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subcentimeter AND lung cancer

Paul E Van Schil
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
Jane Keating, Sunil Singhal
Lung cancer screening has lead to frequent diagnosis of solitary pulmonary nodules, many of which require surgical biopsy for diagnosis and intervention. Subcentimeter and central nodules are particularly difficult to visualize or palpate during surgery, thus nodule localization can be a difficult problem for the thoracic surgeon. Although minimally invasive techniques including transthoracic computed tomography and bronchoscopic-guided biopsy may establish a diagnosis, these methods do not help locate nodules during surgery and can lead to inadequate tissue sampling...
2016: Seminars in Thoracic and Cardiovascular Surgery
Omar Awais, Michael R Reidy, Kunal Mehta, Valentino Bianco, William E Gooding, Matthew J Schuchert, James D Luketich, Arjun Pennathur
BACKGROUND: Computed tomography scans are increasingly used not only for lung cancer screening but also for staging and evaluation of other cancers. As a result, more patients with pulmonary nodules, many with subcentimeter lesions, are being referred to thoracic surgeons, some with concern for primary lung neoplasm and others with possible metastatic lung lesions. Obtaining a definitive diagnosis of these lesions is difficult. Electromagnetic navigational bronchoscopy (ENB)-guided pleural dye marking followed by thoracoscopic resection is a novel alternative technique for definitive diagnosis...
July 2016: Annals of Thoracic Surgery
Hiroyuki Sakurai, Kazuo Nakagawa, Shun-Ichi Watanabe, Hisao Asamura
BACKGROUND: Subcentimeter lung cancers are still rare, and their pathobiologic behavior and management have not yet been fully clarified. METHODS: From 1993 through 2011, 291 patients with resected lung cancers 1.0 cm or less in diameter were studied regarding their clinicopathologic characteristics. According to appearance on high-resolution computed tomography (HRCT), the tumors were classified into four types: type 1 (n = 50), nonsolid ground-glass opacity (GGO) lesion; type 2 (n = 89), part-solid GGO lesion including 50% or more GGO within the lesion; type 3 (n = 62), part-solid GGO lesion including less than 50% GGO within the lesion, and type 4 (n = 90), solid lesion...
May 2015: Annals of Thoracic Surgery
Roy Mano, Emily Vertosick, Alexander I Sankin, Michael S Chevinsky, Yaniv Larish, Christopher D Jakubowski, Andreas M Hötker, A Ari Hakimi, Daniel D Sjoberg, Oguz Akin, Paul Russo
PURPOSE: Renal cell carcinoma most commonly metastasizes to the lung. Indeterminate pulmonary nodules develop preoperatively in half of the patients with localized renal cell carcinoma but clinical significance remains poorly defined. We determined whether the presence of indeterminate pulmonary nodules, or nodule size or number is associated with renal cell carcinoma outcomes. MATERIALS AND METHODS: We reviewed data on 1,102 patients with renal cell carcinoma in whom chest computerized tomography was done within 6 months before nephrectomy from 2002 to 2012...
March 2015: Journal of Urology
Ninoska N Silva, Cathy Eng
Case Study Ms. S.G., a 56-year-old woman with a poorly differentiated squamous cell carcinoma of the anal canal, American Joint Committee on Cancer stage III (T2, N1, M0), was initially diagnosed in December, 2007 at an outside institution after she had noted blood in her stool for approximately 6 months. Her medical history was unremarkable. She had no known history of HIV or other sexually transmitted diseases. At the time of presentation, Ms. S.G. had an Eastern Cooperative Oncology Group performance status of 1 related to cancer-related pain...
May 2012: Journal of the Advanced Practitioner in Oncology
Stephanie T Chang, Dennis C Nguyen, Constantine Raptis, Christine O Menias, Gongfu Zhou, Andrea Wang-Gillam, David C Linehan, William G Hawkins, Steven M Strasberg, Ryan C Fields
OBJECTIVE: To determine the detection rate, radiologic characteristics, and natural history of incidental subcentimeter pulmonary nodules (SCPN) among patients with resectable pancreatic adenocarcinoma and to clarify whether further preoperative evaluation should be considered. BACKGROUND: The clinical significance of SCPN detected by routine preoperative abdominal imaging in patients with pancreatic adenocarcinoma is unknown. METHODS: Patients who underwent resection for pancreatic adenocarcinoma between 2000 and 2010 were queried from a prospectively maintained database at a single institution...
