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https://www.readbyqxmd.com/read/29778901/3d-printed-drug-delivery-and-testing-systems-a-passing-fad-or-the-future
#1
Seng Han Lim, Himanshu Kathuria, Justin Jia Yao Tan, Lifeng Kang
The US Food and Drug Administration approval of the first 3D printed tablet in 2015 has ignited growing interest in 3D printing, or additive manufacturing (AM), for drug delivery and testing systems. Beyond just a novel method for rapid prototyping, AM provides key advantages over traditional manufacturing of drug delivery and testing systems. These includes the ability to fabricate complex geometries to achieve variable drug release kinetics; ease of personalising pharmacotherapy for patient and lowering the cost for fabricating personalised dosages...
May 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29778877/an-insight-into-the-multi-scale-structures-and-pasting-behaviors-of-starch-following-citric-acid-treatment
#2
Yinqiang Huo, Binjia Zhang, Meng Niu, Caihua Jia, Siming Zhao, Qilin Huang, Hongying Du
Using combined analytical techniques, this work discloses how citric acid (CA) treatment affects the pasting features of starch from a view of multi-scale structural evolutions. The treatment induced disruption events in starch multi-level structures and thus modulated the pasting behaviors. A structure-property relationship was proposed to rationalize CA effects on starch pasting properties. Specifically, CA disrupted starch structures from molecular scale to micron scale, eventually reducing pasting temperature and paste viscosities...
May 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29778368/oral-dydrogesterone-for-luteal-phase-support-in-fresh-in-vitro-fertilization-cycles-a-new-standard
#3
REVIEW
Georg Griesinger, Christophe Blockeel, Herman Tournaye
Oral dydrogesterone has been used for luteal phase support on an empirical basis since the early days of in vitro fertilization (IVF) treatment. Systematic comparisons of oral dydrogesterone with vaginal progesterone, so far considered to be the standard of care, started to appear in the middle 2000s. Recently, a large, randomized, double-blind, double-dummy phase III trial on the use of daily 30 mg oral dydrogesterone versus daily 600 mg micronized vaginal progesterone for LPS in IVF was published. This company-sponsored trial confirmed the efficacy findings from previous independent researchers and firmly established the noninferiority of daily 30 mg oral dydrogesterone for luteal phase support...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778146/performance-and-mechanism-of-cr-vi-removal-by-zero-valent-iron-loaded-onto-expanded-graphite
#4
Congbin Xu, Wenjie Yang, Weijiang Liu, Hongliang Sun, Chunlei Jiao, Ai-Jun Lin
Zero-valent iron (ZVI) was loaded on expanded graphite (EG) to produce a composite material (EG-ZVI) for efficient removal of hexavalent chromium (Cr(VI)). EG and EG-ZVI were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) analysis. EG-ZVI had a high specific surface area and contained sub-micron sized particles of zero-valent iron. Batch experiments were employed to evaluate the Cr(VI) removal performance...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#5
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777389/iron-based-metal-organic-frameworks-as-a-theranostic-carrier-for-local-tuberculosis-therapy
#6
Gabriela Wyszogrodzka, Przemysław Dorożyński, Barbara Gil, Wieslaw J Roth, Maciej Strzempek, Bartosz Marszałek, Władysław P Węglarz, Elżbieta Menaszek, Weronika Strzempek, Piotr Kulinowski
PURPOSE: The purpose of the study was initial evaluation of applicability of metal organic framework (MOF) Fe-MIL-101-NH2 as a theranostic carrier of antituberculous drug in terms of its functionality, i.e. drug loading, drug dissolution, magnetic resonance imaging (MRI) contrast and cytotoxic safety. METHODS: Fe-MIL-101-NH2 was characterized using X-ray powder diffraction, FTIR spectrometry and scanning electron microscopy. The particle size analysis was determined using laser diffraction...
May 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29775544/recovery-of-glucose-from-dried-distiller-s-grain-with-solubles-using-combinations-of-solid-state-fermentation-and-insect-culture
#7
Timothy Howdeshell, Takuji Tanaka
A bioethanol byproduct (dried distiller's grains with solubles; DDGS) contains a high cellulose and starch. We hypothesized combinations of solid-state fermentation (SSF) and digestion by black soldier fly larvae (BSFL) (Hermetia illucens) could increase the recovery of glucose from this byproduct through concentrating and loosening cellulose matrix by their activities. DDGS was individually fermented with Aspergillus niger, Aspergillus fumigatus, Trichoderma koningii, Phanerochaete chrysosporium, or Lactobacillus plantarum...
May 18, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29775438/breakdown-of-water-super-permeation-in-electrically-insulating-graphene-oxide-films-role-of-dual-interlayer-spacing
#8
M K Kavitha, Tushar Sakorikar, Pramitha V, Manu Jaiswal
Conventional graphene oxide is characterized by low sp<sup>2</sup> content in a sp<sup>3</sup> rich matrix, which is responsible both for electrical insulation and water super-permeation. Upon reduction, electrical conduction is achieved at the expense of water permeation ability. Here, we demonstrate that charge conduction and water permeation can be simultaneously restricted in a functionalized form of graphene oxide. Gravimetric studies reveal that diffusion of water vapour through glassy polymer membranes is arrested by loading hydrophobic form of GO in the polymer matrix, even as such water inhibition cannot be realized by substantially increasing the thickness of the bare polymer...
