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Michael G Ficklin, Michael P Kowaleski, Kevin A R Kunkel, Jonathan T Suber
A two-year-old, 44 kg dog with a right Helica cementless total hip replacement (THR) was radiographically diagnosed with implant loosening eight months after the index total hip replacement procedure. Subsequent synoviocentesis and synovial fluid culture revealed a methicillin-resistant coagulase-negative Staphylococcus spp infection of the right THR. A one-stage revision using a hybrid BFX cementless acetabular cup and CFX cemented femoral stem was performed. Vancomycin and micro-silver antimicrobial powder impregnated cement were used in the revision...
October 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Sylvain Legay, Gea Guerriero, Christelle André, Cédric Guignard, Emmanuelle Cocco, Sophie Charton, Marc Boutry, Owen Rowland, Jean-Francois Hausman
A comparison of the transcriptomes of russeted vs nonrusseted apple skins previously highlighted a tight relationship between a gene encoding an MYB-type transcription factor, MdMYB93, and some key suberin biosynthetic genes. The present work assesses the role of this transcription factor in the suberization process. A phylogenetic analysis of MdMYB93 and Arabidopsis thaliana MYBs was performed and the function of MdMYB93 was further investigated using Agrobacterium-mediated transient overexpression in Nicotiana benthamiana leaves...
September 15, 2016: New Phytologist
Rosalia Deeken, Stefanie Saupe, Jörn Klinkenberg, Michael Riedel, Jana Leide, Rainer Hedrich, Thomas Mueller
Non-specific lipid transfer proteins (nsLTPs) reversibly bind different types of lipid molecules in a hydrophobic cavity. They facilitate phospholipid transfer between membranes in vitro, play a role in cuticle and possibly in suberin formation, and might be involved in plant pathogen defense signaling. This study focuses on the role of AtLTPI-4 in crown gall development. Arabidopsis thaliana crown gall tumors, which develop upon infection with the virulent Agrobacterium tumefaciens strain C58, highly expressed the type I nsLTP gene AtLTPI-4...
September 29, 2016: Plant Physiology
Andreia F Sousa, Alessandro Gandini, Ana Caetano, Teresa M R Maria, Carmen S R Freire, Carlos Pascoal Neto, Armando J D Silvestre
The main purpose of this study was to investigate the potential of suberin (a naturally occurring aromatic-aliphatic polyester ubiquitous to the vegetable realm) as a renewable source of chemicals and, in particular, to assess their physical properties. A comparison between cork and birch suberin fragments obtained by conventional depolymerisation processes (hydrolysis or methanolysis) is provided, focusing essentially on their thermal and crystallinity properties. It was found that suberin fragments obtained by the hydrolysis depolymerisation of birch had a high degree of crystallinity, as indicated by their thermal analysis and corroborated by the corresponding XRD diffractions, as opposed to hydrolysis-depolymerised cork suberin counterparts, which were essentially amorphous...
September 12, 2016: International Journal of Biological Macromolecules
Suber S Huang, Chad Marcantonio
No abstract text is available yet for this article.
September 2016: Asia-Pacific Journal of Ophthalmology
Justin Graham Lashbrooke, Hagai Cohen, Dorit Levy-Samocha, Oren Tzfadia, Irina Panizel, Viktoria Zeisler, Hassan Massalha, Adi Stern, Livio Trainotti, Lukas Schreiber, Fabrizio Costa, Asaph Aharoni
Suberin, a polymer composed of both aliphatic and aromatic domains, is deposited as a rough matrix upon plant surface damage and during normal growth in the root endodermis, bark, specialized organs (e.g., Solanum tuberosum (potato) tubers), and seed coats. To identify genes associated with the developmental control of suberin deposition, we investigated the chemical composition and transcriptomes of suberized Solanum lycopersicum (tomato) and russet apple (Malus x domestica) fruit surfaces. Consequently, a gene expression signature for suberin polymer assembly was revealed that is highly conserved in angiosperms...
September 7, 2016: Plant Cell
Madori Osawa, Sohtaro Mine, Shinichiro Ota, Kengo Kato, Tsuyoshi Sekizuka, Makoto Kuroda, Michiyo Kataoka, Hitomi Fukumoto, Yuko Sato, Takayuki Kanno, Hideki Hasegawa, Keiji Ueda, Masashi Fukayama, Takuya Maeda, Soichiro Kanoh, Akihiko Kawana, Yuji Fujikura, Harutaka Katano
BACKGROUND: Primary effusion lymphoma is a rare distinct large B-cell neoplasm that is associated with Kaposi's sarcoma-associated herpesvirus (KSHV) infection. Over recent years, 9 KSHV-positive/Epstein-Barr virus (EBV)-negative PEL cell lines have been established. METHODS: Tumor cells were collected from the pleural effusion of a 49-year-old male with AIDS. Cells were grown in RPMI1640 culture medium supplemented with 10 % fetus bovine serum. Single cell cloning was performed successfully by a limiting dilution method in a 96-well plate...
