pimps

As important building blocks in natural products and organic synthesis, thioethers have a wide range of potential applications. Herein, polyoxometalate-based ionic liquids (POM-ILs-SO3 H) derived from N -alkyl imidazole were synthesized and used for the first time for the thiolation of alcohols to construct C-S bonds in a series of benzyl thioethers. This type of POM-ILs-SO3 H catalyst exhibited high catalytic activity, providing up to 98% yield of thioether within 1 h at 70 °C. The alkyl chain length of the imidazole had a certain effect on the solubility of the POM-ILs-SO3 H catalysts in the reaction solvent, and then affected their catalytic activity...

An effective synthesis of conductive polymer brushes, i.e., self-templating surface-initiated copolymerization (ST-SICP), is developed. It proceeds through copolymerization of pendant thiophene groups in the precursor multimonomer poly(3-methylthienyl methacrylate) (PMTM) brushes with free 3-methylthiophene (3MT) monomers leading to PMTM-co-P3MT brushes. This approach leads to improved conformational freedom of generated conjugated poly(thiophene)-based chains and their higher share in the brushes with respect to conjugation of pendant thiophene groups only...

Porcine intestinal mucosal proteins are novel animal proteins that contain large amounts of free amino acids and peptides. Although porcine intestinal mucosal proteins are widely used in animal nutrition, the peptide bioactivities of their enzymatic products are not yet fully understood. In the present study, we investigated the effect of porcine intestinal mucosal peptides (PIMP) on the RAW264.7 cell model of LPS-induced inflammation. The mRNA expression of inflammatory factors (interleukin 6, tumor necrosis factor-α, and interleukin-1β) and nitrous oxide levels were all measured by quantitative real-time PCR and cyclooxygenase-2 protein expression measured by Western blot...

Flexible dielectrics with large dielectric constant (ε') coupled with low loss are highly pursued in many applications. To bolster the ε' of raw Zn (Zinc)/poly(vinylidene fluoride, PVDF) while maintaining pimping dielectric loss, in this study, the core@double-shell structured Zn@ZnCH (zinc carbonate)@PS (polystyrene) particles were first synthesized through a suspension polymerization of styrene, and then composited with PVDF to elevate the ε' and keep low loss of the composites. By optimizing the PS shells' thickness and tailoring the electrical resistivity of Zn@ZnCH@PS particles, both the slow inter-particle polarization and fast intra-particle polarization in the composites can be decoupled and synergistically tuned, thus, the Zn@ZnCH@PS/PVDF achieve a much higher ε' and lower dielectric loss simultaneously which far exceed the unmodified Zn/PVDF...

The purpose of this research was to analyze the functional portraits and genomic features of carbapenem-resistant Pseudomonas mendocina carrying NDM-1 and IMP-1 . The resistance mechanism of the strain was verified by in vivo experiments. Genomic data were aligned and analyzed in the NCBI database. Growth curve measurements were used to describe the growth characteristics of the bacteria. The virulence of P. mendocina strain was analyzed by serum killing assay and biofilm formation assay. Plasmid conjugation experiments were performed to verify the transferability of plasmids carrying drug-resistance genes...

Toxic heavy gas sulfur dioxide (SO2 ) is a specific life and environmental hazard. Predicting the diffusion of SO2 has become a research focus in fields such as environmental and safety studies. However, traditional methods, such as kinetic models, cannot balance precision and time. Thus, they do not meet the needs of emergency decision-making. Deep learning (DL) models are emerging as a highly regarded solution, providing faster and more accurate predictions of gas concentrations. To this end, this study proposes an innovative hybrid DL model, the parallel-connected convolutional neural network-gated recurrent unit (PC CNN-GRU)...

Currently, numerous ongoing studies are investigating the interaction of free radicals with biological systems, such as lipids, DNA and protein. In the present work, synthesis, characterization, antioxidant, DNA binding and molecular docking studies of Schiff base ligand and its Ni(II), Co(II), Cu(II) and Zn(II) were evaluated. The metal complexes have shown significant dose-dependent antioxidant activities higher than those of the free ligand but lesser than those of the standard antioxidant, ascorbic acid...

OBJECTIVES: We sought to report medical student and faculty perceptions of the purpose and utility of questions on clinical rounds. METHODS: We developed and administered a survey to third and fourth-year medical students and teaching physicians. The survey elicited attitudes about using questions to teach on rounds in both benign and malignant learning environments. RESULTS: Ninety-seven percent of faculty and 85% of students predicted they will use questions to teach...

