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Major depressive disorder disability

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https://www.readbyqxmd.com/read/27908899/undertreatment-of-people-with-major-depressive-disorder-in-21-countries
#1
Graham Thornicroft, Somnath Chatterji, Sara Evans-Lacko, Michael Gruber, Nancy Sampson, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Jordi Alonso, Laura Andrade, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, Jose Miguel Caldas de Almeida, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Josep Maria Haro, Yanling He, Hristo Hinkov, Elie Karam, Norito Kawakami, Sing Lee, Fernando Navarro-Mateu, Marina Piazza, Jose Posada-Villa, Yolanda Torres de Galvis, Ronald C Kessler
BACKGROUND: Major depressive disorder (MDD) is a leading cause of disability worldwide. AIMS: To examine the: (a) 12-month prevalence of DSM-IV MDD; (b) proportion aware that they have a problem needing treatment and who want care; (c) proportion of the latter receiving treatment; and (d) proportion of such treatment meeting minimal standards. METHOD: Representative community household surveys from 21 countries as part of the World Health Organization World Mental Health Surveys...
December 1, 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27901522/the-effect-of-remission-status-on-work-functioning-in-employed-patients-treated-for-major-depressive-disorder
#2
David Sarfati, Kurtis Stewart, Cindy Woo, Sagar V Parikh, Lakshmi N Yatham, Raymond W Lam
BACKGROUND: The ability to function at work is impaired in patients with major depressive disorder (MDD) but few clinical trials include occupational outcome assessments. This study examined whether symptom remission following treatment for MDD is associated with work functioning improvement. METHODS: We conducted a secondary analysis of a 12-week randomized clinical trial comparing escitalopram with or without telephone-administered cognitive therapy in employed patients with MDD (N = 86)...
November 1, 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27900342/cacna1c-protecting-young-hippocampal-neurons-in-the-adult-brain
#3
Héctor De Jesús-Cortés, Anjali M Rajadhyaksha, Andrew A Pieper
Neuropsychiatric disease is the leading cause of disability in the United States, and fourth worldwide.(1,2) Not surprisingly, human genetic studies have revealed a common genetic predisposition for many forms of neuropsychiatric disease, potentially explaining why overlapping symptoms are commonly observed across multiple diagnostic categories. For example, the CACNA1C gene was recently identified in the largest human genome-wide association study to date as a risk loci held in common across 5 major forms of neuropsychiatric disease: bipolar disorder, schizophrenia, major depressive disorder (MDD), autism spectrum disorder and attention deficit-hyperactivity disorder...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27889704/pharmacogenetic-studies-a-tool-to-improve-antidepressant-therapy
#4
Marta Ramos, Cecilia Berrogain, Julia Concha, Laura Lomba, Cristina Belén García, Mª Pilar Ribate
The World Health Organization (WHO) predicts that major depressive disorder (MDD) will be the second leading cause of death and disability by 2020. Nowadays, approximately 60-70% of patients with this disorder have shown the lack of effectiveness and tolerability of the therapy with antidepressants. The US Food and Drug Administration (FDA) and the European Medicine Agency (EMA) are including pharmacogenetic information in the labeling of several antidepressants. The presence of this information represents the relevance of genetic polymorphisms in drug response...
December 1, 2016: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/27882843/somatic-symptom-disorder-treated-with-electroconvulsive-therapy
#5
Anna Borisovskaya, Jay Alan Augsburger
Somatic symptom disorder (SSD) is a challenging condition to treat with chronic pain, a common and disabling symptom. We present a patient who received electroconvulsive therapy (ECT) for SSD with significant improvement in pain and gastrointestinal symptoms. We also present a brief literature review of similar cases treated with ECT. Preliminary evidence suggests that ECT should be considered for treatment of SSD comorbid with major depressive disorder, when standard treatments fail. Further research is needed to clarify whether ECT can be used for SSD without associated depression...
November 24, 2016: Pain Management
https://www.readbyqxmd.com/read/27879500/implications-of-preterm-birth-for-maternal-mental-health-and-infant-development
#6
Cheryl Anderson, Priscila Cacola
Preterm birth remains a major contributor to infant mortality and morbidity including neurodevelopmental delay and childhood disability. Mothers experiencing a preterm birth are at risk for maternal mental health issues, inclusive of depression and posttraumatic stress disorder (PTSD), which may affect mother-infant attachment and infant development. Depression and PTSD, frequently comorbid, following preterm birth and relationships between these symptoms, maternal-infant attachment, and infant development are reviewed...
