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Major depressive disorder disability

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https://www.readbyqxmd.com/read/28423154/association-of-mental-disorders-and-related-medication-use-with-risk-for-major-osteoporotic-fractures
#1
James M Bolton, Suzanne N Morin, Sumit R Majumdar, Jitender Sareen, Lisa M Lix, Helena Johansson, Anders Odén, Eugene V McCloskey, John A Kanis, William D Leslie
Importance: Osteoporotic fractures are a leading cause of disability, costs, and mortality. FRAX is a tool used to assess fracture risk in the general population. Mental disorders and medications to treat them have been reported to adversely affect bone health, but, to date, they have not been systematically studied in relation to osteoporotic fractures. Objective: To examine the association of mental disorders and psychotropic medication use with osteoporotic fracture risk in routine clinical practice...
April 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28423145/brief-behavioral-therapy-for-pediatric-anxiety-and-depression-in-primary-care-a-randomized-clinical-trial
#2
V Robin Weersing, David A Brent, Michelle S Rozenman, Araceli Gonzalez, Megan Jeffreys, John F Dickerson, Frances L Lynch, Giovanna Porta, Satish Iyengar
Importance: Anxiety and depression affect 30% of youth but are markedly undertreated compared with other mental disorders, especially in Hispanic populations. Objective: To examine whether a pediatrics-based behavioral intervention targeting anxiety and depression improves clinical outcome compared with referral to outpatient community mental health care. Design, Setting, and Participants: This 2-center randomized clinical trial with masked outcome assessment conducted between brief behavioral therapy (BBT) and assisted referral to care (ARC) studied 185 youths (aged 8...
April 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28413087/does-social-support-moderate-the-association-among-major-depression-generalized-anxiety-disorder-and-functional-disability-in-adults-with-diabetes
#3
Melanie Levy, Rachel J Burns, Sonya S Deschênes, Norbert Schmitz
BACKGROUND: Diabetes requires complex self-management routines to prevent the development of functional disability. Relative to people without diabetes, those with diabetes are more likely to have comorbid major depressive disorder (MDD) and generalized anxiety disorder (GAD), which also increase the likelihood of functional disability. Social support is associated with positive health outcomes in people with comorbid diabetes and mental disorders and may serve as a buffer against functional disability, though this possibility has yet to be examined...
March 6, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28412090/pituitary-gland-in-bipolar-disorder-and-major-depression-evidence-from-structural-mri-studies
#4
G Delvecchio, A C Altamura, J C Soares, P Brambilla
BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#5
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28364701/restoring-function-in-major-depressive-disorder-a-systematic-review
#6
REVIEW
David V Sheehan, Kazuyuki Nakagome, Yuko Asami, Elizabeth A Pappadopulos, Matthieu Boucher
BACKGROUND: Functional impairment contributes to significant disability and economic burden in major depressive disorder (MDD). Treatment response is measured by improvement in depressive symptoms, but functional improvement often lags behind symptomatic improvement. Residual deficits are associated with relapse of depressive symptoms. METHODS: A literature search was conducted using the following terms: "major depressive disorder," "functional impairment," "functional outcomes," "recovery of function," "treatment outcome," "outcome assessment," "social functioning," "presenteeism," "absenteeism," "psychiatric status rating scales," and "quality of life...
