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Major depressive disorder disability

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https://www.readbyqxmd.com/read/28529691/recent-advances-in-predicting-responses-to-antidepressant-treatment
#1
REVIEW
Thomas Frodl
Major depressive disorder is one of the leading causes of disability in the world since depression is highly frequent and causes a strong burden. In order to reduce the duration of depressive episodes, clinicians would need to choose the most effective therapy for each individual right away. A prerequisite for this would be to have biomarkers at hand that would predict which individual would benefit from which kind of therapy (for example, pharmacotherapy or psychotherapy) or even from which kind of antidepressant class...
2017: F1000Research
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#2
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28506956/web-based-cognitive-behavior-therapy-for-depression-in-people-with-diabetes-mellitus-a-randomized-controlled-trial
#3
Jill Newby, Lisa Robins, Kay Wilhelm, Jessica Smith, Therese Fletcher, Inika Gillis, Trevor Ma, Adam Finch, Lesley Campbell, Gavin Andrews
BACKGROUND: Depression is twice as common in diabetes mellitus (DM) as the general population and is associated with adverse health outcomes, but access to evidence-based therapies such as cognitive behavioral therapy (CBT) is limited in routine diabetes care. Past research has shown that generic Internet-based cognitive behavioral therapy (iCBT) is an effective treatment for depression in the general population, but it has never been evaluated in people with comorbid depression and DM...
May 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28504561/sexual-violence-and-intimate-partner-violence-in-college-women-with-a-mental-health-and-or-behavior-disability
#4
Amy Bonomi, Emily Nichols, Rebecca Kammes, Troye Green
OBJECTIVES: We address questions about (1) how college women with a disability experience sexual violence (SV) and intimate partner violence (IPV) across partners, including disability-specific abuse and (2) how SV/IPV impacts psychological, behavioral, physical, and academic life domains. METHODS/DESIGN: Twenty-seven female college students (mean age, 21.2; 66.6% white; 66.6% heterosexual) were randomly sampled from university registrar records. To be eligible for the study, students had to have at least one experience of SV/IPV since age 18 and a disability (88...
May 15, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28503892/the-ethics-of-clinical-trials-research-in-severe-mood-disorders
#5
Allison C Nugent, Franklin G Miller, Ioline D Henter, Carlos A Zarate
Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are highly prevalent, frequently disabling, and sometimes deadly. Additional research and more effective medications are desperately needed, but clinical trials research in mood disorders is fraught with ethical issues. Although many authors have discussed these issues, most do so from a theoretical viewpoint. This manuscript uses available empirical data to inform a discussion of the primary ethical issues raised in mood disorders research...
May 15, 2017: Bioethics
https://www.readbyqxmd.com/read/28503714/depression-severity-and-concentration-difficulties-are-independently-associated-with-hrqol-in-patients-with-unipolar-depressive-disorders
#6
A Fattori, L Neri, A Bellomo, M Vaggi, C Mencacci
PURPOSE: Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL. METHODS: Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information)...
May 13, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28499574/use-of-computer-and-mobile-technologies-in-the-treatment-of-depression
#7
REVIEW
Judith A Callan, Jesse Wright, Greg J Siegle, Robert H Howland, Britney B Kepler
Major depression (MDD) is a common and disabling disorder. Research has shown that most people with MDD receive either no treatment or inadequate treatment. Computer and mobile technologies may offer solutions for the delivery of therapies to untreated or inadequately treated individuals with MDD. The authors review currently available technologies and research aimed at relieving symptoms of MDD. These technologies include computer-assisted cognitive-behavior therapy (CCBT), web-based self-help, Internet self-help support groups, mobile psychotherapeutic interventions (i...
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28498421/molecular-analysis-of-the-mouse-brain-exposed-to-chronic-mild-stress-the-influence-of-hepatocyte-nuclear-factor-4%C3%AE-on-physiological-homeostasis
#8
Kaoru Ikubo, Kyosuke Yamanishi, Nobutaka Doe, Takuya Hashimoto, Miho Sumida, Yuko Watanabe, Yosif El-Darawish, Wen Li, Haruki Okamura, Hiromichi Yamanishi, Hisato Matsunaga
Major depressive disorder (MDD) is a prevalent disorder that causes considerable disability in social functioning and is a risk factor for physical diseases. Recent clinical reports have demonstrated a marked association between MDD and physiological dyshomeostasis induced by metabolic disorders, including diabetes, hormone abnormalities and autoimmune diseases. The authors of the present study have previously analyzed comparative gene expression profiles in the prefrontal cortex (PFC) of a chronic mild stress (CMS) animal model of MDD...