November 22, 2016: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27878517/risks-associated-with-misuse-of-ketamine-as-a-rapid-acting-antidepressant
#7
Weili Zhu, Zengbo Ding, Yinan Zhang, Jie Shi, Kenji Hashimoto, Lin Lu
Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide. Conventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hindered their ability to attain beneficial effects in depressed individuals at high risk of suicide. The non-competitive N-methyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans. The emergence of ketamine as a fast-acting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression...
December 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27870302/the-effect-on-mental-health-of-retiring-during-the-economic-crisis
#8
Michele Belloni, Elena Meschi, Giacomo Pasini
This paper investigates the causal impact of retirement on late-life mental health, a growing concern for public health, because major depressive disorders are the second leading cause of disability. We shed light on the role of economic conditions in shaping the effect of retirement on mental health by exploiting time and regional variation in the severity of the economic crisis across 10 European countries during 2004-2013. We use data from four waves of the Survey of Health, Ageing and Retirement in Europe and address the potential endogeneity of the retirement decision to mental health by applying a fixed-effects instrumental variables approach...
November 2016: Health Economics
https://www.readbyqxmd.com/read/27866430/assessing-catastrophic-thinking-associated-with-debilitating-mental-health-conditions
#9
Emily Moore, Heather Adams, Tamra Ellis, Pascal Thibault, Michael J L Sullivan
PURPOSE: The present study examined the psychometric properties of the Symptom Catastrophizing Scale (SCS). The SCS items were drawn from the Pain Catastrophizing Scale but were modified to make them better suited to the context of debilitating mental health conditions that are not necessarily associated with pain. The number of items was reduced from 13 to 7, and the response scale was simplified. METHODS: The SCS was administered to individuals diagnosed with Major Depressive Disorder (MDD) (N = 79) or with a chronic musculoskeletal (MSK) condition (N = 88)...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27863295/the-effect-of-early-psychological-symptom-severity-on-long-term-functional-recovery-a-secondary-analysis-of-data-from-a-cohort-study-of-minor-injury-patients
#10
Sara F Jacoby, Justine Shults, Therese S Richmond
BACKGROUND: The mental health consequences of injuries can interfere with recovery to pre-injury levels of function and long term wellbeing. OBJECTIVES: The purpose of this study was to explore the relationship between psychological symptoms after minor injury and long-term functional recovery and disability. DESIGN: This exploratory study uses secondary data derived from a longitudinal cohort study of psychological outcomes after minor injury...
November 9, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27861191/effects-of-levomilnacipran-extended-release-on-major-depressive-disorder-patients-with-cognitive-impairments-post-hoc-analysis-of-a-phase-iii-study
#11
Keith A Wesnes, Carl Gommoll, Changzheng Chen, Angelo Sambunaris, Roger S McIntyre, Philip D Harvey
Performance-based cognitive data were collected using the Cognitive Drug Research System in a study of levomilnacipran extended-release (ER) 40-120 mg/day (NCT01034462) in adults with major depressive disorder. These data were analyzed post-hoc to explore the relationship between cognitive measures, depression symptoms (Montgomery-Åsberg Depression Rating Scale, MADRS), and self-reported psychosocial functioning (Sheehan Disability Scale; SDS). Changes from baseline were analyzed in the intent-to-treat population and subgroups with impaired attention, as indicated by baseline Cognitive Drug Research System scores for Power of Attention and Continuity of Attention...
November 16, 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27859868/preferences-of-psychiatric-practitioners-for-core-symptoms-of-major-depressive-disorder-a-hidden-conjoint-analysis
#12
Matthias W Riepe, Peter Gritzmann, Andreas Brieden
According to ICD-10 and DSM-V, symptoms of depressive disorder are considered to be equally important for severity judgment. It was the goal to investigate the weight of selected symptom complexes for severity judgment. In workaday life severity judgment results from an overall impression rather than from calculating severity in different symptom complexes, separately. In fact, the drivers for overall judgment may not be known explicitly to the psychiatrist himself. A method of choice to resolve this is conjoint analysis...
November 9, 2016: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/27856684/psychedelics-in-the-treatment-of-unipolar-mood-disorders-a-systematic-review
#13
REVIEW
James Jh Rucker, Luke A Jelen, Sarah Flynn, Kyle D Frowde, Allan H Young
Unipolar mood disorders, including major depressive disorder and persistent depressive disorder (dysthymia), confer high rates of disability and mortality and a very high socioeconomic burden. Current treatment is suboptimal in most cases and there is little of note in the pharmaceutical development pipeline. The psychedelic drugs, including lysergic acid diethylamide and psilocybin, were used extensively in the treatment of mood disorders, and other psychiatric conditions, before their prohibition in the late 1960s...
