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https://www.readbyqxmd.com/read/28918491/dynamics-of-allosteric-modulation-of%C3%A2-lymphocyte-function-associated-antigen-1-closure-open-switch-unveiling-the-structural-mechanisms-associated-with-outside-in-signaling-activation
#1
Maryam Abdullahi, Fisayo A Olotu, Mahmoud E Soliman
OBJECTIVES: To provide insight into the dynamics of the shape-shifting mechanistic events associated with the opening (activation) of Lymphocyte Function Associated Antigen-1 upon allosteric modulation by an activator, ICAM Binding Enhancer-667 (IBE-667), using molecular dynamics simulation. RESULTS: Various parameters were used to appropriately describe and understand the sequence of events that characterized its activation across the simulation period such as residual distances, TriCα angles; as well as the dihedral angle...
September 16, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28916480/factors-associated-with-zonular-instability-during-cataract-surgery-in-eyes-with-acute-angle-closure-attack
#2
Junki Kwon, Kyung Rim Sung
PURPOSE: To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery. DESIGN: Retrospective, case-control study METHODS: Total 68 eyes of 56 patients with a history of AAC attack who underwent cataract surgery were enrolled. Fourteen eyes were assigned to the zonular instability (+) group and 54 were assigned to the zonular instability (-) group based on the presence of zonular instability during cataract surgery...
September 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28910448/iridoschisis-in-angle-closure-glaucoma-associated-with-alkali-burn
#3
Swarup S Swaminathan, Kara M Cavuoto, Ta Chen Chang
No abstract text is available yet for this article.
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28906337/a-three-dimensional-study-of-midfacial-changes-following-le-fort-ii-distraction-with-zygomatic-repositioning-in-syndromic-patients
#4
James M Smartt, Carey Campbell, Rami Hallac, Jake Alford, Christopher A Derderian
Le Fort II distraction with zygomatic repositioning introduced the ability to restore central midfacial height and convexity independent of changes in orbital morphology. This study analyzes midfacial and orbital morphology before and after Le Fort II distraction with zygomatic repositioning.All patients who underwent Le Fort II Distraction with zygomatic repositioning between 2013 and 2015 were included. Two- and 3-dimensional measurements were made using 3dMD Vultus software to assess canthal tilt, nasolabial angle, ratio of midfacial to lower facial height, and absolute change in nasal length...
September 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28904900/advance-male-sling
#5
REVIEW
Amanda S J Chung, Oscar A Suarez, Kurt A McCammon
The AdVance sling (American Medical Systems, Minnetonka, MN, United States of America) is a synthetic transobturator sling, which is a safe and effective minimally invasive treatment for mild to moderate stress urinary incontinence (SUI) in male patients. This article provides a step-by-step description of our technique for placement of the AdVance male sling, including details and nuances gained from surgical experience, advice for avoidance of complications and discussion on management of complications and sling failures...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28894266/generation-of-a-new-mouse-model-of-glaucoma-characterized-by-reduced-expression-of-the-ap-2%C3%AE-and-ap-2%C3%AE-proteins
#6
Maria Monica Barzago, Mami Kurosaki, Maddalena Fratelli, Marco Bolis, Chiara Giudice, Laura Nordio, Elisa Cerri, Luciano Domenici, Mineko Terao, Enrico Garattini
We generated 6 transgenic lines with insertion of an expression plasmid for the R883/M xanthine dehydrogenase (XDH) mutant protein. Approximately 20% of the animals deriving from one of the transgenic lines show ocular abnormalities and an increase in intra-ocular pressure which are consistent with glaucoma. The observed pathologic phenotype is not due to expression of the transgene, but rather the consequence of the transgene insertion site, which has been defined by genome sequencing. The insertion site maps to chromosome 1qA3 in close proximity to the loci encoding AP-2β and AP-2δ, two proteins expressed in the eye...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887985/cerium-oxide-nanoparticle-containing-poly-%C3%AE%C2%B5-caprolactone-gelatin-electrospun-film-as-a-potential-wound-dressing-material-in-vitro-and-in-vivo-evaluation
#7
Mahdi Naseri-Nosar, Saeed Farzamfar, Hamed Sahrapeyma, Sadegh Ghorbani, Farshid Bastami, Ahmad Vaez, Majid Salehi
In the present study, cerium oxide (CeO2) nanoparticles were incorporated into poly (ε-caprolactone)/gelatin films in order to develop a potential wound dressing material. The wound dressings were prepared by electrospinning of poly (ε-caprolactone)/gelatin (1:1 (w/w)) solutions containing 1.50%, 3% and 6% (w/w) CeO2 nanoparticles. The electrospun films were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile strength and cellular response. The film containing 1...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887138/-the-role-of-phacoemulsification-in-glaucoma-therapy-a-systematic-review-and-meta-analysis
#8
REVIEW
Marisse Masis, Patrick J Mineault, Eileen Phan, Shan C Lin
Cataract extraction is a safe and effective surgery that has been performed in its modern form for several decades. Many studies have noted that cataract extraction could also have a clinically significant role in the control of co-morbid glaucoma. Lens extraction decreases the pressure within the eye, and intraocular pressure is the only controllable risk factor in glaucoma proven to be effective. A systematic analysis of current evidence is needed to establish strong practice patterns and identify areas where further research is required...
