keyword
https://read.qxmd.com/read/38447791/ribosome-profiling-and-mass-spectrometry-reveal-widespread-mitochondrial-translation-defects-in-a-striatal-cell-model-of-huntington-disease
#1
JOURNAL ARTICLE
Sunayana Dagar, Manish Sharma, George Tsaprailis, Catherina Scharager Tapia, Gogce Crynen, Preksha Sandipkumar Joshi, Neelam Shahani, Srinivasa Subramaniam
Huntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin (mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric, cognitive, and choreiform movements. Multiple lines of evidence point to an association between HD and aberrant striatal mitochondrial functions; however, the present knowledge about whether (or how) mitochondrial mRNA translation is differentially regulated in HD remains unclear. We found that protein synthesis is diminished in HD mitochondria compared to healthy control striatal cell models...
March 4, 2024: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/38412332/elevations-in-the-mitochondrial-matrix-protein-cyclophilin-d-correlate-with-reduced-parvalbumin-expression-in-the-prefrontal-cortex-of-patients-with-schizophrenia
#2
JOURNAL ARTICLE
John T O'Brien, Sophia P Jalilvand, Neha A Suji, Rohan K Jupelly, Aarron Phensy, Juliet M Mwirigi, Hajira Elahi, Theodore J Price, Sven Kroener
BACKGROUND AND HYPOTHESIS: Cognitive deficits in schizophrenia are linked to dysfunctions of the dorsolateral prefrontal cortex (DLPFC), including alterations in parvalbumin (PV)-expressing interneurons (PVIs). Redox dysregulation and oxidative stress may represent convergence points in the pathology of schizophrenia, causing dysfunction of GABAergic interneurons and loss of PV. Here, we show that the mitochondrial matrix protein cyclophilin D (CypD), a critical initiator of the mitochondrial permeability transition pore (mPTP) and modulator of the intracellular redox state, is altered in PVIs in schizophrenia...
February 27, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38375982/the-neurobiological-mechanisms-and-therapeutic-prospect-of-extracellular-atp-in-depression
#3
REVIEW
Kaixin Wang, Shiqian Huang, Daan Fu, Xinxin Yang, Lulin Ma, Tianhao Zhang, Wenjing Zhao, Daling Deng, Yuanyuan Ding, Yanyan Zhang, Li Huang, Xiangdong Chen
BACKGROUND: Depression is a prevalent psychiatric disorder with high long-term morbidities, recurrences, and mortalities. Despite extensive research efforts spanning decades, the cellular and molecular mechanisms of depression remain largely unknown. What's more, about one third of patients do not have effective anti-depressant therapies, so there is an urgent need to uncover more mechanisms to guide the development of novel therapeutic strategies. Adenosine triphosphate (ATP) plays an important role in maintaining ion gradients essential for neuronal activities, as well as in the transport and release of neurotransmitters...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38223491/bipolar-disorder
#4
REVIEW
Madeline R Scott, Colleen A McClung
This review focuses on recent advances made towards understanding the neurobiology of bipolar disorder (BD), a chronic neuropsychiatric illness characterized by altered mood and energy states. The past few years have seen the completion of the largest genetic studies by far, which have emphasized the polygenic nature of BD as well as it's connection to other psychiatric illnesses. Furthermore, the use of inducible pluripotent stem cells has rapidly expanded. These studies support previous work that implicates dysregulation of neurodevelopment, mitochondria, and calcium homeostasis, while also allowing for investigation into the underlying mechanisms of individual responsivity to lithium...
December 2023: Current Opinion in Neurobiology
https://read.qxmd.com/read/38206471/significance-of-melatonin-in-the-regulation-of-circadian-rhythms-and-disease-management
#5
REVIEW
K B Megha, A Arathi, Saini Shikha, Rao Alka, Prabhu Ramya, P V Mohanan
Melatonin, the 'hormone of darkness' is a neuronal hormone secreted by the pineal gland and other extra pineal sites. Responsible for the circadian rhythm and seasonal behaviour of vertebrates and mammals, melatonin is responsible for regulating various physiological conditions and the maintenance of sleep, body weight and the neuronal activities of the ocular sites. With its unique amphiphilic structure, melatonin can cross the cellular barriers and elucidate its activities in the subcellular components, including mitochondria...
