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https://www.readbyqxmd.com/read/27890596/monoacyl-phosphatidylcholine-inhibits-the-formation-of-lipid-multilamellar-structures-during-in-vitro-lipolysis-of-self-emulsifying-drug-delivery-systems
#1
Thuy Tran, Scheyla D V S Siqueira, Heinz Amenitsch, Thomas Rades, Anette Müllertz
The colloidal structures formed during lipolysis of self-emulsifying drug delivery systems (SEDDS) might affect the solubilisation and possibly the absorption of drugs. The aim of the current study is to elucidate the structures formed during the in vitro lipolysis of four SEDDS containing medium-chain glycerides and caprylocaproyl polyoxyl-8 glycerides (Labrasol), with or without monoacyl phosphatidylcholine (MAPC). In situ synchrotron small-angle X-ray scattering (SAXS) was combined with ex situ cryogenic transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS) to elucidate the generated structures...
November 24, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27704164/human-multipotent-adult-progenitor-cells-enhance-islet-function-and-revascularisation-when-co-transplanted-as-a-composite-pellet-in-a-mouse-model-of-diabetes
#2
João Paulo M C M Cunha, Gunter Leuckx, Peter Sterkendries, Hannelie Korf, Gabriela Bomfim-Ferreira, Lutgart Overbergh, Bart Vaes, Harry Heimberg, Conny Gysemans, Chantal Mathieu
AIMS/HYPOTHESIS: Hypoxia in the initial days after islet transplantation leads to considerable loss of islet mass and contributes to disappointing outcomes in the clinical setting. The aim of the present study was to investigate whether co-transplantation of human non-endothelial bone marrow-derived multipotent adult progenitor cells (MAPCs), which are non-immunogenic and can secrete angiogenic growth factors during the initial days after implantation, could improve islet engraftment and survival...
January 2017: Diabetologia
https://www.readbyqxmd.com/read/27465071/clinical-grade-human-multipotent-adult-progenitor-cells-block-cd8-cytotoxic-t-lymphocytes
#3
Jeroen Plessers, Emily Dekimpe, Matthias Van Woensel, Valerie D Roobrouck, Dominique M Bullens, Jef Pinxteren, Catherine M Verfaillie, Stefaan W Van Gool
: : MultiStem cells are clinical-grade multipotent adult bone marrow-derived progenitor cells (MAPCs), with extensive replication potential and broader differentiation capacity compared with mesenchymal stem cells. Human MAPCs suppress T-cell proliferation induced by alloantigens and mutually interact with allogeneic natural killer cells. In this study, the interaction between MultiStem and CD8(+) cytotoxic T lymphocytes (CTLs) was addressed for the first time. In an in vitro setting, the immunogenicity of MultiStem, the susceptibility of MultiStem toward CTL-mediated lysis, and its effects on CTL function were investigated...
July 27, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27424992/bone-marrow-cells-differentiation-into-organ-cells-using-stem-cell-therapy
#4
Y-J Yang, X-L Li, Y Xue, C-X Zhang, Y Wang, X Hu, Q Dai
Bone marrow cells (BMC) are progenitors of bone, cartilage, skeletal tissue, the hematopoiesis-supporting stroma and adipocyte cells. BMCs have the potential to differentiate into neural cells, cardiac myocytes, liver hepatocytes, chondrocytes, renal, corneal, blood, and myogenic cells. The bone marrow cell cultures from stromal and mesenchymal cells are called multipotent adult progenitor cells (MAPCs). MAPCs can differentiate into mesenchymal cells, visceral mesoderm, neuroectoderm and endoderm in vitro. It has been shown that the stem cells derived from bone marrow cells (BMCs) can regenerate cardiac myocytes after myocardial infarction (MI)...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27239552/osteogenic-potential-of-multipotent-adult-progenitor-cells-for-calvaria-bone-regeneration
#5
Dong Joon Lee, Yonsil Park, Wei-Shou Hu, Ching-Chang Ko
Osteogenic cells derived from rat multipotent adult progenitor cells (rMAPCs) were investigated for their potential use in bone regeneration. rMAPCs are adult stem cells derived from bone marrow that have a high proliferation capacity and the differentiation potential to multiple lineages. They may also offer immunomodulatory properties favorable for applications for regenerative medicine. rMAPCs were cultivated as single cells or as 3D aggregates in osteogenic media for up to 38 days, and their differentiation to bone lineage was then assessed by immunostaining of osteocalcin and collagen type I and by mineralization assays...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27075768/using-mirna-mrna-interaction-analysis-to-link-biologically-relevant-mirnas-to-stem-cell-identity-testing-for-next-generation-culturing-development
#6
Marian A E Crabbé, Kristel Gijbels, Aline Visser, David Craeye, Sara Walbers, Jef Pinxteren, Robert J Deans, Wim Annaert, Bart L T Vaes
UNLABELLED: Therapeutic benefit of stem cells has been demonstrated in multiple disease models and clinical trials. Robust quality assurance is imperative to make advancements in culturing procedures to enable large-scale cell manufacturing without hampering therapeutic potency. MicroRNAs (miRNAs or miRs) are shown to be master regulators of biological processes and are potentially ideal quality markers. We determined miRNA markers differentially expressed under nonclinical multipotent adult progenitor cell (MAPC) and mesenchymal stem cell (MSC) culturing conditions that regulate important stem cell features, such as proliferation and differentiation...
