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https://www.readbyqxmd.com/read/28945060/benefits-of-micronized-purified-flavonoid-fraction-as-adjuvant-therapy-on-the-inflammatory-response-after-sclerotherapy
#1
Vadim Y Bogachev, Boris V Boldin, Victor N Lobanov
BACKGROUND: Sclerotherapy is the treatment of choice for telangiectasias. The aim of this study was to investigate the systemic and local inflammatory response after sclerotherapy in women with chronic venous disease (CVD) and to assess the effects of micronized purified flavonoid fraction (MPFF) in combination with sclerotherapy on markers of inflammation and endothelial dysfunction. METHODS: 60 women with primary CVD CEAP class C1 were randomly assigned sclerotherapy in combination with MPFF treatment (N=30) or sclerotherapy alone (control) group (N=30)...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28944279/imaging-subcellular-dynamics-with-fast-and-light-efficient-volumetrically-parallelized-microscopy
#2
Kevin M Dean, Philippe Roudot, Erik S Welf, Theresa Pohlkamp, Gerard Garrelts, Joachim Herz, Reto Fiolka
In fluorescence microscopy, the serial acquisition of 2D images to form a 3D volume limits the maximum imaging speed. This is particularly evident when imaging adherent cells in a light-sheet fluorescence microscopy format, as their elongated morphologies require ~200 image planes per image volume. Here, by illuminating the specimen with three light-sheets, each independently detected, we present a light-efficient, crosstalk free, and volumetrically parallelized 3D microscopy technique that is optimized for high-speed (up to 14 Hz) subcellular (300 nm lateral, 600 nm axial resolution) imaging of adherent cells...
February 20, 2017: Optica
https://www.readbyqxmd.com/read/28942068/in-situ-crosslinking-of-surface-initiated-ring-opening-metathesis-polymerization-of-polynorbornene-for-improved-stability
#3
Ishan A Fursule, Ashkan Abtahi, Charles B Watkins, Kenneth R Graham, Brad J Berron
HYPOTHESIS: In situ crosslinking is expected to increase the solvent stability of coatings formed by surface-initiated ring opening metathesis polymerization (SI ROMP). Solvent-associated degradation limits the utility of SI ROMP coatings. SI ROMP coatings have a unique capacity for post-functionalization through reaction of the unsaturated site on the polymer backbone. Any post-reaction scheme which requires a liquid solvent has the potential to degrade the coating and lower the thickness of the resulting film...
September 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28942008/transport-of-ellipsoid-fibers-in-oscillatory-shear-flows-implications-for-aerosol-deposition-in-deep-airways
#4
Lihi Shachar-Berman, Yan Ostrovski, Alessandro De Rosis, Stavros Kassinos, Josué Sznitman
It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their aerodynamic properties; these particles tend to align with the flow and thus stay longer airborne relative to their spherical counterpart, due to higher drag forces that resist sedimentation. Together with a high surface-to-volume ratio, such characteristics may render non-spherical particles, and fibers in particular, potentially attractive airborne carriers for drug delivery...
September 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28941957/challenges-associated-with-the-behaviour-of-radioactive-particles-in-the-environment
#5
Brit Salbu, Valery Kashparov, Ole Christian Lind, Rafael Garcia-Tenorio, Mathew P Johansen, David P Child, Per Roos, Carlos Sancho
A series of different nuclear sources associated with the nuclear weapon and fuel cycles have contributed to the release of radioactive particles to the environment. Following nuclear weapon tests, safety tests, conventional destruction of weapons, reactor explosions and fires, a major fraction of released refractory radionuclides such as uranium (U) and plutonium (Pu) were present as entities ranging from sub microns to fragments. Furthermore, radioactive particles and colloids have been released from reprocessing facilities and civil reactors, from radioactive waste dumped at sea, and from NORM sites...
