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Fatty Acid Metabolism Suberate

Kathlyn N Woolfson, Meghan L Haggitt, Yanni Zhang, Alexandra Kachura, Anica Bjelica, M Alejandra Rey Rincon, Karina M Kaberi, Mark A Bernards
Wound-induced suberin deposition involves the temporal and spatial coordination of phenolic and fatty acid metabolism. Phenolic metabolism leads to both soluble metabolites that accumulate as defense compounds as well as hydroxycinnamoyl derivatives that form the basis of the poly(phenolic) domain found in suberized tissue. Fatty acid metabolism involves the biosynthesis of very-long-chain fatty acids, 1-alkanols, ω-hydroxy fatty acids and α,ω-dioic acids that form a poly(aliphatic) domain, commonly referred to as suberin...
March 2018: Plant Journal: for Cell and Molecular Biology
Søren Drud Nielsen, Bashar Amer, Karoline Blaabjerg, Trine K Dalsgaard, Randi Jessen, Bjørn Petrat-Melin, Martin Krøyer Rasmussen, Hanne D Poulsen, Jette F Young
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes...
January 18, 2017: Journal of Agricultural and Food Chemistry
L Qi, C Cao, L Hu, S Chen, X Zhao, C Sun
The present study aims to investigate the protective effect of quercetin against the joint toxic action induced by the mixture of four organophosphate pesticides (mixture-OPs) (dimethoate, acephate, dichlorvos, and phorate) at their corresponding no observed adverse effect level (NOAEL) using metabonomics. Rats were randomly divided into control, quercetin-treated, mixture-OPs-treated, and quercetin plus mixture-OPs-treated groups. Mixture-OPs and quercetin were given to the rats daily through drinking water and intragastric administration, respectively, for 90 days...
May 2017: Human & Experimental Toxicology
Camille Delude, Laetitia Fouillen, Palash Bhar, Marie-Josée Cardinal, Stephanie Pascal, Patricia Santos, Dylan K Kosma, Jérôme Joubès, Owen Rowland, Frédéric Domergue
Suberin is a complex hydrophobic polymer that acts as a barrier controlling water and solute fluxes and restricting pathogen infections. Suberin is deposited immediately outside of the plasmalemma in the cell wall of certain tissues such as endodermis of roots, aerial and underground periderms, and seed coats. Suberin consists of a variety of fatty acid derivatives polymerized with glycerol and phenolics. In this study, we show using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry techniques that most of the fatty alcohols not covalently linked to the suberin polymer are in the form of alkyl hydroxycinnamates (AHCs), with alkyl caffeates predominating...
July 2016: Plant Physiology
Maria Anderson, Kathrin Eliot, Patrick Kelly, James Shoemaker
PURPOSE: Infant formulas are often supplemented with medium-chain triglycerides (MCTs) to optimize calories for small for gestational age or preterm infants. High amounts of MCTs have been associated with an increase in dicarboxylic acid (DCA) in the urine. Elevated DCA in the urine is also a clinical indicator for fatty acid metabolism disorders. The purpose of this study was to identify if there is an amount of MCTs that can be provided without elevating urinary DCA excretion. METHODS: A metabolic screening laboratory provided urinary DCA excretion data for 175 infants...
May 6, 2016: Nutrition in Clinical Practice
Jun-sheng Tian, Cai-chun Liu, Huan Xiang, Xiao-fen Zheng, Guo-jiang Peng, Xiang Zhang, Guan-hua Du, Xue-mei Qin
Depression is one of the prevalent and serious mental disorders and the number of depressed patients has been on the rise globally during the recent decades. Sea buckthorn seed oil from traditional Chinese medicine (TCM) is edible and has been widely used for treatment of different diseases for a long time. However, there are few published reports on the antidepressant effect of sea buckthorn seed oil. With the objective of finding potential biomarkers of the therapeutic response of sea buckthorn seed oil in chronic unpredictable mild stress (CUMS) rats, urine metabolomics based on gas chromatography-mass spectrometry (GC-MS) coupled with multivariate analysis was applied...
November 2015: Food & Function
Chunfang Qiu, Daniel A Enquobahrie, Ihunnaya O Frederick, Tanya K Sorensen, Miguel Angel Luque Fernandez, Robert M David, J Alexander Bralley, Michelle A Williams
AIMS: Alterations in organic acid biomarkers from fatty acid and carbohydrate metabolism have been documented in type 2 diabetes patients. However, their association with gestational diabetes mellitus (GDM) is largely unknown. METHODS: Participants were 25 GDM cases and 25 non-GDM controls. Biomarkers of fatty acid (adipate, suberate and ethylmalonate) and carbohydrate (pyruvate, l-lactate and β-hydroxybutyrate) metabolism were measured in maternal urine samples collected in early pregnancy (17 weeks) using liquid chromatography-mass spectrometry methods...
