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Major depressive disorder disability

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https://www.readbyqxmd.com/read/29140227/categorical-improvement-in-functional-impairment-in-depressed-patients-treated-with-desvenlafaxine
#1
Claudio N Soares, Min Zhang, Matthieu Boucher
OBJECTIVE: This post-hoc pooled analysis evaluated categorical change in functional impairment in patients with major depressive disorder (MDD) treated with desvenlafaxine versus placebo and examined whether early improvement in functioning predicted functional outcomes at study endpoint. METHODS: Data were pooled from eight randomized, double-blind, placebo-controlled studies of desvenlafaxine for the treatment of MDD, including adults who were randomly assigned to receive desvenlafaxine 50 or 100 mg/d or placebo (N=3,384)...
November 15, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29131091/apathy-profile-in-parkinson-s-and-huntington-s-disease-a-comparative-cross-sectional-study
#2
Mário Sousa, Fradique Moreira, Joana Jesus-Ribeiro, Inês Marques, Flávia Cunha, Nádia Canário, António Freire, Cristina Januário
BACKGROUND/AIMS: Apathy is one of the most frequent, disabling and difficult-to-treat symptoms that show up in many neurodegenerative disorders. The aim of this study was to assess and compare apathy profile in Parkinson's and Huntington's patients using the same comprehensive instruments to measure apathy, cognition and depressive symptoms. MATERIALS AND METHODS: We consecutively assessed Parkinson's disease (PD) and Huntington's disease (HD) patients recruited from a Movement Disorders Unit...
November 13, 2017: European Neurology
https://www.readbyqxmd.com/read/29121983/early-psychological-screening-of-intensive-care-unit-survivors-a-prospective-cohort-study
#3
Anna Milton, Emily Brück, Anna Schandl, Matteo Bottai, Peter Sackey
BACKGROUND: A majority of patients survive their episode of critical illness but up to 30% of patients suffer from psychological problems such as post-traumatic stress, anxiety and depression in the year after intensive care unit (ICU) stay. A method to identify discharged patients at risk for adverse psychological outcome would be helpful in the triage for ICU follow-up and could enable early intervention. The aim of this study was to evaluate whether early screening with validated questionnaires after ICU discharge can identify patients at risk for symptoms of post-traumatic stress, anxiety and depression 3 months after ICU stay...
November 9, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29117922/depression-anxiety-and-post-traumatic-stress-disorder-among-youth-in-low-and-middle-income-countries-a-review-of-prevalence-and-treatment-interventions
#4
REVIEW
Swetha Yatham, Shalini Sivathasan, Rosalia Yoon, Tricia L da Silva, Arun V Ravindran
BACKGROUND: Low and middle income countries (LMICs) not only have the majority of the world's population but also the largest proportion of youth. Poverty, civil conflict and environmental stressors tend to be endemic in these countries and contribute to significant psychiatric morbidity, including depression, anxiety and post-traumatic stress disorder (PTSD). However, mental health data from LMICs is scarce, particularly data on youth. Evaluation of such information is crucial for planning services and reducing the burden of disability...
October 31, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29113521/efficacy-and-safety-of-vortioxetine-for-the-treatment-of-major-depressive-disorder-a-randomised-double-blind-placebo-controlled-study
#5
Jing Wang, Xi-Fang Liu, Chong Feng, Quan Bao, Hong-Ran Fu
OBJECTIVE: This study aimed to evaluate the efficacy and adverse events of vortioxetine for Chinese patients with major depressive disorder (MDD) over 10 weeks. METHODS: A total of 120 patients with MDD were randomly assigned to two groups that received vortioxetine 20 mg or placebo for 10 weeks. The outcomes were the change from baseline in the Montgomery-Åsberg Depression Rating Scale (MADRS), Hamilton Anxiety Rating Scale (HAM-A), Clinical Global Impressions-Improvement (CGI-I) scale, Sheehan Disability Scale (SDS) at Week 10, and the presence of adverse events...
November 7, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29107762/major-depression-prevention-effects-for-a-cognitive-behavioral-adolescent-indicated-prevention-group-intervention-across-four-trials
#6
Paul Rohde, Frédéric N Brière, Eric Stice
Major depressive disorder (MDD) in young people is a leading cause of disability but most depressed youth are not treated, emphasizing the need for effective prevention. Our goal is to synthesize MDD onset prevention effects for the Blues Program, a brief cognitive-behavioral (CB) indicated prevention group, by merging data from four trials (three of which included CB bibliotherapy) and conducting an individual patient data (IPD) meta-analysis. Data were available from 766 high school/college students (M age = 16...