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27836433/sex-differences-in-the-epidemiology-clinical-features-and-pathophysiology-of-migraine
#14
REVIEW
Kjersti Grøtta Vetvik, E Anne MacGregor
Migraine is two to three times more prevalent in women than men, and women report a longer attack duration, increased risk of headache recurrence, greater disability, and a longer period of time required to recover. Conditions recognised to be comorbid with migraine include asthma, anxiety, depression, and other chronic pain conditions, and these comorbidities add to the amount of disability in both sexes. Migraine-specifically migraine with aura-has been identified as a risk factor for vascular disorders, particularly in women, but because of the scarcity of data, the comparative risk in men has yet to be established...
November 8, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27836390/agmatine-a-potential-novel-therapeutic-strategy-for-depression
#15
Andiara E Freitas, Vivian B Neis, Ana Lúcia S Rodrigues
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence of up to 20% worldwide. It is responsible for more years lost to disability than any other disorder. Despite the fact that current available antidepressant drugs are safe and effective, they are far from ideal. In addition to the need to administer the drugs for weeks or months to obtain clinical benefit, side effects are still a serious problem. Agmatine is an endogenous polyamine synthesized by the enzyme arginine decarboxylase...
November 8, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27822276/demographic-and-diagnostic-features-of-3147-inpatients-with-mood-disorders-in-iran
#16
Atefeh Ghanbari Jolfaei, Pari Ghadamgahi, Masoud Ahmadzad-Asl, Amir Shabani
OBJECTIVES: To assess and compare demographic and diagnostic characteristics of inpatients with mood disorders in Iran. MATERIALS AND METHODS: We collected the demographic, clinical, and treatment characteristics of patients, who were hospitalized during five years from April 2006 to March 2010, in Iran hospital of psychiatry, a residency training center to evaluate the general clinical picture of the disorder. RESULTS: Overall, 95.3% of subjects had a diagnosis of bipolar I disorder (BID), 2...
September 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27822042/efficacy-and-safety-of-multiple-doses-of-levomilnacipran-extended-release-for-the-treatment-of-major-depressive-disorder
#17
Qunlian Huang, Xiaoyan Zhong, Ye Yun, Bin Yu, Yilan Huang
OBJECTIVE: The aim of this meta-analysis was to evaluate the efficacy and safety of levomilnacipran extended-release (ER) in the treatment of major depressive disorder (MDD). METHODS: Randomized controlled trials were searched by electronic databases. Unpublished data were also searched by the relevant websites. Weighted mean difference (WMD) and risk ratio (RR) with 95% confidence interval (CI) were calculated and pooled using fixed-effects model or random-effects model...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27819782/-dynamic-long-term-and-institutional-psychotherapy-to-treat-persistent-depressive-disorders
#18
Jorge Garibay
BACKGROUND: Major depression is a public health problem that threatens to become the second leading cause of disability in the world. In this study we show the results obtained once we applied a psychodynamic psychotherapeutic and long-term process in patients with major depressive disorder, attending a public health institution (PHI). METHODS: From a list of female volunteers, we randomly selected 30 patients who met the diagnostic criteria of major depression...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27807927/perceptions-of-stigma-and-its-correlates-among-patients-with-major-depressive-disorder-a-multicenter-survey-from-china
#19
Feng Shi-Jie, Gao Hong-Mei, Wang Li, Wang Bin-Hong, Fang Yi-Ru, Wang Gang, Si Tian-Mei
BACKGROUND: The stigma of major depressive disorder (MDD) is an important public health problem. This study evaluated stigma in MDD patients in China using explanatory model interview catalogue (EMIC) questionnaire and the demographic and clinical symptom factors associated with the stigma of these patients. METHODS: A total of 158 MDD patients from domestic 3 mental health centers were surveyed. We used the EMIC questionnaire to assess stigma of these patients, Montgomery and Asberg depression rating scale (MADRS) to assess depressive severity, self-reporting inventory (SCL-90) to assess mental health level, Sheehan disability scale (SDS) to assess social function, and fatigue severity scale (FSS) to assess degree of fatigue...
November 2, 2016: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/27792800/cutaneous-allodynia-and-its-risk-factors-in-korean-patients-with-migraine-a-survey-of-two-tertiary-care-hospitals
#20
Sun-Young Kim, Sung-Pa Park
AIMS: To measure the prevalence of cutaneous allodynia in Korean patients with migraine and to characterize the differential risks of migraine-associated factors and psychiatric disorders in its development. METHODS: The study included consecutive patients with migraine who visited headache clinics at two tertiary care hospitals. Questionnaires including the 12-item Allodynia Symptom Checklist (ASC-12) and the Migraine Disability Assessment (MIDAS) were administered to the patients...
October 2016: Journal of Oral & Facial Pain and Headache
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