February 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28350396/genetic-effects-influencing-risk-for-major-depressive-disorder-in-china-and-europe
#7
T B Bigdeli, S Ripke, R E Peterson, M Trzaskowski, S-A Bacanu, A Abdellaoui, T F M Andlauer, A T F Beekman, K Berger, D H R Blackwood, D I Boomsma, G Breen, H N Buttenschøn, E M Byrne, S Cichon, T-K Clarke, B Couvy-Duchesne, N Craddock, E J C de Geus, F Degenhardt, E C Dunn, A C Edwards, A H Fanous, A J Forstner, J Frank, M Gill, S D Gordon, H J Grabe, S P Hamilton, O Hardiman, C Hayward, A C Heath, A K Henders, S Herms, I B Hickie, P Hoffmann, G Homuth, J-J Hottenga, M Ising, R Jansen, S Kloiber, J A Knowles, M Lang, Q S Li, S Lucae, D J MacIntyre, P A F Madden, N G Martin, P J McGrath, P McGuffin, A M McIntosh, S E Medland, D Mehta, C M Middeldorp, Y Milaneschi, G W Montgomery, O Mors, B Müller-Myhsok, M Nauck, D R Nyholt, M M Nöthen, M J Owen, B W J H Penninx, M L Pergadia, R H Perlis, W J Peyrot, D J Porteous, J B Potash, J P Rice, M Rietschel, B P Riley, M Rivera, R Schoevers, T G Schulze, J Shi, S I Shyn, J H Smit, J W Smoller, F Streit, J Strohmaier, A Teumer, J Treutlein, S Van der Auwera, G van Grootheest, A M van Hemert, H Völzke, B T Webb, M M Weissman, J Wellmann, G Willemsen, S H Witt, D F Levinson, C M Lewis, N R Wray, J Flint, P F Sullivan, K S Kendler
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30-40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects...
March 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28342535/-professional-stressors-and-common-mental-health-disorders-causal-links
#8
C Nicolas, N Chawky, C Jourdan-Ionescu, M-S Drouin, C Page, N Houlfort, G Beauchamp, M Séguin
According to the World Health Organization, depression has become the leading cause of disability in the world, contributing significantly to the burden of health issues especially in the industrialized countries. This is a major public health problem, with potential impact on work climates, productivity at work and the continued existence of the organizations. Some recent studies have examined potential links between professional factors and common mental health disorders, but none have demonstrated a direct causal link...
March 22, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28337525/phosphodiesterase-1b-pde1b-knockout-mice-are-resistant-to-forced-swim-and-tail-suspension-induced-immobility-and-show-upregulation-of-pde10a
#9
Jillian R Hufgard, Michael T Williams, Matthew R Skelton, Olivera Grubisha, Filipa M Ferreira, Helen Sanger, Mary E Wright, Tracy M Reed-Kessler, Kurt Rasmussen, Ronald S Duman, Charles V Vorhees
RATIONALE: Major depressive disorder is a leading cause of suicide and disability. Despite this, current antidepressants provide insufficient efficacy in more than 60% of patients. Most current antidepressants are presynaptic reuptake inhibitors; postsynaptic signal regulation has not received as much attention as potential treatment targets. OBJECTIVES: We examined the effects of disruption of the postsynaptic cyclic nucleotide hydrolyzing enzyme, phosphodiesterase (PDE) 1b, on depressive-like behavior and the effects on PDE1B protein in wild-type (WT) mice following stress...
March 23, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28322440/psychological-therapies-for-the-treatment-of-anxiety-disorders-in-chronic-obstructive-pulmonary-disease
#10
REVIEW
Zafar A Usmani, Kristin V Carson, Karen Heslop, Adrian J Esterman, Anthony De Soyza, Brian J Smith
BACKGROUND: Chronic obstructive pulmonary disease (COPD) (commonly referred to as chronic bronchitis and emphysema) is a chronic lung condition characterised by the inflammation of airways and irreversible destruction of pulmonary tissue leading to progressively worsening dyspnoea. It is a leading international cause of disability and death in adults. Evidence suggests that there is an increased prevalence of anxiety disorders in people with COPD. The severity of anxiety has been shown to correlate with the severity of COPD, however anxiety can occur with all stages of COPD severity...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28303025/targeting-glutamate-signalling-in-depression-progress-and-prospects
#11
REVIEW
James W Murrough, Chadi G Abdallah, Sanjay J Mathew
Major depressive disorder (MDD) is severely disabling, and current treatments have limited efficacy. The glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine was recently repurposed as a rapidly acting antidepressant, catalysing the vigorous investigation of glutamate-signalling modulators as novel therapeutic agents for depressive disorders. In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants...
