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Trabeculectomy

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https://www.readbyqxmd.com/read/28542372/revision-of-encapsulated-blebs-after-trabeculectomy-long-term-comparison-of-standard-bleb-needling-and-modified-needling-procedure-combined-with-transconjunctival-scleral-flap-sutures
#1
P Laspas, P D Culmann, F H Grus, V Prokosch-Willing, A Poplawksi, N Pfeiffer, E M Hoffmann
PURPOSE: To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1. bleb needling alone vs. 2. a combined approach of needling with additional transconjunctival scleral flap sutures, to prevent early ocular hypotony. METHODS: Forty-six patients with failing blebs after trabeculectomy with mitomycin C were enrolled in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28540081/a-system-review-and-meta-analysis-of-canaloplasty-outcomes-in-glaucoma-treatment-in-comparison-with-trabeculectomy
#2
REVIEW
Bing Zhang, Jie Kang, Xiaoming Chen
Purpose. This system review studied the efficiency and safety of canaloplasty (CP) and compared the outcomes between CP and trabeculectomy (TE). Methods. Literatures were searched in PubMed and EMBASE. The meta-analysis was conducted on the postoperative outcomes in CP and then on the differences of outcomes between CP and TE. Results. In the meta-analysis, IOP decreased by 9.94 (95% CI 8.42 to 11.45) mmHg with an average AGM reduction of 2.11 (95% CI 1.80 to 2.42) one year after CP. The IOP reduction was significantly higher after TE than after CP, with an average difference of 3...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28537521/the-water-drinking-test-revisited-an-analysis-of-test-results-in-subjects-with-glaucoma
#3
M Reza Razeghinejad, Zahra Tajbakhsh, M Hossein Nowroozzadeh, Shane J Havens, Deepta Ghate, Vikas Gulati
PURPOSE: The Water-Drinking Test (WDT) has been shown to predict the diurnal IOP change. This study evaluates the factors that may affect the WDT results. METHODS: This study was conducted on 203 glaucoma patients who had undergone trabeculectomy (53) or tube surgery (31), or had a medically controlled open-angle (82) or closed-angle (37) glaucoma. IOP was measured at baseline and then every 15 minutes over a one-hour period after drinking water. The main outcome measures were IOP change (increase in IOP from baseline) at all measurement time points, IOP peak (highest IOP after drinking water), IOP fluctuation (difference between IOP peak and baseline), and assessing the association of these IOPs with a patient's demographic and management modalities...
May 24, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28536636/a-simple-and-effective-protocol-for-fast-isolation-of-human-tenon-s-fibroblasts-from-a-single-trabeculectomy-biopsy-a-comparison-of-cell-behaviour-in-different-culture-media
#4
Agata Przekora, Tomasz Zarnowski, Grazyna Ginalska
BACKGROUND: Human Tenon's fibroblasts (HTFs) play a crucial role in wound healing. They cause postoperative scarring of the filtering bleb and are thus responsible for trabeculectomy failure. This study aimed to find an effective and fast protocol for HTF isolation from trabeculectomy biopsies. The protocol was compared with the commonly recommended HTF isolation procedure, which uses Dulbecco's modified Eagle's medium (DMEM). We used Eagle's minimum essential medium (EMEM) enriched with fibroblast growth factor (FGF), which selectively promoted the proliferation of HTF cells...
2017: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/28529695/training-strategies-and-outcomes-of-ab-interno-trabeculectomy-with-the-trabectome
#5
Katherine Fallano, Igor Bussel, Larry Kagemann, Kira L Lathrop, Nils Loewen
Plasma-mediated ab interno trabeculectomy with the trabectome was first approved by the US Food and Drug Administration in 2004 for use in adult and pediatric glaucomas. Since then, increased clinical experience and updated outcome data have led to its expanded use, including a range of glaucomas and angle presentations, previously deemed to be relatively contraindicated. The main benefits are a high degree of safety, ease, and speed compared to traditional filtering surgery and tube shunts. The increasing burden of glaucoma and expanding life expectancy has resulted in demand for well-trained surgeons...
2017: F1000Research
https://www.readbyqxmd.com/read/28513505/practice-of-trabeculectomy-by-ophthalmologists-in-nigeria
#6
N N Kizor-Akaraiwe, C E Ogbonnaya
AIM: To assess the practice of trabeculectomy among ophthalmologists in Nigeria. MATERIALS AND METHODS: This was a cross-sectional study in which structured, self- administered questionnaires were distributed to 80 consenting ophthalmologists present during the 2010 annual scientific session of the Ophthalmological Society of Nigeria. All consenting ophthalmologists treat glaucoma patients. Information obtained were demographic characteristics, glaucoma outpatient load, number of trabeculectomies performed in the preceding 1 year and during residency training, and factors influencing trabeculectomy practice...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28499445/vision-related-quality-of-life-following-glaucoma-filtration-surgery
#7
Kazuyuki Hirooka, Eri Nitta, Kaori Ukegawa, Akitaka Tsujikawa
BACKGROUND: To evaluate vision-related quality of life (VR-QOL) following glaucoma filtration surgery. METHODS: A total of 103 glaucoma patients scheduled to undergo glaucoma filtration surgery. Prior to and at three months after glaucoma filtration surgery, trabeculectomy or EX-PRESS, all patients completed the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). A total of 48 patients underwent combined cataract and filtration surgery. The clinical data collected pre- and postoperatively included best-corrected visual acuity (BCVA) and intraocular pressure (IOP)...
