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Eric R Carlson
No abstract text is available yet for this article.
September 21, 2016: Journal of Oral and Maxillofacial Surgery
Wei Feng, Dongsheng Zhou, Qian Wang, Wenbo Luo, Defu Zhang, Qiang Sun, Yigang Tong, Weijun Chen, Fengjun Sun, Peiyuan Xia
A total of 26 blaIMP-4-carrying strains of Pseudomonas aeruginosa and Klebsiella pneumoniae were isolated from 2009 to 2013 in a Chinese teaching hospital, and these strains can be assigned into multiple sequence types or allelic profiles as determined by multilocus sequence typing. Of these strains, P. aeruginosa P378 and K. pneumoniae 1220 harbor the IMP-4-encoding plasmids pP378-IMP and p1220-IMP, respectively, whose complete nucleotide sequences are determined to be genetically closely related to the IncN1-type plasmid pIMP-HZ1...
September 19, 2016: Scientific Reports
Judith J Voogt, Elizabeth L J van Rensen, Marieke F van der Schaaf, Mirko Noordegraaf, Margriet Me Schneider
OBJECTIVE: To develop an educational intervention that targets residents' beliefs and attitudes to quality Improvement (QI) and leadership in order to demonstrate proactive behaviour. DESIGN: Theory-driven, mixed methods study including document analysis, interviews, observations and open-ended questionnaires. SETTING: Six Dutch teaching hospitals. INTERVENTION: Using expertise from medicine, psychology, organizational and educational sciences we developed a situated learning programme named Ponder and IMProve (PIMP)...
September 2, 2016: International Journal for Quality in Health Care
Qingsheng Liu, Wenchen Li, Hua Wang, Bi-Min Zhang Newby, Fang Cheng, Lingyun Liu
The surfaces or coatings that can effectively suppress bacterial adhesion in the long term are of critical importance for biomedical applications. Herein, a group of amino acid-based zwitterionic polymers (pAAZ) were investigated for their long-term resistance to bacterial adhesion. The polymers were derived from natural amino acids including serine, ornithine, lysine, aspartic acid, and glutamic acid. The pAAZ brushes were grafted on gold via the surface-initiated photoiniferter-mediated polymerization (SI-PIMP)...
August 9, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Janice E Chambers, Howard W Chambers, Kristen E Funck, Edward C Meek, Ronald B Pringle, Matthew K Ross
Pyridinium oximes are strong nucleophiles and many are effective reactivators of organophosphate-inhibited cholinesterase (ChE). However, the current oxime reactivators are ineffective at crossing the blood-brain barrier and reactivating brain ChE in the intact organism. Our laboratories have developed a series of substituted phenoxyalkyl pyridinium oximes (US patent 9,227,937 B2) with the goal of identifying reactivators effective in crossing the blood-brain barrier. The first 35 of the series were found to have similar in vitro efficacy as reactivators of ChE inhibited by a sarin surrogate (phthalimidyl isopropyl methylphosphonate, PIMP) or a VX surrogate (nitrophenyl ethyl methylphosphonate, NEMP) in bovine brain preparations as previously observed in rat brain preparations...
July 4, 2016: Chemico-biological Interactions
Shunjie Yan, Lingjie Song, Zhihong Li, Shifang Luan, Hengchong Shi, Zhirong Xin, Shenghai Li, Yuming Yang, Jinghua Yin
The bacteria-repellent and bactericidal functionalities in a single system are generally need to be carefully optimized in order to obtain the highest antibacterial performance. In this study, the controlled SI-PIMP strategy was developed for creating hierarchical polymer brushes possessing the bacteria-repellent and bactericidal functionalities. To obtain a bactericidal surface with minimal interference to its nonfouling property, optimization studies were conducted by facilely tailoring the surface density of the quaternary ammonium compound moieties through control over the monomer concentration...
October 2016: Journal of Biomaterials Science. Polymer Edition
Douglas Reifler
No abstract text is available yet for this article.
May 24, 2016: JAMA: the Journal of the American Medical Association
Cian P McCarthy, John W McEvoy
No abstract text is available yet for this article.
May 24, 2016: JAMA: the Journal of the American Medical Association
Anita Ravi
No abstract text is available yet for this article.
May 24, 2016: JAMA: the Journal of the American Medical Association
Susan E Crosby
No abstract text is available yet for this article.
May 24, 2016: JAMA: the Journal of the American Medical Association
Matthew Imm
No abstract text is available yet for this article.
May 24, 2016: JAMA: the Journal of the American Medical Association
Hugh A Stoddard, David V O'Dell
Medical students and residents are familiar with clinical teaching methods in which a faculty member poses a series of questions to them. This technique is often called the "Socratic method," but it is frequently perceived by learners as an attempt to demean them, a practice that is colloquially known as "pimping." The distinction between Socratic teaching and pimping lies in the perception of "psychological safety." Psychological safety allows learners to answer questions or ask for help without threats to their dignity or worthiness...
