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subcentimeter AND lung cancer

Jarrod D Predina, Andrew D Newton, Jane Keating, Ashley Dunbar, Courtney Connolly, Michael Baldassari, Jack Mizelle, Leilei Xia, Charuhas Deshpande, John Kucharczuk, Philip S Low, Sunil Singhal
BACKGROUND: Intraoperative identification of pulmonary nodules, particularly small lesions, can be challenging. We hypothesize that folate receptor-targeted intraoperative molecular imagining can be safe and improve localization of pulmonary nodules during resection. METHODS: Twenty subjects with biopsy-proven pulmonary adenocarcinomas were enrolled in a phase I clinical trial to test the safety and feasibility of OTL38, a novel folate receptor-α (FRα) targeted optical contrast agent...
February 1, 2018: Annals of Thoracic Surgery
Tomoyoshi Takenaka
No abstract text is available yet for this article.
December 2017: Journal of Thoracic Disease
Jarrod D Predina, Andrew D Newton, Courtney Connolly, Ashley Dunbar, Michael Baldassari, Charuhas Deshpande, Edward Cantu, Jason Stadanlick, Sumith A Kularatne, Philip S Low, Sunil Singhal
Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients succumb to recurrent disease. High recurrence rates may be partially explained by data suggesting that 20% of NSCLC patients harbor synchronous disease that is missed during resection. In this report, we describe the use of a novel folate receptor-targeted near-infrared contrast agent (OTL38) to improve the intraoperative localization of NSCLC during pulmonary resection...
February 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Florian J Fintelmann, Jesaja K Brinkmann, William R Jeck, Fabian M Troschel, Subba R Digumarthy, Mari Mino-Kenudson, Jo-Anne O Shepard
PURPOSE: The aim of the study was to investigate the natural history of non-small cell lung cancers (NSCLCs) associated with cystic airspaces, including histopathology and molecular analysis. MATERIALS AND METHODS: A total of 34,801 computed tomographic (CT) scans of 2954 patients diagnosed with NSCLC between 2010 and 2015 were evaluated for association with a cystic airspace. Characteristics on serial CT, 18F-fludeoxyglucose positron emission tomography, and pathologic analysis were recorded...
May 2017: Journal of Thoracic Imaging
Amparo Wolf, Svetlana Kvint, Abraham Chachoua, Anna Pavlick, Melissa Wilson, Bernadine Donahue, John G Golfinos, Joshua Silverman, Douglas Kondziolka
OBJECTIVE The incidence of brain metastases is increasing with improved systemic therapies, many of which have a limited impact on intracranial disease. Stereotactic radiosurgery (SRS) is a first-line management option for brain metastases. The purpose of this study was to determine if there is a threshold tumor size below which local control (LC) rates approach 100%, and to relate these findings to the use of routine surveillance brain imaging. METHODS From a prospective registry, 200 patients with 1237 brain metastases were identified who underwent SRS between December 2012 and May 2015...
January 2018: Journal of Neurosurgery
Aritoshi Hattori, Takeshi Matsunaga, Takuo Hayashi, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
INTRODUCTION: Subcentimeter NSCLC is not always an early-stage disease despite its small tumor size. We investigated the prognostic impact of such cancers on the basis of the findings of thin-section computed tomography (CT). METHODS: We evaluated the clinicopathological features and prognosis of 328 surgically resected clinical-N0 NSCLCs 1.0 cm or less in size. Consolidation-to-tumor ratio (CTR) was evaluated for all, and tumors were classified into three groups, namely, pure ground glass opacity (GGO) (CTR = 0 [n = 139]), part solid (0 < CTR < 1...
June 2017: Journal of Thoracic Oncology
Marjolein A Heuvelmans, Harry J M Groen, Matthijs Oudkerk
Lung cancer screening by low-dose chest computed tomography is currently implemented in the U.S. After implementation of screening, a stage shift may be observed from around 15% stage I non-small cell lung cancers (NSCLCs) in routine clinical practice to up to 70% in screening patients. This indicates a move in treatment options from advanced to early lung cancers, especially in those with small suspected intrapulmonary nodules. Areas covered: We have reviewed the current status of lung cancer screening from the different randomized controlled lung cancer screening studies and the clinical evidence so far for both surgical and non-surgical treatment options for (screen-detected) stage I NSCLC...
