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Pyroglutamate very low

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https://www.readbyqxmd.com/read/25481042/porphyromonas-pogonae-sp-nov-an-anaerobic-but-low-concentration-oxygen-adapted-coccobacillus-isolated-from-lizards-pogona-vitticeps-or-human-clinical-specimens-and-emended-description-of-the-genus-porphyromonas-shah-and-collins-1988
#1
Yoshiaki Kawamura, Saki Kuwabara, Stephen A Kania, Hisayuki Kato, Manami Hamagishi, Nagatoshi Fujiwara, Takuichi Sato, Junko Tomida, Kaori Tanaka, David A Bemis
During the process of identifying a Gram-negative coccobacillus isolated from a human clinical specimen, we found that the isolate's 16S rRNA gene had very close sequence identity with that of a variant Porphyromonas isolated from polymicrobial infections in the central bearded dragon, a species of lizard [2]. The 16S rRNA gene sequences of the human isolate and of six isolates from lizards were nearly identical (99.9-100%). Phylogenetic analysis placed all of these isolates in a single phylogenetic cluster well separated from other species in the genus Porphyromonas...
March 2015: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/24389621/-stereoselective-synthesis-of-polyhydroxylated-amines-using-s-pyroglutamic-acid-derivatives
#2
REVIEW
Nobuo Ikota
Naturally occurring polyhydroxylated amines such as (+)-1-deoxynojirimycin, polyoxamic acid, anisomycin, (-)swainsonine, and alexine stereoisomers, which have interesting biological activities including glucosidase- and mannosidase-inhibitory activity, immunoregulatory activity, and antibacterial effects, were synthesized stereoselectively starting from (S)-pyroglutamic acid derivatives. α,β-Unsaturated lactams ((S)-5-hydroxymethyl-2-oxo-3-pyrroline derivatives), α,β-unsaturated δ-lactone ((S)-4-amino-2-penten-5-olide derivative), and E-olefin ((S,E)-methyl-4-amino-5-hydroxypent-2-enoate derivative) from (S)-pyroglutamic acid derivatives were dihydroxylated using OsO4 in the presence of N-methyl morpholine N-oxide (NMO) to afford various chiral building blocks with different configurations...
2014: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/24235282/acetaminophen-toxicity-and-5-oxoproline-pyroglutamic-acid-a-tale-of-two-cycles-one-an-atp-depleting-futile-cycle-and-the-other-a-useful-cycle
#3
REVIEW
Michael Emmett
The acquired form of 5-oxoproline (pyroglutamic acid) metabolic acidosis was first described in 1989 and its relationship to chronic acetaminophen ingestion was proposed the next year. Since then, this cause of chronic anion gap metabolic acidosis has been increasingly recognized. Many cases go unrecognized because an assay for 5-oxoproline is not widely available. Most cases occur in malnourished, chronically ill women with a history of chronic acetaminophen ingestion. Acetaminophen levels are very rarely in the toxic range; rather, they are usually therapeutic or low...
January 2014: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/19699792/developmental-expression-and-subcellular-localization-of-glutaminyl-cyclase-in-mouse-brain
#4
Maike Hartlage-Rübsamen, Katharina Staffa, Alexander Waniek, Michael Wermann, Torsten Hoffmann, Holger Cynis, Stephan Schilling, Hans-Ulrich Demuth, Steffen Rossner
Glutaminyl cyclase (QC) converts N-terminal glutaminyl residues into pyroglutamate (pE), thereby stabilizing these peptides/proteins. Recently, we demonstrated that QC also plays a pathogenic role in Alzheimer's disease by generating the disease-associated pE-Abeta from N-terminally truncated Abeta peptides in vivo. This newly identified function makes QC an interesting pharmacological target for Alzheimer's disease therapy. However, the expression of QC in brain and peripheral organs, its cell type-specific and subcellular localization as well as developmental profiles in brain are not known...
December 2009: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/14685659/unexplained-metabolic-acidosis-in-critically-ill-patients-the-role-of-pyroglutamic-acid
#5
Barry A Mizock, Stanislav Belyaev, Carter Mecher
OBJECTIVE: To determine the role of pyroglutamic acid (PGA) in the pathogenesis of unexplained metabolic acidosis in critically ill patients. DESIGN AND SETTING: Case series in the medical ICU of an urban hospital. PATIENTS: 23 patients admitted to the medical ICU with acidemia (pH <7.35 or HC0(3) < or = 16 mEq/l) not explained by the presence of ketoacidosis, lactic acidosis, renal failure or ingestion of drugs or toxins and who had an increase in the strong ion gap (SIG) greater than 5...
March 2004: Intensive Care Medicine
https://www.readbyqxmd.com/read/10698709/cloning-and-characterization-of-a-novel-nuclease-from-shrimp-hepatopancreas-and-prediction-of-its-active-site
#6
W Y Wang, S H Liaw, T H Liao
Approximately 95% of the amino acid sequence of a shrimp (Penaeus japonicus) nuclease was derived from protease-digested peptides. A 1461-base cDNA for the nuclease was amplified and sequenced with degenerate primers based on the amino acid sequence and then specific primers by 3' and 5' RACE (rapid amplification of cDNA ends). It contains an open reading frame encoding a putative 21-residue signal peptide and a 381-residue mature protein. The N-terminus of the enzyme is pyroglutamate, deduced from composition and matrix-assisted laser desorption ionization-time-of-flight MS analyses, and confirmed by a glutamine residue in the cDNA sequence...
