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https://www.readbyqxmd.com/read/29344476/acute-angle-closure-precipitated-by-hemorrhage-and-necrosis-of-a-large-uveal-melanoma-in-the-setting-of-systemic-immunomodulatory-therapy
#1
Chau M Pham, Krishna Kalyam, Bradley T Smith, Justin Floyd, John B Holds
Management of nonmetastatic uveal melanoma has been well studied and a large body of work has been published by the Collaborative Ocular Melanoma Study (amongst many others). Management of uveal melanoma that is found to be metastatic upon initial diagnosis, however, is less well defined. We report an interesting case of acute angle closure caused by necrosis and hemorrhage into a large uveal melanoma occurring shortly after initiation of immunomodulatory therapy with ipilimumab and nivolumab for metastatic disease...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29340640/in-vivo-three-dimensional-lamina-cribrosa-strains-in-healthy-ocular-hypertensive-and-glaucoma-eyes-following-acute-intraocular-pressure-elevation
#2
Meghna R Beotra, Xiaofei Wang, Tin A Tun, Liang Zhang, Mani Baskaran, Tin Aung, Nicholas G Strouthidis, Michaël J A Girard
Purpose: To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation in healthy, glaucoma, and ocular hypertensive subjects. Methods: There were 20 healthy, 20 high-tension primary open-angle glaucoma (POAG), 16 primary angle-closure glaucoma (PACG), and 20 ocular hypertensive (OHT; with normal visual fields) eyes studied. For each test eye, the optic nerve head was imaged three times (at baseline IOP, following an acute elevation of IOP to approximately 35 then 45 mm Hg using an ophthalmodynamomter) using optical coherence tomography (OCT)...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29339320/primary-obstruction-of-the-foramen-of-luschka-anatomy-histology-and-clinical-significance
#3
Laszlo Barany, Gabor Baksa, Patonay Lajos, Gergely Racz, Oliver Ganslandt, Michael Buchfelder, Peter Kurucz
BACKGROUND: The foramen of Luschka is a natural aperture between the fourth ventricle and the subarachnoid space at the cerebellopontine angle (CPA). Membranous closure of this foramen is referred to as primary obstruction. The available information about this variant and its role in the development of the cysts of the posterior fossa are contradictory in the literature. METHODS: Sixty-one formalin-fixed human brains (122 foramina) were involved in this study. Both the macroscopic and the histological features of the obstructed foramina were examined...
January 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29332228/comparative-evaluation-of-the-aqueous-humor-proteome-of-primary-angle-closure-and-primary-open-angle-glaucomas-and-age-related-cataract-eyes
#4
Inderjeet Kaur, Jasbir Kaur, K Sooraj, Sandeep Goswami, Rohit Saxena, Virander Singh Chauhan, Ramanjit Sihota
PURPOSE: To analyze and compare the total proteome of aqueous humor (AH) from patients having primary angle closure glaucoma (PACG), primary open angle glaucoma (POAG) and age-related cataract. MATERIALS AND METHODOLOGY: Aqueous humor was collected from age-matched PACG, POAG and cataract patients who underwent surgery, and it was immediately stored at - 80 °C until analysis. From each sample, 25 µg of total protein was subjected to trypsin digestion and subsequently LC-MS/MS analysis was performed for the deep proteome analysis...
January 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29324594/intraoperative-and-postoperative-complications-in-phacovitrectomy-for-epiretinal-membrane-and-macular-hole-a-clinical-audit-of-1000-consecutive-eyes
#5
Mark A P Fajgenbaum, James E Neffendorf, Roger S Wong, David A H Laidlaw, Tom H Williamson
PURPOSE: The aim of this study was to report the intraoperative and postoperative complications of phacovitrectomy for epiretinal membrane (ERM) and macular hole (MH). METHODS: This was a retrospective audit of 1,052 phacovitrectomy operations (410 for ERM and 642 for MH) by the same surgical team between 1998 and 2017. Outcome measures included rates of intraoperative anterior segment and posterior segment complications such as posterior capsule rupture and retinal breaks...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29310965/evaluation-of-primary-angle-closure-glaucoma-susceptibility-loci-in-patients-with-early-stages-of-angle-closure-disease
#6
Monisha E Nongpiur, Ching-Yu Cheng, Roopam Duvesh, Saravanan Vijayan, Mani Baskaran, Chiea-Chuen Khor, John Allen, Srinivasan Kavitha, Rengaraj Venkatesh, David Goh, Rahat Husain, Pui Yi Boey, Desmond Quek, Ching Lin Ho, Tina T Wong, Shamira Perera, Tien Yin Wong, Subbiah R Krishnadas, Periasamy Sundaresan, Tin Aung, Eranga N Vithana
PURPOSE: To investigate whether newly identified genetic loci for primary angle-closure glaucoma (PACG) are associated with early stage angle-closure disease defined as primary angle closure suspect (PACS). DESIGN: Case-control study. PARTICIPANTS: A total of 1397 PACS patients and 943 controls of Chinese ethnicity from Singapore and 604 PACS patients and 287 controls of Indian ethnicity. METHODS: The 8 PACG single nucleotide polymorphisms (SNPs; rs11024102 at PLEKHA7, rs3753841 at COL11A1, rs1015213 located between PCMTD1 and ST18 son chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were genotyped by Taqman assays...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29303875/outcome-following-laser-peripheral-iridotomy-and-predictors-of-future-lens-extraction
