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Major depressive disorder disability

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https://www.readbyqxmd.com/read/29790996/dna-methylation-and-inflammation-marker-profiles-associated-with-a-history-of-depression
#1
Bethany Crawford, Zoe Craig, Georgina Mansell, Isobel White, Adam Smith, Steve Spaull, Jennifer Imm, Eilis Hannon, Andrew Wood, Hanieh Yaghootkar, Yingjie Ji, Niamh Mullins, Cathryn M Lewis, Jonathan Mill, Therese M Murphy
Depression is a common and disabling disorder, representing a major social and economic health issue. Moreover, depression is associated with the progression of diseases with an inflammatory etiology including many inflammatory-related disorders. At the molecular level, the mechanisms by which depression might promote the onset of these diseases and associated immune-dysfunction are not well understood. In this study we assessed genome-wide patterns of DNA methylation in whole blood-derived DNA obtained from individuals with a self-reported history of depression (n = 100) and individuals without a history of depression (n = 100) using the Illumina 450K microarray...
May 22, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29766809/associations-between-depressive-disorders-and-inflammatory-rheumatic-diseases
#2
Ozkan Varan, Hakan Babaoglu, Berna Goker
Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression coexists, the quality of life is worse and medical treatment and management is compromised. Depression-like symptoms, such as fatigue and disinterest are also common in inflammatory rheumatic diseases and often associated with poor quality of life. Medical therapy targeting inflammation results in alleviation of these symptoms in many patients...
May 15, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29761101/fibromyalgia-syndrome-a-case-report-on-controlled-remission-of-symptoms-by-a-dietary-strategy
#3
Silvia Maria Lattanzio, Francesca Imbesi
A 34-year-old woman suffered from significant chronic pain, depression, non-restorative sleep, chronic fatigue, severe morning stiffness, leg cramps, irritable bowel syndrome, hypersensitivity to cold, concentration difficulties, and forgetfulness. Blood tests were negative for rheumatic disorders. The patient was diagnosed with Fibromyalgia syndrome (FMS). Due to the lack of effectiveness of pharmacological therapies in FMS, she approached a novel metabolic proposal for the symptomatic remission. Its core idea is supporting serotonin synthesis by allowing a proper absorption of tryptophan assumed with food, while avoiding, or at least minimizing the presence of interfering non-absorbed molecules, such as fructose and sorbitol...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29761007/behavioral-changes-induced-through-adenosine-a2a-receptor-ligands-in-a-rat-depression-model-induced-by-olfactory-bulbectomy
#4
Karla Margarita Padilla, Andres Quintanar-Setephano, Fabian López-Vallejo, Laura Cristina Berumen, Ricardo Miledi, Guadalupe García-Alcocer
Background: Major depressive disorders are characterized by their severity and long-lasting symptoms, which make such disorders highly disabling illnesses. Unfortunately, 50% of major depressive patients experience relapses, perhaps partly because drug research has been performed only in animal models that screen for antidepressant drugs that appear to only ameliorate acute depression symptoms. The bilateral olfactory bulbectomy (OBX) animal model presents the advantage of mimicking the symptoms of chronic depression by means of brain surgery...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29759000/biological-sex-differences-in-depression-a-systematic-review
#5
Ainitze Labaka, Olatz Goñi-Balentziaga, Andrea Lebeña, Joana Pérez-Tejada
Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. We conducted a literature search using the Medline, PsycInfo, PubMed, and Web of Science databases, selecting English-language studies that included physiological measures compared by sex in addition to MDD...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29751238/prevalence-of-anxiety-and-depressive-disorders-among-youth-with-intellectual-disabilities-a-systematic-review-and-meta-analysis
#6
REVIEW
Christophe Maïano, Sylvain Coutu, Danielle Tracey, Stéphane Bouchard, Geneviève Lepage, Alexandre J S Morin, Grégory Moullec
BACKGROUND: The purpose of this meta-analytic study was to determine the pooled prevalence estimates of anxiety and depressive disorders among children and adolescents with intellectual disabilities (ID) and to assess the extent to which these pooled prevalence rates differed according to studies' characteristics. METHOD: A systematic literature search was performed in nine databases and 21 studies, published between 1975 and 2015, met the inclusion criteria. RESULTS: The resulting pooled prevalence estimates of combined subtypes of anxiety and depressive disorders were respectively (a) 5...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29749006/predictors-of-recurrence-in-remitted-late-life-depression
#7
Yi Deng, Douglas R McQuoid, Guy G Potter, David C Steffens, Kimberly Albert, Meghan Riddle, John L Beyer, Warren D Taylor
BACKGROUND: Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict recurrence in remitted LLD. METHODS: Individuals of age 60 years or older with a Diagnostic and Statistical Manual - IV (DSM-IV) diagnosis of major depressive disorder were enrolled in the neurocognitive outcomes of depression in the elderly study. Participants received manualized antidepressant treatment and were followed longitudinally for an average of 5 years...