June 2014: Diabetes Research and Clinical Practice
Konstantin Kulichikhin, Takaki Yamauchi, Kohtaro Watanabe, Mikio Nakazono
The formation of a barrier to radial oxygen (O2 ) loss (ROL) in the root is an important adaptation of plants to root flooding, but the biochemical changes in plant roots where the barrier is formed are unclear. In this study, we analysed metabolic profiles and gene expression profiles in roots of rice (Oryza sativa L.) plants grown under stagnant deoxygenated conditions, which induce suberization in the outer cell layers of the roots and formation of barrier to ROL. Under these conditions, two distinctive biochemical features of the roots were the accumulations of malic acid and very long chain fatty acids (VLCFAs)...
October 2014: Plant, Cell & Environment
H Lange, G Kahl, G Rosenstock
Isolation of tissue fragments from the potato tuber can initiate either periderm formation including suberin synthesis or cell proliferation without cicatrization effects. TCA-cycle activity has been shown to develop only in causal correlation with suberin synthesis (Lange, 1970). Biochemical pathways of carbohydrate metabolism are analysed by investigating the changing levels of 10 intermediates and the activities of 12 corresponding enzymes. Differences between the metabolic kinetics of the two contrasting types of tissue are discussed as the biochemical background of different respiratory behaviour and different histogenetic development...
March 1970: Planta
Zhijing Feng, Xiaowei Sun, Jindan Yang, Dongfang Hao, Longfei Du, Hong Wang, Wei Xu, Xiujuan Zhao, Changhao Sun
This study assessed the effects of long-term, low-dose dimethoate administration to rats by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Dimethoate (0.04, 0.12, and 0.36 mg/kg body weight/day) was administered daily to male Wistar rats through their drinking water for 24 weeks. Significant changes in serum clinical chemistry were observed in the middle- and high-dose groups. UPLC-MS revealed evident separate clustering among the different dose groups using global metabolic profiling by supervised partial least squares-discriminant analysis...
September 30, 2012: Chemico-biological Interactions
Lindsay Tomlinson, Mark A Tirmenstein, Evan B Janovitz, Nelly Aranibar, Karl-Heinz Ott, John C Kozlosky, Laura M Patrone, William E Achanzar, Karen A Augustine, Kimberly C Brannen, Kenneth E Carlson, Jeffrey H Charlap, Katherine M Dubrow, Liya Kang, Laura T Rosini, Julieta M Panzica-Kelly, Oliver P Flint, Frederic J Moulin, John R Megill, Haiying Zhang, Michael J Bennett, Joseph J Horvath
Ibipinabant (IBI), a potent cannabinoid-1 receptor (CB1R) antagonist, previously in development for the treatment of obesity, causes skeletal and cardiac myopathy in beagle dogs. This toxicity was characterized by increases in muscle-derived enzyme activity in serum and microscopic striated muscle degeneration and accumulation of lipid droplets in myofibers. Additional changes in serum chemistry included decreases in glucose and increases in non-esterified fatty acids and cholesterol, and metabolic acidosis, consistent with disturbances in lipid and carbohydrate metabolism...
October 2012: Toxicological Sciences: An Official Journal of the Society of Toxicology
Sander M Houten, Simone Denis, Carmen A Argmann, Yuzhi Jia, Sacha Ferdinandusse, Janardan K Reddy, Ronald J A Wanders
L-bifunctional enzyme (Ehhadh) is part of the classical peroxisomal fatty acid β-oxidation pathway. This pathway is highly inducible via peroxisome proliferator-activated receptor α (PPARα) activation. However, no specific substrates or functions for Ehhadh are known, and Ehhadh knockout (KO) mice display no appreciable changes in lipid metabolism. To investigate Ehhadh functions, we used a bioinformatics approach and found that Ehhadh expression covaries with genes involved in the tricarboxylic acid cycle and in mitochondrial and peroxisomal fatty acid oxidation...
July 2012: Journal of Lipid Research
Jindan Yang, Xiaowei Sun, Zhijing Feng, Dongfang Hao, Maoqing Wang, Xiujuan Zhao, Changhao Sun
The purpose of the current study was to assess the effects of long-term exposure to low levels of DDVP on the biochemical parameters and metabolic profiles of rats. Three different doses (2.4, 7.2, and 21.6 mg/kg body weight/day) of DDVP were administered to rats through their drinking water over 24 weeks. Significant changes in blood cholinesterase, creatinine, urea nitrogen, aspartate aminotransferase, alanine aminotransferase, and albumin concentrations were observed in the middle and high dose groups. Changes in the concentration of some urine metabolites were detected via ultra performance liquid chromatography-mass spectrometry (UPLC-MS)...