May 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29775315/strain-mapping-of-two-dimensional-heterostructures-with-sub-picometer-precision
#9
Yimo Han, Kayla X Nguyen, Michael Cao, Paul D Cueva, Saien Xie, Mark W Tate, Prafull Purohit, Sol M Gruner, Jiwoong Park, David A Muller
Next-generation, atomically thin devices require in-plane, one-dimensional heterojunctions to electrically connect different two-dimensional (2D) materials. However, the lattice mismatch between most 2D materials leads to unavoidable strain, dislocations, or ripples, which can strongly affect their mechanical, optical, and electronic properties. We have developed an approach to map 2D heterojunction lattice and strain profiles with sub-picometer precision and the ability to identify dislocations and out-of-plane ripples...
May 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29774920/the-design-and-fabrication-of-supramolecular-semiconductor-nanowires-formed-by-benzothienobenzothiophene-btbt-conjugated-peptides
#10
Mohammad Aref Khalily, Hakan Usta, Mehmet Ozdemir, Gokhan Bakan, F Begum Dikecoglu, Charlotte Edwards-Gayle, Jessica A Hutchinson, Ian W Hamley, Aykutlu Dana, Mustafa O Guler
π-Conjugated small molecules based on a [1]benzothieno[3,2-b]benzothiophene (BTBT) unit are of great research interest in the development of solution-processable semiconducting materials owing to their excellent charge-transport characteristics. However, the BTBT π-core has yet to be demonstrated in the form of electro-active one-dimensional (1D) nanowires that are self-assembled in aqueous media for potential use in bioelectronics and tissue engineering. Here we report the design, synthesis, and self-assembly of benzothienobenzothiophene (BTBT)-peptide conjugates, the BTBT-peptide (BTBT-C3-COHN-Ahx-VVAGKK-Am) and the C8-BTBT-peptide (C8-BTBT-C3-COHN-Ahx-VVAGKK-Am), as β-sheet forming amphiphilic molecules, which self-assemble into highly uniform nanofibers in water with diameters of 11-13(±1) nm and micron-size lengths...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29771636/subcellular-topography-modulates-actin-dynamics-and-signaling-in-b-cells
#11
Christina M Ketchum, Xiaoyu Sun, Alexandra Suberi, John T Fourkas, Wenxia Song, Arpita Upadhyaya
B cell signaling activation is most effectively triggered by the binding of B cell receptors (BCRs) to membrane-bound antigens.  In vivo, B cells encounter antigen on antigen presenting cells (APC), which possess complex surfaces with convoluted topographies, a fluid membrane and deformable cell bodies. However, whether and how the physical properties of antigen presentation affect B cell activation is not well understood. Here, we use nanotopographic surfaces that allow systematic variation of geometric parameters to show that surface features on a subcellular scale influence B cell signaling and actin dynamics...
May 17, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29770999/paramagnetic-metal-ion-dopants-as-polarization-agents-for-dnp-nmr-spectroscopy-in-inorganic-solids
#12
Tanmoy Chakrabrty, Nir Goldin, Akiva Feintuch, Lothar Houben, Michal Leskes
Dynamic nuclear polarization (DNP), a technique in which the high electron spin polarization is transferred to surrounding nuclei via microwaves irradiation, equips solid state NMR spectroscopy with unprecedented sensitivity. The most commonly used polarization agents for DNP are nitroxide radicals. However, their applicability to inorganic materials is mostly limited to surface detection. Paramagnetic metal ions were recently introduced as alternatives for nitroxides. Doping inorganic solids with paramagnetic ions can be used to tune material properties and introduces endogenous DNP agents that can potentially provide sensitivity in the particles' bulk and surface...
May 17, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29770380/estimation-of-quantum-yields-of-weak-fluorescence-from-eosin-y-dimers-formed-in-aqueous-solutions
#13
Masami Enoki, Ryuzi Katoh
We studied the weak fluorescence from the dimer of eosin Y (EY) in aqueous solutions. We used a newly developed ultrathin optical cell with a thickness ranging from of the order of microns to several hundreds of microns to successfully measure the fluorescence spectra of highly concentrated aqueous solutions of EY without artifacts caused by the reabsorption of fluorescence. The spectra we obtained were similar to the fluorescence spectrum of the EY monomer; almost no fluorescence was observed from the EY dimer...
