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MTHFR C677T 76-83

Mengmeng Zhao, Xuelian Li, Chengzhong Xing, Baosen Zhou
Colorectal cancer (CRC) is one of the most common types of cancer worldwide and a leading cause of cancer-related mortality. This meta-analysis was conducted to determine the effect of methylenetetrahydrofolate reductase (MTHFR) mutants on the risk of CRC. A literature search was conducted on PubMed, Medline and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were collected based on rigorous criteria of inclusion. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by the fixed- or random-effects model...
September 2013: Biomedical Reports
J Gao, Q He, D Hua, Y Mao, Y Li, L Shen
PURPOSE: Capecitabine-containing chemotherapy was widely used in clinic medication. We investigated the association of the thymidylate synthase (TS), methylenetetrahydrofolate reductase (MTHFR), and dihydropyrimidine dehydrogenase (DPD) polymorphisms with the clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel. METHODS: Blood samples were collected prior to treatment from 125 patients with advanced gastric cancer and the TS (two or three repeats of a 28 bp sequence in 5'-untranslated region and 6 bp insertion or deletion in 3'-untranslated region), MTHFR (C677T) and DPD (IVS14+1G > A) polymorphisms were determined using PCR amplification and Sanger sequencing...
August 2013: Clinical & Translational Oncology
Yan-yan Li
Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. To explore the relationship between MTHFR C677T gene polymorphism and CAD in the Chinese Han population, a meta-analysis was performed. Fourteen separate studies were included and 2981 subjects were involved in the current meta-analysis. The pooled odds ratio (OR) between CAD size to CAD size and control size (CAD/CAD + control) and the corresponding 95% confidence interval (95% CI) between the CC and TT genotype groups were estimated by a random-effects model...
June 2012: Metabolism: Clinical and Experimental
A Oussalah, J-L Guéant, L Peyrin-Biroulet
BACKGROUND: The magnitude of association between homocysteine metabolism and inflammatory bowel diseases (IBD) remains unknown, whereas the association between hyperhomocysteinaemia and thrombosis remains controversial in IBD. AIM: To conduct a systematic review and meta-analysis to examine these issues. METHODS: The literature search was conducted using MEDLINE database and international conference abstracts from January 1966 to April 2011 and included all studies that evaluated plasma homocysteine level in IBD...
November 2011: Alimentary Pharmacology & Therapeutics
Jin-zhen Guo, Xiao-ming Song, Yun Wang, Wen-li Zhu, Shu-qin Li, Yong Li
OBJECTIVE: To explore the relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate in Chinese population. METHODS: There were 97 NSCL/P case-parent triads that were selected as case group. At the same period, 104 healthy subjects were selected together with their biological parents as control group. For all the subjects the polymorphism of MTHFR C677T was examined by PCR-RFLP method. RESULTS: There was no statistical difference in genotype and gene frequencies for MTHFR C677T variants among family members between case group and control group in the offspring, fathers and mothers...
August 18, 2009: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Stefania Boccia, Paolo Boffetta, Paul Brennan, Gualtiero Ricciardi, Francesco Gianfagna, Keitaro Matsuo, Cornelia M van Duijn, Rayjean J Hung
Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C). The summary odds ratio (OR) of head and neck cancer was 0.92 (95% CI: 0.76-1...
January 8, 2009: Cancer Letters
Jaime Raúl Zúñiga-Noriega, María del Roble Velazco-Campos, Alejandra Aguirre-Rodríguez, Laura Martínez-de Villarreal, Elvira Garza-González, Héctor Jesús Maldonado-Garza, Francisco Javier Bosques-Padilla
BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism has been associated to a higher risk to develop proximal gastric cancer. AIM: To study the role of the MTHFR C677T polymorphism as a risk factor for the development of distal gastric cancer (DGC) in a Mexican population. PATIENTS AND METHODS: Fifty-one histologically confirmed DGC (mean age = 57.6y, F:M = 0.76) and 83 ethnically matched non-GC controls (mean age 51...
October 2007: Revista de Gastroenterología de México
Rima Obeid, Tarek Hakki, Muhidien Jouma, Wolfgang Herrmann
Venous thromboembolism (VTE) is a multi-factorial disease involving numerous genetic and environmental risk factors. In this study we investigated the occurrence and the risk associated with factor V Leiden, hyperhomocysteinemia and low folate and vitamin B12 levels in young patients with thrombosis. We studied 78 patients (33 females/45 males, mean age 33 years) with a history of thrombosis in a lower limb. Additionally, 98 healthy subjects (45 females/54 males, mean age 44 years) were included. Serum levels of homocysteine (Hcy), folate and vitamin B12 were assayed...
October 2003: Clinical Chemistry and Laboratory Medicine: CCLM
B Brenner, G Sarig, Z Weiner, J Younis, Z Blumenfeld, N Lanir
An association between fetal loss and thrombophilia has recently been described but has not been yet fully elucidated. We have evaluated prospectively the prevalence of the three common thrombophilic polymorphisms (TP) factor V G1691A (Leiden), thermolabile-methylenetetrahydrofolate reductase (TL-MTHFR) C677T and factor II G20210A mutations, in 76 women with fetal loss (> or =3 in first, > or =2 in second, > or =1 in third trimester) without apparent cause and 106 controls without fetal loss. Thirty seven out of 76 (49%) of the women in the fetal loss group had at least one TP compared to only 23/106 (22%) in the control group (p = 0...
July 1999: Thrombosis and Haemostasis
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