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https://www.readbyqxmd.com/read/29535231/real-life-observational-studies-provide-actionable-data-for-family-medicine
#1
EDITORIAL
Marjorie A Bowman, Anne Victoria Neale, Dean A Seehusen
This issue includes several excellent observational studies prompted by physicians' clinical questions. Many people use lots of menthol cough drops-does the menthol overall lengthen the cough duration? When should we intensify treatment of older individuals with diabetes? Do occipital nerve blocks work for acute migraine headaches? Did you know that the plantar fascia can rupture? What happens to those patients with chest pain but low pretest probability for serious cardiac disease who are admitted to the hospital? Acupuncture can work well-for the patients-but how can we incorporate it into the usual pace of the family medicine office? Is it a win-lose situation when medical assistant roles are expanded? How many practice sites do physicians have and does that make a difference in the number or type of health personnel shortage areas? What would you guess on the presence of humor in the medical office-more or less than half of the visits; introduced by doctors or patients; primary care or specialty doctors?...
March 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29488143/targeted-5-ht-1f-therapies-for-migraine
#2
REVIEW
Marta Vila-Pueyo
Migraine is a common neurological disease characterised by the presence of attacks of unilateral, severe head pain accompanied by other symptoms. Although it has been classified as the sixth most disabling disorder, the available therapeutic options to treat this condition have not progressed accordingly. The advance in the development of 5-HT1 receptor agonists for migraine, including 5-HT1B/D and 5-HT1F receptor agonists, has meant a major step forward towards the progression of a better treatment for migraine...
February 27, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29350303/a-short-review-of-the-non-invasive-transcutaneous-pericranial-electrical-stimulation-techniques-and-their-application-in-headache
#3
REVIEW
Licia Grazzi, Emanuela Sansone, Paul Rizzoli
PURPOSE OF REVIEW: In this short review, the most common non-invasive neuromodulatory techniques will be described, along with their advantages and disadvantages and their application in headache. Available preventive treatments can be unhelpful or may have unpleasant side effects; moreover, the rate of response to preventive drugs does not exceed 50%, lower in chronic migraine; alternative options would be welcome. Though the concept of neuromodulation was originally developed with invasive methods, newer non-invasive techniques are appearing...
January 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29226466/childhood-onset-cluster-headache-observations-from-a-personal-case-series-and-review-of-the-literature
#4
Arens Taga, Gian Camillo Manzoni, Marco Russo, Maria Vittoria Paglia, Paola Torelli
BACKGROUND/OBJECTIVES: Puberty seems to be a turning point in cluster headache (CH) onset. To verify its influence on CH phenotype, we focused on cases with onset ≤13 years. A review of the literature follows. METHOD: We considered CH cases with age-of-onset ≤13 years evaluated at our center between 1975 and 2015; these cases were matched by sex to two consecutive patients with age-of-onset as close as possible (±2 years) to the median age-of-onset of the overall CH population...
March 2018: Headache
https://www.readbyqxmd.com/read/29209105/effects-of-nsaids-on-the-release-of-calcitonin-gene-related-peptide-and-prostaglandin-e-2-from-rat-trigeminal-ganglia
#5
Vittorio Vellani, Giorgia Moschetti, Silvia Franchi, Chiara Giacomoni, Paola Sacerdote, Giada Amodeo
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat migraine, but the mechanisms of their effects in this pathology are not fully elucidated. The trigeminal ganglia and calcitonin gene-related peptide (CGRP) have been implicated in the pathophysiology of migraine. The release of CGRP and prostaglandin E2 (PGE2 ) from freshly isolated rat trigeminal ganglia was evaluated after oral administration of nimesulide, etoricoxib, and ketoprofen, NSAIDs with different pharmacological features...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29193050/antagonistic-relationship-between-vep-potentiation-and-gamma-power-in-visual-snow-syndrome
#6
Sebastian Luna, Daniel Lai, Alison Harris
OBJECTIVE: Using a "double-pulse" adaptation paradigm, in which two stimuli are presented in quick succession, this study examines the neural mechanisms underlying potentiation of the visual evoked potential (VEP) in visual snow syndrome. BACKGROUND: Visual snow is a persistent visual disturbance characterized by rapid flickering dots throughout the visual field. Like the related condition of migraine with aura, visual snow has been hypothesized to arise from abnormal neuronal responsiveness, as demonstrated by a lack of typical VEP habituation to repeated visual stimulation...
