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https://www.readbyqxmd.com/read/29340891/mitomycin-c-0-02-and-0-002-efficacy-in-preventing-haze-after-photorefractive-keratectomy
#1
L M Coelho, R O Sieiro
PURPOSE: To compare MMC 0.002% efficacy in preventing haze after PRK in relation to MMC 0.02%. PATIENTS AND METHODS: We conducted a prospective study with patients with myopia or myopic astigmatism undergoing PRK in the same conditions. After PRK, MMC was applied for 30 s in a concentration of 0.02% on the right eye (group 1) and 0.002% on the left eye (group 2). Age, gender, spherical equivalent and haze intensity (1, 3, 6 and 12 months postoperatively) were assessed...
January 16, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29339978/increase-of-somatic-cell-mutations-in-oxidative-damage-sensitive-drosophila
#2
Ryota Koike, Tomoyo Uchiyama, Sakae Arimoto-Kobayashi, Keinosuke Okamoto, Tomoe Negishi
Background: Oxidative damage is an important genotoxic source for almost all organisms. To efficiently detect mutations induced by oxidative damage, we previously developed a urate-null Drosophila strain. Using this Drosophila strain, we showed the mutagenic activity of environmental cigarette smoke (ECS) and the herbicide paraquat, which are known to produce reactive oxygen species (ROS). In the present study, we examined the mutagenic activities of carcinogenic mutagens that are considered to cause mutations by adduct formation, alkylation, or crosslinking of cellular DNA in the oxidative damage-sensitive Drosophila to evaluate how the oxidative damage induced by these mutagens is involved in causing mutations...
2018: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/29332339/p21-does-but-p53-does-not-predict-pathological-response-to-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#3
Suzana Stojanovic-Rundic, Radmila Jankovic, Marjan Micev, Vladimir Nikolic, Ivan Popov, Dusica Gavrilovic, Vesna Plesinac-Karapandzic, Aleksandra Djuric-Stefanovic, Zoran Krivokapic, Sinisa Radulovic
PURPOSE: Preoperative chemoradiotherapy (CRT) is the standard treatment option in locally advanced rectal cancer. The tumor response is assessed through tumor and nodal downstaging and the tumor regression grade. Currently, there is no method to predict a tumor response to CRT. We aimed to evaluate whether p21 and p53 expressions could be a reliable predictors of pathological response to CRT. METHODS: Fifty patients with locally advanced rectal cancer were treated with preoperative radiotherapy combined with mitomycin C and capecitabine...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331663/a-multi-center-randomized-trial-to-evaluate-hematologic-toxicities-after-hyperthermic-intraperitoneal-chemotherapy-with-oxaliplatin-or-mitomycin-in-patients-with-appendiceal-tumors
#4
Edward A Levine, Konstantinos I Votanopoulos, Perry Shen, Greg Russell, Joyce Fenstermaker, Paul Mansfield, David Bartlett, John H Stewart
BACKGROUND: Appendiceal cancer is a rare disease, which has proven difficult to study in prospective trials. Cytoreductive surgery with HIPEC is an established therapy for peritoneal dissemination from appendiceal cancer. The optimal chemotherapeutic agent to use in the HIPEC is not clear. Mitomycin has long been the utilized, however our previous phase I experience, and European retrospective studies suggest oxaliplatin as an alternative. Therefore, we initiated a multicenter randomized trial to compare mitomycin to oxaliplatin HIPEC for appendiceal cancer...