March 15, 2000: Biochemical Journal
https://www.readbyqxmd.com/read/9266695/an-angiogenic-protein-from-bovine-serum-and-milk-purification-and-primary-structure-of-angiogenin-2
#7
COMPARATIVE STUDY
D J Strydom, M D Bond, B L Vallee
Bovine serum and milk contain a basic angiogenic protein that binds tightly to placental ribonuclease inhibitor. It was purified from both sources by ion-exchange and reversed-phase chromatographies. Its amino acid sequence revealed that it is a member of the ribonuclease superfamily. It contains 123 amino acids in a single polypeptide chain, is cross-linked by three disulfide bonds, is glycosylated at Asn33, and is 57% identical to bovine angiogenin. The amino-terminal and carboxyl-terminal residues are pyroglutamic acid and proline, respectively...
July 15, 1997: European Journal of Biochemistry
https://www.readbyqxmd.com/read/6801013/delta1-piperideine-2-carboxylate-reductase-of-pseudomonas-putida
#8
C W Payton, Y F Chang
Pseudomonas putida metabolizes D-lysine to delta 1-piperideine-2-carboxylate and L-pipecolate. The second step of this catabolic pathway is catalyzed by delta 1-piperideine-2-carboxylate reductase. This enzyme was isolated and purified from cells grown on DL-lysine as substrate. The enzyme was very unstable, resulting in low recovery of activity and low purity after a six-step purification procedure. The enzyme had a pH optimum of 8.0 to 8.3. The Km values for delta 1-piperideine-2-carboxylate and NADPH were 0...
March 1982: Journal of Bacteriology
https://www.readbyqxmd.com/read/6202194/the-role-of-enzyme-lysyl-amino-groups-in-the-reaction-with-alpha-2-macroglobulin
#9
R D Feinman, D Wang, S R Windwer, K Wu
The primary observation, from our laboratory and others, of the effect of blocking the lysyl amino groups of enzymes is the reduction in the fraction of complexes that are resistant to SDS. The blocked enzyme derivatives do cause the specific proteolysis of the alpha 2M subunit to the 85K/100K fragments, and do cause the appearance of new thiol groups. With respect to the sequence of reaction, we may summarize the results by saying that if the reversible DMM-trypsin is, in fact, a model for the native enzyme, proteolysis can precede formation of the presumed covalent bond between bound enzyme and inhibitor...
1983: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/6111350/inactivation-of-pyroglutamyl-aminopeptidase-by-l-pyroglutamyl-chloromethyl-ketone
#10
K Fujiwara, T Kitagawa, D Tsuru
A chloromethyl ketone derivative of pyroglutamic acid was newly synthesized and its reactivity with bacterial pyroglutamyl aminopeptidase (L-pyroglutamyl-peptide hydrolas, EC 3.4.11.8) as an affinity labelling reagent was examined. The compound was found to inactivate the enzyme markedly and rapidly at very low concentrations, though the enzyme was resistant to N-tosyl-phenylalanyl chloromethyl ketone. The rate of the enzyme inactivation by pyroglutamyl chloromethyl ketone was retarded in the presence of a poor substrate, pyroglutamyl valine...
March 13, 1981: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/2871517/possible-role-of-neuropeptide-degrading-enzymes-on-thyroliberin-secretion-in-fetal-hypothalamic-cultures-grown-in-serum-free-medium
#11
A Faivre-Bauman, C Loudes, A Barret, A Tixier-Vidal, K Bauer
In the present work, we have looked for the presence of two tissular neuropeptide degrading activities, the pyroglutamate aminopeptidase (PAP) and the post-proline cleaving enzyme (PPCE), in dissociated brain cell cultures. These two activities are present in extracts of cells grown in serum-free medium and are detected at a very low level in incubation media. Depolarization of hypothalamic neurons by 60 mM K+ does not specifically increase the level of PAP and PPCE in the medium. We have also used an inhibitor of PPCE: Z-Gly-ProCHN2...
February 1986: Neuropeptides
https://www.readbyqxmd.com/read/1350761/purification-and-sequencing-of-molluscan-insulin-related-peptide-ii-from-the-neuroendocrine-light-green-cells-in-lymnaea-stagnalis
#12
K W Li, W P Geraerts, J Joosse
The growth-controlling neuroendocrine light green cells of the freshwater snail, Lymnaea stagnalis, express a family of genes encoding structurally related, yet distinct, molluscan insulin-related peptides (MIPs). In the present study one of these peptides, MIP II, has been isolated and structurally identified. MIP II is a heterodimer of A and B chains connected by disulfide bonds. Both chains are N-terminally blocked with pyroglutamate. After cleaving of the A and B chains and deblocking with pyroglutamate amino-peptidase their sequences have been determined as: A chain: pQRTTNLVCECCFNYCTPDVVRKYCY and B chain: pQSSCSLSSRPHPRGICGSNLAGFRAFICSNQNSPS...
June 1992: Endocrinology
https://www.readbyqxmd.com/read/1304358/amino-acid-sequence-of-fibrolase-a-direct-acting-fibrinolytic-enzyme-from-agkistrodon-contortrix-contortrix-venom
#13
COMPARATIVE STUDY
A Randolph, S H Chamberlain, H L Chu, A D Retzios, F S Markland, F R Masiarz
The complete amino acid sequence of fibrolase, a fibrinolytic enzyme from southern copperhead (Agkistrodon contortrix contortrix) venom, has been determined. This is the first report of the sequence of a direct-acting, nonhemorrhagic fibrinolytic enzyme found in snake venom. The majority of the sequence was established by automated Edman degradation of overlapping peptides generated by a variety of selective cleavage procedures. The amino-terminus is blocked by a cyclized glutamine (pyroglutamic acid) residue, and the sequence of this region of the molecule was determined by mass spectrometry...
May 1992: Protein Science: a Publication of the Protein Society
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