May 17, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29769763/quantitative-analysis-of-mast-cell-count-and-density-in-chronic-periodontal-disease
#14
Surekha Rathod, Anubha Raj, Ishita Wanikar
Background: Mast cells play a crucial role in activation of acquired immune response to inflammatory conditions of periodontal diseases. They promote inflammation by releasing pro-inflammatory mediators and bring about angiogenesis, degeneration of the extracellular matrix, and tissue remodeling. Since there is little literature regarding the role of mast cells in periodontitis, the present study was aimed to evaluate mast cell count (MCC) and density in periodontitis. Materials and Methods: A total of eighty participants, Group I ( n = 40) healthy participants and Group II ( n = 40) participants with moderate chronic periodontitis, were included in the study...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29768947/linking-back-to-back-stimulation-cycles-with-oral-contraceptives-or-progestins-in-women-undergoing-embryo-accumulation-for-preimplantation-genetic-testing-a-retrospective-study
#15
Jorge Rodriguez-Purata, Marta Devesa, Mónica Parriego, Clara Pardos, Ignacio Rodriguez, Nikolaos P Polyzos, Francisca Martínez, Buenaventura Coroleu
This retrospective study was carried out to determine which strategy is associated with improved outcomes in two back-to-back cycles when undergoing embryo accumulation. Eighty patients with two stimulation cycles performed with <45 days between retrievals between Jan'16-Mar'17 were included. Patients were segregated according to the strategy used to link stimulations: spontaneous menses (SM), vaginal micronized progesterone (VMP) or oral contraceptive pills (OCP). Main outcome measure was oocytes retrieved...
May 17, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29768485/choroidal-thickness-in-normal-indian-subjects-using-swept-source-optical-coherence-tomography
#16
Zeeshan Akhtar, Pukhraj Rishi, Ramasubramanian Srikanth, Ekta Rishi, Muna Bhende, Rajiv Raman
AIM: To determine choroidal thickness in healthy Indian subjects using Swept source optical coherence tomography (SS-OCT). METHODS: In this prospective, observational, cross-sectional study; healthy Indian subjects (n = 230) with no history of ocular and/or systemic disorders were enrolled in the study. Choroidal thickness was measured for 230 eyes using SS-OCT. Subjects were divided into six age groups. Main outcome measures were subfoveal choroidal thickness (SFCT) and macular choroidal thickness (MCT) up to 3 mm at 500-micron interval from the fovea was measured in eight different quadrants...
2018: PloS One
https://www.readbyqxmd.com/read/29765939/comparing-the-relative-interfacial-affinity-of-soft-colloids-with-different-crosslinking-densities-in-pickering-emulsions
#17
Man-Hin Kwok, To Ngai
Pickering emulsions prepared by various kinds of soft colloids such as the poly( N -isopropylacrylamide) (PNIPAM)-based microgels, have been studied for decades in order to fabricate stimuli-responsive emulsions. It has been generally viewed that the interfacial properties of the microgel monolayers and the emulsion stability are dominated by the softness or deformability of the microgel particles. However, there is still no convenient way to characterize the adsorption/desorption energy of the microgels at the interface although this is an essential topic for microgel-stabilized emulsions...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29764922/introduction-to-thematic-review-series-on-extracellular-vesicles-a-focus-on-the-role-of-lipids
#18
Michel Record
An additional mechanism of intercellular communication has been unveiled by the characterization of extracellular vesicles, namely exosomes and microvesicles, released from viable cells and concentrating selected molecules from the parental cells and able to be addressed far from the emitting cells. Exosomes are naturally engineered nanovesicles, while microvesicles scale up to micron size. Among the numerous and diverse molecules they carry, these extracellular vesicles also contain a variety of lipid mediators...
May 15, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29763298/cooperative-assembly-of-hsp70-subdomain-clusters
#19
Maya A Wright, Francesco Antonio Aprile, Mathias Mj Bellaiche, Thomas C T Michaels, Thomas Müller, Paolo Arosio, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles
Many molecular chaperones exist as oligomeric complexes in their functional states, yet the physical determinants underlying such self-assembly behaviour, as well as the role of oligomerisation in the activity of molecular chaperones in inhibiting protein aggregation, have proved difficult to define. Here, we demonstrate direct measurements under native conditions of the changes in the average oligomer populations of a chaperone system as a function of concentration and time, and thus determine the thermodynamic and kinetic parameters governing the self-assembly process...
May 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29762732/calcium-particle-size-effects-on-plasma-excreta-and-urinary-ca-and-p-changes-in-broiler-breeder-hens
#20
M K Manangi, P Maharjan, C N Coon
An experiment was conducted using non-colostomized and colostomized broiler breeder hens to determine the effects of feeding limestone of 2 different mean particle sizes (185 microns and 3490 microns) on P excretion, total P and Ca retention, and urinary P and Ca excretion during a 6-week feeding study. Additionally, changes in plasma inorganic P (iP) and ionic Ca (Ca++) and urinary excretion of P and Ca were determined in one egg laying cycle of 24 hours. One-hundred-fifty non-colostomized and 6 colostomized broiler breeder hens, 30 wk of age, were divided into 2 groups and fed broiler breeder diets supplemented with either small particle or large particle limestone...
May 11, 2018: Poultry Science
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