January 10, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29330444/lidocaine-enhances-the-effects-of-chemotherapeutic-drugs-against-bladder-cancer
#5
Xihua Yang, Lili Zhao, Meiping Li, Lei Yan, Shengwan Zhang, Zhenguo Mi, Liansheng Ren, Jun Xu
This study aimed to investigate whether lidocaine, alone or in combination with other chemotherapeutic agents, inhibits the growth of human bladder cancer cells in vitro and orthotopically transplanted bladder tumors in vivo. The effects of lidocaine (1.25, 2.5 or 5 mg/mL), mitomycin C (MMC, 0.66 mg/mL), pirarubicin (0.75 mg/mL) and Su Fu'ning lotion (SFN, 0.0625 mg/mL) on the proliferation of human bladder cancer (BIU-87) cells were studied using the MTT assay. A Balb/c nude mouse model of bladder cancer was developed by orthotopic transplantation of BIU-87 cells, and the effects of intravesical instillation of lidocaine and MMC on bladder wet weight (a measure of tumor size) and survival (over 60 days) were studied...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319922/the-effect-of-timing-of-an-immediate-instillation-with-mitomycin-c-after-transurethral-resection-in-941-non-muscle-invasive-bladder-cancer-patients
#6
Judith Bosschieter, R Jeroen A van Moorselaar, André N Vis, Tessa van Ginkel, Birgit I Lissenberg-Witte, Goedele M A Beckers, Jakko A Nieuwenhuijzen
OBJECTIVES: To investigate whether timing of an immediate instillation (on the day of transurethral resection or one day later) has impact on time to recurrence of non-muscle-invasive bladder cancer. PATIENTS AND METHODS: All patients with non-muscle-invasive bladder cancer who were enrolled in a prospective trial between 1998 and 2003 and treated with an early mitomycin C instillation (on the day of transurethral resection or one day later), were selected. Statistical analysis was performed with Kaplan-Meier curves and multivariable Cox regression...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29317300/mesenchymal-stem-cells-therapy-protects-fetuses-from-resorption-and-induces-th2-type-cytokines-profile-in-abortion-prone-mouse-model
#7
Amir Salek Farrokhi, Amir-Hassan Zarnani, Seyed Mohammad Moazzeni
The imbalance of Th1/Th2 cytokines is well known in recurrent spontaneous abortion (RSA) mouse model. Mesenchymal stem cells (MSCs) possess potent immunoregulatory properties that could modulate the Th1 cytokine responses in benefit of Th2 types. In this study, we aimed to analyze the local and systemic balance of Th1/Th2 cytokines following MSCs therapy. Syngeneic adipose derived MSCs were administered to abortion prone mice during the implantation window. The abortion rate was determined and IL-4, IL-6, IL-12, IL-2, IFN-γ and GM-CSF gene expression was evaluated by Real-Time-PCR in decidual and placental tissues of pregnant mice at day 13...
January 6, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29315438/femtosecond-laser-assisted-lasik-with-and-without-the-adjuvant-use-of-mitomycin-c-to-correct-hyperopia
#8
Montserrat Garcia-Gonzalez, MariLuz Iglesias-Iglesias, Pilar Drake Rodriguez-Casanova, Juan Gros-Otero, Miguel A Teus
PURPOSE: To compare the visual and refractive results of femtosecond laser-assisted LASIK (FS-LASIK) with and without the adjuvant use of mitomycin C (MMC) to correct hyperopia. METHODS: A total of 152 consecutive hyperopic eyes were included in this retrospective, observational cohort study, comparing 76 eyes treated with FS-LASIK + MMC with 76 age- and refraction-matched eyes treated with FS-LASIK without MMC. Visual and refractive results were evaluated 1 day, 1 week, and 1, 3, 6, and 15 months postoperatively...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29307285/incidence-of-fanconi-anaemia-in-phenotypically-normal-aplastic-anaemia-patients-in-west-bengal
#9
Atreyee Dutta, Rajib De, Tuphan Kanti Dolai, Pritha Pal, Shanoli Ghosh, Pradip Kumar Mitra, Ajanta Halder
OBJECTIVES: Fanconi anaemia (FA) is a rare inherited bone marrow failure and autosomal recessive blood disorder. FA patients have a higher risk of cancer, including acute myeloid leukaemia and squamous cell carcinoma. Maximum, but not all, affected individuals have one or more somatic abnormalities, including skin, skeletal, genitourinary, gastrointestinal, cardiac and neurological anomalies, etc. Positive stress cytogenetics has immense implications for the treatment and management of FA...