May 10, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29723343/early-psychiatric-morbidity-in-a-brazilian-sample-of-acute-ischemic-stroke-patients
#8
Vinicius S P Pedroso, Andre R Brunoni, Érica L M Vieira, Ricardo E Jorge, Edward C Lauterbach, Antonio L Teixeira
OBJECTIVE: Stroke is a major public health problem worldwide, and its neuropsychiatric sequelae are frequent and disabling. Furthermore, there is evidence that these sequelae impair recovery. Brazil has the highest stroke rates in Latin America, but data on the frequency of neuropsychiatric disorders in these patients are scarce. This study aimed to identify mental disorders among in-hospital patients with acute ischemic stroke. METHODS: The Mini International Neuropsychiatric Interview-Plus (MINI-Plus) was applied to 60 patients during the first week of hospitalization...
2018: Clinics
https://www.readbyqxmd.com/read/29719381/suicide-in-older-adults-current-perspectives
#9
REVIEW
Ismael Conejero, Emilie Olié, Philippe Courtet, Raffaella Calati
Suicidal behavior in older adults (65 years old and over) is a major public health issue in many countries. Suicide rates increase during the life course and are as high as 48.7/100,000 among older white men in the USA. Specific health conditions and stress factors increase the complexity of the explanatory model for suicide in older adults. A PubMed literature search was performed to identify most recent and representative studies on suicide risk factors in older adults. The aim of our narrative review was to provide a critical evaluation of recent findings concerning specific risk factors for suicidal thoughts and behaviors among older people: psychiatric and neurocognitive disorders, social exclusion, bereavement, cognitive impairment, decision making and cognitive inhibition, physical illnesses, and physical and psychological pain...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29705763/development-of-prediction-models-of-stress-and-long-term-disability-among-claimants-to-injury-compensation-systems-a-cohort-study
#10
Matthew J Spittal, Genevieve Grant, Meaghan O'Donnell, Alexander C McFarlane, David M Studdert
OBJECTIVES: We sought to develop prognostic risk scores for compensation-related stress and long-term disability using markers collected within 3 months of a serious injury. DESIGN: Cohort study. Predictors were collected at baseline and at 3 months postinjury. Outcome data were collected at 72 months postinjury. SETTING: Hospitalised patients with serious injuries recruited from four major trauma hospitals in Australia. PARTICIPANTS: 332 participants who made claims for compensation for their injuries to a transport accident scheme or a workers' compensation scheme...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29704969/a-pilot-study-of-emotion-regulation-therapy-for-generalized-anxiety-and-depression-findings-from-a-diverse-sample-of-young-adults
#11
Megan E Renna, Jean M Quintero, Ariella Soffer, Martin Pino, Leslie Ader, David M Fresco, Douglas S Mennin
Emotion regulation therapy (ERT) for generalized anxiety disorder (GAD) and accompanying major depressive disorder (MDD) is a theoretically derived, evidence-based treatment that integrates principles from traditional and contemporary cognitive-behavioral and experiential approaches with basic and translational findings from affect science to offer a blueprint for improving intervention by focusing on the motivational responses and corresponding self-referential regulatory characteristics. Preliminary evidence supports the efficacy of a 20-session version of ERT...
