Iván Menéndez-Valle, Cristina Cachán-Vega, José Antonio Boga, Laura González-Blanco, Eduardo Antuña, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Pilar Saiz, Julio Bobes, Paz García-Portilla, Ana Coto-Montes
Schizophrenia (SCH) and bipolar disorder (BD) are two of the most important psychiatric pathologies due to their high population incidence and disabling power, but they also present, mainly in their debut, high clinical similarities that make their discrimination difficult. In this work, the differential oxidative stress, present in both disorders, is shown as a concatenator of the systemic alterations-both plasma and erythrocyte, and even at the level of peripheral blood mononuclear cells (PBMC)-in which, for the first time, the different affectations that both disorders cause at the level of the cellular interactome were observed...
November 1, 2023: Antioxidants (Basel, Switzerland)