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https://www.readbyqxmd.com/read/29054084/occurrence-and-levels-of-persistent-organic-pollutants-pops-in-farmed-and-wild-marine-fish-from-tanzania-a-pilot-study
#1
Eliezer Brown Mwakalapa, Aviti John Mmochi, Mette Helen Bjorge Müller, Robinson Hammerthon Mdegela, Jan Ludvig Lyche, Anuschka Polder
In 2016, farmed and wild milkfish (Chanos chanos) and mullet (Mugil cephalus) from Tanzania mainland (Mtwara) and Zanzibar islands (Pemba and Unguja) were collected for analyses of persistent organic pollutants (POPs). Fish livers were analysed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs). Muscle tissue was used for analyses of perfluoroalkyl substances (PFASs). The major contaminant was p,p'-DDE. The highest p,p'-DDE concentration was found in wild milkfish from Mtwara (715...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29053992/biomarker-guided-stratification-of-autoimmune-patients-for-biologic-therapy
#2
REVIEW
Sabine Ivison, Christine des Rosiers, Sylvie Lesage, John D Rioux, Megan K Levings
Autoimmunity results from an intersection of genetic and environmental factors that cause patient-specific perturbations in immune homeostasis. Defining autoimmunity-associated genetic factors has led to mechanistic insight into underlying etiologies, and the development of many biologic therapies that target the immune system. However, biomarker-informed pairing of patients with optimal biologic therapy is lacking. Here, we discuss platforms commonly used to find biomarkers that predict response to biologic therapy in autoimmunity and highlight recent biomarker discoveries...
October 17, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29053977/suicidal-ideation-declines-with-improvement-in-the-subjective-symptoms-of-major-depression
#3
John G Keilp, Steven P Ellis, Marianne Gorlyn, Ainsley K Burke, Maria A Oquendo, J John Mann, Michael F Grunebaum
BACKGROUND: Suicidal ideation appears to be more strongly associated with subjective rather than neurovegetative symptoms of depression. Effective treatment, then, should produce reductions in suicidal ideation to the degree that these subjective symptoms are alleviated relative to treatment effects on other symptoms. METHODS: In a randomized clinical trial comparing paroxetine and bupropion for treatment of depression in patients with either suicidal ideation or past attempt, depression severity and suicidal ideation were assessed weekly during the 8-week study...
September 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053969/pebp1-wardens-ferroptosis-by-enabling-lipoxygenase-generation-of-lipid-death-signals
#4
Sally E Wenzel, Yulia Y Tyurina, Jinming Zhao, Claudette M St Croix, Haider H Dar, Gaowei Mao, Vladimir A Tyurin, Tamil S Anthonymuthu, Alexandr A Kapralov, Andrew A Amoscato, Karolina Mikulska-Ruminska, Indira H Shrivastava, Elizabeth M Kenny, Qin Yang, Joel C Rosenbaum, Louis J Sparvero, David R Emlet, Xiaoyan Wen, Yoshinori Minami, Feng Qu, Simon C Watkins, Theodore R Holman, Andrew P VanDemark, John A Kellum, Ivet Bahar, Hülya Bayır, Valerian E Kagan
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates. Mechanisms of the altered 15-LO substrate specificity are enigmatic. We sought a common ferroptosis regulator for 15LO. We discovered that PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-PE...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053951/heme-binding-biguanides-target-cytochrome-p450-dependent-cancer-cell-mitochondria
#5
Zhijun Guo, Irina F Sevrioukova, Ilia G Denisov, Xia Zhang, Ting-Lan Chiu, Dafydd G Thomas, Eric A Hanse, Rebecca A D Cuellar, Yelena V Grinkova, Vanessa Wankhede Langenfeld, Daniel S Swedien, Justin D Stamschror, Juan Alvarez, Fernando Luna, Adela Galván, Young Kyung Bae, Julia D Wulfkuhle, Rosa I Gallagher, Emanuel F Petricoin, Beverly Norris, Craig M Flory, Robert J Schumacher, M Gerard O'Sullivan, Qing Cao, Haitao Chu, John D Lipscomb, William M Atkins, Kalpna Gupta, Ameeta Kelekar, Ian A Blair, Jorge H Capdevila, John R Falck, Stephen G Sligar, Thomas L Poulos, Gunda I Georg, Elizabeth Ambrose, David A Potter
No abstract text is available yet for this article.
