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https://www.readbyqxmd.com/read/28522251/very-long-term-success-of-pterygium-surgery-with-conjunctival-graft
#1
Ofira Zloto, Nachum Rosen, Ari Leshno, Mordechai Rosner
PURPOSE: To examine to the very long term prognosis (16 years in average) of pterygium surgery with superior or inferior conjunctival graft. METHODS: Clinical data for patients that underwent pterygium surgery with conjunctival graft by two surgeons at the Goldschleger Eye Institute, Sheba Medical Center, Israel, between the years 1997-2001 were retrieved from medical records. For all the included patients, data about their eye examinations was summarized and a questionnaire about their eye history was done...
May 15, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#2
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28514739/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-improves-survival-for-peritoneal-carcinomatosis-from-colorectal-cancer-a-systematic-review-and-meta-analysis-of-current-evidence
#3
REVIEW
Chao-Qun Huang, Yao Min, Shu-Yi Wang, Xiao-Jun Yang, Yang Liu, Bin Xiong, Yutaka Yonemura, Yan Li
Objectives The therapeutic efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is still under debate. This meta-analysis and systematic review of published literature on this comprehensive strategy aims to evaluate its efficacy on CRC patients with PC.Methods A systemic review with meta-analysis of published literatures on treatment of CRS plus HIPEC for patients with PC from CRC was performed...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28513491/results-of-a-new-mirror-tuck-technique-for-fixation-of-lacrimal-bypass-tube-in-conjunctivodacryocystorhinostomy
#4
Ruchi Goel, Divya Kishore, Smriti Nagpal, Sushil Kumar, Neha Rathie
CONTEXT: Conjunctivodacryocystorhinostomy (CDCR) is the procedure of choice for proximal canalicular blocks. However, the complications of tube migration and extrusion limit its widespread practice. AIM: The aim of this study is to evaluate the efficacy and complications of the new "mirror tuck technique" for fixation of lacrimal bypass glass tube without holes in proximal canalicular blocks in laser CDCR. MATERIALS AND METHODS: A prospective interventional study was conducted in forty consecutive eyes of adult patients, undergoing 980 nm diode laser CDCR for proximal canalicular blocks...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28507799/characterization-of-a-human-anti-tumoral-nk-cell-population-expanded-after-bcg-treatment-of-leukocytes
#5
Eva M García-Cuesta, Gloria Esteso, Omodele Ashiru, Sheila López-Cobo, Mario Álvarez-Maestro, Ana Linares, Mei M Ho, Luis Martínez-Piñeiro, Hugh T Reyburn, Mar Valés-Gómez
Immunotherapy, via intra-vesical instillations of BCG, is the therapy of choice for patients with high-risk non-muscle invasive bladder cancer. The subsequent recruitment of lymphocytes and myeloid cells, as well as the release of cytokines and chemokines, is believed to induce a local immune response that eliminates these tumors, but the detailed mechanisms of action of this therapy are not well understood. Here, we have studied the phenotype and function of the responding lymphocyte populations as well as the spectrum of cytokines and chemokines produced in an in vitro model of human peripheral blood mononuclear cells (PBMCs) co-cultured with BCG...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28506884/enhancing-effect-of-50%C3%A2-hz-rotating-magnetic-field-on-induction-of-shiga-toxin-converting-lambdoid-prophages
#6
M Struk, B Grygorcewicz, P Nawrotek, A Augustyniak, M Konopacki, M Kordas, R Rakoczy
Studies aimed at investigating factors and mechanism of induction of prophages, a major pathogenesis factor of Shiga toxin-producing Escherichia coli (STEC), are considered important to develop an effective treatment for STEC infections. In this study, we demonstrated the synergistic effect of the rotating magnetic field (RMF) of induction B = 34 mT and frequency ƒ = 50 Hz at a constant temperature of 37 °C and mitomycin C (MMC), that resulted in a higher level of induction of stx-carrying lambdoid Stx prophages...