January 2018: Headache
https://www.readbyqxmd.com/read/29050521/glutamate-receptor-antagonists-with-the-potential-for-migraine-treatment
#7
REVIEW
Anna Ferrari, Cecilia Rustichelli, Carlo Baraldi
Preclinical, clinical, and other (e.g., genetic) evidence support the concept that migraine susceptibility may at least partially result from a glutamatergic system disorder. Therefore, the receptors of the glutamatergic system are considered relatively new targets for investigational drugs to treat migraine. Investigational and established glutamate receptor antagonists (GluRAs) have been shown to possess antinociceptive properties in preclinical models of trigeminovascular nociception and have been evaluated in clinical trials...
December 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28940251/evaluation-of-retinal-nerve-fibre-layer-ganglion-cell-layer-and-choroidal-thickness-with-optical-coherence-tomography-in-migraine-patients-a-case-control-study
#8
Aygül Gunes, Ayse Sevgi Karadag, Serpil Yazgan, Haci Ugur Celik, Ali Simsek
BACKGROUND: Evaluation of retinal nerve fibre layer (RNFL), ganglion cell layer (GCL) and choroidal thickness (CT) with optical coherence tomography (OCT) in chronic migraine patients, to compare with healthy controls. MATERIAL AND METHOD: Ninety-four eyes of 47 chronic migraine patients (Group 1) and 68 eyes of 34 healthy individuals (Group 2) were included in this prospective case-control study. The right and left eyes were separately evaluated. Mean peripapillary RNFL thicknesses, mean GCL measured from superior and inferior quadrants, and mean CT were measured at three different regions (central, 500 μm nasal and temporal region of the fovea)...
January 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28931491/global-regional-and-national-burden-of-neurological-disorders-during-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#9
(no author information available yet)
BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level...
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28694040/the-effect-of-anxiety-and-depression-on-the-risk-of-irritable-bowel-syndrome-in-migraine-patients
#10
Mei-Fong Wu, Yu-Wen Yang, Yen-Yu Chen
Bidirectional co-morbidity between migraine and depression has been observed. Mood disorders are associated with an increased risk of both migraine and irritable bowel syndrome (IBS). The aim of this study was to evaluate the risk of developing IBS in patients with migraine and to compare the risks between those with and without anxiety or depression. This research used the data contained in the National Health Insurance Research Database (NHIRD). A total of 2859 subjects with migraine and 5718 age-, sex-, hypertension-, diabetes-, mood disorder-matched controls were identified...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28431779/propranolol
#11
Abdulrahman A Al-Majed, Ahmed H H Bakheit, Hatem A Abdel Aziz, Fahad M Alajmi, Haitham AlRabiah
Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. It is also used to control symptoms of sympathetic overactivity in the management of hyperthyroidism, anxiety disorders, and tremor. Other indications cover the prophylaxis of migraine and of upper gastrointestinal bleeding in patients with portal hypertension...
2017: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/28386945/post-hoc-subanalysis-of-two-randomized-controlled-phase-3-trials-evaluating-diclofenac-potassium-for-oral-solution-impact-of-migraine-associated-nausea-and-prior-triptan-use-on-efficacy
#12
Richard B Lipton, Pete Schmidt, Hans-Christoph Diener
OBJECTIVE: To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine. BACKGROUND: A great deal of variability exists in patients' response to migraine medications. Migraine-associated nausea is common and debilitating and can reduce the effectiveness of oral medications. It may cause patients to delay taking oral medications, which is known to diminish therapeutic outcomes, or to avoid taking them altogether...
May 2017: Headache
https://www.readbyqxmd.com/read/28359726/migraine-a-look-down-the-nose
#13
Thomas Muehlberger, Justin C R Wormald, Nadine Hachach-Haram, Afshin Mosahebi
BACKGROUND: Studies have suggested that contact between opposing mucosal surfaces in the nasal wall and cavity can be a target of the surgical treatment of migraines. Unfortunately, not enough is known about the role of nasal pathology in the pathogenesis of this condition. The co-existence of further rhinological disorders can be an impediment to defining the cause and effect of anatomical variants. The authors compared the MRI scans of migraine- and non-migraine patients (MPs and NMPs, respectively) to determine the prevalence of such mucosal contact points in order to extrapolate whether there is a significant association with migraines...
July 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28320330/self-monitoring-of-health-data-by-patients-with-a-chronic-disease-does-disease-controllability-matter
#14
Martine W J Huygens, Ilse C S Swinkels, Judith D de Jong, Monique J W M Heijmans, Roland D Friele, Onno C P van Schayck, Luc P de Witte
BACKGROUND: There is a growing emphasis on self-monitoring applications that allow patients to measure their own physical health parameters. A prerequisite for achieving positive effects is patients' willingness to self-monitor. The controllability of disease types, patients' perceived self-efficacy and health problems could play an essential role in this. The purpose of this study is to investigate the relationship between patients' willingness to self-monitor and a range of disease and patient specific variables including controllability of disease type, patients' perceived self-efficacy and health problems...