October 19, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29053946/measurement-of-area-and-personal-breathing-zone-concentrations-of-diesel-particulate-matter-dpm-during-oil-and-gas-extraction-operations-including-hydraulic-fracturing
#6
Eric J Esswein, Marissa Alexander-Scott, John Snawder, Michael Breitenstein
Diesel engines serve many purposes in modern oil and gas extraction activities. Diesel particulate matter (DPM) emitted from diesel engines is a complex aerosol that may cause adverse health effects depending on exposure dose and duration. This study reports on personal breathing zone (PBZ) and area measurements for DPM (expressed as elemental carbon) during oil and gas extraction operations including drilling, completions (which includes hydraulic fracturing) and servicing work. Researchers at the National Institute for Occupational Safety and Health (NIOSH) collected 104 full-shift air samples (49 PBZ and 55 area) in Colorado, North Dakota, Texas, and New Mexico during a four year period from 2008-2012 The arithmetic mean (AM) of the full shift TWA PBZ samples was 10 µg/m(3); measurements ranged from 0...
October 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29053886/a-historical-perspective-and-evolution-of-the-treatment-of-male-urinary-incontinence
#7
Julio T Chong, Vannita Simma-Chiang
AIMS: To describe the historical changes from antiquity until present in the presentation and treatment of male urinary incontinence. METHODS: A literature review of PubMed articles in English pertaining to male incontinence was performed. RESULTS: Male urinary incontinence was first mentioned in Egyptian manuscripts in 1500 B.C. In 1564, Ambroise Pare designed portable urinals for incontinent males. Wilhem Hildanus created the first condom catheter with pig bladder in the 1600s and was also credited with fashioning the first penile clamp...
October 20, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29053880/electrodiagnostic-errors-contribute-to-cidp-misdiagnosis
#8
Jeffrey A Allen, John Ney, Richard A Lewis
INTRODUCTION: Documentation of peripheral nerve demyelination is an important part of the CIDP diagnostic process. METHODS: We performed a retrospective analysis of patients referred with a diagnosis of CIDP who were found to have a different condition. Electrodiagnostic study data and interpretations performed at the time of the initial diagnosis were compared to those obtained during the re-evaluation. RESULTS: Thirty-nine of 86 patients were found to not have CIDP...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053868/lagos-ne-a-multi-scaled-geospatial-and-temporal-database-of-lake-ecological-context-and-water-quality-for-thousands-of-u-s-lakes
#9
Patricia A Soranno, Linda C Bacon, Michael Beauchene, Karen E Bednar, Edward G Bissell, Claire K Boudreau, Marvin G Boyer, Mary T Bremigan, Stephen R Carpenter, Jamie W Carr, Kendra S Cheruvelil, Samuel T Christel, Matt Claucherty, Sarah M Collins, Joseph D Conroy, John A Downing, Jed Dukett, C Emi Fergus, Christopher T Filstrup, Clara Funk, Maria J Gonzalez, Linda T Green, Corinna Gries, John D Halfman, Stephen K Hamilton, Paul C Hanson, Emily N Henry, Elizabeth M Herron, Celeste Hockings, James R Jackson, Kari Jacobson-Hedin, Lorraine L Janus, William W Jones, John R Jones, Caroline M Keson, Katelyn B S King, Scott A Kishbaugh, Jean-Francois Lapierre, Barbara Lathrop, Jo A Latimore, Yuehlin Lee, Noah R Lottig, Jason A Lynch, Leslie J Matthews, William H McDowell, Karen E B Moore, Brian P Neff, Sarah J Nelson, Samantha K Oliver, Michael L Pace, Donald C Pierson, Autumn C Poisson, Amina I Pollard, David M Post, Paul O Reyes, Donald O Rosenberry, Karen M Roy, Lars G Rudstam, Orlando Sarnelle, Nancy J Schuldt, Caren E Scott, Nicholas K Skaff, Nicole J Smith, Nick R Spinelli, Joseph J Stachelek, Emily H Stanley, John L Stoddard, Scott B Stopyak, Craig A Stow, Jason M Tallant, Pang-Ning Tan, Anthony P Thorpe, Michael J Vanni, Tyler Wagner, Gretchen Watkins, Kathleen C Weathers, Katherine E Webster, Jeffrey D White, Marcy K Wilmes, Shuai Yuan
Background: Understanding the factors that affect water quality and the ecological services provided by freshwater ecosystems is an urgent global environmental issue. Predicting how water quality will respond to global changes not only requires water quality data, but also information about the ecological context of individual water bodies across broad spatial extents. Because lake water quality is usually sampled in limited geographic regions, often for limited time periods, assessing the environmental controls of water quality requires compilation of many datasets across broad regions and across time into an integrated database...