May 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28475675/primary-care-physicians-use-of-the-proposed-classification-of-common-mental-disorders-for-icd-11
#9
David P Goldberg, Tai-Pong Lam, Fareed Minhas, Bushra Razzaque, Rebeca Robles, Julio Bobes, Celso Iglesias, Sandra Fortes, Jair de Jesus Mari, Linda Gask, José Ángel García, Anthony C Dowell, Marianne Rosendal, Geoffrey M Reed
Background.: The World Health Organization is revising the classification of common mental disorders in primary care for ICD-11. Major changes from the ICD-10 primary care version have been proposed for: (i) mood and anxiety disorders; and (ii) presentations of multiple somatic symptoms (bodily stress syndrome). This three-part field study explored the implementation of the revised classification by primary care physicians (PCPs) in five countries. Methods.: Participating PCPs in Brazil, China, Mexico, Pakistan and Spain were asked to use the revised classification, first in patients that they suspected might be psychologically distressed (Part 1), and second in patients with multiple somatic symptoms causing distress or disability not wholly attributable to a known physical pathology, or with high levels of health anxiety (Part 2)...
May 4, 2017: Family Practice
https://www.readbyqxmd.com/read/28462588/mental-disorders-in-australian-4-to-17-year-olds-parent-reported-need-for-help
#10
Sarah E Johnson, David Lawrence, Michael Sawyer, Stephen R Zubrick
OBJECTIVE: To describe the extent to which parents report that 4- to 17-year-olds with symptoms meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for mental disorders need help, the types of help needed, the extent to which this need is being met and factors associated with a need for help. METHOD: During 2013-2014, a national household survey of the mental health of Australia's young people (Young Minds Matter) was conducted, involving 6310 parents (and carers) of 4- to 17-year-olds...
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28442715/work-disability-before-and-after-a-major-cardiovascular-event-a-ten-year-study-using-nationwide-medical-and-insurance-registers
#11
Marianna Virtanen, Jenni Ervasti, Ellenor Mittendorfer-Rutz, Tea Lallukka, Linnea Kjeldgård, Emilie Friberg, Mika Kivimäki, Erik Lundström, Kristina Alexanderson
We examined the trajectories of work disability before and after IHD and stroke events. New IHD (n = 13521) and stroke (n = 7162) cases in 2006-2008 were retrieved from nationwide Swedish hospital records and their annual work disability days five years before and after the date of diagnosis were retrieved from a nationwide disability register. There was no pre-event differences in disability days between the IHD and stroke cases and five years prior to the event, they were close to those observed in the general population...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441923/lowered-pon1-activities-are-strongly-associated-with-depression-and-bipolar-disorder-recurrence-of-hypo-mania-and-depression-increased-disability-and-lowered-quality-of-life
#12
Estefania Gastaldello Moreira, Dalmo Guilherme Correia, Kamila Landucci Bonifácio, Juliana Brum de Moraes, Fernanda Liboni Cavicchioli, Carolina Sampaio Nunes, Sandra Odebrecht Vargas Nunes, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, Michael Maes
BACKGROUND: Mood disorders (MD) frequently co-exist with cardiovascular disease (CVD) and immune-inflammatory and oxidative stress are important shared pathophysiological pathways. Even though there is an extensive investigation of the enzyme paraoxonase 1 (PON1) as a biomarker of susceptibility for CVD, there are only few reports studying PON1 in MD. OBJECTIVES: To determine the association between PON1 activities as well as functional genotypes and MD diagnosis, clinical characteristics and outcomes...
April 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28439594/the-effect-of-chronotherapy-on-depressive-symptoms-evidence-based-practice
#13
Anas H Khalifeh
The global prevalence of depression is increasing, along with rates of depression-associated disability and mortality, rendering depressive disorders a major public health issue. Chronotherapy involves a variety of strategies that control exposure to environmental stimuli that influence the biological clock, such as sleep deprivation (SD) or wake therapy (WT), sleep phase advance (SPA), and light and dark therapy (LT, DT). The purpose of this Evidence-Based Practice (EBP) paper is to answer PICOT questions by a review the effectiveness of chronotherapeutics interventions on depressive symptoms with depression and the depressive episode in the course of bipolar disorder...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28423154/association-of-mental-disorders-and-related-medication-use-with-risk-for-major-osteoporotic-fractures
#14
James M Bolton, Suzanne N Morin, Sumit R Majumdar, Jitender Sareen, Lisa M Lix, Helena Johansson, Anders Odén, Eugene V McCloskey, John A Kanis, William D Leslie
Importance: Osteoporotic fractures are a leading cause of disability, costs, and mortality. FRAX is a tool used to assess fracture risk in the general population. Mental disorders and medications to treat them have been reported to adversely affect bone health, but, to date, they have not been systematically studied in relation to osteoporotic fractures. Objective: To examine the association of mental disorders and psychotropic medication use with osteoporotic fracture risk in routine clinical practice...
