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Neutrophil lymphocytic ratio in cancer

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https://www.readbyqxmd.com/read/29766456/prognostic-role-for-the-derived-neutrophil-to-lymphocyte-ratio-in-early-breast-cancer-a-geicam-9906-substudy
#1
A J Templeton, Á Rodríguez-Lescure, A Ruíz, E Alba, L Calvo, M Ruíz-Borrego, A Santaballa, C A Rodríguez, C Crespo, M Ramos, J M Gracia-Marco, A Lluch, I Álvarez, M I Casas, M Sánchez-Aragó, R Caballero, E Carrasco, E Amir, M Martin, A Ocaña
PURPOSE: Elevated markers of host inflammation, a hallmark of cancer, have been associated with worse outcomes in several solid tumors. Here, we explore the prognostic role of the derived neutrophil-to-lymphocyte ratio (dNLR), across different tumor subtypes, in patients with early breast cancer. PATIENTS AND METHODS: This was a retrospective analysis of 1246 patients with lymph node-positive, operable early breast cancer enrolled in the GEICAM/9906 trial, a multicenter randomized phase 3 study evaluating adjuvant chemotherapy...
May 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29765248/preoperative-neutrophil-to-lymphocyte-ratio-as-a-prognostic-predictor-after-curative-intent-surgery-for-hepatocellular-carcinoma-experience-from-a-developing-country
#2
Danijel Galun, Aleksandar Bogdanovic, Jelena Djokic Kovac, Predrag Bulajic, Zlatibor Loncar, Marinko Zuvela
Purpose: The aim of the study was to evaluate a prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on long-term survival of cirrhotic and noncirrhotic hepatocellular cancer (HCC) patients managed by a curative-intent liver surgery in a developing country. Patients and methods: During the study period between November 1, 2001, and December 31, 2012, 109 patients underwent potentially curative hepatectomy for HCC. Data were retrospectively reviewed from the prospectively collected database...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29761858/predictive-impact-of-the-inflammation-based-indices-in-colorectal-cancer-patients-with-adjuvant-chemotherapy
#3
Yong Tao, Lei Ding, Guan Gen Yang, Jian Ming Qiu, Dong Wang, Hongtao Wang, Chao Fu
Increasing evidences reported that cancer-triggered inflammation was associated with survival prognosis from colorectal cancer (CRC). However, the comprehensive effects of inflammatory-based coNLR-PLR that combines neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) rarely remain to be determined during chemotherapy. We retrospectively analyzed clinical data and baseline laboratory parameters from 153 colorectal cancer patients who underwent palliative adjuvant chemotherapy between January 2009 to January 2012...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29761587/neutrophil-to-lymphocyte-ratio-as-a-prognostic-indicator-in-head-and-neck-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Tristan Tham, Yonatan Bardash, Saori Wendy Herman, Peter David Costantino
BACKGROUND: The purposes of this systematic review and meta-analysis were to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in head and neck cancer. METHODS: A systematic review and meta-analysis were done to investigate the role of NLR in overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and progression-free survival (PFS). RESULTS: For qualitative analysis, 33 cohorts with over 10 072 patients were included...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761518/the-value-of-inflammation-based-prognostic-scores-in-patients-undergoing-surgical-resection-for-oesophageal-and-gastric-carcinoma
#5
Jiaxin Wen, Matthew Bedford, Ruksana Begum, Harriet Mitchell, James Hodson, John Whiting, Ewen Griffiths
BACKGROUND AND OBJECTIVES: Surgical interventions for oesophagogastric cancer carry a significant burden of morbidity and mortality. A range of inflammation based prognostic scores have been proposed in an attempt to predict outcome. This study evaluated five such prognostic scores in oesophageal and gastric carcinoma patients. METHODS: The modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI), and Prognostic Nutrition Index (PNI) were calculated for 723 consecutive patients undergoing oesophagectomy or gastrectomy at a single center...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29758203/pretreatment-neutrophil-lymphocyte-and-platelet-lymphocyte-ratio-predict-clinical-outcome-and-prognosis-for-cervical-cancer