#7
Jenny Bo, Tulsi Changulani, Mei-Ling Cheng, Andrew J Tatham
PURPOSE: To examine the outcome of laser peripheral iridotomy (LPI) for primary angle closure (PAC) and determine predictors of future lens extraction (LE). METHODS: A retrospective chart review of 218 eyes from 128 consecutive patients undergoing LPI between 2010 and 2012 at a university hospital. Baseline factors including age, peak intraocular pressure (IOP) prior to LPI, diagnosis (primary angle closure suspect (PACS), PAC, primary angle closure glaucoma (PACG), and acute or non-acute presentation were recorded...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303395/acute-primary-angle-closure-after-periorbital-facial-procedures-report-of-four-cases-and-literature-review
#8
Mohsen Bahmani Kashkouli, Maria Sharepour, Hamed Sianati, Parya Abdolalizadeh
AIMS: To report four cases of acute primary angle closure (PAC) after blepharoplasty and forehead lifting procedures and review the previous reported cases in the literature. METHODS: Four female subjects with age range of 50-67 years developed PAC 2-5 days after blepharoplasty and endoscopic forehead lifting procedures. All presented with pain, nausea, blurred vision, red eye, and eyelid swelling. Diagnosis was delayed in the first subject because of considering the signs and symptoms as usual postoperative ones...
January 5, 2018: Orbit
https://www.readbyqxmd.com/read/29302683/association-of-functional-loss-with-the-biomechanical-response-of-the-optic-nerve-head-to-acute-transient-intraocular-pressure-elevations
#9
Tin A Tun, Eray Atalay, Mani Baskaran, Monisha E Nongpiur, Hla M Htoon, David Goh, Ching-Yu Cheng, Shamira A Perera, Tin Aung, Nicholas G Strouthidis, Michaël J A Girard
Importance: The acute biomechanical response of the optic nerve head (ONH) to intraocular pressure (IOP) elevations may serve as a biomarker for the development and progression of glaucoma. Objective: To evaluate the association between visual field loss and the biomechanical response of the ONH to acute transient IOP elevations. Design, Setting, and Participants: In this observational study, 91 Chinese patients (23 with primary open-angle glaucoma [POAG], 45 with primary angle-closure glaucoma, and 23 without glaucoma) were recruited from September 3, 2014, through February 2, 2017...
January 4, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29302324/national-and-subnational-prevalence-and-burden-of-glaucoma-in-china-a-systematic-analysis
#10
Peige Song, Jiawen Wang, Kajo Bucan, Evropi Theodoratou, Igor Rudan, Kit Yee Chan
Background: Glaucoma, the second leading cause of blindness, affects approximately 64.3 million individuals worldwide. In China, demographic ageing is in rapid progress. Yet detailed and up-to-date estimates of the scale of glaucoma are rare. We aimed to quantify and understand the prevalence and burden of glaucoma in China from 1990 to 2015, with projections until 2050. Methods: For this systematic review and meta-analysis, we searched China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedicine Literature Database (CBM-SinoMed), PubMed, Embase and Medline using comprehensive search strategies to identify all relevant articles that have reported the prevalence of glaucoma in the general Chinese population...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29300213/chronic-and-intermittent-angle-closure-caused-by-in-the-bag-capsular-tension-ring-and-intraocular-lens-dislocation-in-patients-with-pseudoexfoliation-syndrome-erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29290065/pathophysiology-of-primary-open-angle-glaucoma-from-a-neuroinflammatory-and-neurotoxicity-perspective-a-review-of-the-literature
#12
REVIEW
Karine Evangelho, Maria Mogilevskaya, Monica Losada-Barragan, Jeinny Karina Vargas-Sanchez
PURPOSE: Glaucoma is the leading cause of blindness in humans, affecting 2% of the population. This disorder can be classified into various types including primary, secondary, glaucoma with angle closure and with open angle. The prevalence of distinct types of glaucoma differs for each particular region of the world. One of the most common types of this disease is primary open-angle glaucoma (POAG), which is a complex inherited disorder characterized by progressive retinal ganglion cell death, optic nerve head excavation and visual field loss...
December 30, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29286775/evidence-for-the-role-of-proton-shell-closure-in-quasifission-reactions-from-x-ray-fluorescence-of-mass-identified-fragments
#13
M Morjean, D J Hinde, C Simenel, D Y Jeung, M Airiau, K J Cook, M Dasgupta, A Drouart, D Jacquet, S Kalkal, C S Palshetkar, E Prasad, D Rafferty, E C Simpson, L Tassan-Got, K Vo-Phuoc, E Williams
The atomic numbers and the masses of fragments formed in quasifission reactions are simultaneously measured at scission in ^{48}Ti+^{238}U reactions at a laboratory energy of 286 MeV. The atomic numbers are determined from measured characteristic fluorescence x rays, whereas the masses are obtained from the emission angles and times of flight of the two emerging fragments. For the first time, thanks to this full identification of the quasifission fragments on a broad angular range, the important role of the proton shell closure at Z=82 is evidenced by the associated maximum production yield, a maximum predicted by time-dependent Hartree-Fock calculations...
