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Major depressive disorder disability

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https://www.readbyqxmd.com/read/28718346/effect-of-desvenlafaxine-50-mg-and-100-mg-on-energy-and-lassitude-in-patients-with-major-depressive-disorder-a-pooled-analysis
#1
Raymond W Lam, Dalia B Wajsbrot, Ellen Meier, Elizabeth Pappadopulos, Joan A Mackell, Matthieu Boucher
Nine randomized, double-blind, placebo-controlled studies of major depressive disorder were pooled to evaluate the effects of desvenlafaxine 50- and 100-mg/d on energy and lassitude in adults with major depressive disorder ( n=4279). Changes from baseline to endpoint in 17-item Hamilton Rating Scale for Depression (HAM-D17) Work and Activities, Retardation, and Somatic Symptoms General items, HAM-D17 psychomotor retardation factor, and Montgomery-Åsberg Depression Rating Scale Lassitude item were analyzed with a mixed model for repeated measures analysis of variance...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28711797/symptom-severity-and-disability-in-psychiatric-disorders-the-u-s-collaborative-psychiatric-epidemiology-survey
#2
R García-Velázquez, M Jokela, T H Rosenström
BACKGROUND: While most psychiatric diagnoses are based on simple counts of symptoms, some symptoms may be sign of a more severe mental syndrome than others. This calls for validated estimates of the relative severity specific symptoms imply within a disorder. We focused on four diagnostic disorders: Manic Episode (ME), Major Depressive Episode (MDE), Post-traumatic Stress Disorder (PTSD) and Generalized Anxiety Disorder (GAD). Symptom-specific severity parameters were estimated, and validated by examining their association with levels of self-reported disability in daily activities over and above the number of symptoms...
July 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28702811/a-machine-learning-framework-involving-eeg-based-functional-connectivity-to-diagnose-major-depressive-disorder-mdd
#3
Wajid Mumtaz, Syed Saad Azhar Ali, Mohd Azhar Mohd Yasin, Aamir Saeed Malik
Major depressive disorder (MDD), a debilitating mental illness, could cause functional disabilities and could become a social problem. An accurate and early diagnosis for depression could become challenging. This paper proposed a machine learning framework involving EEG-derived synchronization likelihood (SL) features as input data for automatic diagnosis of MDD. It was hypothesized that EEG-based SL features could discriminate MDD patients and healthy controls with an acceptable accuracy better than measures such as interhemispheric coherence and mutual information...
July 13, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28681620/the-burden-of-mood-disorder-cerebrovascular-disease-comorbidity-essential-neurobiology-psychopharmacology-and-physical-activity-interventions
#4
Michele Fornaro, Marco Solmi, Nicola Veronese, Domenico De Berardis, Elisabetta Filomena Buonaguro, Carmine Tomasetti, Giampaolo Perna, Antonio Preti, Mauro Giovanni Carta
Cardio-vascular diseases (CVDs) and CVD-related disorders (including cerebrovascular diseases; CBVDs) are a major public health concern as they represent the leading cause of mortality and morbidity in developed countries. Patients with CVDs and CBVDs co-morbid with mood disorders, especially bipolar disorder (BD) and major depressive disorder (MDD), suffer reduced quality-of-life and significant disability adjusted for years of life and mortality. The relationship between CVDs/CBVDs and mood disorders is likely to be bidirectional...
July 6, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28681617/depression-comorbidity-in-migraine
#5
Farnaz Amoozegar
Migraine and Major Depressive Disorder (MDD) are highly prevalent conditions that can lead to significant disability. These conditions are often comorbid, and several studies shed light on the underlying reasons for this comorbidity. The purpose of this review article is to have a closer look at the epidemiology, pathophysiology, genetic and environmental factors, temporal association, treatment options, and prognosis of patients suffering from both conditions, to allow a better understanding of what factors underlie this comorbidity...