October 19, 2017: GigaScience
https://www.readbyqxmd.com/read/29053861/physical-function-following-a-long-term-lifestyle-intervention-among-middle-aged-and-older-adults-with-type-2-diabetes-the-look-ahead-study
#10
Denise K Houston, Rebecca H Neiberg, Michael E Miller, James O Hill, John M Jakicic, Karen C Johnson, Edward W Gregg, Van S Hubbard, Xavier Pi-Sunyer, W Jack Rejeski, Rena R Wing, John P Bantle, Elizabeth Beale, Robert I Berkowitz, Maria Cassidy-Begay, Jeanne M Clark, Mace Coday, Linda M Delahanty, Gareth Dutton, Caitlin Egan, John P Foreyt, Frank L Greenway, Helen P Hazuda, Andrea Hergenroeder, Edward S Horton, Robert W Jeffery, Steven E Kahn, Anne Kure, William C Knowler, Cora E Lewis, Corby K Martin, Sara Michaels, Maria G Montez, David M Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A Wadden, Karen White, Susan Z Yanovski, Ping Zhang, Stephen B Kritchevsky
Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods: Overweight and obese (BMI ≥25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years post-randomization and 1...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053860/clinicopathological-correlations-in-behavioural-variant-frontotemporal-dementia
#11
David C Perry, Jesse A Brown, Katherine L Possin, Samir Datta, Andrew Trujillo, Anneliese Radke, Anna Karydas, John Kornak, Ana C Sias, Gil D Rabinovici, Maria Luisa Gorno-Tempini, Adam L Boxer, Mary De May, Katherine P Rankin, Virginia E Sturm, Suzee E Lee, Brandy R Matthews, Aimee W Kao, Keith A Vossel, Maria Carmela Tartaglia, Zachary A Miller, Sang Won Seo, Manu Sidhu, Stephanie E Gaus, Alissa L Nana, Jose Norberto S Vargas, Ji-Hye L Hwang, Rik Ossenkoppele, Alainna B Brown, Eric J Huang, Giovanni Coppola, Howard J Rosen, Daniel Geschwind, John Q Trojanowski, Lea T Grinberg, Joel H Kramer, Bruce L Miller, William W Seeley
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical for the success of disease-modifying therapies. We sought to improve pathological prediction by exploring clinicopathological correlations in a large bvFTD cohort. Among 438 patients in whom bvFTD was either the top or an alternative possible clinical diagnosis, 117 had available autopsy data, including 98 with a primary pathological diagnosis of frontotemporal lobar degeneration (FTLD), 15 with Alzheimer's disease, and four with amyotrophic lateral sclerosis who lacked neurodegenerative disease-related pathology outside of the motor system...
October 6, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053808/the-impact-of-supplemental-antioxidants-on-visual-function-in-nonadvanced-age-related-macular-degeneration-a-head-to-head-randomized-clinical-trial
#12
Kwadwo Owusu Akuffo, Stephen Beatty, Tunde Peto, Jim Stack, Jim Stringham, David Kelly, Irene Leung, Laura Corcoran, John M Nolan
Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29053792/2017-infectious-diseases-society-of-america-clinical-practice-guidelines-for-the-diagnosis-and-management-of-infectious-diarrhea
#13
Andi L Shane, Rajal K Mody, John A Crump, Phillip I Tarr, Theodore S Steiner, Karen Kotloff, Joanne M Langley, Christine Wanke, Cirle Alcantara Warren, Allen C Cheng, Joseph Cantey, Larry K Pickering
These guidelines are intended for use by healthcare professionals who care for children and adults with suspected or confirmed infectious diarrhea. They are not intended to replace physician judgement regarding specific patients or clinical or public health situations. This document does not provide detailed recommendations on infection prevention and control aspects related to infectious diarrhea.