#6
MeiLin Zhu, Min Feng, Fei He, BangCai Han, Ke Ma, XinYu Zeng, ZhiRong Liu, XinLian Liu, Juan Li, Hui Cao, YunDan Liang, Cui Jia, LuShun Zhang
Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. In this study, we aimed to evaluate the predictive and prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in cervical cancer. We retrospectively investigated 616 patients who underwent initial radical hysterectomy with pelvic lymphadenectomy for cervical cancer between July 2012 and December 2014 in China. Their clinical and histopathological markers and complete blood counts were obtained and analyzed...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29756613/neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-for-pharyngocutaneous-fistula-after-total-laryngectomy
#7
F T Aires, R A Dedivitis, M A V Kulcsar, D M Ramos, C R Cernea
The role of systemic inflammatory response as a prognostic factor has been proposed in a variety of cancers. The purpose of this study was to investigate the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the incidence of pharyngocutaneous fistula (PCF) in patients who underwent total laryngectomy. We conducted a retrospective cohort analysis of 141 patients with squamous cell carcinoma of larynx who underwent total laryngectomy from 2009 to 2015. The incidence of PCF was 49.6%...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29755670/systemic-inflammatory-status-predict-the-outcome-of-k-ras-wt-metastatic-colorectal-cancer-patients-receiving-the-thymidylate-synthase-poly-epitope-peptide-anticancer-vaccine
#8
Pierpaolo Correale, Cirino Botta, Nicoletta Staropoli, Valerio Nardone, Pierpaolo Pastina, Cristina Ulivieri, Claudia Gandolfo, Tatiana Cosima Baldari, Stefano Lazzi, Domenico Ciliberto, Rocco Giannicola, Antonella Fioravanti, Antonio Giordano, Silvia Zappavigna, Michele Caraglia, Pierfrancesco Tassone, Luigi Pirtoli, Maria Grazia Cusi, Pierosandro Tagliaferri
TSPP is an anticancer poly-epitope peptide vaccine to thymidylate synthase, recently investigated in the multi-arm phase Ib TSPP/VAC1 trial. TSPP vaccination induced immune-biological effects and showed antitumor activity in metastatic colorectal cancer (mCRC) patients and other malignancies. Progression-free and overall survival of 41 mCRC patients enrolled in the study correlated with baseline levels of CEA, immune-inflammatory markers (neutrophil/lymphocyte ratio, CRP, ESR, LDH, ENA), IL-4 and with post-treatment change in p-ANCA and CD56dim CD16bright NKs ( p < 0...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754852/predictors-of-survival-after-yttrium-90-radioembolization-for-colorectal-cancer-liver-metastases
#9
Ashley A Weiner, Bin Gui, Neil B Newman, John L Nosher, Fady Yousseff, Shou-En Lu, Gretchen M Foltz, Darren Carpizo, Jonathan Lowenthal, Darryl A Zuckerman, Ben Benson, Jeffrey R Olsen, Salma K Jabbour, Parag J Parikh
PURPOSE: To identify clinical parameters that are prognostic for improved overall survival (OS) after yttrium-90 radioembolization (RE) in patients with liver metastases from colorectal cancer (CRC). MATERIALS AND METHODS: A total of 131 patients who underwent RE for liver metastases from CRC, treated at 2 academic centers, were reviewed. Twenty-one baseline pretreatment clinical factors were analyzed in relation to OS by the Kaplan-Meier method along with log-rank tests and univariate and multivariate Cox regression analyses...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29751991/influence-of-ca125-platelet-count-and-neutrophil-to-lymphocyte-ratio-on-the-immune-system-of-ovarian-cancer-patients
#10
Thaïs Baert, Joke Van Camp, Lisa Vanbrabant, Pieter Busschaert, Annouschka Laenen, Sileny Han, Els Van Nieuwenhuysen, Ignace Vergote, An Coosemans
OBJECTIVE: The effect of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis on survival has been studied in ovarian cancer. This study explores the link between these variables and serum markers of ovarian cancer patients, such as signaling proteins and cytokines. METHODS: Serum samples of 39 patients with high-grade serous ovarian cancer (HGSOC) were collected at diagnosis and were retrospectively analysed for clinical characteristics, clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2...