January 7, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29306498/concurrent-chemoradiotherapy-for-bladder-cancer-practice-patterns-and-outcomes-in-the-general-population
#10
Ketan Ghate, Kelly Brennan, Safiya Karim, D Robert Siemens, William J Mackillop, Christopher M Booth
BACKGROUND: Clinical trials have shown that chemoradiotherapy (CRT) improves survival compared to radiation therapy (RT) alone in muscle-invasive bladder cancer. We describe uptake of CRT and comparative effectiveness in routine practice. METHODS: Electronic treatment records were linked to the population-based Ontario Cancer Registry to identify all patients with bladder cancer treated with curative-intent RT in 1999-2013. Modified Poisson regression was used to analyze factors associated with use of CRT...
January 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29303888/systemic-absorption-of-mitomycin-c-when-used-in-pterygium-surgery
#11
Michael Yulish, Ahmed Khatib, Joseph Pikkel
PURPOSE: To determine whether scleral topical application of mitomycin-C (MMC) results in measurable plasma levels of systemic absorption. METHODS: The study comprised 27 patients who were treated with MMC 0.2 mg/mL (0.02%) for 60 seconds during pterygium surgery. Blood samples were taken 30 minutes after surgery and evaluated by the human plasma liquid chromatography tandem-mass spectrometry method to determine the presence of MMC. RESULTS: The amount of MMC in 27 samples tested was determined as below 0...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29303877/trypan-blue-for-the-assessment-of-filtering-bleb-function-during-cataract-surgery
#12
Edward Stephen Yung, Marlene R Moster, Carina Sanvicente, John Pluta, Kamran Rahmatnejad, Arjun S Patel, Alice Williams, Ben Abramowitz, L Jay Katz, Michael Pro
PURPOSE: Phacoemulsification has been cited as a possible cause of bleb failure in eyes with prior trabeculectomy. No method has been developed to directly evaluate the risk of bleb failure after phacoemulsification. We investigate the use of trypan blue during cataract surgery in the setting of a pre-existing trabeculectomy to evaluate the functional status of the bleb and predict post-operative bleb function. PATIENTS AND METHODS: 14 patients contributing one eye each with a history of prior trabeculectomy with mitomycin C undergoing phacoemulsification with intraocular lens implantation were enrolled in this prospective, nonrandomized clinical trial...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303876/optical-coherence-tomography-angiography-description-of-ocular-decompression-retinopathy-after-deep-sclerectomy-in-traumatic-glaucoma
#13
Lauriane Salinas, Ankita Chaudhary, Kaweh Mansouri
PURPOSE: To present a case of ocular decompression retinopathy (ODR) occurring after uncomplicated deep sclerectomy with Mitomycin C using optical coherence tomography angiography (OCTA). PATIENT AND METHOD: Single case report. RESULTS: A 55-year-old man with traumatic glaucoma in the right eye complained of blurred vision. Visual acuity was 20/25 and intraocular pressure (IOP) was 50▒mm Hg. Deep sclerectomy with Mitomycin C was performed...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29297460/topical-mitomycin-c-application-for-the-control-of-recurrent-tracheal-stenosis-even-after-tracheal-surgery
#14
Jung Soo Kim, Jun Hyeok Lim, Sang-Hoon Jeon, Jeong-Seok Choi, Young Sam Kim, Hae-Seong Nam
No abstract text is available yet for this article.
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29291026/can-kushen-injection-combined-with-tace-improve-therapeutic-efficacy-and-safety-in-patients-with-advanced-hcc-a-systematic-review-and-network-meta-analysis
#15
Yingshi Zhang, Fuhai Hui, Yue Yang, Haixiao Chu, Xiaochun Qin, Mingyi Zhao, Qingchun Zhao
Objective: To assess the comparative efficacy and safety of combination treatment with Compound Kushen Injection (CKI) and transarterial chemoembolization (TACE) in patients with advanced hepatocellular carcinoma (HCC) through a systematic review and network meta-analysis and to identify the best conditions for using CKI. Materials and Methods: We performed a network meta-analysis based on randomized controlled trials. We searched databases for studies published by August 2017...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286884/antigenotoxicity-properties-of-copaifera-multijuga-oleoresin-and-its-chemical-marker-the-diterpene-copalic-acid
#16
Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
In view of the biological activities and growing therapeutic interest in oleoresin obtained from Copaifera multijuga, this study aimed to determine the genotoxic and antigenotoxic potential of this oleoresin (CMO) and its chemical marker, diterpene (-)-copalic acid (CA). The micronucleus (MN) assay in V79 cell cultures and the Ames test were used for in vitro analyses, as well as MN and comet assays in Swiss mice for in vivo analyses. The in vitro genotoxicity/mutagenicity results showed that either CMO (30, 60, or 120 µg/ml-MN assay; 0...
