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Abdulrahman A Al-Majed, Ahmed H H Bakheit, Hatem A Abdel Aziz, Fahad M Alajmi, Haitham AlRabiah
Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. It is also used to control symptoms of sympathetic overactivity in the management of hyperthyroidism, anxiety disorders, and tremor. Other indications cover the prophylaxis of migraine and of upper gastrointestinal bleeding in patients with portal hypertension...
2017: Profiles of Drug Substances, Excipients, and related Methodology
Richard B Lipton, Pete Schmidt, Hans-Christoph Diener
OBJECTIVE: To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine. BACKGROUND: A great deal of variability exists in patients' response to migraine medications. Migraine-associated nausea is common and debilitating and can reduce the effectiveness of oral medications. It may cause patients to delay taking oral medications, which is known to diminish therapeutic outcomes, or to avoid taking them altogether...
April 6, 2017: Headache
Thomas Muehlberger, Justin C R Wormald, Nadine Hachach-Haram, Afshin Mosahebi
BACKGROUND: Studies have suggested that contact between opposing mucosal surfaces in the nasal wall and cavity can be a target of the surgical treatment of migraines. Unfortunately, not enough is known about the role of nasal pathology in the pathogenesis of this condition. The co-existence of further rhinological disorders can be an impediment to defining the cause and effect of anatomical variants. The authors compared the MRI scans of migraine- and non-migraine patients (MPs and NMPs, respectively) to determine the prevalence of such mucosal contact points in order to extrapolate whether there is a significant association with migraines...
March 7, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Martine W J Huygens, Ilse C S Swinkels, Judith D de Jong, Monique J W M Heijmans, Roland D Friele, Onno C P van Schayck, Luc P de Witte
BACKGROUND: There is a growing emphasis on self-monitoring applications that allow patients to measure their own physical health parameters. A prerequisite for achieving positive effects is patients' willingness to self-monitor. The controllability of disease types, patients' perceived self-efficacy and health problems could play an essential role in this. The purpose of this study is to investigate the relationship between patients' willingness to self-monitor and a range of disease and patient specific variables including controllability of disease type, patients' perceived self-efficacy and health problems...
March 20, 2017: BMC Family Practice
Eva Cernuda-Morollón, Nuria Riesco, Pablo Martínez-Camblor, Esther Serrano-Pertierra, Carmen García-Cabo, Julio Pascual
OBJECTIVE: To determine total pituitary adenylate cyclase activating polypeptide (PACAP) in peripheral blood as a potential marker of the activation of the parasympathetic arm of the trigemino-vascular system in chronic migraine (CM) in a case-control study. METHODS: Women older than 17 and diagnosed as CM were recruited. Healthy women with no headache history and women with episodic migraine (EM) served as control groups. Total PACAP and vasoactive intestinal peptide (VIP) levels were determined in blood samples obtained from the right antecubital vein by ELISA outside a migraine attack and having taken no symptomatic medication the day before...
October 2016: Headache
Nirosen Vijiaratnam, Daniel Barber, Kai Zheong Lim, Eldho Paul, Matthew Jiang, Benjamin Chosich, Tissa Wijeratne
OBJECTIVES: Migraine is a debilitating condition that affects approximately 15% of the general population. It represents a huge proportion of presentations to the emergency department and a significant number of neurology admissions. Patients are often investigated with imaging. This is particularly the case with migraine with aura (MA). The yield of imaging is however low. There is limited information on Australian hospital presentations and utility of imaging. We aimed to analyse the demographics of migraine presentations to our hospital and the yield of imaging in our centre to help guide future approaches to these patients...
September 2016: Clinical Neurology and Neurosurgery
Tamara Pringsheim, William Jeptha Davenport, Michael J Marmura, Todd J Schwedt, Stephen Silberstein
The "Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies" provides levels of evidence for medication efficacy for acute treatment of migraine. The goal of this companion paper is to provide guidance on how to choose between evidence-based treatment options, and, based on the clinical characteristics of the patient and their migraine attacks, to provide guidance on designing an individualized strategy for managing migraine attacks. The acute pharmacological treatments described in the American Headache Society evidence assessment can be divided into those initially taken by the patient during the headache phase of the migraine attack, those taken by the patient later in the attack when initial treatments fail, and those administered intravenously or intramuscularly in urgent care settings...
