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Neutrophil lymphocytic ratio in cancer

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https://www.readbyqxmd.com/read/27911876/neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-their-dynamic-changes-during-chemotherapy-is-useful-to-predict-a-more-accurate-prognosis-of-advanced-biliary-tract-cancer
#1
Kyoung-Min Cho, Hyunkyung Park, Do-Youn Oh, Tae-Yong Kim, Kyung-Hun Lee, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang
BACKGROUND AND PURPOSE: Systemic inflammation is known to promote carcinogenesis in biliary tract cancer (BTC). Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are indicative of systemic inflammation. We evaluated the clinical significance of systemic inflammation measured by NLR and PLR in patients with advanced BTC. Additionally, we also co-analyzed the dynamics of NLR and PLR during chemotherapy. METHODS: We reviewed 450 patients with unresectable BTC receiving palliative chemotherapy...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911233/elevated-preoperative-neutrophil-to-lymphocyte-ratio-as-a-predictor-of-worse-survival-after-resection-in-patients-with-brain-metastasis
#2
Koichi Mitsuya, Yoko Nakasu, Takeshi Kurakane, Nakamasa Hayashi, Hideyuki Harada, Kazuhiko Nozaki
OBJECTIVE The median postoperative survival duration of patients with brain metastases who undergo tumor resection is 12 months. Most of these patients die of systemic metastases or the progression of primary cancer but not brain metastases. The criteria for indicating resection are still controversial. Systemic assessment is restricted, especially in patients who need emergent management for their large-size or life-threatening brain metastases. The neutrophil-to-lymphocyte ratio (NLR) is reported to correlate with survival time or progression-free survival in patients with various cancers...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27909873/neutrophil-to-lymphocyte-ratio-associated-with-prognosis-of-lung-cancer
#3
V Bar-Ad, J Palmer, L Li, Y Lai, B Lu, R E Myers, Z Ye, R Axelrod, J M Johnson, M Werner-Wasik, S W Cowan, N R Evans, B T Hehn, C C Solomides, C Wang
PURPOSE: Many studies recently focus on complicated and expensive genomic tests, but the prognostic values of biochemical markers which are easily obtained in clinics are largely overlooked and without further exploration. This study assesses the association of neutrophil-lymphocyte-ratio (NLR) with prognosis of lung cancer patients. METHODS: In 1032 patients with histologically confirmed lung cancer, the association of pretreatment NLR values with overall survival (OS) was evaluated using a Cox proportional hazards model and the temporal relationship of longitudinal NLR was assessed using a mixed effects model...
December 1, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27907929/critical-evaluation-of-the-potential-prognostic-value-of-the-pretreatment-derived-neutrophil-lymphocyte-ratio-under-consideration-of-c-reactive-protein-levels-in-clear-cell-renal-cell-carcinoma
#4
Orietta Dalpiaz, Theresa Luef, Maximilian Seles, Michael Stotz, Tatjana Stojakovic, Karl Pummer, Richard Zigeuner, Georg C Hutterer, Martin Pichler
BACKGROUND: We investigated the prognostic value of the pretreatment-derived neutrophil-lymphocyte ratio (dNLR) and original NLR in relation to the commonly used inflammation marker C-reactive protein (CRP) in a large cohort of patients with clear cell renal cell carcinoma (RCC). METHODS: Clinicopathological data from 587 consecutive non-metastatic clear cell RCC patients, operated between 2000 and 2010 at a single tertiary academic center, were evaluated retrospectively...