September 5, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28887118/trabecular-meshwork-height-in-primary-open-angle-glaucoma-versus-primary-angle-closure-glaucoma
#9
Marisse Masis, Rebecca Chen, Travis Porco, Shan C Lin
PURPOSE: To determine if trabecular meshwork (TM) height differs between primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) eyes. Design; Prospective, cross-sectional clinical study. METHODS: Adult patients were consecutively recruited from glaucoma clinics at the University of California, San Francisco, from January 2012 to July 2015. Images were obtained from spectral-domain optical coherence tomography (Cirrus OCT, CarlZeiss Meditec, Inc...
September 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28887116/residual-angle-closure-one-year-after-laser-peripheral-iridotomy-in-primary-angle-closure-suspects
#10
Mani Baskaran, Elizabeth Yang, Sameer Trikha, Rajesh S Kumar, Hon Tym Wong, Mingguang He, Paul Tk Chew, Paul J Foster, David Friedman, Tin Aung
PURPOSE: To determine the incidence and baseline clinical and anterior segment optical coherence tomography (AS-OCT) predictors associated with residual angle closure as assessed by gonioscopy 1 year after laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS). DESIGN: Sub-analysis of randomized controlled trial data METHODS: AS-OCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from 181 PACS subjects ≥ 50 years of age, were analyzed using customized software, prior to, and 1 year after LPI...
September 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28886632/efficient-molecular-density-functional-theory-using-generalized-spherical-harmonics-expansions
#11
Lu Ding, Maximilien Levesque, Daniel Borgis, Luc Belloni
We show that generalized spherical harmonics are well suited for representing the space and orientation molecular density in the resolution of the molecular density functional theory. We consider the common system made of a rigid solute of arbitrary complexity immersed in a molecular solvent, both represented by molecules with interacting atomic sites and classical force fields. The molecular solvent density ρ(r,Ω) around the solute is a function of the position r≡(x,y,z) and of the three Euler angles Ω≡(θ,ϕ,ψ) describing the solvent orientation...
September 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28885674/the-outcome-of-transscleral-cyclophotocoagulation-for-the-management-of-acute-angle-closure
#12
Patrick J Chiam, Velota C T Sung
PURPOSE: To investigate the outcome of transscleral cyclophotocoagulation (TCP) in the treatment of acute angle closure (AAC) refractory to medical treatment. METHODS: This is a retrospective interventional case series. The inclusion criteria include patients diagnosed with AAC who had TCP. Pre-TCP and post-TCP intraocular pressure (IOP), visual acuity, and AAC treatment were analyzed. The complications and the results of subsequent treatments including lens extraction if performed were also assessed...
September 7, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28861686/bell-s-phenomenon-in-thyroid-associated-inferior-rectus-myopathy
#13
Yasuhiro Takahashi, Maria Suzanne Sabundayo, Hidenori Mito, Hidetaka Miyazaki, Hirohiko Kakizaki
PURPOSE: To examine Bell's phenomenon in patients with unilateral thyroid-associated inferior rectus myopathy and changes in this phenomenon after inferior rectus muscle recession. METHODS: This prospective interventional study included 12 patients who underwent inferior rectus muscle recession with or without nasal transposition. Bell's phenomenon was examined before and 3 months after surgery. The upper eyelid was held open by a finger to prevent complete eyelid closure...