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28293465/the-effect-of-vortioxetine-on-overall-patient-functioning-in-patients-with-major-depressive-disorder
#12
Ioana Florea, Henrik Loft, Natalya Danchenko, Benoît Rive, Melanie Brignone, Elizabeth Merikle, Paula L Jacobsen, David V Sheehan
BACKGROUND: The objectives of this meta-analysis of data from randomized, placebo-controlled studies were to assess the effect of vortioxetine on overall functioning (primary) and functional remission (secondary) using the Sheehan Disability Scale (SDS) in adults with major depressive disorder (MDD). METHODS: Data from nine short-term (6/8 weeks) pivotal studies that included patient functioning assessments were included in this random-effects meta-analysis, which used aggregated study-level data for all therapeutic vortioxetine doses and a mixed-effect model for repeated measures using the full analysis set...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28274333/smoking-and-common-mental-disorders-in-patients-with-chronic-conditions-an-analysis-of-data-collected-via-a-web-based-screening-system
#13
Faith Matcham, Amy Carroll, Natali Chung, Victoria Crawford, James Galloway, Anna Hames, Karina Jackson, Clare Jacobson, Dulka Manawadu, Lance McCracken, John Moxham, Lauren Rayner, Deborah Robson, Anna Simpson, Nicky Wilson, Matthew Hotopf
OBJECTIVE: Smoking is the largest preventable cause of death and disability in the UK and remains pervasive in people with mental disorders and in general hospital patients. We aimed to quantify the prevalence of mental disorders and smoking, examining associations between mental disorders and smoking in patients with chronic physical conditions. METHOD: Data were collected via routine screening systems implemented across two London NHS Foundation Trusts. The prevalence of mental disorder, current smoking, nicotine dependence and wanting help with quitting smoking were quantified, and the relationships between mental disorder and smoking were examined, adjusting for age, gender and physical illness, with multiple regression models...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28273041/the-burden-of-generalized-anxiety-disorder-in-canada
#14
Louise Pelletier, Siobhan O'Donnell, Louise McRae, Jean Grenier
INTRODUCTION: Although generalized anxiety disorder (GAD) is common and disabling, there are few Canadian studies on this mental illness. We compared the characteristics, health status, health services use and health care needs of Canadians with GAD to those with depression. METHODS: Data are from the 2012 Canadian Community Health Survey-Mental Health, which surveyed a nationally representative sample of Canadians aged 15 years and older (n = 23 709; response rate of 68...
February 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28271741/the-preclinical-discovery-and-development-of-quetiapine-for-the-treatment-of-mania-and-depression
#15
Aline Silva de Miranda, Fabrício A Moreira, Antônio Lúcio Teixeira
Bipolar disorder is a chronic disabling condition characterized by alternating manic and depressive episodes. Bipolar disorder has been associated with functional impairment, poor quality of life, morbidity and mortality. Despite its significant clinical, social and economic burden, treatment options for bipolar disorder are still limited. Several clinical trials have shown efficacy of the atypical antipsychotic quetiapine (QTP) in the treatment of this condition. However, the mechanisms underlying the antidepressant and anti-manic effects of QTP remain poorly understood...
March 14, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28264739/remission-and-recovery-associated-with-lurasidone-in-the-treatment-of-major-depressive-disorder-with-subthreshold-hypomanic-symptoms-mixed-features-post-hoc-analysis-of-a-randomized-placebo-controlled-study-with-longer-term-extension
#16
Joseph F Goldberg, Daisy Ng-Mak, Cynthia Siu, Chien-Chia Chuang, Krithika Rajagopalan, Antony Loebel
OBJECTIVE: This post-hoc analysis assessed rates of symptomatic and functional remission, as well as recovery (combination of symptomatic and functional remission), in patients treated with lurasidone for major depressive disorder (MDD) associated with subthreshold hypomanic symptoms (mixed features). METHOD: Patients with MDD plus two or three manic symptoms (defined as per the DSM-5 mixed-features specifier) were randomly assigned to flexible-dose lurasidone 20-60 mg/day (n=109) or placebo (n=100) for 6 weeks, followed by a 3-month open-label, flexible-dose extension study for U...