June 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27036558/assessment-of-metal-artifact-reduction-methods-in-pelvic-ct
#7
Mehrsima Abdoli, Abolfazl Mehranian, Angeliki Ailianou, Minerva Becker, Habib Zaidi
PURPOSE: Metal artifact reduction (MAR) produces images with improved quality potentially leading to confident and reliable clinical diagnosis and therapy planning. In this work, the authors evaluate the performance of five MAR techniques for the assessment of computed tomography images of patients with hip prostheses. METHODS: Five MAR algorithms were evaluated using simulation and clinical studies. The algorithms included one-dimensional linear interpolation (LI) of the corrupted projection bins in the sinogram, two-dimensional interpolation (2D), a normalized metal artifact reduction (NMAR) technique, a metal deletion technique, and a maximum a posteriori completion (MAPC) approach...
April 2016: Medical Physics
https://www.readbyqxmd.com/read/27025689/development-of-a-functional-biomarker-for-use-in-cell-based-therapy-studies-in-seropositive-rheumatoid-arthritis
#8
Gali Shalev-Malul, David C Soler, Anthony E Ting, Nicholas A Lehman, Emma Barnboym, Thomas S McCormick, Donald D Anthony, Hillard M Lazarus, Arnold I Caplan, Maya Breitman, Nora G Singer
UNLABELLED: Cell-based therapy has potential therapeutic value in autoimmune diseases such as rheumatoid arthritis (RA). In RA, reduction of disease activity has been associated with improvement in the function of regulatory T cells (Treg) and attenuated responses of proinflammatory effector T cells (Teff). Mesenchymal stem cells (MSCs) and related multipotent adult progenitor cells (MAPC) have strong anti-inflammatory and immunomodulatory properties and may be able to "reset" the immune system to a pre-RA state...
May 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26949962/characterization-of-odorant-compounds-from-mechanical-aerated-pile-composting-and-static-aerated-pile-composting
#9
Priyanka Kumari, Joonhee Lee, Hong-Lim Choi
We studied airborne contaminants (airborne particulates and odorous compounds) emitted from compost facilities in South Korea. There are primarily two different types of composting systems operating in Korean farms, namely mechanical aerated pile composting (MAPC) and aerated static pile composting (SAPC). In this study, we analyzed various particulate matters (PM10, PM7, PM2.5, PM1, and total suspended particles), volatile organic compounds and ammonia, and correlated these airborne contaminants with microclimatic parameters, i...
April 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26915809/formulation-and-characterization-of-self-nanoemulsifying-drug-delivery-systems-containing-monoacyl-phosphatidylcholine
#10
Thuy Tran, Xi Xi, Thomas Rades, Anette Müllertz
The study investigated the use of monoacyl phosphatidylcholine (MAPC) in self-nanoemulsifying drug delivery system (SNEDDS). A D-optimal design was used to generate two sets of formulations containing long-chain (LC) or medium-chain (MC) glycerides, caprylocaproyl macrogol-8 glycerides (Labrasol), Lipoid S LPC 80 (LPC) (80% MAPC) and ethanol. The formulations were characterized using dynamic light scattering, microscopy, in vitro lipolysis and viscometric measurements. All LC formulations within the investigated range were predicted to generate polydisperse emulsions while MC formulations generated nanoemulsions with droplet sizes from 23 to 167 nm...