April 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28423145/brief-behavioral-therapy-for-pediatric-anxiety-and-depression-in-primary-care-a-randomized-clinical-trial
#15
V Robin Weersing, David A Brent, Michelle S Rozenman, Araceli Gonzalez, Megan Jeffreys, John F Dickerson, Frances L Lynch, Giovanna Porta, Satish Iyengar
Importance: Anxiety and depression affect 30% of youth but are markedly undertreated compared with other mental disorders, especially in Hispanic populations. Objective: To examine whether a pediatrics-based behavioral intervention targeting anxiety and depression improves clinical outcome compared with referral to outpatient community mental health care. Design, Setting, and Participants: This 2-center randomized clinical trial with masked outcome assessment conducted between brief behavioral therapy (BBT) and assisted referral to care (ARC) studied 185 youths (aged 8...
April 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28413087/does-social-support-moderate-the-association-among-major-depression-generalized-anxiety-disorder-and-functional-disability-in-adults-with-diabetes
#16
Melanie Levy, Rachel J Burns, Sonya S Deschênes, Norbert Schmitz
BACKGROUND: Diabetes requires complex self-management routines to prevent the development of functional disability. Relative to people without diabetes, those with diabetes are more likely to have comorbid major depressive disorder (MDD) and generalized anxiety disorder (GAD), which also increase the likelihood of functional disability. Social support is associated with positive health outcomes in people with comorbid diabetes and mental disorders and may serve as a buffer against functional disability, though this possibility has yet to be examined...
March 6, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28412090/pituitary-gland-in-bipolar-disorder-and-major-depression-evidence-from-structural-mri-studies-special-section-on-translational-and-neuroscience-studies-in-affective-disorders-section-editor-maria-nobile-md-phd-this-section-of-jad-focuses-on-the-relevance-of
#17
G Delvecchio, A C Altamura, J C Soares, P Brambilla
BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#18
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28364701/restoring-function-in-major-depressive-disorder-a-systematic-review
#19
REVIEW
David V Sheehan, Kazuyuki Nakagome, Yuko Asami, Elizabeth A Pappadopulos, Matthieu Boucher
BACKGROUND: Functional impairment contributes to significant disability and economic burden in major depressive disorder (MDD). Treatment response is measured by improvement in depressive symptoms, but functional improvement often lags behind symptomatic improvement. Residual deficits are associated with relapse of depressive symptoms. METHODS: A literature search was conducted using the following terms: "major depressive disorder," "functional impairment," "functional outcomes," "recovery of function," "treatment outcome," "outcome assessment," "social functioning," "presenteeism," "absenteeism," "psychiatric status rating scales," and "quality of life...
February 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28350396/genetic-effects-influencing-risk-for-major-depressive-disorder-in-china-and-europe
#20
T B Bigdeli, S Ripke, R E Peterson, M Trzaskowski, S-A Bacanu, A Abdellaoui, T F M Andlauer, A T F Beekman, K Berger, D H R Blackwood, D I Boomsma, G Breen, H N Buttenschøn, E M Byrne, S Cichon, T-K Clarke, B Couvy-Duchesne, N Craddock, E J C de Geus, F Degenhardt, E C Dunn, A C Edwards, A H Fanous, A J Forstner, J Frank, M Gill, S D Gordon, H J Grabe, S P Hamilton, O Hardiman, C Hayward, A C Heath, A K Henders, S Herms, I B Hickie, P Hoffmann, G Homuth, J-J Hottenga, M Ising, R Jansen, S Kloiber, J A Knowles, M Lang, Q S Li, S Lucae, D J MacIntyre, P A F Madden, N G Martin, P J McGrath, P McGuffin, A M McIntosh, S E Medland, D Mehta, C M Middeldorp, Y Milaneschi, G W Montgomery, O Mors, B Müller-Myhsok, M Nauck, D R Nyholt, M M Nöthen, M J Owen, B W J H Penninx, M L Pergadia, R H Perlis, W J Peyrot, D J Porteous, J B Potash, J P Rice, M Rietschel, B P Riley, M Rivera, R Schoevers, T G Schulze, J Shi, S I Shyn, J H Smit, J W Smoller, F Streit, J Strohmaier, A Teumer, J Treutlein, S Van der Auwera, G van Grootheest, A M van Hemert, H Völzke, B T Webb, M M Weissman, J Wellmann, G Willemsen, S H Witt, D F Levinson, C M Lewis, N R Wray, J Flint, P F Sullivan, K S Kendler
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30-40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects...
March 28, 2017: Translational Psychiatry
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