May 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29747314/-prognostic-significance-of-inflammatory-indicators-for-advanced-stage-diffuse-large-b-cell-lymphoma
#11
Y Han, Y Qin, X H He, J L Yang, P Liu, C G Zhang, L Q Zhou, S Y Zhou, L Gui, Y Sun, Y K Shi
Objective: To explore the prognostic significance of inflammatory indicator, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), for advanced-stage diffuse large B-cell lymphoma (DLBCL). Methods: The data of advanced stage DLBCL cases was retrospectively collected, and all the patients were seen from January 2006 to December 2012 in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences. The patients were divided into the low NLR group (≤5∶1) and the high NLR group (>5∶1); the low PLR group (≤300∶1) and the high PLR group (>300∶1)...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29742685/the-plasma-levels-of-12-cytokines-and-growth-factors-in-patients-with-gastric-cancer
#12
Zhengyun Zou, Lianjun Zhao, Shu Su, Qin Liu, Lixia Yu, Jia Wei, Yang Yang, Juan Du, Jie Shen, Xiaoping Qian, Xiangshan Fan, Wenxian Guan, Baorui Liu
To assess the association of plasma cytokines and growth factor levels with clinical characteristics and inflammatory indices in patients with gastric cancer.Plasma samples derived from 99 gastric cancer patients were used for analysis. Levels of interferon (IFN)-γ, tumor growth factor (TGF)-β1, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, and vascular endothelial growth factor (VEGF) were measured by Luminex suspension array technology. The association between cytokine/growth factor levels and demographic/clinical characteristics was assessed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29738752/neutrophil-to-lymphocyte-ratio-as-predictor-of-treatment-response-in-esophageal-squamous-cell-cancer
#13
Arianna Barbetta, Tamar B Nobel, Smita Sihag, Meier Hsu, Kay See Tan, Manjit S Bains, James M Isbell, Yelena Y Janjigian, Abraham J Wu, Matthew J Bott, David R Jones, Daniela Molena
BACKGROUND: The aim of this study was to assess the variation of NLR (ΔNLR), before and after chemoradiotherapy, as a predictor of treatment response and a prognostic factor for recurrence and disease-free survival (DFS) in patients with esophageal squamous cell cancer (ESCC) treated with chemoradiotherapy with or without surgery. METHODS: Patients with locally advanced ESCC, treated with chemoradiation with and without surgery that had a complete blood count, before and after chemoradiotherapy, were included...
May 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29737944/a-new-prognostic-model-using-the-nccn-ipi-and-neutrophil-to-lymphocyte-ratio-in-diffuse-large-b-cell-lymphoma
#14
Se-Il Go, Sungwoo Park, Jung Hoon Kim, Hye Ree Kim, Minyoung Kim, Kyunglan Moon, Jangho Seo, Gyeong-Won Lee
Background The neutrophil-to-lymphocyte ratio (NLR) has been known to predict the prognosis in diffuse large B-cell lymphoma (DLBCL). We planned to design a new prognostic model in DLBCL using well-known prognostic index and NLR. Methods The data of 232 DLBCL patients treated with first-line R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) from 2004 to 2017 were retrospectively reviewed. Patients with NLR ≥6 and <6 were determined as the high and low NLR groups, respectively...