April 11, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26700169/multipotent-adult-progenitor-cells-for-hypoxic-ischemic-injury-in-the-preterm-brain
#11
Reint K Jellema, Daan R M G Ophelders, Alex Zwanenburg, Maria Nikiforou, Tammo Delhaas, Peter Andriessen, Robert W Mays, Robert Deans, Wilfred T V Germeraad, Tim G A M Wolfs, Boris W Kramer
BACKGROUND: Preterm infants are at risk for hypoxic-ischemic encephalopathy. No therapy exists to treat this brain injury and subsequent long-term sequelae. We have previously shown in a well-established pre-clinical model of global hypoxia-ischemia (HI) that mesenchymal stem cells are a promising candidate for the treatment of hypoxic-ischemic brain injury. In the current study, we investigated the neuroprotective capacity of multipotent adult progenitor cells (MAPC®), which are adherent bone marrow-derived cells of an earlier developmental stage than mesenchymal stem cells and exhibiting more potent anti-inflammatory and regenerative properties...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/26582249/intravenous-multipotent-adult-progenitor-cell-treatment-decreases-inflammation-leading-to-functional-recovery-following-spinal-cord-injury
#12
Marc A DePaul, Marc Palmer, Bradley T Lang, Rochelle Cutrone, Amanda P Tran, Kathryn M Madalena, Annelies Bogaerts, Jason A Hamilton, Robert J Deans, Robert W Mays, Sarah A Busch, Jerry Silver
Following spinal cord injury (SCI), immune-mediated secondary processes exacerbate the extent of permanent neurological deficits. We investigated the capacity of adult bone marrow-derived stem cells, which exhibit immunomodulatory properties, to alter inflammation and promote recovery following SCI. In vitro, we show that human multipotent adult progenitor cells (MAPCs) have the ability to modulate macrophage activation, and prior exposure to MAPC secreted factors can reduce macrophage-mediated axonal dieback of dystrophic axons...
November 19, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26494783/solution-phase-crosstalk-and-regulatory-interactions-between-multipotent-adult-progenitor-cells-and-peripheral-blood-mononuclear-cells
#13
Gregory G Burrows, Wouter Van't Hof, Ashok P Reddy, Phillip A Wilmarth, Larry L David, Amy Raber, Annelies Bogaerts, Lien Timmerman, Jef Pinxteren, Valerie D Roobrouck, Robert J Deans, Richard T Maziarz
UNLABELLED: Multipotent adult progenitor cells (MAPCs) are adult adherent stromal stem cells currently being assessed in clinical trials for acute graft versus host disease with demonstrated immunomodulatory capabilities and the potential to ameliorate detrimental autoimmune and inflammation-related processes. Anti-CD3/anti-CD28 (3/28) activation of T cells within the peripheral blood mononuclear cell (PBMC) compartment was performed in the presence or absence of MAPCs. Liquid chromatography-coupled tandem mass spectrometry was used to characterize the differential secretion of proteins, and transcriptional profiling was used to monitor mRNA expression changes in both cell populations...
December 2015: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26457195/risk-factors-for-refractory-diabetic-macular-oedema-after-sub-tenon-s-capsule-triamcinolone-acetonide-injection
#14
Toshiyuki Oshitari, Yuta Kitamura, Sakiko Nonomura, Miyuki Arai, Yoko Takatsuna, Eiju Sato, Takayuki Baba, Shuichi Yamamoto
The purpose of this study is to identify the risk factors for a recurrence or persistence of diabetic macular oedema (DME) after a sub-Tenon's capsule triamcinolone acetonide (STTA) injection. The medical records of 124 patients (124 eyes) treated by STTA were reviewed. The age, sex, HbA1c level, best-corrected visual acuity, central macular thickness, insulin use, pioglitazone use, systemic hypertension, serous retinal detachment, proteinuria, panretinal photocoagulation, microaneurysm photocoagulation (MAPC), subthreshold micropulse diode laser photocoagulation (SMDLP), cataract surgery, and history of vitrectomy were examined by logistic regression analysis...
2015: Journal of Ophthalmology
https://www.readbyqxmd.com/read/26377390/neuroinflammatory-signals-enhance-the-immunomodulatory-and-neuroprotective-properties-of-multipotent-adult-progenitor-cells
#15
Stylianos Ravanidis, Jeroen F J Bogie, Raf Donders, David Craeye, Robert W Mays, Robert Deans, Kristel Gijbels, Annelies Bronckaers, Piet Stinissen, Jef Pinxteren, Niels Hellings
INTRODUCTION: Stem cell-based therapies are currently widely explored as a tool to treat neuroimmune diseases. Multipotent adult progenitor cells (MAPC) have been suggested to have strong immunomodulatory and neuroprotective properties in several experimental models. In this study, we investigate whether MAPC are of therapeutic interest for neuroinflammatory disorders such as multiple sclerosis by evaluating their capacities to modulate crucial pathological features and gain insights into the molecular pathways involved...