May 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29698729/axonal-transport-proteins-and-depressive-like-behavior-following-chronic-unpredictable-mild-stress-in-male-rat
#12
Fatemeh Bakhtiarzadeh, Arezo Nahavandi, Mina Goudarzi, Sakine Shirvalilou, Kamran Rakhshan, Somayeh Niknazar
BACKGROUND: A common mood disorder, depression has long been considered a leading cause of disability worldwide. Chronic stress is involved in the development of various psychiatric diseases including major depressive disorder. Stress can induce depressive-like symptoms and initiate neurodegenerative processes in the brain. The neurodegenerative theory of depression holds impaired axonal transport as a negative factor in neural survival. Axonal transport is a critical mechanism for normal neuronal function, playing crucial roles in axon growth, neurotransmitter secretion, normal mitochondrial function and neural survival...
April 23, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29697881/the-dsm-5-nonsuicidal-self-injury-disorder-among-incoming-college-students-prevalence-and-associations-with-12-month-mental-disorders-and-suicidal-thoughts-and-behaviors
#13
Glenn Kiekens, Penelope Hasking, Laurence Claes, Philippe Mortier, Randy P Auerbach, Mark Boyes, Pim Cuijpers, Koen Demyttenaere, Jennifer G Green, Ronald C Kessler, Matthew K Nock, Ronny Bruffaerts
BACKGROUND: Approximately one in five college students report a history of nonsuicidal self-injury. However, it is unclear how many students meet criteria for the recently proposed DSM-5 nonsuicidal self-injury disorder (NSSI-D). In this study, we used full NSSI-D criteria to identify those students most in need of clinical care. METHODS: Using data from the Leuven College Surveys (n = 4,565), we examined the 12-month prevalence of DSM-5 NSSI-D in a large and representative sample of incoming college students...
April 26, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29697850/depressive-symptoms-pain-and-disability-for-adolescent-patients-with-juvenile-idiopathic-arthritis-results-from-the-childhood-arthritis-prospective-study
#14
Laura Hanns, Lis Cordingley, James Galloway, Sam Norton, Livia A Carvalho, Deborah Christie, Debajit Sen, Roberto Carrasco, Amir Rashid, Helen Foster, Eileen Baildam, Alice Chieng, Joyce Davidson, Lucy R Wedderburn, Kimme Hyrich, Wendy Thomson, Yiannis Ioannou
Objectives: To determine if depressive symptoms assessed near diagnosis associate with future measures of pain, disability and disease for adolescent patients diagnosed with JIA. Methods: Data were analysed from JIA patients aged 11-16 years recruited to the Childhood Arthritis Prospective Study, a UK-based inception cohort of childhood-onset arthritis. Depressive symptoms (using the Mood and Feelings Questionnaire; MFQ), active and limited joint count, disability score (Childhood Health Assessment Questionnaire), pain visual analogue scale and patient's general evaluation visual analogue scale were collected...