May 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28497175/characterization-and-role-of-a-2-3-cyclic-phosphodiesterase-from-deinococcus-radiodurans
#7
Wanchun Han, Congli Zhou, Jiahui Cheng, Mingzhe Pan, Yuejin Hua, Ye Zhao
OBJECTIVES: A 2',3'-cyclic phosphodiesterase gene (drCPDase) has been characterized from Deinococcus radiodurans and is involved in the robust resistance of this organism. RESULTS: Cells lacking 2',3'-cyclic phosphodiesterase gene (drCPDase) showed modest growth defects and displayed increased sensitivities to high doses of various DNA-damaging agents including ionizing radiation, mitomycin C, UV and H2O2. The transcriptional level of drCPDase increased after H2O2 treatment...
May 11, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28487972/mmc-controlled-release-membranes-attenuate-epidural-scar-formation-in-rat-models-after-laminectomy
#8
Hao Xie, Binbin Wang, Xun Shen, Jian Qin, Longhai Jiang, Chen Yu, Dawei Geng, Tangbo Yuan, Tao Wu, Xiaojian Cao, Jun Liu
Epidural scar formation after laminectomy impede surgical outcomes of decompression. Mitomycin C (MMC) has been demonstrated to have significant inhibitory effects on epidural scar. This study was undertaken to develop an effective MMC controlled‑release membrane and to investigate its effects on epidural scar in rat models of laminectomy. A total of 72 rats that underwent laminectomy were divided into three groups. Among them, 24 were treated with mitomycin C‑polylactic acid (MMC-PLA) controlled‑release membrane, 24 with mitomycin C-polyethylene glycol (MMC-PEG) controlled-release membrane, and no treatment was performed for the remaining 24 rats (control group)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28486276/outcomes-for-ab-interno-bleb-revision-with-a-novel-translimbal-sclerostomy-spatula
#9
Davinder S Grover, Ronald L Fellman
PURPOSE: To report outcomes for a novel ab interno bleb revision technique and spatula. PATIENTS AND METHODS: This is a retrospective chart review. RESULTS: A total of 21 eyes of 21 patients underwent ab interno bleb revision with the Grover-Fellman biplanar sclerostomy spatula. Mitomycin C was given at least 1 week preoperation. The mean age of the patients and blebs were 67 and 6.75 years, respectively. The mean follow-up is 10.6 months (range: 3 to 17 mo)...
May 8, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28476356/an-italian-multicentre-experience-in-endoscopic-endonasal-treatment-of-congenital-choanal-atresia-proposal-for-a-novel-classification-system-of-surgical-outcomes
#10
Apostolos Karligkiotis, Paolo Farneti, Stefania Gallo, Alessandro Pusateri, Francesco Zappoli-Thyrion, Vittorio Sciarretta, Fabio Pagella, Paolo Castelnuovo, Ernesto Pasquini
OBJECTIVE: The purposes of this study were to report our experience with endoscopic treatment of choanal atresia (CA), to illustrate our surgical technique and analyse the different factors that may affect outcomes. MATERIAL AND METHODS: A retrospective review was performed of patients affected by congenital CA and treated between June 1996 and November 2013 at three referral centres which follow a uniform policy. RESULTS: Eighty-four patients with CA (55 unilateral and 29 bilateral), aged between one day and 76 years (mean, 13 years) were included...
