Mojtaba Oraki Kohshour, Eva C Schulte, Urs Heilbronner, Monika Budde, Janos L Kalman, Fanny Senner, Maria Heilbronner, Daniela Reich-Erkelenz, Sabrina K Schaupp, Thomas Vogl, Kristina Adorjan, Ion-George Anghelescu, Volker Arolt, Bernhardt T Baune, Udo Dannlowski, Detlef Dietrich, Andreas Fallgatter, Christian Figge, Markus Jäger, Fabian U Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Eva Z Reininghaus, Max Schmauß, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Jörg Zimmermann, Till F M Andlauer, Markus M Nöthen, Franziska Degenhardt, Andreas J Forstner, Marcella Rietschel, Stephanie H Witt, Andre Fischer, Peter Falkai, Sergi Papiol, Thomas G Schulze
BACKGROUND: Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance. METHODS: We leveraged cross-sectional data from 1320 individuals with a severe psychiatric disorder and 466 neurotypical individuals from the PsyCourse Study...
January 5, 2023: Journal of Affective Disorders