October 31, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29100658/the-role-of-genes-and-environment-on-brain-alterations-in-major-depressive-disorder-a-review-of-twin-studies
#7
A Pigoni, G Delvecchio, A C Altamura, J C Soares, C Fagnani, P Brambilla
BACKGROUND: Although it has been consistently reported the important role of genetic and environmental risk factors on structural and functional alterations in Major Depressive Disorder (MDD), the mechanism and the magnitude of the interactions between specific genetic and/or environmental risk factors on brain structures in this disabling disorder are still elusive. Therefore, in the last two decades an increased interest has been devoted to neuroimaging investigations on monozygotic and dizygotic twin samples mainly because their intrinsic characteristics may help to separate the effects of genetic and environmental risk factors on clinical phenotypes, including MDD...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29097256/the-pathophysiological-mechanisms-of-motivational-deficits-in-parkinson-s-disease
#8
REVIEW
A Chagraoui, L Boukhzar, F Thibaut, Y Anouar, D Maltête
Parkinson's disease (PD) is a progressive degenerative disorder that leads to disabling motor symptoms and a wide variety of neuropsychiatric symptoms. Apathy is the most common psychiatric disorder in the early stages of untreated PD and can be defined as a hypodopaminergic syndrome, which also includes anxiety and depression. Apathy is also considered the core feature of the parkinsonian triad (apathy, anxiety and depression) of behavioural non-motor signs, including a motivational deficit. Moreover, apathy is recognised as a distinct chronic neuropsychiatric behavioural disorder based on specific diagnostic criteria...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29096528/the-presence-of-co-morbid-mental-health-problems-in-a-cohort-of-adolescents-with-chronic-fatigue-syndrome
#9
Maria Elizabeth Loades, Katharine A Rimes, Sheila Ali, Kate Lievesley, Trudie Chalder
OBJECTIVE: To report on the prevalence of mental health disorders in adolescents with chronic fatigue syndrome (CFS) and to compare the diagnoses identified by a brief clinician-administered psychiatric interview with self-report screening questionnaires. DESIGN: Cross-sectional study. SETTING: Consecutive attenders to specialist CFS clinics in the United Kingdom. PATIENTS: N = 52 adolescents, age 12-18 years with CFS...
October 1, 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/29076893/major-depression-and-its-treatment-micrornas-as-peripheral-biomarkers-of-diagnosis-and-treatment-response
#10
Juan P Lopez, Aron Kos, Gustavo Turecki
PURPOSE OF REVIEW: Major depressive disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Despite its considerable burden, our understanding of its pathophysiology remains rudimentary, and a validated biomarker has yet to be identified. Antidepressants are the most common treatment for MDD, yet roughly one-third of patients experience an inadequate response. Thus, there is a great need for not only identifying biomarkers of MDD but also those that can predict and monitor or just monitor response to treatment...
October 25, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29057368/intervention-development-for-the-indicated-prevention-of-depression-in-later-life-the-dil-protocol-in-goa-india
#11
Amit Dias, Fredric Azariah, Public Health, Alex Cohen, Stewart Anderson, Jennifer Morse, Pim Cuijpers, Miriam Sequeira, M A Psychology, Vithoba Gaude, Salvino Soares, Vikram Patel, Charles F Reynolds
Because depression is a major source of the global burden of illness- related disability, developing effective strategies for reducing its incidence is an important public health priority, especially in low-income countries, where resources for treating depression are scarce. We describe in this report an intervention development project, funded by the US National Institute of Mental Health, to address "indicated" prevention of depression in older adults attending rural and urban primary care clinics in Goa, India...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29055445/systematic-review-of-depression-in-patients-with-multiple-sclerosis-and-its-relationship-to-interferon%C3%AE-treatment
#12
REVIEW
Leila Alba Palé, Jordi León Caballero, Berta Samsó Buxareu, Purificación Salgado Serrano, Víctor Pérez Solà
BACKGROUND: Multiple sclerosis is a chronic disease considered the major cause of neurological disability in young adults worldwide. While depression is considered a determinant factor of impaired quality of life and poorer prognosis among patients with multiple sclerosis, it is very often dismissed and undertreated by physicians. Depression has been related to treatment with some immunomodulatory drugs, such as IFNβ. Data from patients who committed suicide during the pivotal study of interferon used as a disease modifying treatment in multiple sclerosis support this association...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29051086/depression-subtyping-based-on-evolutionary-psychiatry-proximate-mechanisms-and-ultimate-functions
#13
REVIEW
Markus J Rantala, Severi Luoto, Indrikis Krams, Hasse Karlsson
Major depressive disorder constitutes one of the leading causes of disability worldwide. However, it is not a unitary disease-it is a heterogeneous syndrome, with patients differing remarkably in symptom profile, pathophysiology and treatment responsiveness. Previous attempts to subtype major depressive disorder have showed limited clinical applicability. We present a classification of major depressive disorder episodes based on the proximate mechanisms that led to the original mood change that caused the depressive episode...