December 1, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27901490/prognostic-value-of-preoperative-plasma-fibrinogen-level-and-platelet-to-lymphocyte-ratio-f-plr-in-patients-with-localized-upper-tract-urothelial-carcinoma
#5
Jiwei Huang, Yichu Yuan, Yanqing Wang, Jin Zhang, Wen Kong, Haige Chen, Yonghui Chen, Yiran Huang
PURPOSE: Hemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: A total of 481 patients who underwent radical nephroureterectomy for localized UTUC (pTa-4N0M0) were identified between January 2002 and June 2013...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900086/pretreatment-prognostic-nutritional-index-is-a-significant-predictor-of-prognosis-in-patients-with-cervical-cancer-treated-with-concurrent-chemoradiotherapy
#6
Junko Haraga, Keiichiro Nakamura, Chiaki Omichi, Takeshi Nishida, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki, Hisashi Masuyama, Norihisa Katayama, Susumu Kanazawa, Yuji Hiramatsu
This study investigated whether pretreatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI) are prognostic factors in patients with cervical cancer who undergo concurrent chemoradiotherapy (CCRT) and radiotherapy (RT). A total of 131 patients who underwent CCRT and RT for cervical cancer were retrospectively investigated and the correlations of NLR, PLR and PNI with clinical parameters and prognosis were assessed in CCRT and RT. The CCRT and RT groups had a median progression-free survival (PFS) of 41...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896506/inflammation-based-prognostic-scores-utility-in-prognostication-and-patient-selection-for-cytoreduction-and-perioperative-intraperitoneal-chemotherapy-in-patients-with-peritoneal-metastasis-of-colonic-origin
#7
Chukwuemeka Ihemelandu
BACKGROUND: Tumor-associated systemic inflammatory response has been correlated with prognosis. Our aim was to analyze the utility of inflammation-based prognostic scores for prognostication and patient selection for cytoreduction and perioperative intraperitoneal chemotherapy (POIC) in patients diagnosed with peritoneal metastasis of colonic origin. METHODS: A retrospective analysis of a prospectively maintained database for all patients treated for peritoneal metastasis of colonic origin from February 2001 to April 2015...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27891517/prognostic-significance-of-preoperative-neutrophil-to-lymphocyte-ratio-in-nonmetastatic-renal-cell-carcinoma-a-large-multicenter-cohort-analysis
#8
Seok-Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Yong-June Kim, Won Ki Lee
Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27888711/preoperative-monocyte-to-lymphocyte-ratio-in-peripheral-blood-predicts-stages-metastasis-and-histological-grades-in-patients-with-ovarian-cancer
#9
Jiangdong Xiang, Lina Zhou, Xing Li, Wei Bao, Taizhong Chen, Xiaowei Xi, Yinyan He, Xiaoping Wan
PURPOSE: The monocyte-to-lymphocyte ratio (MLR) has been shown to be associated with the prognosis of various solid tumors. This study sought to evaluate the important value of the MLR in ovarian cancer patients. METHODS: A total of 133 ovarian cancer patients and 43 normal controls were retrospectively reviewed. The patients' demographics were analyzed along with clinical and pathologic data. The counts of peripheral neutrophils, lymphocytes, monocytes, and platelets were collected and used to calculate the MLR, neutrophil-to-lymphocyte ratio (NLR)...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27881836/relationship-between-lesions-in-adenomatous-polyp-dysplasia-colorectal-cancer-sequence-and-neutrophil-to-lymphocyte-ratio
#10
Feyzullah Uçmak, Elif Tuğba Tuncel
BACKGROUND The aim of our study was to evaluate all lesions in the adenoma-dysplasia-cancer sequence of the colon and to examine whether the neutrophil-to-lymphocyte ratio (NLR) can distinguish polyps indicating dysplasia and cancer. MATERIAL AND METHODS A total of 397 patients who had colonoscopic polypectomy between January 2010 and December 2014 were included in our retrospective study. The patients were divided into four groups: patients with hyperplastic polyps, patients with adenomatous polyps, patients with dysplasia, and patients with cancer...