2016: Infectious Agents and Cancer
Roger Verdaguer, Marçal Soler, Olga Serra, Aïda Garrote, Sandra Fernández, Dolors Company-Arumí, Enriqueta Anticó, Marisa Molinas, Mercè Figueras
Suberin and wax deposited in the cork (phellem) layer of the periderm form the lipophilic barrier that protects mature plant organs. Periderm lipids have been widely studied for their protective function with regards to dehydration and for how they respond to environmental stresses and wounding. However, despite advances in the biosynthetic pathways of suberin and associated wax, little is known about the regulation of their deposition. Here, we report on a potato NAC transcription factor gene, StNAC103, induced in the tuber phellem (skin)...
October 2016: Journal of Experimental Botany
Suber S Huang, Katherine High, Raffaella Toso
No abstract text is available yet for this article.
July 2016: Asia-Pacific Journal of Ophthalmology
Devrim Coskun, Dev T Britto, Wayne Q Huynh, Herbert J Kronzucker
Although deemed a "non-essential" mineral nutrient, silicon (Si) is clearly beneficial to plant growth and development, particularly under stress conditions, including salinity and drought. Here, we review recent research on the physiological, biochemical, and molecular mechanisms underlying Si-induced alleviation of osmotic and ionic stresses associated with salinity and drought. We distinguish between changes observed in the apoplast (i.e., suberization, lignification, and silicification of the extracellular matrix; transpirational bypass flow of solutes and water), and those of the symplast (i...
2016: Frontiers in Plant Science
Devon H Ghodasra, Adrienne Chen, J Fernando Arevalo, David G Birch, Kari Branham, Brian Coley, Gislin Dagnelie, Eugene de Juan, Robert G Devenyi, Jessy D Dorn, Andy Fisher, Duane R Geruschat, Ninel Z Gregori, Robert J Greenberg, Paul Hahn, Allen C Ho, Ashley Howson, Suber S Huang, Raymond Iezzi, Naheed Khan, Byron L Lam, Jennifer I Lim, Kirsten G Locke, Michelle Markowitz, Anne-Marie Ripley, Mark Rankin, Hannah Schimitzek, Fay Tripp, James D Weiland, Jiong Yan, David N Zacks, K Thiran Jayasundera
No abstract text is available yet for this article.
2016: BMC Ophthalmology
Michael G Ficklin, Kevin A R Kunkel, Jonathan T Suber, Patrick D Gerard, Michael P Kowaleski
OBJECTIVES: Numerous studies have examined the biomechanics of polymethyl methacrylate (PMMA) with added antibiotics, but direct comparison between studies is difficult. Our purpose was to evaluate the effects of the addition of antibiotic drugs and silver on compressive and bending strength of PMMA. Our null hypothesis was that there would be no significant difference in the compressive strength or bending strength of PMMA with the addition of silver or varying amounts of antibiotic drugs...
September 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Gregory M Treich, Shamima Nasreen, Arun Mannodi Kanakkithodi, Rui Ma, Mattewos Tefferi, James Flynn, Yang Cao, Rampi Ramprasad, Gregory A Sotzing
Recently, there has been a growing interest in developing wide band gap dielectric materials as the next generation insulators for capacitors, photovoltaic devices, and transistors. Organotin polyesters have shown promise as high dielectric constant, low loss, and high band gap materials. Guided by first-principles calculations from density functional theory (DFT), in line with the emerging codesign concept, the polymer poly(dimethyltin 3,3-dimethylglutarate), p(DMTDMG), was identified as a promising candidate for dielectric applications...