October 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29049554/genetic-association-of-major-depression-with-atypical-features-and-obesity-related-immunometabolic-dysregulations
#14
Yuri Milaneschi, Femke Lamers, Wouter J Peyrot, Bernhard T Baune, Gerome Breen, Abbas Dehghan, Andreas J Forstner, Hans J Grabe, Georg Homuth, Carol Kan, Cathryn Lewis, Niamh Mullins, Matthias Nauck, Giorgio Pistis, Martin Preisig, Margarita Rivera, Marcella Rietschel, Fabian Streit, Jana Strohmaier, Alexander Teumer, Sandra Van der Auwera, Naomi R Wray, Dorret I Boomsma, Brenda W J H Penninx
Importance: The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. Objective: To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin)...
October 18, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29019415/pain-characteristics-of-older-persons-with-medically-unexplained-symptoms-older-persons-with-medically-explained-symptoms-and-older-persons-with-depression
#15
Denise J C Hanssen, Peter L B J Lucassen, Paul Naarding, Margot W M de Waal, Richard C Oude Voshaar
OBJECTIVES: The main objective of the current study is to compare chronic pain characteristics of older patients with Medically Unexplained Symptoms (MUS), to those of patients with Medically Explained Symptoms (MES), and to those of patients with Major Depressive Disorder (MDD). METHOD: By combining data from the OPUS and NESDO study, we compared pain characteristics of 102 older (>60 years) MUS-patients to 145 older MES-patients and 275 older MDD-patients in a case-control study design...
October 11, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28993544/distress-related-to-individual-depressive-symptoms-a-cross-sectional-study-in-thai-patients-with-major-depression
#16
T Rungpetchwong, S Likhitsathian, S Jaranai, M Srisurapanont
OBJECTIVE: To examine the distress related to individual depressive symptoms, the correlation between symptom distress and disability, and the gender difference in distress levels in patients with major depressive disorder. METHODS: This was a cross-sectional, observational study carried out at a university hospital providing tertiary care in northern Thailand. Participants were patients with major depressive disorder aged between 18 and 65 years. Depression severity was self-rated using the 9-item Patient Health Questionnaire (PHQ-9)...
September 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/28992527/sex-differences-in-the-mediators-of-functional-disability-in-major-depressive-disorder
#17
Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Danielle S Cha, Yena Lee, Dominika Fus, Roger S McIntyre
The aim of this study was to investigate sex differences in discrete domains of psychopathology as mediators of functional disability among individuals with Major Depressive Disorder (MDD). Adults (ages 18-65) with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls (HC; n = 100) participated in a clinical trial validating the THINC-integrated tool, a newly developed cognitive assessment tool for patients with MDD. Variables assessed as possible mediators included depression symptom severity, anxiety symptoms, sleep disturbance, perceived cognitive deficits, and objective cognitive performance...
September 30, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28988102/number-of-illness-episodes-as-predictor-of-residual-symptoms-in-major-depressive-disorder
#18
Gianluca Serafini, Jacopo Nebbia, Nicolò Cipriani, Claudia Conigliaro, Denise Erbuto, Maurizio Pompili, Mario Amore
Notwithstanding major depressive disorder (MDD) is a recurring and chronic condition, relatively few variables have consistently been shown to predict its course. Residual depressive symptoms may be associated with disability and functional impairment but few studies evaluated clinical correlates associated with these symptoms and their impact on functioning after adjustment for potential confounders. Therefore, our study aimed to investigate factors associated with residual depressive symptoms and their impact on the course of MDD...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28960863/impact-of-pain-and-remission-in-the-functioning-of-patients-with-depression-in-mainland-china-taiwan-and-hong-kong
#19
Diego Novick, Qiang Shi, Li Yue, Maria Victoria Moneta, Sara Siddi, Josep Maria Haro
INTRODUCTION: The present study analyzes functioning during the course of treatment of a major depressive disorder in Mainland China, Taiwan, and Hong Kong. METHODS: Data in this post hoc analysis were taken from a 24-week prospective, observational study in 12 countries worldwide. Of these, 422 patients were included from Mainland China (N = 205; 48.6%), Taiwan (N = 199; 47.2%), and Hong Kong (N = 18; 4.2%). Functioning was measured with the Sheehan Disability Scale, pain with the Somatic Symptom Inventory, and depression severity with the Quick Inventory of Depressive Symptomatology Self Report 16...
September 28, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/28953809/depression-sleep-disturbances-and-anxiety-in-patients-with-relapsing-remitting-multiple-sclerosis-a-longitudinal-cohort-observation
#20
Paulina Brozek, Marta Brachmanska, Katarzyna Rabiczko, Weronika Bulska, Marta Ciulkowicz, Ewa Krzystanek
BACKGROUND: Depression, sleep disturbances and anxiety may affect almost half of the population of patients with multiple sclerosis (MS) and they are major determinants of poor quality of life in young adults. The aim of our study was to assess their incidence in patients with MS in Poland, and whether they change during longitudinal observation in routine clinical practice. SUBJECTS AND METHODS: We included 53 consecutive patients with relapsing-remitting form of MS in this prospective study, who were treated in our department...
September 2017: Psychiatria Danubina
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