May 2015: Annals of Surgery
Kyung Eun Shin, Kyung Soo Lee, Chin A Yi, Myung Jin Chung, Myung-Hee Shin, Yoon-Ho Choi
BACKGROUND AND OBJECTIVE: Subcentimeter nodules without change in size during long-term follow-up period (for minimum 2 years) are assumed as benign lesions. However, the 2-year stability rule has not been fully verified so far and is still questionable. Thus, we aimed to retrospectively investigate long-term follow-up results for 2-year stable subcentimeter nodules at screening low-dose computed tomography (LDCT). METHODS: A total of 635 subjects having had follow-up LDCTs for the initial 2-year screening period and additional 3 years thereafter and having had non-calcified subcentimeter nodules were included...
August 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Wei Jiang, Xuguang Pang, Junjie Xi, Xiaoke Chen, Qun Wang, Cheng Qian, Hong Fan
BACKGROUND: The detection of subcentimeter lung cancers has significantly improved with advances in computed tomography and the emergence of screening protocols. We reviewed the clinicopathological features and surgical outcomes of patients with subcentimeter non-small cell lung cancer (NSCLC) in our institution. METHODS: A total of 105 patients who underwent lobectomy or sublobar resection for subcentimeter NSCLCs were retrospectively reviewed. Clinicopathological characteristics and survival were analyzed statistically using Student's t-test for continuous variables, Fisher's exact for categorical variables and Cox regression for multivariable analysis...
September 2014: Journal of Surgical Oncology
Subhashini Yaturu, Raina A Patel
Though the thyroid gland has a rich vascular supply, incidence of metastatic disease from distant organs is rare. Here we present an unusual case of metastases to the thyroid with several interesting features. A 63-year-old male with history of adenocarcinoma of the right lobe lung (5 years prior to presentation), treated with surgery and chemotherapy, followed by new adenosquamous lung cancer in the left lobe of the lung (one year prior to presentation), treated surgically followed by adjuvant chemotherapy, was referred to Endocrinology section for evaluation of an incidental thyroid nodule on CT chest...
2014: Case Reports in Endocrinology
Yang Zhang, Haiquan Chen, Jiaqing Xiang, Yawei Zhang, Yihua Sun, Hong Hu
SESSION TYPE: Thoracic Surgery IPRESENTED ON: Monday, October 22, 2012 at 11:15 AM - 12:30 PMPURPOSE: Over the last two decades, many studies sought to find reliable predictors of N0 status in small-sized (≤2 cm in diameter) non-small cell lung cancers (NSCLC). However, the way of tumor size measurement was usually not standardized, and controversy remains as to whether systematic lymph node dissection should be performed in patients with subcentimeter tumors. Moreover, the correlations between lung adenocarcinoma subtypes in line with the new classification and lymph node metastasis have not yet been determined specifically in small peripheral tumors...
October 1, 2012: Chest
Yang Zhang, Yihua Sun, Lei Shen, Yuan Li, Jiaqing Xiang, Yawei Zhang, Hong Hu, Haiquan Chen
BACKGROUND: During the past two decades, many studies have sought to find reliable predictors of N0 status in small-sized lung cancers. However, the way of tumor size measurement was usually not clearly stated, and controversy remains as to whether systematic lymph node dissection should be performed in patients with subcentimeter tumors. METHODS: We reviewed correlations between lymph node involvement and clinicopathological variables in 243 small peripheral non-small cell lung cancers with their size measured in fresh specimens before formalin fixation...
June 2013: Annals of Surgical Oncology
Karthikeshwar Kasirajan, Anand Dayama
BACKGROUND: Computed tomography angiography (CTA) is routinely used to diagnose thoracic aortic pathology and for surveillance after thoracic endovascular aortic repair. The purpose of our study was to assess the prevalence of unsuspected disease identified on CTA examination for thoracic aortic pathology and to determine potential clinical significance of these findings. METHODS: A retrospective review of 242 patients (136 men and 106 women; mean age, 65.7 ± 13...