Metal nanoparticles are widely used in catalysis. Loading metal nanoparticles into polymer brushes has aroused wide attention, but regulation of catalytic performance still needs to be improved. The novel diblock polymer brushes, polystyrene@sodium polystyrene sulfonate-b-poly (N-isopropylacrylamide) (PSV@PSS-b-PNIPA) and PSV@PNIPA-b-PSS with reversed block sequence, were prepared by surface initiated photoiniferter-mediated polymerization (SI-PIMP) and used as nanoreactors to load silver nanoparticles (AgNPs)...

Context: Patients over the age of 65 years are more likely to experience higher severity and mortality rates than other populations from COVID-19. Clinicians need assistance in supporting their decisions regarding the management of these patients. Artificial Intelligence (AI) can help with this regard. However, the lack of explainability-defined as "the ability to understand and evaluate the internal mechanism of the algorithm/computational process in human terms"-of AI is one of the major challenges to its application in health care...

INTRODUCTION: Digital data collection and the associated mobile health technologies have allowed for the recent exploration of artificial intelligence as a tool for combatting the HIV epidemic. Machine learning has been found to be useful both in HIV risk prediction and as a decision support tool for guiding pre-exposure prophylaxis (PrEP) treatment. This paper reports data from two sequential studies evaluating the viability of using machine learning to predict the susceptibility of adults to HIV infection using responses from a digital survey deployed in a high burden, low-resource setting...

No abstract text is available yet for this article.

Nursing home residents often are poly-medicated, which increases their risks of receiving potentially inappropriate medications. This problem has become a major public health issue in many countries, and in particular in France. Indeed, high uses of potentially inappropriate medication prescriptions can lead to adverse effects that are likely to increase emergency room (ER) visits. However, there is a lack of empirical evidence on the causal relationship between the amount of use of potentially inappropriate medications and ER visit risks among nursing homes residents...

Despite the wealth of research on injury prevention and biomechanical risk factors for running related injuries, their incidence remains high. It was suggested that injury prevention and reconditioning strategies should consider spontaneous running forms in a more holistic view and not only the injury location or specific biomechanical patterns. Therefore, we propose an approach using the preferred running form assessed through the Volodalen® method to guide injury prevention, rehabilitation, and retraining exercise prescription...

The spread of multidrug-resistant enterobacteria strains has posed a significant concern in public health, especially when the strain harbors metallo-beta-lactamase (MBL)-encoding and mobilized colistin resistance ( mcr ) genes as such genetic components potentially mediate multidrug resistance. Here we report an IncHI2/2A plasmid carrying bla IMP-26 and mcr-9 in multidrug-resistant Serratia marcescens human isolates YL4. Antimicrobial susceptibility testing was performed by the broth microdilution method. According to the results, S...

In Bangladesh, traffickers have trapped socially and economically marginalised girls and women and sold them into sex work. Furthermore, multiple sociocultural factors shape women's forced and voluntary movement into sex work. However, there are limited peer-reviewed studies of how sex work operators and sociocultural and economic factors shape women's forced and voluntary engagement in sex work in Bangladesh and worldwide. This study examines how sex work operators and various factors shape Bangladeshi women's forced and voluntary involvement in sex work...

INTRODUCTION: Punitive legal environments remain a challenge to HIV prevention efforts in Central Asia, and female sex workers who use drugs are vulnerable to police violence. Little is known about the heterogeneity of police violence against female sex workers who use drugs and factors associated with HIV risk in Central Asia, despite the growing HIV epidemic. METHODS: We recruited a community-based sample of 255 female sex workers who use drugs in Almaty, Kazakhstan between February 2015 and May 2017...

Increased awareness of the role of power and privilege in medical education demands reevaluation and critical reflection on the role of pimping, both in name and practice. The authors use an intersectional approach to explore the ways in which the term pimping is rooted in sexist, racist, and classist stereotypes. In using this term to describe a pedagogical approach rooted in hierarchical power and stark knowledge differentials, the medical community intentionally or unintentionally reinforces racist stereotypes, acts of carceral violence, gender-based violence, and harmful ways of referring to sex work...

No abstract text is available yet for this article.

This study utilized sulfamethoxazole (SMX) acclimatization to enhance the tolerance and biodegradation capacity of Chlorella vulgaris. Compared to wild C. vulgaris, the growth inhibition and oxidative damage induced by SMX evidently decreased in acclimated C. vulgaris, and meanwhile photosynthetic and antioxidant activities were significantly promoted. The physiological analyses with the aid of principal component analysis revealed the increase of catalase and glutathione reductase activities was the critical tolerant mechanism of acclimated C...