May 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28487512/rapid-learning-curve-assessment-in-an-ex-vivo-training-system-for-microincisional-glaucoma-surgery
#8
Yalong Dang, Susannah Waxman, Chao Wang, Hardik A Parikh, Igor I Bussel, Ralitsa T Loewen, Xiaobo Xia, Kira L Lathrop, Richard A Bilonick, Nils A Loewen
Increasing prevalence and cost of glaucoma have increased the demand for surgeons well trained in newer, microincisional surgery. These procedures occur in a highly confined space, making them difficult to learn by observation or assistance alone as is currently done. We hypothesized that our ex vivo outflow model is sensitive enough to allow computing individual learning curves to quantify progress and refine techniques. Seven trainees performed nine trabectome-mediated ab interno trabeculectomies in pig eyes (n = 63)...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28486513/angle-stability-and-outflow-in-dual-blade-ab-interno-trabeculectomy-with-active-versus-passive-chamber-management
#9
Chao Wang, Yalong Dang, Susannah Waxman, Xiaobo Xia, Robert N Weinreb, Nils A Loewen
PURPOSE: To compare intraoperative angle stability and postoperative outflow of two ab interno trabeculectomy devices that excise the trabecular meshwork with or without active aspiration and irrigation. We hypothesized that anterior segment optical coherence tomography (AS-OCT) allows for a quantitative comparison of intraoperative angle stability in a microincisional glaucoma surgery (MIGS) pig eye training model. METHODS: Twelve freshly enucleated porcine eyes were measured with AS-OCT at baseline, at the beginning of the procedure and at its conclusion to determine the anterior chamber depth (ACD) and the nasal angle α in degrees...
2017: PloS One
https://www.readbyqxmd.com/read/28484852/-long-term-prognosis-of-peters-anomaly
#10
S Reichl, D Böhringer, O Richter, W Lagrèze, T Reinhard
BACKGROUND: Peters anomaly normally presents in early childhood. Common features are central corneal opacities and dysgeneses of the anterior eye segment. Early surgery is commonly warranted to prevent deep amblyopia or because of severe glaucoma. We herein present the clinical outcomes of all patients treated in the Eye Center of the Albert Ludwigs University of Freiburg since 2005. Emphasis is placed on the Peters subtype. METHODS: Data were collected retrospectively by means of chart review...
May 8, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28468021/comparison-of-the-outcomes-of-trabeculectomy-with-5-fluorouracil-versus-ologen-implant-in-primary-open-angle-glaucoma
#11
Wisam Shihadeh, Ihab Massad, Yousef Khader, Ahmed Al-Rawi, Tala Alshalakhti
PURPOSE: To compare the outcomes of trabeculectomy with 5-fluorouracil (5-FU) versus Ologen™ implant in patients with primary open-angle glaucoma. METHODS: A retrospective chart review was performed of patients with primary open-angle glaucoma who underwent trabeculectomy using either Ologen or 5-FU over 12 consecutive months. The patients had moderate-to-advanced primary open-angle glaucoma and uncontrolled intraocular pressure (IOP) on maximally tolerated medical treatment...
May 4, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28455543/-early-atrophy-of-the-conjunctiva-after-trabeculectomy-with-mitomycin-c-and-collagen-matrix-implant
#12
R Siggel, T Dietlein
Complete atrophy of the filtration bleb is a very rare complication after trabeculectomy with mitomycin C and collagen matrix implant (Ologen®, Aeon Astron Corporation, Taipei, Taiwan). Clinically, the atrophy can present similar to blebitis. We report the case of a 71-year-old woman, in whom we resected the atrophic conjunctiva and reconstructed a filtration bleb using an amniotic membrane.
April 28, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28449000/three-year-follow-up-of-trabeculectomy-with-5-fluorouracil
#13
Friederike Lindemann, Niklas Plange, David Kuerten, Hannah Schimitzek, Antonis Koutsonas
PURPOSE: To evaluate the long-term outcome of trabeculectomy with intra- and postoperative 5-fluorouracil (5-FU) application in glaucoma. METHODS: Eighty-six patients with glaucoma planned for primary trabeculectomy with 5-FU and a minimum follow-up of 3 years were retrospectively analyzed. Success rates, postsurgical 5-FU injections, needling procedures, and complications were analyzed. RESULTS: Mean intraocular pressure (IOP) decreased from 27...