December 1, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29283136/single-pass-four-throw-pupilloplasty-for-angle-closure-glaucoma
#14
Priya Narang, Amar Agarwal, Dhivya A Kumar
Angle-closure glaucoma is characterized by appositional or synechial closure of the anterior chamber angle with glaucomatous field defects that may or may not be associated with a pupillary block. Surgical pupilloplasty with single-pass four-throw technique helps to alleviate the appositional closure along with the breakage of peripheral anterior synechia, thereby increasing the aqueous outflow and decreasing intraocular pressure.
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29275324/use-of-clinical-vignette-questionnaires-to-investigate-the-variation-in-management-of-keratoconjunctivitis-sicca-and-acute-glaucoma-in-dogs
#15
Constance N White, Martin J Downes, Gareth Jones, Corinne Wigfall, Rachel S Dean, Marnie L Brennan
There is little peer-reviewed research assessing therapeutic effectiveness in canine eye disease. Current treatments used in first opinion and ophthalmology referral practices are also somewhat poorly documented. The aim of this study was to investigate the current management of canine keratoconjunctivitis sicca (KCS) and acute primary angle-closure glaucoma (PACG) by veterinary surgeons. Questionnaires using clinical vignettes were administered to a cross section of general practitioners ('GPs') and veterinarians engaged in or training for postgraduate ophthalmology practice ('PGs')...
December 23, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29261364/tp53-codon-72-polymorphism-and-the-risk-of-glaucoma-in-a-north-indian-cohort-a-genetic-association-study
#16
Shashank Gupta, Souradip Chatterjee, Abhishek Chandra, Om Prakash Singh Maurya, Ravindra Nath Mishra, Ashim Mukherjee, Mousumi Mutsuddi
BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma. Considering the earlier findings about enhanced apoptotic potential by the Arg variant of TP53 P72R and the conflicting results about its association with glaucoma, we initiated a hospital-based case-control association study in a north Indian cohort to investigate the association of TP53 P72R with glaucoma...
December 20, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29260096/an-unusual-case-of-acute-angle-closure-glaucoma-following-deep-anterior-lamellar-keratoplasty-using-the-big-bubble-technique
#17
Samir Jabbour, Adam Muzychuk, Younes Agoumi, Mona Harissi-Dagher
Purpose: To report the first case of acute angle closure due to a high-pressure Descemet membrane detachment following deep anterior lamellar keratoplasty (DALK) using the "big bubble" technique. Observations: A 25-year-old man underwent DALK surgery for keratoconus using the "big bubble" technique in which an air bubble is injected in deep stroma to promote dissection of underlying Descemet membrane from stroma. Surgery was uneventful and the patient was discharged home in good conditions...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260088/acute-hypotony-maculopathy-following-the-initiation-of-a-topical-aqueous-suppressant-in-a-patient-with-a-history-of-panuveitis-without-prior-filtering-surgery
#18
Dagny Zhu, Hossein Ameri, Alena Reznik, Narsing A Rao
Purpose: To report a case of profound hypotony maculopathy as a complication of single-agent glaucoma therapy in a patient with a history of panuveitis without previous filtering surgery. Observations: A 70-year old Hispanic male with a history of resolved bilateral panuveitis, chronic angle closure glaucoma, and pars plana vitrectomy was started on topical timolol 0.5% daily in the left eye for mildly elevated intraocular pressure (15 mmHg). The patient returned 1...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29251401/corneal-hysteresis-and-anterior-segment-optical-coherence-tomography-anatomical-parameters-in-primary-angle-closure-suspects
#19
Syed Amal Hussnain, Kyle D Kovacs, Joshua L Warren, Christopher C Teng
IMPORTANCE: Corneal hysteresis (CH) is a dynamic marker of structural and functional changes in the cornea associated with IOP and central corneal thickness, but its utility in assessing primary angle closure suspects (PACS) has not been fully elucidated. BACKGROUND: This study assesses if anterior segment measurements correlate with CH in PACS patients. DESIGN: IRB-approved retrospective review of imaging and records at a university practice...
December 18, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29243035/systemic-lupus-erythematosus-and-ocular-involvement-an-overview
#20
REVIEW
Rosanna Dammacco
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. An early diagnosis and the adoption of suitable therapeutic measures are necessary to prevent sight-threatening consequences, especially in patients with juvenile SLE. Periocular lesions, such as eyelid involvement and orbital inflammation, are relatively rare and, in case of orbital masses, may require a biopsy control...
December 14, 2017: Clinical and Experimental Medicine
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