July 6, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28676432/pathophysiological-mechanisms-involved-in-the-relationship-between-diabetes-and-major-depressive-disorder
#6
REVIEW
Gislaine Z Reus, Maria Augusta B Dos Santos, Ana Paula Strassi, Helena M Abelaira, Luciane B Ceretta, João Quevedo
Diabetes mellitus (DM) and major depressive disorder (MDD) are diseases that are expanding globally. Separately, each presents with several comorbidities for patients. When the two diseases present simultaneously in the same subject, there is a drastic worsening in the quality of life of the patient. This study reviewed the literature relating to the relationship between MDD and DM, bringing forward studies showing that DM develops due to MDD, and others that report the opposite. According to the studies reviewed, DM and MDD are both debilitating conditions that are associated with significant morbidity, mortality, and healthcare costs...
July 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28667888/cognitive-impairment-as-measured-by-the-thinc-integrated-tool-thinc-it-association-with-psychosocial-function-in-major-depressive-disorder
#7
Danielle S Cha, Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Yena Lee, Jae Hon Lee, JungGoo Lee, Joshua D Rosenblat, Margarita Shekotikhina, Caroline Park, Carola Rong, Tracy L Greer, Raymond Lam, Bernhard T Baune, John Harrison, Roger S McIntyre
BACKGROUND: Psychosocial impairment represents an important treatment target in major depressive disorder (MDD). The majority of patients with MDD do not regain premorbid levels of psychosocial functioning despite the resolution of core depressive symptoms. This study aimed to investigate the respective effects of cognitive function and depression severity on impaired psychosocial function in MDD. METHODS: Adults aged 18-65 with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls participated in a cross-sectional study validating the THINC-integrated tool (THINC-it), a cognitive screening tool comprised of objective and subjective measures of cognitive function...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28654682/low-intensity-cognitive-behaviour-therapy-interventions-for-obsessive-compulsive-disorder-compared-to-waiting-list-for-therapist-led-cognitive-behaviour-therapy-3-arm-randomised-controlled-trial-of-clinical-effectiveness
#8
RANDOMIZED CONTROLLED TRIAL
Karina Lovell, Peter Bower, Judith Gellatly, Sarah Byford, Penny Bee, Dean McMillan, Catherine Arundel, Simon Gilbody, Lina Gega, Gillian Hardy, Shirley Reynolds, Michael Barkham, Patricia Mottram, Nicola Lidbetter, Rebecca Pedley, Jo Molle, Emily Peckham, Jasmin Knopp-Hoffer, Owen Price, Janice Connell, Margaret Heslin, Christopher Foley, Faye Plummer, Christopher Roberts
BACKGROUND: Obsessive-compulsive disorder (OCD) is prevalent and without adequate treatment usually follows a chronic course. "High-intensity" cognitive-behaviour therapy (CBT) from a specialist therapist is current "best practice." However, access is difficult because of limited numbers of therapists and because of the disabling effects of OCD symptoms. There is a potential role for "low-intensity" interventions as part of a stepped care model. Low-intensity interventions (written or web-based materials with limited therapist support) can be provided remotely, which has the potential to increase access...
June 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28653857/anti-inflammatory-treatment-for-major-depressive-disorder-implications-for-patients-with-an-elevated-immune-profile-and-non-responders-to-standard-antidepressant-therapy
#9
Paula Kopschina Feltes, Janine Doorduin, Hans C Klein, Luis Eduardo Juárez-Orozco, Rudi Ajo Dierckx, Cristina M Moriguchi-Jeckel, Erik Fj de Vries
Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates of non-responsiveness to antidepressants ranging from 30-50%. Historically, the monoamine depletion hypothesis has dominated the view on the pathophysiology of depression. However, the lack of responsiveness to antidepressants and treatment resistance suggests that additional mechanisms might play a role. Evidence has shown that a subgroup of depressive patients may have an underlying immune deregulation that could explain the lack of therapeutic benefit from antidepressants...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28652752/cognitive-dysfunction-in-major-depression-and-alzheimer-s-disease-is-associated-with-hippocampal-prefrontal-cortex-dysconnectivity
#10
REVIEW
Dayalan Sampath, Monica Sathyanesan, Samuel S Newton
Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28645799/genotype-phenotype-evaluation-of-med13l-defects-in-the-light-of-a-novel-truncating-and-a-recurrent-missense-mutation
#11
Reza Asadollahi, Markus Zweier, Laura Gogoll, Raphael Schiffmann, Heinrich Sticht, Katharina Steindl, Anita Rauch
A decade after the designation of MED13L as a gene and its link to intellectual disability (ID) and dextro-looped transposition of great arteries in 2003, we previously described a recognizable syndrome due to MED13L haploinsufficiency. Subsequent reports of 22 further patients diagnosed by genome-wide testing further delineated the syndrome with expansion of the phenotypic spectrum and showed reduced penetrance for congenital heart defects. We now report two novel patients identified by whole exome sequencing, one with a de novo MED13L truncating mutation and the other with a de novo missense mutation...