November 24, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27858908/predictive-value-of-neutrophil-to-lymphocyte-ratio-in-diagnosis-of-prostate-cancer-among-men-who-underwent-template-guided-prostate-biopsy-a-strobe-compliant-study
#11
Tian-Bao Huang, Shi-Yu Mao, Sheng-Ming Lu, Jun-Jie Yu, Yang Luan, Xiao Gu, Hao Liu, Guang-Chen Zhou, Xue-Fei Ding
To evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) in diagnosis of prostate cancer (PCa). Data of 662 patients who underwent prostate biopsy from January 2012 to June 2016 were retrospectively reviewed. The receiver operating characteristic-derived area under the curve analyses were performed to assess the predictive accuracy. Simultaneously, Youden's index was calculated to determine the optimal NLR cutoff. Furthermore, univariate and multivariate logistic regression analyses were performed to determine the association between NLR value and PCa detection...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858496/inverse-association-between-platelet-lymphocyte-ratio-and-prognosis-in-terminally-ill-cancer-patients-a-preliminary-study
#12
Yoonjoo Lee, Ye Won Kim, Dong Kyun Park, In Cheol Hwang
BACKGROUND: An elevated platelet-lymphocyte ratio (PLR) is an indicator for worse outcomes in cancer, but its significance at the end of life remains unclear. OBJECTIVE: This study aimed to investigate the value of PLR as an independent prognostic factor in terminally ill cancer patients. METHODS: This retrospective cohort study included 312 terminal cancer patients and was conducted in a palliative care unit of a tertiary cancer center. Patient demographic data, clinical information, and laboratory values, including complete blood cell count, were obtained...
November 18, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27854304/a-novel-inflammation-based-stage-i-stage-predicts-overall-survival-of-patients-with-nasopharyngeal-carcinoma
#13
Jian-Pei Li, Shu-Lin Chen, Xiao-Min Liu, Xia He, Shan Xing, Yi-Jun Liu, Yue-Hao Lin, Wan-Li Liu
Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified GPS (mGPS) and C-reactive protein/Albumin (CRP/Alb) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC). In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted...
November 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27852294/neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-predict-chemotherapy-outcomes-and-prognosis-in-patients-with-colorectal-cancer-and-synchronous-liver-metastasis
#14
Yuchen Wu, Cong Li, Jiang Zhao, Li Yang, Fangqi Liu, Hongtu Zheng, Zhimin Wang, Ye Xu
BACKGROUND: Recent evidence indicates that inflammatory parameters could be useful to predict metastasis from colorectal cancer. However, their roles in predicting chemotherapy response and prognosis in patients with synchronous colorectal liver metastasis (CLM) are unknown. METHODS: The clinical data and baseline laboratory parameters of 55 patients with synchronous CLM were retrospectively reviewed. All patients underwent palliative resection of the primary tumor and oxaliplatin-based chemotherapy...
November 16, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27852046/elevated-neutrophil-to-lymphocyte-ratio-and-monocyte-to-lymphocyte-ratio-and-decreased-platelet-to-lymphocyte-ratio-are-associated-with-poor-prognosis-in-multiple-myeloma
#15
Lihui Shi, Xiaoqi Qin, Huijun Wang, Yonghui Xia, Yuanyuan Li, Xuejing Chen, Lei Shang, Yu-Tzu Tai, Xiaoyan Feng, Prakrati Acharya, Chirag Acharya, Yan Xu, Shuhui Deng, Mu Hao, Dehui Zou, Yaozhong Zhao, Kun Ru, Lugui Qiu, Gang An
Elevated inflammatory markers are associated with poor outcomes in various types of cancers; however, their clinical significance in multiple myeloma (MM) have seldom been explored. This study investigated the prognostic relevance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in MM. Totally 559 MM patients were included in this study. NLR, PLR and MLR were calculated from whole blood counts prior to therapy. Kaplan-Meier curves and multivariate Cox proportional models were used for the evaluation of the survival...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27845912/preoperative-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratios-are-independent-prognostic-factors-for-patients-undergoing-lung-cancer-radical-surgery-a-single-institutional-cohort-study
#16
Haidan Lan, Leng Zhou, Dongmei Chi, Qinghua Zhou, XiaoJun Tang, Daxing Zhu, Jianmin Yue, Bin Liu
BACKGROUND: The aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection. METHODS: In this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27845694/neutrophil-to-lymphocyte-and-neutrophil-to-monocyte-rates-in-the-decision-for-a-prostate-re-biopsy-in-patients-with-a-previous-benign-pathology-and-consistently-2-5-10-ng-ml-psa-value
#17
Yasin Ceylan, Bülent Günlüsoy, Tansu Degirmenci, Deniz Bolat, Zafer Kozacioglu, Enver Vardar, Yusuf Kadir Topçu, Salih Polat
OBJECTIVES: In this study we compared neutrophil-to-lymphocyte ratio (NLR) and neutrophilto- monocyte ratio(NMR) between patients with prostate cancer after first transrectal ultrasound (TRUS)- guided biopsy and patients with benign prostate hyperplasia(BPH) after second TRUS-guided biyopsy. METHODS: A total of 224 patients who underwent multi (≥12)-core TRUS -guided biopsy at our clinic for elevated PSA or abnormal digital rectal examination in between January 2008 and March 2015 were retrospectively analyzed...
