Chrislean Jun Botanas, Raly James Perez Custodio, Hee Jin Kim, June Bryan de la Pena, Leandro Val Sayson, Darlene Mae Ortiz, Mikyung Kim, Hyun Jun Lee, Srijan Acharya, Kyeong-Man Kim, Cheol Jung Lee, Jong Hoon Ryu, Yong Sup Lee, Jae Hoon Cheong
The newfound antidepressant efficacy of ketamine has provided opportunities for the development of new-generation, rapid-acting, glutamate-based antidepressants. We previously identified that methoxetamine (MXE), a ketamine analog, and an N-Methyl-d-aspartate (NMDA) receptor antagonist, produced rapid and sustained antidepressant effects in mice. MXE (R, S (±)-MXE) is a racemic mixture containing equal parts of S (+)-MXE and R (-)-MXE. However, studies have yet to investigate the antidepressant effects of its enantiomers...
August 1, 2021: Neuropharmacology