June 20, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28642690/autonomy-in-depressive-patients-undergoing-dbs-treatment-informed-consent-freedom-of-will-and-dbs-potential-to-restore-it
#12
Timo Beeker, Thomas E Schlaepfer, Volker A Coenen
According to the World Health Organization, depression is one of the most common and most disabling psychiatric disorders, affecting at any given time approximately 325 million people worldwide. As there is strong evidence that depressive disorders are associated with a dynamic dysregulation of neural circuits involved in emotional processing, recently several attempts have been made to intervene directly in these circuits via deep brain stimulation (DBS) in patients with treatment-resistant major depressive disorder (MDD)...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28640037/epidemiology-of-major-depressive-disorder-disability-in-the-us-military-fy-2007-2012
#13
Elizabeth R Packnett, Hoda Elmasry, Christine F Toolin, David N Cowan, Michael R Boivin
This study assesses the incidence of major depressive disorder (MDD) disability discharge and retirement in the Army, Navy, Marine Corps and Air Force and describes MDD comorbidity. Service members with a disability discharge for either MDD (n = 2,882) or any nonpsychiatric disability (n = 56,145), between fiscal years 2007 and 2012, were included in the study population. Those with MDD disability at first evaluation but not at last evaluation were excluded. The incidence of MDD disability discharge increased significantly in the Army and Air Force between fiscal years 2007 and 2012...
June 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28638210/why-is-diagnosing-mdd-challenging
#14
Xiaohua Liu, Kaida Jiang
Depression is highly prevalent and one of the major contributors to disability worldwide. However, one of the findings from the DSM-5 field trials was that inter-rater reliability for diagnosing major depressive disorder was very poor. Why is diagnosing MDD so challenging? This article attempts to explain why undefined pathogenesis and complicated phenotypes complicate the diagnosis of MDD. However, further biomarker and translational research is still necessary to help clinicians screen and diagnose depression in the future rather than relying solely on current subjective diagnostic criteria...
December 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28632428/clinical-and-socio-demographic-correlates-of-anxious-distress-in-asian-outpatients-with-major-depressive-disorder
#15
Narong Maneeton, Sirijit Suttajit, Benchalak Maneeton, Surinporn Likhitsathian, Kanokkwan Eurviyanukul, Pichet Udomratn, Edwin Shih-Yen Chan, Tian-Mei Si, Ahmad Hatim Sulaiman, Chia-Hui Chen, Dianne Bautista, Manit Srisurapanont
BACKGROUND: Anxious distress in major depressive disorder (MDD) is common and associated with poor outcomes and management difficulties. AIMS: This post hoc analysis aimed to examine the socio-demographic and clinical correlates of anxiety distress in Asian outpatients with MDD. METHODS: Instead of two out of five specifiers defined by the Diagnostic and Statistical Manual Version-5, anxious distress defined in this study was operationalized as the presence of at least two out of four proxy items drawn from the 90-item Symptom Checklist, Revised (SCL-90-R)...
