Daniela Theodoridou, Christos-Orestis Tsiantis, Angeliki-Maria Vlaikou, Vasiliki Chondrou, Victoria Zakopoulou, Pavlos Christodoulides, Emmanouil D Oikonomou, Katerina D Tzimourta, Charilaos Kostoulas, Alexandros T Tzallas, Konstantinos I Tsamis, Dimitrios Peschos, Argyro Sgourou, Michaela D Filiou, Maria Syrrou
Developmental dyslexia (DD) is a learning disorder. Although risk genes have been identified, environmental factors, and particularly stress arising from constant difficulties, have been associated with the occurrence of DD by affecting brain plasticity and function, especially during critical neurodevelopmental stages. In this work, electroencephalogram (EEG) findings were coupled with the genetic and epigenetic molecular signatures of individuals with DD and matched controls. Specifically, we investigated the genetic and epigenetic correlates of key stress-associated genes ( NR3C1 , NR3C2 , FKBP5 , GILZ , SLC6A4 ) with psychological characteristics (depression, anxiety, and stress) often included in DD diagnostic criteria, as well as with brain EEG findings...
January 28, 2024: Brain Sciences