January 11, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38199392/identification-of-7-mitochondria-related-genes-as-diagnostic-biomarkers-of-mdd-and-their-correlation-with-immune-infiltration-new-insights-from-bioinformatics-analysis
#6
JOURNAL ARTICLE
Xiaolan Liu, Yong Wu, Mingxing Li
BACKGROUND: Major depressive disorder (MDD) is one of the most prevalent and debilitating psychiatric disorders. It becomes more recognized that mitochondrial dysfunction contributes to the pathophysiology of depression. However, little research has systematically investigated the mitochondria-related biomarkers for MDD diagnosis. This study aimed to develop a novel diagnostic gene signature in MDD based on mitochondria-related genes. METHOD: We identified the differentially expressed mitochondrial-related genes (DeMRGs) by combing the gene expression data of the GEO database with mitochondria-related gene lists obtained from the MitoCarta3...
January 8, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38028782/potential-oxidative-stress-related-targets-of-mitochondria-focused-therapy-of-ptsd
#7
REVIEW
Hanna Kmita, Graziano Pinna, Volodymyr I Lushchak
Post-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid with major depressive disorder, suicidality, and substance use disorder. Several biomarkers have been proposed but have yet to be implemented into clinical practice. Treatments, including selective serotonin reuptake inhibitors, are efficacious in only a small number of patients, which underscores the need to develop novel, efficient treatments...
2023: Frontiers in Physiology
https://read.qxmd.com/read/38025801/mitochondrial-interaction-with-serotonin-in-neurobiology-and-its-implication-in-alzheimer-s-disease
#8
REVIEW
Jing Tian, Eric Du, Lan Guo
Alzheimer's disease (AD) is a lethal neurodegenerative disorder characterized by severe brain pathologies and progressive cognitive decline. While the exact cause of this disease remains unknown, emerging evidence suggests that dysregulation of neurotransmitters contributes to the development of AD pathology and symptoms. Serotonin, a critical neurotransmitter in the brain, plays a pivotal role in regulating various brain processes and is implicated in neurological and psychiatric disorders, including AD. Recent studies have shed light on the interplay between mitochondrial function and serotonin regulation in brain physiology...
2023: JAD Reports
https://read.qxmd.com/read/38001801/differential-cellular-interactome-in-schizophrenia-and-bipolar-disorder-discriminatory-biomarker-role
#9
JOURNAL ARTICLE
Iván Menéndez-Valle, Cristina Cachán-Vega, José Antonio Boga, Laura González-Blanco, Eduardo Antuña, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Pilar Saiz, Julio Bobes, Paz García-Portilla, Ana Coto-Montes
Schizophrenia (SCH) and bipolar disorder (BD) are two of the most important psychiatric pathologies due to their high population incidence and disabling power, but they also present, mainly in their debut, high clinical similarities that make their discrimination difficult. In this work, the differential oxidative stress, present in both disorders, is shown as a concatenator of the systemic alterations-both plasma and erythrocyte, and even at the level of peripheral blood mononuclear cells (PBMC)-in which, for the first time, the different affectations that both disorders cause at the level of the cellular interactome were observed...
November 1, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37946741/involvement-of-coenzyme-q10-in-various-neurodegenerative-and-psychiatric-diseases
#10
REVIEW
Alireza Ebrahimi, Amirhossein Kamyab, Sahar Hosseini, Sedigheh Ebrahimi, Soheil Ashkani-Esfahani
Coenzyme Q10 (CoQ10), commonly known as ubiquinone, is a vitamin-like component generated in mitochondrial inner membranes. This molecule is detected broadly in different parts of the human body in various quantities. This molecule can be absorbed by the digestive system from various nutritional sources as supplements. CoQ10 exists in three states: in a of reduced form (ubiquinol), in a semiquinone radical form, and in oxidized ubiquinone form in different organs of the body, playing a crucial role in electron transportation and contributing to energy metabolism and oxygen utilization, especially in the musculoskeletal and nervous systems...