April 25, 2018: Rheumatology
https://www.readbyqxmd.com/read/29695168/cortical-spreading-depression-as-a-site-of-origin-for-migraine-role-of-cgrp
#15
Liesl N Close, Sajedeh Eftekhari, Minyan Wang, Andrew C Charles, Andrew F Russo
Premise Migraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood. Problem One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Despite the importance of both cortical spreading depression and calcitonin gene-related peptide in migraine, the relationship between these two players has been relatively unexplored...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29680774/targeting-hypothalamic-pituitary-adrenal-axis-hormones-and-sex-steroids-for-improving-cognition-in-major-mood-disorders-and-schizophrenia-a-systematic-review-and-narrative-synthesis
#16
REVIEW
Virginia Soria, Alexandre González-Rodríguez, Elena Huerta-Ramos, Judith Usall, Jesús Cobo, Miquel Bioque, Juan David Barbero, Clemente García-Rizo, Meritxell Tost, José Antonio Monreal, Javier Labad
Cognitive deficits are a core feature of serious mental illnesses such as schizophrenia, major depressive disorder (MDD) and bipolar disorder (BD) and are a common cause of functional disability. There is limited efficacy of pharmacological interventions for improving the cognitive deficits in these disorders. As pro-cognitive pharmacological treatments are lacking, hormones or drugs that target the endocrine system may become potential candidates for 'repurposing' trials aiming to improve cognition. We aimed to study whether treatment with drugs targeting the hypothalamic-pituitary-adrenal (HPA) axis and sex steroids can improve cognition in patients with schizophrenia, MDD or BD...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29679991/empirical-evidence-for-discrete-neurocognitive-subgroups-in-patients-with-non-psychotic-major-depressive-disorder-clinical-implications
#17
Shenghong Pu, Takamasa Noda, Shiori Setoyama, Kazuyuki Nakagome
BACKGROUND: Neuropsychological deficits are present across various cognitive domains in major depressive disorder (MDD). However, a consistent and specific profile of neuropsychological abnormalities has not yet been established. METHODS: We assessed cognition in 170 patients with non-psychotic MDD using the Brief Assessment of Cognition in Schizophrenia and the scores were compared with those of 42 patients with schizophrenia as a reference for severity of cognitive impairment...
April 22, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29679072/polyunsaturated-fatty-acids-metabolism-purine-metabolism-and-inosine-as-potential-independent-diagnostic-biomarkers-for-major-depressive-disorder-in-children-and-adolescents
#18
Xinyu Zhou, Lanxiang Liu, Xinghui Lan, David Cohen, Yuqing Zhang, Arun V Ravindran, Shuai Yuan, Peng Zheng, David Coghill, Lining Yang, Sarah E Hetrick, Xiaofeng Jiang, Jean-Jacques Benoliel, Andrea Cipriani, Peng Xie
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma samples based on ultra-high-performance liquid chromatography equipped with quadrupole time-offlight mass spectrometry to explore the potential biomarkers of depression in children and adolescents with MDD. We identified several perturbed pathways, including fatty acid metabolism-particularly the polyunsaturated fatty acids metabolism, and purine metabolism-that were associated with MDD in these young patients...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29671046/digeorge-syndrome-relevance-of-psychiatric-symptoms-in-undiagnosed-adult-patients
#19
Christoph Kraus, Thomas Vanicek, Ana Weidenauer, Tav Khanaqa, Mara Stamenkovic, Rupert Lanzenberger, Matthäus Willeit, Siegfried Kasper
DiGeorge syndrome or 22q11.2 deletion syndrome is one of the most common genetic microdeletion syndromes in humans. In addition to physical manifestations, DiGeorge syndrome is associated with a high prevalence of psychiatric disorders, such as intellectual disability, schizophrenia and attention-deficit/hyperactivity disorder. Usually, the diagnosis of DiGeorge syndrome is made in early childhood. This article reports on the late diagnosis of a patient with panic disorder and comorbid major depression at the age of 51...
April 18, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29662059/genome-wide-association-study-of-depression-phenotypes-in-uk-biobank-identifies-variants-in-excitatory-synaptic-pathways
#20
David M Howard, Mark J Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E Marioni, Gail Davies, Jonathan R I Coleman, Clara Alloza, Xueyi Shen, Miruna C Barbu, Eleanor M Wigmore, Jude Gibson, Saskia P Hagenaars, Cathryn M Lewis, Joey Ward, Daniel J Smith, Patrick F Sullivan, Chris S Haley, Gerome Breen, Ian J Deary, Andrew M McIntosh
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10-8 ) across the three phenotypes...
April 16, 2018: Nature Communications
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