February 2017: Expert Review of Respiratory Medicine
Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
BACKGROUND: This study evaluated the clinical significance of maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in patients with subcentimeter non-small cell lung cancer (NSCLC). METHODS: Between 2008 and 2014, 189 patients were investigated preoperatively by PET for c-N0 subcentimeter NSCLC, and SUVmax was reviewed. Pathologic invasiveness (PI) was defined as having at least one of the following factors: lymphatic invasion, vascular invasion, pleural invasion, or nodal metastasis...
May 2017: Annals of Thoracic Surgery
Paul E Van Schil
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
Jane Keating, Sunil Singhal
Lung cancer screening has lead to frequent diagnosis of solitary pulmonary nodules, many of which require surgical biopsy for diagnosis and intervention. Subcentimeter and central nodules are particularly difficult to visualize or palpate during surgery, thus nodule localization can be a difficult problem for the thoracic surgeon. Although minimally invasive techniques including transthoracic computed tomography and bronchoscopic-guided biopsy may establish a diagnosis, these methods do not help locate nodules during surgery and can lead to inadequate tissue sampling...
2016: Seminars in Thoracic and Cardiovascular Surgery
Omar Awais, Michael R Reidy, Kunal Mehta, Valentino Bianco, William E Gooding, Matthew J Schuchert, James D Luketich, Arjun Pennathur
BACKGROUND: Computed tomography scans are increasingly used not only for lung cancer screening but also for staging and evaluation of other cancers. As a result, more patients with pulmonary nodules, many with subcentimeter lesions, are being referred to thoracic surgeons, some with concern for primary lung neoplasm and others with possible metastatic lung lesions. Obtaining a definitive diagnosis of these lesions is difficult. Electromagnetic navigational bronchoscopy (ENB)-guided pleural dye marking followed by thoracoscopic resection is a novel alternative technique for definitive diagnosis...
July 2016: Annals of Thoracic Surgery
Hiroyuki Sakurai, Kazuo Nakagawa, Shun-Ichi Watanabe, Hisao Asamura
BACKGROUND: Subcentimeter lung cancers are still rare, and their pathobiologic behavior and management have not yet been fully clarified. METHODS: From 1993 through 2011, 291 patients with resected lung cancers 1.0 cm or less in diameter were studied regarding their clinicopathologic characteristics. According to appearance on high-resolution computed tomography (HRCT), the tumors were classified into four types: type 1 (n = 50), nonsolid ground-glass opacity (GGO) lesion; type 2 (n = 89), part-solid GGO lesion including 50% or more GGO within the lesion; type 3 (n = 62), part-solid GGO lesion including less than 50% GGO within the lesion, and type 4 (n = 90), solid lesion...
May 2015: Annals of Thoracic Surgery
Roy Mano, Emily Vertosick, Alexander I Sankin, Michael S Chevinsky, Yaniv Larish, Christopher D Jakubowski, Andreas M Hötker, A Ari Hakimi, Daniel D Sjoberg, Oguz Akin, Paul Russo
PURPOSE: Renal cell carcinoma most commonly metastasizes to the lung. Indeterminate pulmonary nodules develop preoperatively in half of the patients with localized renal cell carcinoma but clinical significance remains poorly defined. We determined whether the presence of indeterminate pulmonary nodules, or nodule size or number is associated with renal cell carcinoma outcomes. MATERIALS AND METHODS: We reviewed data on 1,102 patients with renal cell carcinoma in whom chest computerized tomography was done within 6 months before nephrectomy from 2002 to 2012...
March 2015: Journal of Urology
Ninoska N Silva, Cathy Eng
Case Study Ms. S.G., a 56-year-old woman with a poorly differentiated squamous cell carcinoma of the anal canal, American Joint Committee on Cancer stage III (T2, N1, M0), was initially diagnosed in December, 2007 at an outside institution after she had noted blood in her stool for approximately 6 months. Her medical history was unremarkable. She had no known history of HIV or other sexually transmitted diseases. At the time of presentation, Ms. S.G. had an Eastern Cooperative Oncology Group performance status of 1 related to cancer-related pain...