December 1, 2017: Tumori
https://www.readbyqxmd.com/read/29732389/the-prognostic-role-of-the-change-in-neutrophil-to-lymphocyte-ratio-during-neoadjuvant-chemotherapy-in-patients-with-muscle-invasive-bladder-cancer-a-retrospective-multi-institutional-study
#15
Jeenan Kaiser, Haocheng Li, Scott A North, Raya Leibowitz-Amit, Jo-An Seah, Nisha Morshed, Caroline Chau, Richard Lee-Ying, Daniel Y C Heng, Srikala Sridhar, Simon J Crabb, Nimira S Alimohamed
Background: The impact of the change in the neutrophil-to-lymphocyte ratio (NLR) during neoadjuvant chemotherapy (NAC) on outcomes in patients with muscle-invasive bladder cancer (MIBC) is poorly understood. Objective: To evaluate the prognostic impact of the change in NLR during NAC for patients with MIBC. Methods: Patients referred to academic, community, and quaternary referral centres in Alberta, Canada from 2005 to 2015, Ontario, Canada from 2005 to 2013, and Southampton, UK from 2004 to 2010 were evaluated...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29731989/statin-use-and-survival-in-patients-with-metastatic-castration-resistant-prostate-cancer-treated-with-abiraterone-or-enzalutamide-after-docetaxel-failure-the-international-retrospective-observational-staben-study
#16
Jacob A Gordon, Carlo Buonerba, Gregory Pond, Daniel Crona, Silke Gillessen, Giuseppe Lucarelli, Sabrina Rossetti, Tanya Dorff, Salvatore Artale, Jennifer A Locke, Davide Bosso, Matthew Ivan Milowsky, Mira Sofie Witek, Michele Battaglia, Sandro Pignata, Cyrus Cherhroudi, Michael E Cox, Pietro De Placido, Dario Ribera, Aurelius Omlin, Gaetano Buonocore, Kim Chi, Christian Kollmannsberger, Daniel Khalaf, Gaetano Facchini, Guru Sonpavde, Sabino De Placido, Bernhard J Eigl, Giuseppe Di Lorenzo
Background: Statins may potentiate the effects of anti-hormonal agents for metastatic castration-resistant prostate cancer (mCRPC) through further disruption of essential steroidogenic processes. We investigated the effects of statin use on clinical outcomes in patients with mCRPC receiving abiraterone or enzalutamide. Materials and methods: This was a retrospective multicenter study including patients that received abiraterone or enzalutamide for mCRPC. The effect of concurrent statin use on outcomes was evaluated...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29725410/low-neutrophil-lymphocyte-ratio-correlates-with-extended-survival-in-patients-with-metastatic-breast-cancer-who-achieved-clinically-complete-response-following-multidisciplinary-therapy-a-retrospective-study
#17
Haruko Takuwa, Wakako Tsuji, Yoshihiro Yamamoto, Masayuki Shintaku, Fumiaki Yotsumoto
The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospective study, which included 171 patients treated for MBC between 2011 and 2017 at the Shiga Medical Center for Adults. Neutrophil to lymphocytes ratios (NLRs) were determined in blood samples. The median follow-up period following diagnosis of MBC was 44 months (range, 0-217 months)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29722249/the-neutrophil-to-lymphocyte-ratio-prechemotherapy-and-postchemotherapy-as-a-prognostic-marker-in-metastatic-gastric-cancer
#18
Hyunho Kim, Sang Mi Ro, Ji Hyun Yang, Joon Won Jeong, Ji Eun Lee, Sang Young Roh, In-Ho Kim
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC). Methods: We retrospectively reviewed the records of 502 patients who received first-line palliative chemotherapy for mGC between 2007 and 2013. The neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS) were assessed before and after chemotherapy to evaluate their association with survival...
May 4, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29720123/combined-neutrophil-platelet-lymphocyte-differentiation-score-predicts-chemosensitivity-in-advanced-gastric-cancer
#19
Zhenhua Huang, Yantan Liu, Chen Yang, Xiaoyin Li, Changqie Pan, Jinjun Rao, Nailin Li, Wangjun Liao, Li Lin
BACKGROUND: Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as differentiation status, were associated with cancer progression. Hence, we introduced a novel combined Neutrophil/platelet/lymphocyte/differentiation Score (cNPLDS) to improve the prediction value of palliative chemotherapeutic response in advanced gastric cancer...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29719435/neutrophil-lymphocyte-ratio-predicts-response-to-chemotherapy-in-triple-negative-breast-cancer
#20
S Chae, K M Kang, H J Kim, E Kang, S Y Park, J H Kim, S H Kim, S W Kim, E K Kim
Background: The neutrophil-lymphocyte ratio (nlr) has been reported to correlate with patient outcome in several cancers, including breast cancer. We evaluated whether the nlr can be a predictive factor for pathologic complete response (pcr) after neoadjuvant chemotherapy (nac) in patients with triple-negative breast cancer (tnbc). Methods: We analyzed the correlation between response to nac and various factors, including the nlr, in 87 patients with tnbc who underwent nac...
April 2018: Current Oncology
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