March 28, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28472781/comparison-of-the-efficacy-among-multiple-chemotherapeutic-interventions-combined-with-radiation-therapy-for-patients-with-cervix-cancer-after-surgery-a-network-meta-analysis
#11
Lei Chang, Ruixia Guo
BACKGROUND: Cervix cancer was the second most common cancer in female. However, there was no network meta-analysis (NMA) comparing the efficacy of the multiple chemotherapeutic interventions combined with radiation therapy in patients after operation. METHODS: Randomized controlled trials were retrieved from PubMed, Embase and Cochrane Library. Overall survival (OS), recurrence-free survival (RFS), incidence of recurrence and distant metastasis were the main outcomes, particularly 5-year OS and PFS were considered as primary outcomes...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472011/multifocal-ocular-surface-squamous-neoplasia
#12
Swati Singh, Ruchi Mittal, Suryasnata Rath
A 64-year-old healthy female presented with a papillomatous limbal lesion involving 6 clock hours of superior limbus and diffuse involvement of upper tarsal conjunctiva of left eye of 6 months duration. Excision of superior limbal lesion on histopathology showed carcinoma in situ with focal breach in basement membrane and moderate degree of differentiation. The surgical base and margins were uninvolved. The tarsal lesion was initially treated with subconjunctival interferon alpha 2b (IFN alpha 2b) (3 cycles of IFN alpha 2b) with poor response...
May 2, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28470465/solubilization-and-stability-of-mitomycin-c-solutions-prepared-for-intravesical-administration
#13
Alan L Myers, Yan-Ping Zhang, Jitesh D Kawedia, Ximin Zhou, Stacey M Sobocinski, Michael J Metcalfe, Mark A Kramer, Colin P N Dinney, Ashish M Kamat
BACKGROUND: Mitomycin C (MMC) is an antitumor agent that is often administered intravesically to treat bladder cancer. Pharmacologically optimized studies have suggested varying methods to optimize delivery, with drug concentration and solution volume being the main drivers. However, these MMC concentrations (e.g. 2.0 mg/mL) supersede its solubility threshold, raising major concerns of inferior drug delivery. OBJECTIVE: In this study, we seek to confirm that the pharmacologically optimized MMC concentrations are achievable in clinical practice through careful modifications of the solution preparation methods...
May 3, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28469303/comparison-of-sterile-water-irrigation-versus-intravesical-mitomycin-c-in-preventing-recurrence-of-nonmuscle-invasive-bladder-cancer-after-transurethral-resection
#14
Priyank Bijalwan, Ginil Kumar Pooleri, Appu Thomas
INTRODUCTION: Early recurrence of nonmuscle invasive bladder cancer (NMIBC) following transurethral resection (TUR) remains relatively high. An immediate single instillation of mitomycin C (MMC) reduces the recurrence rates in the first 2 years but has not shown benefits in tumor progression or overall survival. Distilled water irrigation has shown to delay tumor recurrence by osmolysis of tumor cells. There are only limited clinical studies comparing the efficacy of MMC with continuous sterile water irrigation (CSWI) in preventing the recurrence of NMIBC after TUR in clinical setting...
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28468910/the-sos-and-rpos-regulons-contribute-to-bacterial-cell-robustness-to-genotoxic-stress-by-synergistically-regulating-dna-polymerase-pol-ii
#15
Tanja Dapa, Sébastien Fleurier, Marie-Florence Bredeche, Ivan Matic
Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stresses that slow growth. Thus, induction of the RpoS regulon by MMC may be coincidental, because DNA damage slows growth; alternatively, the RpoS regulon may be an adaptive response contributing to cell survival...
May 3, 2017: Genetics
https://www.readbyqxmd.com/read/28467172/simple-and-fast-detection-of-resistance-to-antibiotic-inhibitors-of-protein-synthesis-in-gram-negative-pathogens-through-evaluation-of-mitomycin-c-induced-cell-elongation
#16
Fátima Otero, Jaime Gosálvez, Germán Bou, José Luis Fernández
Increasing the resistance of Gram-negative pathogens to antibiotics that inhibit protein synthesis is of great concern. In life-threatening situations, an early detection of antibiotic resistance may improve patient outcome. A rapid assay for the identification of antibiotic resistance to gentamicin, tobramycin, and tigecycline has been designed and tested in clinical strains of Acinetobacter baumannii, Pseudomonas aeruginosa, and the Enterobacteriaceae Escherichia coli and Klebsiella pneumoniae. Exponentially growing cultures were incubated with 0...