2023: Biochemistry Research International
https://read.qxmd.com/read/37906730/nmr-based-mitochondria-metabolomic-profiling-a-new-approach-to-reveal-cancer-associated-alterations
#11
JOURNAL ARTICLE
Inés Domingo-Ortí, Patricia Ferrer-Torres, Ana Armiñán, María J Vicent, Antonio Pineda-Lucena, Martina Palomino-Schätzlein
Studying metabolism may assist in understanding the relationship between normal and dysfunctional mitochondrial activity and various diseases, such as neurodegenerative, cardiovascular, autoimmune, psychiatric, and cancer. Nuclear magnetic resonance-based metabolomics represents a powerful method to characterize the chemical content of complex samples and has been successfully applied to studying a range of conditions. However, an optimized methodology is lacking for analyzing isolated organelles, such as mitochondria...
October 31, 2023: Analytical Chemistry
https://read.qxmd.com/read/37869512/targeting-mitophagy-for-depression-amelioration-a-novel-therapeutic-strategy
#12
REVIEW
Wangjun Xu, Weiping Gao, Yukun Guo, Feng Xue, Lulu Di, Shaojie Fang, Linlin Fan, Yangyang He, Yunfeng Zhou, Xinmei Xie, Xiaobin Pang
Major depressive disorder is a global psychiatric condition characterized by persistent low mood and anhedonia, which seriously jeopardizes the physical and mental well-being of affected individuals. While various hypotheses have been proposed to explicate the etiology of depression, the precise pathogenesis and effective treatment of this disorder remain elusive. Mitochondria, as the primary organelles responsible for cellular energy production, possess the ability to meet the essential energy demands of the brain...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37802007/exposure-to-nonylphenol-in-early-life-causes-behavioural-deficits-related-with-autism-spectrum-disorders-in-rats
#13
JOURNAL ARTICLE
Mingdan You, Siyao Li, Siyu Yan, Dianqi Yao, Tingyu Wang, Yi Wang
Early-life exposure to environmental endocrine disruptors (EDCs) is a potential risk factor for autism spectrum disorder (ASD). Exposure to nonylphenol (NP), a typical EDC, is known to cause some long-term behavioural abnormalities. Moreover, these abnormal behaviours are the most frequent psychiatric co-morbidities in ASD. However, the direct evidence for the link between NP exposure in early life and ASD-like behavioural phenotypes is still missing. In the present study, typical ASD-like behaviours induced by valproic acid treatment were considered as a positive behavioural control...
September 27, 2023: Environment International
https://read.qxmd.com/read/37801903/mitochondrial-dysfunction-a-fatal-blow-in-depression
#14
REVIEW
Yu Song, Huan Cao, Chengchao Zuo, Zhongya Gu, Yaqi Huang, Jinfeng Miao, Yufeng Fu, Yu Guo, Yongsheng Jiang, Furong Wang
Mitochondria maintain the normal physiological function of nerve cells by producing sufficient cellular energy and performing crucial roles in maintaining the metabolic balance through intracellular Ca2+ homeostasis, oxidative stress, and axonal development. Depression is a prevalent psychiatric disorder with an unclear pathophysiology. Damage to the hippocampal neurons is a key component of the plasticity regulation of synapses and plays a critical role in the mechanism of depression. There is evidence suggesting that mitochondrial dysfunction is associated with synaptic impairment...
November 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37764806/aspartic-acid-in-health-and-disease
#15
REVIEW
Milan Holeček
Aspartic acid exists in L- and D-isoforms (L-Asp and D-Asp). Most L-Asp is synthesized by mitochondrial aspartate aminotransferase from oxaloacetate and glutamate acquired by glutamine deamidation, particularly in the liver and tumor cells, and transamination of branched-chain amino acids (BCAAs), particularly in muscles. The main source of D-Asp is the racemization of L-Asp. L-Asp transported via aspartate-glutamate carrier to the cytosol is used in protein and nucleotide synthesis, gluconeogenesis, urea, and purine-nucleotide cycles, and neurotransmission and via the malate-aspartate shuttle maintains NADH delivery to mitochondria and redox balance...