December 29, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29283127/rescue-of-failing-or-failed-trabeculectomy-blebs-with-slit-lamp-needling-and-adjunctive-mitomycin-c-in-indian-eyes
#17
Vanita Pathak-Ray, Nikhil Choudhari
PURPOSE: The aim of this study is to investigate the efficacy and safety of needling-revision augmented with a high dose of mitomycin C (MMC) in failing or failed blebs after trabeculectomy in Indian eyes. METHODS: Prospective, noncomparative, interventional study. All patients (>18 years) who had raised intraocular pressure (IOP) following trabeculectomy (>6 weeks and <2 years), who had a flat bleb, bleb encapsulation, and/or required antiglaucoma medication (AGM) for IOP control were eligible for inclusion...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283126/comparison-of-surgical-outcomes-between-canaloplasty-and-trabeculectomy-with-mitomycin-c-at-2-year-follow-up-a-longitudinal-cohort-study
#18
Winston J Garris, Crystal Le, David Zurakowski, Ramesh S Ayyala
PURPOSE: To compare operative outcomes of patients after canaloplasty and trabeculectomy with mitomycin C (MMC) through 2-year follow-up. METHODS: We included 31 eyes of 31 patients with primary open-angle glaucoma (POAG) who underwent canaloplasty and 37 eyes of 37 patients with POAG who underwent trabeculectomy with MMC with 24 months of postoperative follow-up. All surgeries were performed by a single surgeon between January 2005 and May 2011. Failure was defined as intraocular pressure (IOP> 18 or <4 mmHg at 2 years), second operative procedure, or loss of light perception...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29281929/protective-effect-of-aspirin-against-mitomycin-c-induced-carcinogenicity-assessed-by-the-test-for-detection-of-epithelial-tumor-clones-warts-in-drosophila-melanogaster
#19
Victor Constante Oliveira, Sarah Alves Rodrigues Constante, Lorena Polloni, Priscila Capelari Orsolin, Rosiane Gomes Silva-Oliveira, Nayane Moreira Machado, Robson José de Oliveira-Júnior, Júlio César Nepomuceno
The present study assessed the protective effect of aspirin against carcinogenicity induced by mitomycin C (MMC) by the test for detection of warts/epithelial tumor clones in Drosophila melanogaster. Larvae were treated with different concentrations of aspirin alone (10, 20 or 40 mg/mL) or aspirin in association with MMC. MMC and ultrapure water were employed as the positive and negative control, respectively. Antioxidant activity was determined using the DPPH method. For performing cytotoxicity assay on HeLa cells, the aspirin concentrations used ranged from 200 mmol/L to 3,125 mmol/L...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29277751/regimens-of-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis-from-colorectal-cancer
#20
REVIEW
Koji Murono, Kazushige Kawai, Keisuke Hata, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Takeshi Nishikawa, Kensuke Otani, Toshiaki Tanaka, Hiroaki Nozawa
Although systemic chemotherapy has been improved, peritoneal carcinomatosis remains a factor of poor prognosis in patients with colorectal cancer. In order to achieve a higher drug concentration in the peritoneal cavity, intraperitoneal chemotherapy has been performed. However, the optimal regimen for intraperitoneal chemotherapy has not been determined. In this review of intraperitoneal chemotherapy for colorectal cancer, we summarize regimens of hyperthermic intraperitoneal chemotherapy (HIPEC) and other intraperitoneal chemotherapy modalities, such as early postoperative intraperitoneal chemotherapy (EPIC) and sequential postoperative intraperitoneal chemotherapy (SPIC)...
January 2018: Anticancer Research
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