July 2016: Headache
Sertaç Yetiser, Meltem Hale Alpsan Gokmen
INTRODUCTION: Whether clinical features in patients with BPPV and migraine differ from patients with BPPV without migraine is unknown. OBJECTIVES: The aim of this study is to compare clinical aspects of patients with or without migraine. MATERIALS AND METHOD: 263 patients with BPPV were enrolled. Patients were investigated in terms of age, gender, symptoms, affected side, type of BPPV and the cure rate. Data were compared in patients with and without migraine...
2015: International Tinnitus Journal
Hida Nierenburg, Lawrence C Newman
New daily persistent headache (NDPH) is an uncommon and under-recognized primary headache disorder. Clinically, NDPH may resemble migraine or tension-type headache. Unlike migraine or tension-type headaches, however, a distinguishing feature of NDPH is that the majority of patients with NDPH can pinpoint the exact date of onset of symptoms. While cases can arise de novo, in multiple reports, a viral illness precedes the onset of headache. NDPH has two temporal profiles: a self-limited form that resolves spontaneously without treatment and a refractory, persistent form in which headaches continue unabated for years...
June 2016: Current Treatment Options in Neurology
M Torres-Ferrús, M Quintana, J Fernandez-Morales, J Alvarez-Sabin, P Pozo-Rosich
Introduction According to the IHCD-3β classification, chronic migraine (CM) is headache occurring on 15 or more days/month. Episodic migraine (EM) can be divided into low frequency (LFEM) and high frequency (HFEM) depending on the headache days suffered per month. Methods We performed a clinical comparison of migraine characteristics according to monthly headache days suffered. Patients were divided into three groups: LFEM (1-9 headache days/month), HFEM (10-14 headache days/month) and CM (≥15 headache days/month)...
February 2017: Cephalalgia: An International Journal of Headache
Nauman Tariq, Stewart J Tepper, Jennifer S Kriegler
BACKGROUND: A link between patent foramen ovale (PFO) and migraine as well as the utility of closure of PFO and its effect on migraine have been subjects of debate. The present review is an effort to gather the available evidence on this topic and formulate recommendations. METHODS: A systematic search of electronic databases (Medline, Embase, Cochrane Library) was performed. A separate search in associated reference lists of identified studies was done. Observational studies and clinical trials published in English using the International Headache Society criteria for diagnosis of migraine were included in the analysis...
March 2016: Headache
M Serraille, P Y Courand, N Girerd, G Demarquay, H Milon, B Harbaoui, P Lantelme
BACKGROUND: The cardiovascular prognostic value of various types of headache, particularly migraine, in the general population is still controversial. The aim of the present study was to assess this prognostic value for all-cause, cardiovascular and stroke mortalities, in hypertensive patients. METHODS: 1914 hypertensive individuals were categorized first, according to the absence or the presence of headache and then according to 3 subtypes of headache: migraine, "daily headache" and "other headache"...
December 2015: Annales de Cardiologie et D'angéiologie
Shannon W Clark, Chengyuan Wu, David W Boorman, Nohra Chalouhi, Mario Zanaty, Michael Oshinsky, William B Young, Stephen D Silberstein, Ashwini D Sharan
BACKGROUND: Dual supraorbital and occipital nerve stimulation (SONS and ONS) have shown promising efficacy in treating primary headaches. However, its functional outcome is not well studied. OBJECTIVE: To present functional outcome studies of combined SONS and ONS for chronic migraine using verified metrics. METHOD: Consecutive patients with both SONS and ONS assessed with Migraine Disability Assessment (MIDAS) and Beck Depression Index (BDI) both preoperatively and postoperatively were studied...