September 17, 2023: Nutrients
https://read.qxmd.com/read/37760929/mitochondria-and-brain-disease-a-comprehensive-review-of-pathological-mechanisms-and-therapeutic-opportunities
#16
REVIEW
Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Ana Isabel Beltrán-Velasco, Domingo Jesús Ramos-Campo, Pedro Belinchón-deMiguel, Ismael Martinez-Guardado, Athanasios A Dalamitros, Rodrigo Yáñez-Sepúlveda, Alexandra Martín-Rodríguez, José Francisco Tornero-Aguilera
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities...
September 7, 2023: Biomedicines
https://read.qxmd.com/read/37759960/lactate-a-theranostic-biomarker-for-metabolic-psychiatry
#17
REVIEW
Edward Caddye, Julien Pineau, Joshua Reyniers, Itamar Ronen, Alessandro Colasanti
Alterations in neurometabolism and mitochondria are implicated in the pathophysiology of psychiatric conditions such as mood disorders and schizophrenia. Thus, developing objective biomarkers related to brain mitochondrial function is crucial for the development of interventions, such as central nervous system penetrating agents that target brain health. Lactate, a major circulatory fuel source that can be produced and utilized by the brain and body, is presented as a theranostic biomarker for neurometabolic dysfunction in psychiatric conditions...
August 22, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37654512/gestational-stress-decreases-postpartum-mitochondrial-respiration-in-the-prefrontal-cortex-of-female-rats
#18
JOURNAL ARTICLE
Erin Gorman-Sandler, Breanna Robertson, Jesseca Crawford, Gabrielle Wood, Archana Ramesh, Olufunke O Arishe, R Clinton Webb, Fiona Hollis
Postpartum depression (PPD) is a major psychiatric complication of childbirth, affecting up to 20% of mothers, yet remains understudied. Mitochondria, dynamic organelles crucial for cell homeostasis and energy production, share links with many of the proposed mechanisms underlying PPD pathology. Brain mitochondrial function is affected by stress, a major risk factor for development of PPD, and is linked to anxiety-like and social behaviors. Considering the importance of mitochondria in regulating brain function and behavior, we hypothesized that mitochondrial dysfunction is associated with behavioral alterations in a chronic stress-induced rat model of PPD...
September 2023: Neurobiology of Stress
https://read.qxmd.com/read/37597078/reactive-oxygen-species-toxicity-oxidative-stress-and-antioxidants-chronic-diseases-and-aging
#19
REVIEW
Klaudia Jomova, Renata Raptova, Suliman Y Alomar, Saleh H Alwasel, Eugenie Nepovimova, Kamil Kuca, Marian Valko
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor 2 (Nrf2) and other processes...
October 2023: Archives of Toxicology
https://read.qxmd.com/read/37549811/mitochondrial-health-nlrp3-inflammasome-activation-and-white-matter-integrity-in-adolescent-mood-disorders-a-pilot-study
#20
JOURNAL ARTICLE
Xinyang Y Zhou, Michelle Thai, Donovan Roediger, Bryon A Mueller, Kathryn R Cullen, Bonnie Klimes-Dougan, Ana C Andreazza
Adolescence is a particularly important period for brain development and is also when mood disorders typically emerge. Several psychiatric illnesses exhibit mitochondrial dysfunction, elevated inflammation, and impaired white matter integrity. This study explored the intersection of mitochondrial health, NLRP3 inflammasome activation, and white matter integrity in a small cohort of 29 adolescent patients with mood disorders (bipolar disorder (BD): n = 11, major depressive disorder (MDD): n = 19) and 19 healthy controls...
August 5, 2023: Journal of Affective Disorders
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