August 24, 2016: ACS Applied Materials & Interfaces
Hai Song, Hua Xiong, Jing Che, Qing-Song Xi, Liu Huang, Hui-Hua Xiong, Peng Zhang
The ubiquitin-proteasome system plays a pivotal role in breast tumorigenesis by controlling transcription factors, thus promoting cell cycle growth, and degradation of tumor suppressor proteins. However, breast cancer patients have failed to benefit from proteasome inhibitor treatment partially due to proteasome heterogeneity, which is poorly understood in malignant breast neoplasm. Chemical crosslinking is an increasingly important tool for mapping protein three-dimensional structures and proteinprotein interactions...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
José María Maya-Manzano, Santiago Fernández-Rodríguez, Matt Smith, Rafael Tormo-Molina, Andrew M Reynolds, Inmaculada Silva-Palacios, Ángela Gonzalo-Garijo, Magdalena Sadyś
The pollen grains of Quercus spp. (oak trees) are allergenic. This study investigates airborne Quercus pollen in SW Spain with the aim identifying favourable conditions for atmospheric transport and potential sources areas. Two types of Quercus distribution maps were produced. Airborne Quercus pollen concentrations were measured at three sites located in the Extremadura region (SW Spain) for 3 consecutive years. The seasonal occurrence of Quercus pollen in the air was investigated, as well as days with pollen concentrations ≥80Pm(-3)...
November 15, 2016: Science of the Total Environment
Leila Birolo, Silvia Sacchi, Giovanni Smaldone, Gianluca Molla, Gabriella Leo, Laura Caldinelli, Luciano Pirone, Patrick Eliometri, Sonia Di Gaetano, Ida Orefice, Emilia Pedone, Piero Pucci, Loredano Pollegioni
The human flavoenzyme d-amino acid oxidase (hDAAO) degrades the NMDA-receptor modulator d-serine in the brain. Although hDAAO has been extensively characterized, little is known about its main modulator pLG72, a small protein encoded by the primate-specific gene G72 that has been associated with schizophrenia susceptibility. pLG72 interacts with neosynthesized hDAAO, promoting its inactivation and degradation. In this work, we used low-resolution techniques to characterize the surface topology of the hDAAO-pLG72 complex...
September 2016: FEBS Journal
William P Clafshenkel, Hironobu Murata, Jill Andersen, Yehuda Creeger, Richard R Koepsel, Alan J Russell
Erythrocytes have been described as advantageous drug delivery vehicles. In order to ensure an adequate circulation half-life, erythrocytes may benefit from protective enhancements that maintain membrane integrity and neutralize oxidative damage of membrane proteins that otherwise facilitate their premature clearance from circulation. Surface modification of erythrocytes using rationally designed polymers, synthesized via atom-transfer radical polymerization (ATRP), may further expand the field of membrane-engineered red blood cells...
2016: PloS One
Xiaohe Huo, Peipei Liu, Jie Zhu, Xiaoqiang Liu, Huangxian Ju
A ternary TiO2 nanotube (TNT) composite and a signal antibody and horseradish peroxidase (HRP) functionalized TNT were designed as an electrode scaffold for immobilization of high quantity of capture antibody and a tracing tag for immunosensing, respectively. The polyaniline (PANI) was coated on TNTs by chemical oxidative polymerization, and gold nanoparticles were deposited on TNT-PANI with a routine chemical reduction. Various techniques including scanning electron microscopy, energy dispersive X-ray, transmission electron microscope, X-ray diffraction, Fourier transform infrared spectra, X-ray photoelectron spectra, impedance and electrochemical techniques were used to characterize the nano-materials...
November 15, 2016: Biosensors & Bioelectronics
Carmen Puig-Alcaraz, Milagros Fuentes-Albero, Omar Cauli
Dicarboxylic acids are an important source of information about metabolism and potential physiopathological alterations in children with autism spectrum disorders (ASDs). We measured the concentration between dicarboxylic adipic and suberic acids in children with an ASD and typically-developing (TD) children and analyzed any relationships between the severity of the core symptoms of ASDs and other clinical features (drugs, supplements, drugs, or diet). The core symptoms of autism were evaluated using the DSM-IV criteria, and adipic acid and suberic acid were measured in urine samples...
August 30, 2016: Psychiatry Research
L Qi, C Cao, L Hu, S Chen, X Zhao, C Sun
The present study aims to investigate the protective effect of quercetin against the joint toxic action induced by the mixture of four organophosphate pesticides (mixture-OPs) (dimethoate, acephate, dichlorvos, and phorate) at their corresponding no observed adverse effect level (NOAEL) using metabonomics. Rats were randomly divided into control, quercetin-treated, mixture-OPs-treated, and quercetin plus mixture-OPs-treated groups. Mixture-OPs and quercetin were given to the rats daily through drinking water and intragastric administration, respectively, for 90 days...
June 1, 2016: Human & Experimental Toxicology
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