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28252881/a-randomized-controlled-pilot-study-on-mindfulness-based-cognitive-therapy-for-unipolar-depression-in-patients-with-chronic-pain
#17
Marasha de Jong, Frenk Peeters, Tim Gard, Heidi Ashih, Jim Doorley, Rosemary Walker, Laurie Rhoades, Ronald J Kulich, Karsten D Kueppenbender, Jonathan E Alpert, Elizabeth A Hoge, Willoughby B Britton, Sara W Lazar, Maurizio Fava, David Mischoulon
OBJECTIVE: Chronic pain is a disabling illness, often comorbid with depression. We performed a randomized controlled pilot study on mindfulness-based cognitive therapy (MBCT) targeting depression in a chronic pain population. METHOD: Participants with chronic pain lasting ≥ 3 months; DSM-IV major depressive disorder (MDD), dysthymic disorder, or depressive disorder not otherwise specified; and a 16-item Quick Inventory of Depressive Symptomatology-Clinician Rated (QIDS-C₁₆) score ≥ 6 were randomly assigned to MBCT (n = 26) or waitlist (n = 14)...
February 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28241025/economic-evaluation-of-a-guided-and-unguided-internet-based-cbt-intervention-for-major-depression-results-from-a-multi-center-three-armed-randomized-controlled-trial-conducted-in-primary-care
#18
Pablo Romero-Sanchiz, Raquel Nogueira-Arjona, Antonio García-Ruiz, Juan V Luciano, Javier García Campayo, Margalida Gili, Cristina Botella, Rosa Baños, Adoración Castro, Yolanda López-Del-Hoyo, Mª Ángeles Pérez Ara, Marta Modrego-Alarcón, Fermín Mayoral Cleríes
Depression is one of the most common mental disorders and will become one of the leading causes of disability in the world. Internet-based CBT programs for depression have been classified as "well established" following the American Psychological Association criteria for empirically supported treatments. The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program "Smiling is fun" with (LITG) and without psychotherapist support (TSG) compared to usual care...
2017: PloS One
https://www.readbyqxmd.com/read/28186152/association-of-polygenic-risk-for-major-psychiatric-illness-with-subcortical-volumes-and-white-matter-integrity-in-uk-biobank
#19
L M Reus, X Shen, J Gibson, E Wigmore, L Ligthart, M J Adams, G Davies, S R Cox, S P Hagenaars, M E Bastin, I J Deary, H C Whalley, A M McIntosh
Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlapping polygenic architecture. Individuals with these disorders, as well as their unaffected relatives, show widespread structural differences in corticostriatal and limbic networks. Structural variation in many of these brain regions is also heritable and polygenic but whether their genetic architecture overlaps with that of major psychiatric disorders is unknown...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28179814/prenatal-stress-immune-programming-of-sex-differences-in-comorbidity-of-depression-and-obesity-metabolic-syndrome
#20
Jill M Goldstein, Laura Holsen, Grace Huang, Bradley D Hammond, Tamarra James-Todd, Sara Cherkerzian, Taben M Hale, Robert J Handa
Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). Women have twice as much risk for MDD and comorbidity with obesity/MetS as men, although pathways for understanding this association remain unclear. On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, excess glucocorticoid expression and associated immune responses) that occurs during the sexual differentiation of the fetal brain has sex-dependent effects on brain development within highly sexually dimorphic regions that regulate mood, stress, metabolic function, the autonomic nervous system, and the vasculature...
December 2016: Dialogues in Clinical Neuroscience
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