning (IP). MATERIALS AND METHODS: One hundred patients were randomly allocated to four groups. For anesthesia maintenance, the inhalation group (Group I) and the inhalation plus IP group (Group IIP) received desflurane at an end-tidal concentration of 4-6 vol% in oxygen/N2O, and the TIVA group (Group T) and TIVA plus IP group (Group TIP) received infusions of propofol and remifentanil...
October 24, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27769988/influencing-the-tumor-microenvironment-phase-2-study-of-copper-depletion-with-tetrathiomolybdate-in-high-risk-breast-cancer-and-preclinical-models-of-lung-metastases
#15
Nancy Chan, Amy Willis, Naomi Kornhauser, Maureen M Ward, Sharrell B Lee, Eleni Nackos, Bo Ri Seo, Ellen Chuang, Tessa Cigler, Anne Moore, Diana Donovan, Marta Vallee Cobham, Veronica Fitzpatrick, Sarah Schneider, Alysia Wiener, Jessica Guillaume-Abraham, Elnaz Anjom, Richard Zelkowitz, J David Warren, Maureen E Lane, Claudia Fischbach, Vivek Mittal, Linda Vahdat
PURPOSE: Bone marrow derived progenitor cells; including VEGFR2+ endothelial progenitor cells (EPCs) and copper-dependent pathways model the tumor microenvironment. We hypothesized that copper depletion (CD) using tetrathiomolybdate (TM) would reduce EPCs in high risk for relapse breast cancer (BC) patients (pts). We investigated the effect of TM on the tumor microenvironment in preclinical models. EXPERIMENTAL DESIGN: Stage 2 triple negative BC (TNBC), Stage 3 and stage 4 without any evidence of disease, (NED) BC pts, received oral TM to maintain ceruloplasmin (Cp) between 8-17mg/dL for 2 years or until relapse...
October 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27765364/phyllanthin-from-phyllanthus-amarus-inhibits-cellular-and-humoral-immune-responses-in-balb-c-mice
#16
Menaga Ilangkovan, Ibrahim Jantan, Syed Nasir Abbas Bukhari
BACKGROUND: Phyllanthin found in many Phyllanthus species has various biochemical and pharmacological properties especially on its hepatoprotective effects. However, its effect on the immune system has not been well documented. PURPOSE: In the present study, phyllanthin isolated from Phyllanthus amarus was investigated for its immunosuppressive effects on various cellular and humoral immune responses in Balb/C mice. METHODS: Male mice were treated daily at 20, 40 and 100mg/kg of phyllanthin for 14 days by oral gavage...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27742903/levels-of-heavy-and-essential-trace-metals-and-their-correlation-with-antioxidant-and-health-status-in-individuals-occupationally-exposed-to-municipal-solid-wastes
#17
Adesina O Odewabi, Martins Ekor
Recent studies have indicated an increased incidence of toxic neuropathies among waste management workers (WMW) possibly linked to increased detection of heavy metals in municipal solid wastes. The present study evaluated serum levels of some heavy and essential trace metals in relation to oxidant/antioxidant status of WMW. One hundred and twenty-six WMW and 84 non-WMW (control) were recruited. Metal/element concentration was measured by atomic absorption spectrophotometry and oxidant/antioxidant markers were determined using standard procedures...
October 13, 2016: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/27695816/dexamethasone-treatment-differentially-alters-viral-shedding-and-the-antibody-and-acute-phase-protein-response-after-multivalent-respiratory-vaccination-in-beef-steers
#18
J T Richeson, J A Carroll, N C Burdick Sanchez, N D May, H D Hughes, S L Roberts, P R Broadway, K P Sharon, M A Ballou
Our objective was to examine immunosuppression induced by dexamethasone (DEX) administration in cattle on immunological responses to a multivalent respiratory vaccine containing replicating and nonreplicating agents. Steers ( = 32; 209 ± 8 kg) seronegative to infectious bovine rhinotracheitis virus (IBRV), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), and parainfluenza-3 virus (PI3V) were stratified by BW and randomly assigned to 1 of 3 treatments: 1) acute immunosuppression (ACU; 0...
August 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27651919/increased-von-willebrand-factor-levels-in-patients-with-systemic-lupus-erythematosus-reflect-inflammation-rather-than-increased-propensity-for-platelet-activation
#19
Johannes C Nossent, Warren D Raymond, Gro Østli Eilertsen
BACKGROUND: von Willebrand factor (VWF) is involved in platelet plug formation and protein transport. Increased VWF levels in systemic lupus erythematous (SLE) are considered risk factors for vascular events. VWF protein levels, however, do not accurately reflect its platelet-aggregating function, which has not been examined in SLE. METHODS: Cross-sectional study with clinical and laboratory data obtained in patients with SLE (n=92) from a regional lupus registry...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27643667/deglycosylation-influences-the-oxidation-activity-and-antigenicity-of-myeloperoxidase
#20
Jia Wang, Jian-Nan Li, Zhao Cui, Ming-Hui Zhao
BACKGROUND: Myeloperoxidase (MPO) is pathogenic in ANCA associated vasculitis. It also acts as bactericidal agent. MPO has five N-linked glycosylation sites on its heavy chains. The effect of glycosylation pattern to the functions of MPO is barely known. METHODS: We used eight glycosidases to remove different glycans on MPO separately. The chlorination activity of MPO, the binding between ceruloplasmin and MPO, and the reversing effect of MPO-ANCA to this binding were measured...
September 19, 2016: Nephrology
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