October 30, 2011: Toxicology Letters
Wei-Li Yang, Mark A Bernards
Suberin, a cell specific, wall-associated biopolymer, is formed during normal plant growth and development as well as in response to stress conditions such as wounding. It is characterized by the deposition of both a poly(phenolic) domain (SPPD) in the cell wall and a poly(aliphatic) domain (SPAD) thought to be deposited between the cell wall and plasma membrane. Although the monomeric components that comprise the SPPD and SPAD are well known, the biosynthesis and deposition of suberin is poorly understood...
March 2006: Plant Signaling & Behavior
Raymond Thomas, Xingxiao Fang, Kosala Ranathunge, Terry R Anderson, Carol A Peterson, Mark A Bernards
Soybean (Glycine max L. Merr.) is a versatile and important agronomic crop grown worldwide. Each year millions of dollars of potential yield revenues are lost due to a root rot disease caused by the oomycete Phytophthora sojae (Kaufmann & Gerdemann). Since the root is the primary site of infection by this organism, we undertook an examination of the physicochemical barriers in soybean root, namely, the suberized walls of the epidermis and endodermis, to establish whether or not preformed suberin (i.e. naturally present in noninfected plants) could have a role in partial resistance to P...
May 2007: Plant Physiology
M Tojo, T Gunji, S Yamaguchi, N Shimizu, Y Koga, I Nonaka
We reported a male infant with multiple acyl CoA dehydrogenase deficiency, probably due to electron transfer flavoprotein dehydrogenase deficiency. He was noted to have severe muscle weakness, a high serum creatine kinase (CK) level up to 6920 IU/L, lipid storage myopathy and fatty liver at 6 months of age. A GC/MS analysis of urinary organic acids showed excess excretion of dicarboxylic acids, including glutaric, 2-hydroxyglutaric, adipic, suberic, sebacic, malonic, ethylmalonic and methylsuccinic acids. On a urinary acylglycine analysis, hexanoylglycine and suberylglycine were increased, but not isovalerylglycine, in amount...
March 2000: No to Hattatsu. Brain and Development
X Ma, E Baraona, B G Goozner, C S Lieber
PURPOSE: Women appear to be more vulnerable to developing alcoholic liver disease than men. In rats, we previously found that the response of certain pathways of fatty acid metabolism to alcohol feeding was less efficient in females than in males, resulting in striking accumulation of fatty acids in the liver of the female rats. We sought to determine whether similar differences occurred in humans. PATIENTS AND METHODS: Urinary excretion of medium chain (C6-C10) dicarboxylic acids (final products of fatty acid omega-oxidation) was determined in 40 recently drinking alcoholic subjects (24 men and 16 women) and 21 nonalcoholic subjects (12 men and nine women)...
January 1999: American Journal of Medicine
M Podell, G D Shelton, W L Nyhan, S O Wagner, A Genders, M Oglesbee, W R Fenner
A 12 week old female Labrador retriever dog with signs of progressive diffuse degeneration of the brain and spinal cord was found to have methylmalonic and malonic aciduria. Over a 5 month period, the dog developed neurologic signs compatible with disease of the central nervous system with predominant diffuse cerebral and right lateralizing brainstem deficits. Gross pathological examination of the brain showed that the lateral, third, and fourth ventricles of the brain were markedly enlarged and associated with white and grey matter atrophy...
September 1996: Metabolic Brain Disease
L Ijlst, R J Wanders
Long-chain acyl-CoA dehydrogenase (LCAD) deficiency is an autosomal recessive disorder of fatty acid metabolism characterized by hypoglycemia, muscle weakness and hepato- and cardiomegaly to varying extents. Analysis of organic acids in urine usually reveals dicarboxylic aciduria with elevated levels of adipic, suberic and sebacic acids as well as longer chain dicarboxylic acids. Correct diagnosis of suspected patients requires measurement of LCAD in tissue or preferably, white blood cells and/or cultured skin fibroblasts...
May 1993: Annals of Clinical Biochemistry
P B Mortensen
Administration of decanoic acid to rats resulted not only in elevated urinary excretions of the C10-dicarboxylic acid (sebacic acid), but also in highly elevated excretions of the beta-oxidation products C8- and C6-dicarboxylic acids (suberic and adipic acids). Activation of the lipid metabolism by starvation, fat-feeding and experimental diabetes increased the excretions of adipic acid and decreased the excretions of sebacic acid, i.e. the rate of oxidation of fatty acids was correlated to the adipic : sebacic acid ratio in urine...
May 22, 1981: Biochimica et Biophysica Acta
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