November 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27843746/prognostic-significance-of-platelet-lymphocyte-ratio-in-patients-receiving-first-line-tyrosine-kinase-inhibitors-for-metastatic-renal-cell-cancer
#18
Tae Ju Park, Yang Hyun Cho, Ho Seok Chung, Eu Chang Hwang, Sung-Hoon Jung, Jun Eul Hwang, Woo Kyun Bae, Jin Woong Kim, Suk Hee Heo, Young Hoe Hur, Seung Il Jung, Dong Deuk Kwon
BACKGROUND: The platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) have been reported as prognostic factors in various cancers, but their roles in metastatic renal cell cancer (mRCC) remain unclear. We investigated the significance of PLR and NLR, along with that of established prognostic factors, in mRCC patients receiving first-line tyrosine kinase inhibitors (TKI). METHODS: Data obtained from 63 mRCC patients who received first-line TKI between 2007 and 2013 were evaluated retrospectively...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27843595/neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-before-chemotherapy-as-potential-prognostic-factors-in-patients-with-newly-diagnosed-epithelial-ovarian-cancer
#19
Agnieszka Badora-Rybicka, Elżbieta Nowara, Danuta Starzyczny-Słota
INTRODUCTION: Recent studies have shown that the presence of systemic inflammation correlates with worse outcomes in many types of cancers. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been proposed as indicators of systemic inflammatory response. The aim of the study was to assess the prognostic value of NLR and PLR before starting chemotherapy among patients with newly diagnosed ovarian cancer. METHODS: We conducted a retrospective analysis of medical documentation of 315 patients with newly diagnosed epithelial ovarian cancer, treated in Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, between 2007 and 2013...
2016: ESMO Open
https://www.readbyqxmd.com/read/27843594/neutrophil-to-lymphocyte-ratio-nlr-for-prediction-of-distant-metastasis-free-survival-dmfs-in-early-breast-cancer-a-propensity-score-matched-analysis
#20
Michele Orditura, Gennaro Galizia, Anna Diana, Ciro Saccone, Luigi Cobellis, Jole Ventriglia, Francesco Iovino, Ciro Romano, Floriana Morgillo, Lavinia Mosca, Maria Rosaria Diadema, Eva Lieto, Eugenio Procaccini, Ferdinando De Vita, Fortunato Ciardiello
OBJECTIVE: To assess the correlation between presurgery neutrophil to lymphocyte ratio (NLR) and distant metastasis-free survival (DMFS) in patients with early breast cancer. DESIGN: Retrospective analysis. PARTICIPANTS: 300 Caucasian patients with early (T1-2, N0-1, non-metastatic) breast cancer who were followed from July 1999 to June 2015 at our Institution. MAIN OUTCOME MEASURES: Distant metastasis-free survival (DMFS)...
2016: ESMO Open
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