July 2016: Neuromodulation: Journal of the International Neuromodulation Society
Ning Fan, Pei Wang, Li Tang, Xuyang Liu
Normal tension glaucoma (NTG) is known as a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and glaucomatous visual field loss, even though the intraocular pressure (IOP) does not exceed the normal range. The pathophysiology of NTG remains largely undetermined. It is hypothesized that the abnormal ocular blood flow is involved in the pathogenesis of this disease. A number of evidences suggested that the vascular factors played a significant role in the development of NTG...
2015: BioMed Research International
Amaranath Karunanayake, Niranga Manjuri Devanarayana, Shaman Rajindrajith
INTRODUCTION: There is evidence that overweight children have a higher prevalence of functional gastrointestinal disorders (FGIDs) than normal-weight children. Objective of this study was to assess the effects of body mass index (BMI) on gastric motility abnormalities in children with abdominal pain-predominant FGIDs (AP-FGIDs). METHODS: Gastric motility parameters of 100 children with AP-FGIDs (61(61%) girls, mean age 8.0 years [SD 2.1years] and 50 healthy controls (30 (30%) boys, mean age 8...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
Katherine M Cobb-Pitstick, Andrew D Hershey, Hope L O'Brien, Marielle A Kabbouche, Susan LeCates, Shannon White, Polly Vaughn, Paula Manning, Ann Segers, Judith Bush, Paul S Horn, Joanne Kacperski
OBJECTIVE: To evaluate factors that influence migraine recurrence after outpatient infusion or inpatient treatment for intractable migraine. BACKGROUND: Recurrence of migraine after acute treatment in an infusion center or an inpatient setting is not well documented in children and adolescents. Given the multifactorial pathogenesis of migraines, multiple factors may influence migraine recurrence. It has been reported that treatment with steroids may reduce the risk of migraine recurrence...
November 2015: Headache
Annette B Steffensen, Jeremy Sword, Deborah Croom, Sergei A Kirov, Nanna MacAulay
UNLABELLED: Spreading depolarizations (SDs) are waves of sustained neuronal and glial depolarization that propagate massive disruptions of ion gradients through the brain. SD is associated with migraine aura and recently recognized as a novel mechanism of injury in stroke and brain trauma patients. SD leads to neuronal swelling as assessed in real time with two-photon laser scanning microscopy (2PLSM). Pyramidal neurons do not express aquaporins and thus display low inherent water permeability, yet SD rapidly induces focal swelling (beading) along the dendritic shaft by unidentified molecular mechanisms...
September 2, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
M Torres-Ferrus, P Pozo-Rosich
Chronic migraine is a disease that affects 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine that is used. It is extraordinarily disabling, since it does not allow the sufferer to carry out any of their scheduled personal, professional or social activities, and it has a great impact on the patients' quality of life, as measured on disability, quality of life and impact on daily activities scales. Yet, nowadays there are treatments that have proven to be effective in cases of chronic migraine, such as OnabotulinumtoxinA...
2015: Revista de Neurologia
Benjamin W Friedman, Lisa Cabral, Victoria Adewunmi, Clemencia Solorzano, David Esses, Polly E Bijur, E John Gallagher
STUDY OBJECTIVE: More than 1 million patients present to US emergency departments (EDs) annually seeking care for acute migraine. Parenteral antihistamines have long been used in combination with antidopaminergics such as metoclopramide to treat acute migraine in the ED. High-quality data supporting this practice do not exist. We determine whether administration of diphenhydramine 50 mg intravenously+metoclopramide 10 mg intravenously results in greater rates of sustained headache relief than placebo+metoclopramide 10 mg intravenously...
January 2016: Annals of Emergency Medicine
Tiago Sousa Veloso, Mariana Seixas Cambão
This clinical vignette presents a 14 years old female, with a past medical history relevant only for migraine with typical aura of less than monthly frequency, complaining of a severe unilateral headache with rising intensity for the previous 4 h, associated with nausea, vomiting, photophobia and phonophobia. This episode of migraine with aura in a patient with recurrent migraine was complicated by side effects of medical diagnostic and therapeutic procedures (extrapyramidal symptoms, delirium, post-lumbar puncture headache, hospital admission) all of which could have been prevented-quaternary prevention...
2015: SpringerPlus
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