September 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28861350/refractive-errors-and-biometry-of-primary-angle-closure-disease-in-a-mixed-malaysian-population
#14
Jelinar Mohamed-Noor, Dhaniah Abd-Salam
AIM: To assess the refractive status, anterior chamber depth (ACD) and axial length (AL) of patients with primary angle-closure disease (PACD). METHODS: Retrospective cohort. Data was collected from charts of all PACD patients treated from April 2013 to December 2015. Analysis was done on 137 patient charts with complete biometric data. Patient demographics, PACD type, refractive status (spherical equivalent), ACD and AL were studied. RESULTS: The median age of 137 subjects [53 with primary angle-closure suspects (PACS), 27 with primary angle-closure (PAC) and 57 with primary angle-closure glaucoma (PACG)] was 68y (range 21-88y)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28860528/pupillary-responses-to-light-are-not-affected-by-narrow-irido-corneal-angles
#15
A V Rukmini, Raymond P Najjar, Eray Atalay, Sourabh Sharma, Jing Zhan Lock, Mani Baskaran, Monisha Nongpiur, Joshua J Gooley, Tin Aung, Dan Milea
Chromatic pupillometry is an emerging method for evaluating ocular health that relies upon the differential stimulation of rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). Although it has been investigated in conditions affecting the outer or inner retina, there is a paucity of studies in conditions where the anterior chamber of the eye is affected. Primary angle closure suspects (PACS) are defined as eyes with narrow anterior chamber angles and intact retina. PACS patients are at risk of developing primary angle closure glaucoma and are prophylactically treated by performing laser peripheral iridotomy (LPI)...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858962/drug-induced-myopia-and-bilateral-angle-closure-secondary-to-zolmitriptan
#16
Jonathan Tak Loong Lee, Simon Edward Skalicky, Ming-Lee Lin
PURPOSE: To describe a unique case of drug-induced transient myopia with angle-closure glaucoma in a patient being treated with zolmitriptan for migraines. METHODS: A 42-year-old woman who had been using increasing amounts of zolmitriptan over the previous 12 months presented with an acute myopic shift and raised intraocular pressures (IOP) with anterior chamber shallowing. Clinical examination findings at presentation and at follow-up visits were reviewed. RESULTS: Initial examination revealed unaided visual acuities of 20/100 in the right eye and 20/125 in the left, with IOP measuring 34 mm Hg bilaterally...
August 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28858162/cost-effectiveness-of-phacoemulsification-versus-combined-phacotrabeculectomy-for-treating-primary-angle-closure-glaucoma
#17
Poemen P Chan, Emmy Y Li, Kelvin K F Tsoi, Yolanda Y Kwong, Clement C Tham
PURPOSE: To compare the cost effectiveness of phacoemulsification and combined phacotrabeculectomy for lowering intraocular pressure (IOP) in primary angle closure glaucoma (PACG) eyes with coexisting cataract. METHODS: Real-life data of two previous randomized control trials that involved 51 medically-uncontrolled PACG eyes and 72 medically-controlled PACG eyes were utilized to calculate the direct cost of treatment. They were followed-up for two years. Cost of pre-operative assessments, surgical interventions, additional procedures for managing complications and maintenance of filtration, post-operative follow-up, and cost of medications were considered...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28852187/in-vivo-confocal-microscopy-of-posner-schlossman-syndrome-comparison-with-herpes-simplex-keratitis-hla-b27-anterior-uveitis-and-acute-attack-of-primary-angle-closure
#18
Ying Hong, Miao Wang, Lingling Wu
To investigate in vivo confocal microscopy (IVCM) findings in patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM findings from the eyes of patients with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 eyes); HLA-B27 anterior uveitis (B27AU) (45 eyes); and with acute attack of primary angle closure (aPAC) (43 eyes). The central Langerhans cells (LCs) grade at the level of corneal basal epithelial cells of the PSS group (2.33 ± 0.55) was similar to that of the HSK group (2.63 ± 0...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833963/a-novel-technique-for-enterotomy-closure-in-stapled-laparoscopic-intracorporeal-anastomosis-ica
#19
Salomone Di Saverio, Arianna Birindelli, Edoardo Segalini, Sofia Todero, Razvan Andrei Botusan, Matteo Novello, Sherman Kwan, Antonio Biondi
INTRODUCTION: The proximal edge of the enterotomy in a side-to-side anastomosis has been shown to be the site at highest risk of leak. Several methods have been described to overcome this vulnerability. The technical challenge of Intra-Corporeal Anastomosis(ICA) is to re-create angles between tissues and instruments, similar to those in an open anastomosis. The axis between the suture line and the needle driver is paramount and this angle should be less than 45°. TECHNIQUE: The crotch-stitch of the enterotomy is difficult because of the narrow space between the loops and the depth of the anastomosis...
August 20, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28832670/peripapillary-retinal-splitting-visualized-on-oct-in-glaucoma-and-glaucoma-suspect-patients
#20
Dilraj S Grewal, Daniel J Merlau, Pushpanjali Giri, Marion R Munk, Amani A Fawzi, Lee M Jampol, Angelo P Tanna
PURPOSE: To identify the risk factors for development of peripapillary retinal splitting (schisis) in patients with glaucoma or suspicion of glaucoma. SETTING: Glaucoma Clinic, Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL. METHODS: In this institutional cross-sectional study, 495 patients (990 eyes) who had undergone spectral-domain optical coherence tomography (OCT Spectralis HRA-OCT, Heidelberg Engineering) optic nerve head (ONH) imaging and did not have identifiable optic nerve pits, pseudopits or coloboma were included...
2017: PloS One
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