June 20, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28630456/rare-disruptive-variants-in-the-disc1-interactome-and-regulome-association-with-cognitive-ability-and-schizophrenia
#16
S Teng, P A Thomson, S McCarthy, M Kramer, S Muller, J Lihm, S Morris, D C Soares, W Hennah, S Harris, L M Camargo, V Malkov, A M McIntosh, J K Millar, D H Blackwood, K L Evans, I J Deary, D J Porteous, W R McCombie
Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that are involved in brain development and signaling. Modulation of DISC1 expression alters the expression of a circumscribed set of genes (DISC1 Regulome) that are also implicated in brain biology and disorder...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28619687/use-of-the-central-sensitization-inventory-csi-as-a-treatment-outcome-measure-for-chronic-spinal-pain-disorder-patients-in-a-functional-restoration-program
#17
Randy Neblett, Meredith M Hartzell, Mark Williams, Kelley R Bevers, Tom G Mayer, Robert J Gatchel
BACKGROUND CONTEXT: The Central Sensitization Inventory (CSI) is a valid and reliable patient-reported instrument designed to identify patients whose presenting symptoms may be related to Central Sensitization (CS). Part A of the CSI measures a full array of 25 somatic and emotional symptoms associated with CS, and Part B asks if patients have previously been diagnosed with one or more specific Central Sensitivity Syndromes (CSSs) and related disorders. The CSI has previously been validated in a group of chronic pain patients who were screened by a trained psychiatrist for specific CSS diagnoses...
June 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28619069/social-determinants-of-depression-and-suicidal-behaviour-in-the-caribbean-a-systematic-review
#18
Catherine R Brown, Ian R Hambleton, Natasha Sobers-Grannum, Shawn M Hercules, Nigel Unwin, E Nigel Harris, Rainford Wilks, Marlene MacLeish, Louis Sullivan, Madhuvanti M Murphy
BACKGROUND: Depressive disorder is the largest contributor to years lived with disability in the Caribbean, adding 948 per 100,000 in 2013. Depression is also a major risk factor for suicidal behaviour. Social inequalities influence the occurrence of depression, yet little is known about the social inequalities of this condition in the Caribbean. In support of the 2011 Rio Political Declaration on addressing health inequities, this article presents a systematic review of the role of social determinants on depression and its suicidal behaviours in the Caribbean...
June 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28610482/randomised-controlled-trial-of-a-healthy-lifestyle-intervention-among-smokers-with-psychotic-disorders-outcomes-to-36%C3%A2-months
#19
Amanda L Baker, Robyn Richmond, Frances J Kay-Lambkin, Sacha L Filia, David Castle, Jill M Williams, Terry J Lewin, Vanessa Clark, Robin Callister, Kerrin Palazzi
OBJECTIVE: People living with psychotic disorders (schizophrenia spectrum and bipolar disorders) have high rates of cardiovascular disease risk behaviours, including smoking, physical inactivity and poor diet. We report cardiovascular disease risk, smoking cessation and other risk behaviour outcomes over 36 months following recruitment into a two-arm randomised controlled trial among smokers with psychotic disorders. METHODS: Participants ( N = 235) drawn from three sites were randomised to receive nicotine replacement therapy plus (1) a Healthy Lifestyles intervention delivered over approximately 9 months or (2) a largely telephone-delivered intervention (designed to control for nicotine replacement therapy provision, session frequency and other monitoring)...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28593878/microbiota-abnormalities-and-the-therapeutic-potential-of-probiotics-in-the-treatment-of-mood-disorders
#20
Adiel C Rios, Pawan Kumar Maurya, Mariana Pedrini, Maiara Zeni-Graiff, Elson Asevedo, Rodrigo B Mansur, Andrea Wieck, Rodrigo Grassi-Oliveira, Roger S McIntyre, Mirian A F Hayashi, Elisa Brietzke
Major depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut microbiota in processes relevant to etiopathology of central nervous system-based disorders. The objective of this article was to critically evaluate the evidence supporting the link between gastrointestinal microbiota and mood disorders and to discuss the potential benefits of using probiotics in the treatment of MDD and BD...
May 8, 2017: Reviews in the Neurosciences
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