May 3, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28463160/predictors-of-radiation-therapy-related-gastrointestinal-toxicity-from-anal-cancer-dose-painted-intensity-modulated-radiation-therapy-secondary-analysis-of-nrg-oncology-rtog-0529
#17
Jeffrey R Olsen, Jennifer Moughan, Robert Myerson, Andre Abitbol, Desiree E Doncals, Douglas Johnson, Tracey E Schefter, Yuhchyau Chen, Barbara Fisher, Jeff Michalski, Samir Narayan, Albert Chang, Christopher H Crane, Lisa Kachnic
PURPOSE: NRG Oncology RTOG 0529 assessed the feasibility of dose-painted intensity modulated radiation therapy (DP-IMRT) to reduce the acute morbidity of chemoradiation with 5-fluorouracil (5FU) and mitomycin-C (MMC) for T2-4N0-3M0 anal cancer. This secondary analysis was performed to identify patient and treatment factors associated with acute and late gastrointestinal (GI) adverse events (AEs). METHODS AND MATERIALS: NRG Oncology RTOG 0529 treatment plans were reviewed to extract dose-volume data for tightly contoured small bowel, loosely contoured anterior pelvic contents (APC), and uninvolved colon outside the target volume (UC)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28462895/irradiation-of-anatomically-defined-pelvic-subsites-and-acute-hematologic-toxicity-in-anal-cancer-patients-undergoing-chemoradiation
#18
Brent Rose, Devarati Mitra, Theodore S Hong, Kyung-Wook Jee, Andrzej Niemierko, Lorraine N Drapek, Lawrence S Blaszkowsky, Jill N Allen, Janet E Murphy, Jeffrey W Clark, David P Ryan, Jennifer Y Wo
PURPOSE: Chemoradiation for the treatment of anal cancer is known to cause significant hematologic toxicity (HT). We sought to investigate if radiation dose to specific pelvic subsites is associated with increased HT risk. METHODS AND MATERIALS: Forty-five patients with nonmetastatic anal cancer who received definitive chemoradiation with intensity modulated radiation therapy and concurrent mitomycin-C and 5-fluorouracil were studied. Total pelvic bone marrow (TBM) was divided into 3 subsites: lumbosacral bone marrow (LSBM), including the entire sacrum and L5 vertebral body; iliac bone marrow (IBM) extending from the iliac crests to the superior border of the femoral head; and lower pelvic bone marrow, including the pubic bones, ischia, acetabula, and proximal femurs...
March 23, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28458663/h-ns-mutation-mediated-crispr-cas-activation-inhibits-phage-release-and-toxin-production-of-escherichia-coli-stx2-phage-lysogen
#19
Qiang Fu, Shiyu Li, Zhaofei Wang, Wenya Shan, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jianhe Sun
Shiga toxin-converting bacteriophages (Stx phages) carry the stx gene and convert nonpathogenic bacterial strains into Shiga toxin-producing bacteria. There is limited understanding of the effect that an Escherichia coli (E. coli) clustered regularly interspaced short palindromic repeats (CRISPR)-Cas adaptive immune system has on Stx phage lysogen. We investigated heat-stable nucleoid-structuring (H-NS) mutation-mediated CRISPR-Cas activation and its effect on E. coli Stx2 phage lysogen. The Δhns mutant (MG1655Δhns) of the E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28455543/-early-atrophy-of-the-conjunctiva-after-trabeculectomy-with-mitomycin-c-and-collagen-matrix-implant
#20
R Siggel, T Dietlein
Complete atrophy of the filtration bleb is a very rare complication after trabeculectomy with mitomycin C and collagen matrix implant (Ologen®, Aeon Astron Corporation, Taipei, Taiwan). Clinically, the atrophy can present similar to blebitis. We report the case of a 71-year-old woman, in whom we resected the atrophic conjunctiva and reconstructed a filtration bleb using an amniotic membrane.
April 28, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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