September 2016: Journal of General Internal Medicine
Paula Gardner
We all do this. We personalize things. We buy leopard-printed seat covers and fuzzy dice for our cars, and display action figures and photographs in our offices. Studying older adults who have extended this process of personalization to their mobility devices, the purpose of the mobility aid personalization (MAPx) project is to examine MAPx and its impact on the health and mobility of older adults. Using a qualitative research design, field observations and interviews were conducted with 72 older adults to gain an in-depth understanding of device customization from an emic (insider's) perspective...
April 6, 2016: Disability and Rehabilitation. Assistive Technology
Vishakha Karnawat, Sonali Mehrotra, Hemalatha Balaram, Mrinalini Puranik
In enzymes that conduct complex reactions involving several substrates and chemical transformations, the active site must reorganize at each step to complement the transition state of that chemical step. Adenylosuccinate synthetase (ADSS) utilizes a molecule each of guanosine 5'-monophosphate (GTP) and aspartate to convert inosine 5'-monophosphate (IMP) into succinyl adenosine 5'-monophosphate (sAMP) through several kinetic intermediates. Here we followed catalysis by ADSS through high-resolution vibrational spectral fingerprints of each substrate and intermediate involved in the forward reaction...
May 3, 2016: Biochemistry
Shunjie Yan, Shifang Luan, Hengchong Shi, Xiaodong Xu, Jidong Zhang, Shuaishuai Yuan, Yuming Yang, Jinghua Yin
Although polycationic surfaces have high antimicrobial efficacies, they suffer from high toxicity to mammalian cells and severe surface accumulation of dead bacteria. For the first time, we propose a surface-initiated photoiniferter-mediated polymerization (SI-PIMP) strategy of constructing a "cleaning" zwitterionic outer layer on a polycationic bactericidal background layer to physically hinder the availability of polycationic moieties for mammalian cells in aqueous service. In dry conditions, the polycationic layer exerts the contact-active bactericidal property toward the adherent bacteria, as the zwitterionic layer collapses...
May 9, 2016: Biomacromolecules
Jennifer Hankel, Susan Dewey, Nina Martinez
Through this article the authors examine data collected from 126 women seeking services at a transitional housing facility, primarily for women leaving street-based prostitution. Descriptive statistics on the women's ethno-racial identity, numbers of children, and experiences with violence are presented and analyzed to determine correlations and implications for social service providers working with this unique population of women. Nearly half of respondents are women of color, a majority have given birth to at least one child, and more than half are in a non-commercial intimate partnership, with a significant number reporting extensive experiences with violent trauma and abuse...
July 2016: Journal of Evidence-informed Social Work
Zindoga Mukandavire, Kate M Mitchell, Peter Vickerman
In many settings, interventions targeting female sex workers (FSWs) could significantly reduce the overall transmission of HIV. To understand the role HIV pre-exposure prophylaxis (PrEP) could play in controlling HIV transmission amongst FSWs, it is important to understand how its impact compares with scaling-up condom use-one of the proven HIV prevention strategies for FSWs. It is important to remember that condoms also have other benefits such as reducing the incidence of sexually transmitted infections and preventing pregnancy...
March 2016: Epidemics
Alper Coban, Russell L Carr, Howard W Chambers, Kenneth O Willeford, Janice E Chambers
Because testing of nerve agents is limited to only authorized facilities, our laboratory developed several surrogates that resemble nerve agents because they phosphylate the acetylcholinesterase (AChE) with the same moiety as the actual nerve agents. The inhibition kinetic parameters were determined for AChE by surrogates of cyclosarin (NCMP), sarin (NIMP, PIMP and TIMP) and VX (NEMP and TEMP) and other organophosphorus compounds derived from insecticides. All compounds were tested with rat brain and a subset was tested with mouse brain and purified human erythrocyte AChE...
April 25, 2016: Toxicology Letters
Haiping Wang, Pan Wang, Li Li, Kun Zhang, Xiaobing Wang, Quanhong Liu
OBJECTIVES: To evaluate the anti-cancer effect of sonodynamic therapy combined with microbubbles both in vitro and in vivo. METHODS: Cell viability was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide and guava viacount assays. Annexin V-FITC/PI staining was adopted to analyze cell apoptosis rate. FD500 uptake assay was performed to assess cell membrane permeability changes. Tumor weight, mice weight and the visual image of tumor size were used to reflect the anti-tumor effect of this combined method...
2015: International Journal of Biological Sciences
Douglas R Reifler
No abstract text is available yet for this article.
December 8, 2015: JAMA: the Journal of the American Medical Association
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