March 20, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/27634731/no-change-in-interictal-pacap-levels-in-peripheral-blood-in-women-with-chronic-migraine
#15
Eva Cernuda-Morollón, Nuria Riesco, Pablo Martínez-Camblor, Esther Serrano-Pertierra, Carmen García-Cabo, Julio Pascual
OBJECTIVE: To determine total pituitary adenylate cyclase activating polypeptide (PACAP) in peripheral blood as a potential marker of the activation of the parasympathetic arm of the trigemino-vascular system in chronic migraine (CM) in a case-control study. METHODS: Women older than 17 and diagnosed as CM were recruited. Healthy women with no headache history and women with episodic migraine (EM) served as control groups. Total PACAP and vasoactive intestinal peptide (VIP) levels were determined in blood samples obtained from the right antecubital vein by ELISA outside a migraine attack and having taken no symptomatic medication the day before...
October 2016: Headache
https://www.readbyqxmd.com/read/27441999/migraine-does-aura-require-investigation
#16
Nirosen Vijiaratnam, Daniel Barber, Kai Zheong Lim, Eldho Paul, Matthew Jiang, Benjamin Chosich, Tissa Wijeratne
OBJECTIVES: Migraine is a debilitating condition that affects approximately 15% of the general population. It represents a huge proportion of presentations to the emergency department and a significant number of neurology admissions. Patients are often investigated with imaging. This is particularly the case with migraine with aura (MA). The yield of imaging is however low. There is limited information on Australian hospital presentations and utility of imaging. We aimed to analyse the demographics of migraine presentations to our hospital and the yield of imaging in our centre to help guide future approaches to these patients...
September 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27322907/how-to-apply-the-ahs-evidence-assessment-of-the-acute-treatment-of-migraine-in-adults-to-your-patient-with-migraine
#17
Tamara Pringsheim, William Jeptha Davenport, Michael J Marmura, Todd J Schwedt, Stephen Silberstein
The "Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies" provides levels of evidence for medication efficacy for acute treatment of migraine. The goal of this companion paper is to provide guidance on how to choose between evidence-based treatment options, and, based on the clinical characteristics of the patient and their migraine attacks, to provide guidance on designing an individualized strategy for managing migraine attacks. The acute pharmacological treatments described in the American Headache Society evidence assessment can be divided into those initially taken by the patient during the headache phase of the migraine attack, those taken by the patient later in the attack when initial treatments fail, and those administered intravenously or intramuscularly in urgent care settings...
July 2016: Headache
https://www.readbyqxmd.com/read/27186935/clinical-aspects-of-benign-paroxysmal-positional-vertigo-associated-with-migraine
#18
Sertaç Yetiser, Meltem Hale Alpsan Gokmen
INTRODUCTION: Whether clinical features in patients with BPPV and migraine differ from patients with BPPV without migraine is unknown. OBJECTIVES: The aim of this study is to compare clinical aspects of patients with or without migraine. MATERIALS AND METHOD: 263 patients with BPPV were enrolled. Patients were investigated in terms of age, gender, symptoms, affected side, type of BPPV and the cure rate. Data were compared in patients with and without migraine...
2015: International Tinnitus Journal
https://www.readbyqxmd.com/read/27080086/update-on-new-daily-persistent-headache
#19
REVIEW
Hida Nierenburg, Lawrence C Newman
New daily persistent headache (NDPH) is an uncommon and under-recognized primary headache disorder. Clinically, NDPH may resemble migraine or tension-type headache. Unlike migraine or tension-type headaches, however, a distinguishing feature of NDPH is that the majority of patients with NDPH can pinpoint the exact date of onset of symptoms. While cases can arise de novo, in multiple reports, a viral illness precedes the onset of headache. NDPH has two temporal profiles: a self-limited form that resolves spontaneously without treatment and a refractory, persistent form in which headaches continue unabated for years...
June 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/26961321/when-does-chronic-migraine-strike-a-clinical-comparison-of-migraine-according-to-the-headache-days-suffered-per-month
#20
COMPARATIVE STUDY
M Torres-Ferrús, M Quintana, J Fernandez-Morales, J Alvarez-Sabin, P Pozo-Rosich
Introduction According to the IHCD-3β classification, chronic migraine (CM) is headache occurring on 15 or more days/month. Episodic migraine (EM) can be divided into low frequency (LFEM) and high frequency (HFEM) depending on the headache days suffered per month. Methods We performed a clinical comparison of migraine characteristics according to monthly headache days suffered. Patients were divided into three groups: LFEM (1-9 headache days/month), HFEM (10-14 headache days/month) and CM (≥15 headache days/month)...
February 2017: Cephalalgia: An International Journal of Headache
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