October 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29053753/3d-morphological-analysis-of-the-mouse-cerebral-vasculature-comparison-of-in-vivo-and-ex-vivo-methods
#14
Joe Steinman, Margaret M Koletar, Bojana Stefanovic, John G Sled
Ex vivo 2-photon fluorescence microscopy (2PFM) with optical clearing enables vascular imaging deep into tissue. However, optical clearing may also produce spherical aberrations if the objective lens is not index-matched to the clearing material, while the perfusion, clearing, and fixation procedure may alter vascular morphology. We compared in vivo and ex vivo 2PFM in mice, focusing on apparent differences in microvascular signal and morphology. Following in vivo imaging, the mice (four total) were perfused with a fluorescent gel and their brains fructose-cleared...
2017: PloS One
https://www.readbyqxmd.com/read/29053709/changes-in-utilization-and-peri-operative-outcomes-of-bariatric-surgery-in-large-u-s-hospital-database-2011-2014
#15
Lu Zhang, John Scott, Lu Shi, Khoa Truong, Qingwei Hu, Joseph A Ewing, Liwei Chen
BACKGROUND: With the epidemic of morbid obesity, bariatric surgery has been accepted as one of the most effective treatments of obesity. OBJECTIVE: To investigate recent changes in the utilization of bariatric surgery, patients and hospital characteristics, and in-hospital complications in a nationwide hospital database in the United States. SETTING: This is a secondary data analysis of the Premier Perspective database. METHODS: ICD-9 codes were used to identify bariatric surgeries performed between 2011 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29053687/bead-based-multiplex-assay-for-analysis-of-tear-cytokine-profiles
#16
Praveen Kumar Balne, Veonice Bijin Au, Louis Tong, Arkasubhra Ghosh, Mukesh Agrawal, John Connolly, Rupesh Agrawal
Tear film is a complex mixture of lipids, proteins and minerals which covers the external surface of the eye, thereby providing lubrication, nutrition and protection to the underlying cells. Analysis of tears is an emerging area for the identification of biomarkers for the prediction, diagnosis, and prognosis of various ocular diseases. Tears are easily accessible and their collection is non-invasive. Therefore, advancing technologies are gaining prominence for identification of multiple analytes in tears to study changes in protein or metabolite composition and its association with pathological conditions...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053638/neuroprotective-surgical-strategies-in-parkinson-s-disease-role-of-preclinical-data
#17
REVIEW
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson's disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053607/does-migration-limit-the-effect-of-health-insurance-on-hypertension-management-in-china
#18
Hai Fang, Yinzi Jin, Miaomiao Zhao, Huyang Zhang, John A Rizzo, Donglan Zhang, Zhiyuan Hou
Background: In China, rapid urbanization has caused migration from rural to urban areas, and raised the prevalence of hypertension. However, public health insurance is not portable from one place to another, and migration may limit the effectiveness of this non-portable health insurance on healthcare. Our study aims to investigate whether migration limits the effectiveness of health insurance on hypertension management in China. Methods: Data were obtained from the national baseline survey of the China Health and Retirement Longitudinal Study in 2011, including 4926 hypertensive respondents with public health insurance...
October 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29053568/mutation-of-a-conserved-nuclear-export-sequence-in-chikungunya-virus-capsid-protein-disrupts-host-cell-nuclear-import
#19
Susan C Jacobs, Adam Taylor, Lara J Herrero, Suresh Mahalingam, John K Fazakerley
Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV is an arthritogenic alphavirus of the Togaviridae family. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nucleus. In encephalitic alphaviruses nuclear translocation induces host cell shut off; however, the role of capsid protein nuclear localisation in arthritogenic alphaviruses remains unclear. Using replicon systems, we investigated a nuclear export sequence (NES) in the N-terminal region of capsid protein; analogous to that found in encephalitic alphavirus capsid but uncharacterised in CHIKV...
October 20, 2017: Viruses
https://www.readbyqxmd.com/read/29053544/the-correlation-between-the-ota-ao-classification-system-and-compartment-syndrome-in-both-bone-forearm-fractures
#20
Thomas S Auld, John S Hwang, Nicholas Stekas, Peter D Gibson, Michael S Sirkin, Mark C Reilly, Mark R Adams
OBJECTIVE: To evaluate the efficacy of using the Orthopaedic Trauma Association (OTA/AO) classification for both bone forearm fractures in predicting compartment syndrome. DESIGN: Retrospective cohort. SETTING: Level 1 Academic Trauma Center. PATIENTS/PARTICIPANTS: One hundred fifty-one patients 18 years of age and older, with both bone forearm fractures diagnosed from 2001 to 2016 were categorized based on the OTA/AO classification...
November 2017: Journal of Orthopaedic Trauma
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