May 2012: Journal of the Advanced Practitioner in Oncology
Stephanie T Chang, Dennis C Nguyen, Constantine Raptis, Christine O Menias, Gongfu Zhou, Andrea Wang-Gillam, David C Linehan, William G Hawkins, Steven M Strasberg, Ryan C Fields
OBJECTIVE: To determine the detection rate, radiologic characteristics, and natural history of incidental subcentimeter pulmonary nodules (SCPN) among patients with resectable pancreatic adenocarcinoma and to clarify whether further preoperative evaluation should be considered. BACKGROUND: The clinical significance of SCPN detected by routine preoperative abdominal imaging in patients with pancreatic adenocarcinoma is unknown. METHODS: Patients who underwent resection for pancreatic adenocarcinoma between 2000 and 2010 were queried from a prospectively maintained database at a single institution...
May 2015: Annals of Surgery
Kyung Eun Shin, Kyung Soo Lee, Chin A Yi, Myung Jin Chung, Myung-Hee Shin, Yoon-Ho Choi
BACKGROUND AND OBJECTIVE: Subcentimeter nodules without change in size during long-term follow-up period (for minimum 2 years) are assumed as benign lesions. However, the 2-year stability rule has not been fully verified so far and is still questionable. Thus, we aimed to retrospectively investigate long-term follow-up results for 2-year stable subcentimeter nodules at screening low-dose computed tomography (LDCT). METHODS: A total of 635 subjects having had follow-up LDCTs for the initial 2-year screening period and additional 3 years thereafter and having had non-calcified subcentimeter nodules were included...
August 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Wei Jiang, Xuguang Pang, Junjie Xi, Xiaoke Chen, Qun Wang, Cheng Qian, Hong Fan
BACKGROUND: The detection of subcentimeter lung cancers has significantly improved with advances in computed tomography and the emergence of screening protocols. We reviewed the clinicopathological features and surgical outcomes of patients with subcentimeter non-small cell lung cancer (NSCLC) in our institution. METHODS: A total of 105 patients who underwent lobectomy or sublobar resection for subcentimeter NSCLCs were retrospectively reviewed. Clinicopathological characteristics and survival were analyzed statistically using Student's t-test for continuous variables, Fisher's exact for categorical variables and Cox regression for multivariable analysis...
September 2014: Journal of Surgical Oncology
Subhashini Yaturu, Raina A Patel
Though the thyroid gland has a rich vascular supply, incidence of metastatic disease from distant organs is rare. Here we present an unusual case of metastases to the thyroid with several interesting features. A 63-year-old male with history of adenocarcinoma of the right lobe lung (5 years prior to presentation), treated with surgery and chemotherapy, followed by new adenosquamous lung cancer in the left lobe of the lung (one year prior to presentation), treated surgically followed by adjuvant chemotherapy, was referred to Endocrinology section for evaluation of an incidental thyroid nodule on CT chest...
2014: Case Reports in Endocrinology
Yang Zhang, Haiquan Chen, Jiaqing Xiang, Yawei Zhang, Yihua Sun, Hong Hu
SESSION TYPE: Thoracic Surgery IPRESENTED ON: Monday, October 22, 2012 at 11:15 AM - 12:30 PMPURPOSE: Over the last two decades, many studies sought to find reliable predictors of N0 status in small-sized (≤2 cm in diameter) non-small cell lung cancers (NSCLC). However, the way of tumor size measurement was usually not standardized, and controversy remains as to whether systematic lymph node dissection should be performed in patients with subcentimeter tumors. Moreover, the correlations between lung adenocarcinoma subtypes in line with the new classification and lymph node metastasis have not yet been determined specifically in small peripheral tumors...
October 1, 2012: Chest
Yang Zhang, Yihua Sun, Lei Shen, Yuan Li, Jiaqing Xiang, Yawei Zhang, Hong Hu, Haiquan Chen
BACKGROUND: During the past two decades, many studies have sought to find reliable predictors of N0 status in small-sized lung cancers. However, the way of tumor size measurement was usually not clearly stated, and controversy remains as to whether systematic lymph node dissection should be performed in patients with subcentimeter tumors. METHODS: We reviewed correlations between lymph node involvement and clinicopathological variables in 243 small peripheral non-small cell lung cancers with their size measured in fresh specimens before formalin fixation...
June 2013: Annals of Surgical Oncology
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