2015: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26345383/assessment-of-bystander-killing-mediated-therapy-of-malignant-brain-tumors-using-a-multimodal-imaging-approach
#16
Cindy Leten, Jesse Trekker, Tom Struys, Tom Dresselaers, Rik Gijsbers, Greetje Vande Velde, Ivo Lambrichts, Annemie Van Der Linden, Catherine M Verfaillie, Uwe Himmelreich
INTRODUCTION: In this study, we planned to assess if adult stem cell-based suicide gene therapy can efficiently eliminate glioblastoma cells in vivo. We investigated the therapeutic potential of mouse Oct4(-) bone marrow multipotent adult progenitor cells (mOct4(-) BM-MAPCs) in a mouse glioblastoma model, guided by multimodal in vivo imaging methods to identify therapeutic windows. METHODS: Magnetic resonance imaging (MRI) of animals, wherein 5 × 10(5) syngeneic enhanced green fluorescent protein-firefly luciferase-herpes simplex virus thymidine kinase (eGFP-fLuc-HSV-TK) expressing and superparamagnetic iron oxide nanoparticle labeled (1 % or 10 %) mOct4(-) BM-MAPCs were grafted in glioblastoma (GL261)-bearing animals, showed that labeled mOct4(-) BM-MAPCs were located in and in close proximity to the tumor...
2015: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26303324/maximising-the-diagnostic-potential-of-aptt-based-screening-assays-for-activated-protein-c-resistance
#17
G W Moore, E Chege, A P Culhane, B J Hunt
INTRODUCTION: Activated protein C resistance (APC-R) due to FV Leiden is the most common hereditary thrombophilia. Rarer FV mutations can also confer APC-R, and acquired APC-R is encountered in a number of conditions. APC-R screening with clotting tests is common, yet they are prone to interferences and elevated baseline clotting times can invalidate testing. METHODS: APTT-based classic APC-R (CAPC-R) screening, and modified screening (MAPC-R) employing dilution in FV-deficient plasma were performed on an automated analyser...
December 2015: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/26264617/immature-myeloid-cells-and-tolerogenic-cytokine-profile-in-lung-adenocarcinoma-metastatic-lymph-nodes-assessed-by-endobronchial-ultrasound
#18
Antonio Bugalho, Catarina Martins, Zelia Silva, Gloria Nunes, Andreia S Mendes, Inês Ferreira, Paula A Videira
In lung cancer, the immune cell compartment of tumor-draining lymph nodes (TDLNs) dictate the response against tumors. This response is predominantly triggered by myeloid antigen-presenting cells (mAPCs) that capture antigens and, if matured, prime anti-tumor-specific T cell populations. However, the clinical role of mAPCs infiltrated in TDLN from lung cancer patients is poorly understood. The purpose of this study was to study mAPCs in TDLN from lung adenocarcinoma patients, in comparison to individuals with non-malignant diseases, using minimally invasive sampling methods...
January 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26216515/suppression-of-il-7-dependent-effector-t-cell-expansion-by-multipotent-adult-progenitor-cells-and-pge2
#19
James L Reading, Bart Vaes, Caroline Hull, Shereen Sabbah, Thomas Hayday, Nancy S Wang, Anthony DiPiero, Nicholas A Lehman, Jen M Taggart, Fiona Carty, Karen English, Jef Pinxteren, Robert Deans, Anthony E Ting, Timothy I M Tree
T-cell depletion therapy is used to prevent acute allograft rejection, treat autoimmunity and create space for bone marrow or hematopoietic cell transplantation. The evolved response to T-cell loss is a transient increase in IL-7 that drives compensatory homeostatic proliferation (HP) of mature T cells. Paradoxically, the exaggerated form of this process that occurs following lymphodepletion expands effector T-cells, often causing loss of immunological tolerance that results in rapid graft rejection, autoimmunity, and exacerbated graft-versus-host disease (GVHD)...
November 2015: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/26104213/genetics-of-peptidoglycan-biosynthesis
#20
REVIEW
Martin S Pavelka, Sebabrata Mahapatra, Dean C Crick
The complex cell envelope is a hallmark of mycobacteria and is anchored by the peptidoglycan layer, which is similar to that of Escherichia coli and a number of other bacteria but with modifications to the monomeric units and other structural complexities that are likely related to a role for the peptidoglycan in stabilizing the mycolyl-arabinogalactan-peptidoglycan complex (MAPc). In this article, we will review the genetics of several aspects of peptidoglycan biosynthesis in mycobacteria, including the production of monomeric precursors in the cytoplasm, assembly of the monomers into the mature wall, cell wall turnover, and cell division...
August 2014: Microbiology Spectrum
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