April 2012: Annals of Vascular Surgery
Benjamin E Lee, Elaine Kletsman, John R Rutledge, Robert J Korst
OBJECTIVE: Invasive mediastinal biopsy is often necessary in the evaluation of non-small cell lung cancer (NSCLC), and mediastinoscopy has long been considered the reference standard. However, the emergence of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has resulted in controversy regarding it represents a suitable replacement for mediastinoscopy. We chose to determine the utility of EBUS-TBNA in evaluating the mediastinum in patients with NSCLC. METHODS: The present study was a retrospective review of a prospective database of consecutive patients with NSCLC who underwent EBUS-TBNA for mediastinal evaluation from 2009 to 2011...
March 2012: Journal of Thoracic and Cardiovascular Surgery
Lyall A Gorenstein, Joshua R Sonett
There have been recent advances in the treatment of non-small cell lung cancer (NSCLC). Surgical resection remains the cornerstone in the treatment of patients with stages I and II NSCLC. Anatomic lobectomy combined with hilar and mediastinal lymphadenectomy constitutes the oncologic basis of surgical resection. The surgical data favor video-assisted thoracic surgery (VATS) lobectomy over open lobectomy and have established VATS lobectomy as a gold standard in the surgical resection of early-stage NSCLC. However, the role of sublobar pulmonary resection, either anatomic segmentectomy or nonanatomic wedge resection, in patients with subcentimeter nodules may become important...
October 2011: Surgical Oncology Clinics of North America
Matthew J Schuchert, Arman Kilic, Arjun Pennathur, Katie S Nason, David O Wilson, James D Luketich, Rodney J Landreneau
BACKGROUND: The recent initiation of screening protocols and greater utilization of computed tomography has led to an increasing proportion of non-small cell lung cancer (NSCLC) patients presenting with subcentimeter stage IA tumors. The aim of this study was to compare the oncologic outcomes of lobectomy, segmentectomy, and wedge resection in patients with NSCLC tumors 1 cm or less in diameter. METHODS: Data were extracted from medical records of patients undergoing surgical resection for stage IA NSCLC and a pathologically confirmed tumor diameter measuring 1 cm or less...
June 2011: Annals of Thoracic Surgery
Nancy L Harthun, Christine L Lau
OBJECTIVES: Serial computed tomography (CT) scanning is routinely used to follow up endovascular exclusion of abdominal aortic aneurysms (AAAs). Nonvascular diseases can be identified, and these exams include images of the lung bases, which can provide information that leads to the diagnosis of pulmonary neoplasms. This study was conducted to determine the rate and type of pulmonary-based oncologic diseases identified by serial CT scanning of patients with endovascular repair of AAAs...
March 2011: Journal of Vascular Surgery
Yeon Joo Jeong, Kyung Soo Lee, O Jung Kwon
The advent of computed tomography (CT) screening with or without the help of computer-aided detection systems has increased the detection rate of solitary pulmonary nodules (SPNs), including that of early peripheral lung cancer. Helical dynamic (HD)CT, providing the information on morphologic and hemodynamic characteristics with high specificity and reasonably high accuracy, can be used for the initial assessment of SPNs. (18)F-fluorodeoxyglucose PET/CT is more sensitive at detecting malignancy than HDCT. Therefore, PET/CT may be selectively performed to characterize SPNs when HDCT gives an inconclusive diagnosis...
December 2008: Expert Review of Respiratory Medicine
Qianjun Zhou, Kenji Suzuki, Yo-ichi Anami, Shiaki Oh, Kazuya Takamochi
Widely used low dose helical thoracic computed tomography (CT) scan in screening results is detecting more and more small-sized lung cancers. Whether systematic lymph node (LN) dissection should be done or not on subcentimeter lung cancers still remains controversial. From June 2000 to December 2008, the records of all patients who underwent resection of primary non-small cell lung cancer (NSCLC) 1 cm or less in diameter were reviewed. LN metastases and lymphatic vessel invasion (LVI) were studied between different subgroups to determine the predictors of metastases...
January 2010: Interactive Cardiovascular and Thoracic Surgery
Janusz Kowalewski
In the majority of the cases it is difficult to evaluate the type of the subcentimeter pulmonary nodule basing on the clinical picture (age of the patient, cigarette smoking history, history of antecedent cancer) and radiographic diagnostics (CT HRCT PET). Usually it is possible only to estimate the probability of malignancy of lesions less than 1 cm. Transthoracic needle aspiration and bronchoscopy have been shown to provide no measurable preoperative benefit to the patient. The high-likelihood nodules should be excised if feasible and the low-likelihood lesions should be followed with serial CTs...
October 2008: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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