April 28, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28448622/goniodysgenesis-variability-and-activity-of-cyp1b1-genotypes-in-primary-congenital-glaucoma
#14
María T García-Antón, Juan J Salazar, Rosa de Hoz, Blanca Rojas, Ana I Ramírez, Alberto Triviño, José-Daniel Aroca-Aguilar, Julián García-Feijoo, Julio Escribano, José M Ramírez
Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clinical phenotypes in human PCG. Surgical pieces from trabeculectomy from patients with PCG (n = 5) and sclerocorneal rims (n = 3) from cadaver donors were processed for transmission electron microscopy. Patients were classified into three groups depending on goniodysgenesis severity, which was influenced by CYP1B1 enzymatic activity...
2017: PloS One
https://www.readbyqxmd.com/read/28448293/trabeculectomy-or-transscleral-cyclophotocoagulation-as-initial-treatment-of-secondary-childhood-glaucoma-in-northern-tanzania
#15
Achim Fieß, Peter Shah, Freda Sii, Furahini Godfrey, Joe Abbott, Richard Bowman, Jacqueline Bauer, Stefan Dithmar, Heiko Philippin
PURPOSE: The purpose is to describe the outcome of trabeculectomy with transscleral cyclophotocoagulation (TSCPC) as an initial intervention for secondary childhood glaucoma in Northern Tanzania. METHODS: A retrospective, consecutive case series was analyzed of all children with secondary childhood glaucoma who underwent initial trabeculectomy or TSCPC between 2000 and 2013 at a referral eye unit in Northern Tanzania. Retrospective data were collected on causes of glaucoma, intraocular pressure (IOP), visual acuity, complications, and subsequent interventions...
April 26, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28442696/surgical-management-of-pediatric-glaucoma
#16
Ingrid Chang, Joseph Caprioli, Yvonne Ou
Pediatric glaucoma surgery is challenging because of the differences in anatomy from the adult, differences in the behavior of the tissues of a child's glaucomatous eye, the variety in causes of the disease, and difficulties with postoperative management. Goniotomy and trabeculotomy are the preferred initial treatments for primary congenital glaucoma. Trabeculectomy with adjunctive mitomycin C is more likely to succeed in older, phakic patients, but carries the long-term risk of bleb-associated endophthalmitis...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442693/ab-interno-schlemm-s-canal-surgery
#17
Brian A Francis, Handan Akil, Benjamin B Bert
In primary open-angle glaucoma, the site of greatest resistance to aqueous outflow is thought to be the trabecular meshwork (TM) and inner wall of Schlemm's canal. Augmentation of the conventional (trabecular) outflow pathway can facilitate physiologic outflow and subsequently lower intraocular pressure. The most recent approach to enhancing the conventional outflow pathway is via an internal approach to the TM and Schlemm's canal. Ab interno Schlemm's canal surgery includes 4 novel surgical approaches: (1) removal of the TM and inner wall of Schlemm's canal by an internal approach (ab interno trabeculectomy), (2) implantation of a microstent to bypass the TM, (3) disruption of the TM and inner wall of Schlemm's canal via an internal approach (ab interno trabeculotomy), and (4) dilation of Schlemm's canal via an internal approach (ab interno canaloplasty)...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442691/laser-assisted-techniques-for-penetrating-and-nonpenetrating-glaucoma-surgery
#18
Noa Geffen, Ehud I Assia, Shlomo Melamed
The use of lasers is slowly pervading all subspecialties of ophthalmology, especially glaucoma, and lasers are slowly replacing many glaucoma surgeries. Conventional trabeculectomy has so far remained the gold standard for glaucoma surgery and efforts are being made to develop a new surgical approach to overcome the limited success rate and safety issues of this traditional procedure. There is a great interest in using lasers for ab interno and ab externo penetrating and nonpenetrating filtering surgery. Theoretically, laser-assisted surgery offers the potential advantage of improved accuracy, repeatability, and safety, although the main drawback of using lasers for this purpose is the potential collateral damage induced by the scattered energy...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442686/glaucoma-drainage-implant-surgery
#19
Ahmad A Aref, Steven J Gedde, Donald L Budenz
Glaucoma drainage implant (GDI) surgery represents a significant advance in the treatment of refractory glaucomas. Recent randomized clinical trials have compared the efficacy and safety of this technique to standard trabeculectomy. Several types of implant are currently available and differ in surface area, shape, composition, and the presence or absence of a flow-restricting valve. Two separate prospective, randomized clinical trials comparing 2 types of GDI have reported results after 5 years of follow-up...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442685/deep-sclerectomy
#20
Sylvain Roy, André Mermoud
Filtering surgery evolved from the classic trabeculectomy, in which penetration into the anterior chamber is a necessary step, toward nonpenetrating deep sclerectomy. The first procedure presents several serious complications, such as durable hypotony, hyphema, flat anterior chamber, choroidal detachment, endophthalmitis, and surgery-induced cataract. To avoid such drawbacks, a novel nonpenetrating technique was designed to improve the predictability of the intraocular pressure (IOP)-lowering action, while reducing the incidence of the immediate postoperative complications encountered with the penetrating method...
2017: Developments in Ophthalmology
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