September 20, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28941170/imaging-flow-cytometry-assays-for-quantifying-pigment-grade-titanium-dioxide-particle-internalization-and-interactions-with-immune-cells-in-whole-blood
#6
Rachel E Hewitt, Bradley Vis, Laetitia C Pele, Nuno Faria, Jonathan J Powell
Pigment grade titanium dioxide is composed of sub-micron sized particles, including a nanofraction, and is widely utilized in food, cosmetic, pharmaceutical, and biomedical industries. Oral exposure to pigment grade titanium dioxide results in at least some material entering the circulation in humans, although subsequent interactions with blood immune cells are unknown. Pigment grade titanium dioxide is employed for its strong light scattering properties, and this work exploited that attribute to determine whether single cell-particle associations could be determined in immune cells of human whole blood at "real life" concentrations...
September 20, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28939809/radiation-forces-of-beams-generated-by-gaussian-mirror-resonator-on-a-rayleigh-dielectric-sphere
#7
Bin Tang, Kai Chen, Lirong Bian, Xin Zhou, Li Huang, Yi Jin
Optical trapping and manipulating of micron-sized particles have attracted enormous interests due to the potential applications in biotechnology and nanoscience. In this work, we investigate numerically and theoretically the radiation forces acting on a Rayleigh dielectric particle produced by beams generated by Gaussian mirror resonator (GMR) in the Rayleigh scattering regime. The results show that the focused beams generated by GMR can be used to trap and manipulate the particles with both high and low index of refractive near the focus point...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28938733/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#8
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
No abstract text is available yet for this article.
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938214/dermal-transfer-and-environmental-release-of-ceo2-nanoparticles-used-as-uv-inhibitors-on-outdoor-surfaces-implications-for-human-and-environmental-health
#9
Justin G Clar, William E Platten, Eric J Baumann, Andrew Remsen, Steve M Harmon, Christina L Bennett-Stamper, Treye A Thomas, Todd P Luxton
A major area of growth for "nano-enabled" consumer products have been surface coatings, including paints stains and sealants. Ceria (CeO2) nanoparticles (NPs) are of interest as they have been used as additives in these these products to increase UV resistance. Currently, there is a lack of detailed information on the potential release, and speciation (i.e., ion vs. particle) of CeO2 NPs used in consumer-available surface coatings during intended use scenarios. In this study, both Micronized-Copper Azole pressure-treated lumber (MCA), and a commercially available composite decking were coated with CeO2 NPs dispersed in Milli-Q water or wood stain...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28937366/correlation-between-human-epidermal-growth-factor-receptor-2-oncoprotein-expression-and-some-prognostic-factors-in-papillary-thyroid-carcinoma
#10
Shervin Rabiee, Mohamadreza Jalali Nadoushan, Neda Mehdizade Rayeni, Iman Ansari
BACKGROUND: Thyroid cancer is one of the increasing cancer diagnoses in the United States. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. There are a few researches done determining the role of human epidermal growth factor receptor 2 HER2 (erbB-2) in PTC prognosis. They also have been controversial. This study is designed to determine the correlation of HER2 expression with tumor size, lymph node involvement, and capsular invasion as prognostic factors. MATERIALS AND METHODS: This research was a cross-sectional descriptive-analytic study...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936528/continuous-electroosmotic-sorting-of-particles-in-grooved-microchannels
#11
Alexander L Dubov, Taras Y Molotilin, Olga I Vinogradova
We propose a novel microfluidic fractionation concept suitable for neutrally buoyant micron-sized particles. This approach takes advantage of the ability of grooved channel walls oriented at an angle to the direction of an external electric field to generate a transverse electroosmotic flow. Using computer simulations, we first demonstrate that the velocity of this secondary transverse flow depends on the distance from the wall, so neutrally buoyant particles, depending on their size and initial location, will experience different lateral displacements...
September 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28936029/silicon-nanoporous-membranes-as-a-rigorous-platform-for-validation-of-biomolecular-transport-models
#12
Benjamin J Feinberg, Jeff C Hsiao, Jaehyun Park, Andrew L Zydney, William H Fissell, Shuvo Roy
Microelectromechanical systems (MEMS), a technology that resulted from significant innovation in semiconductor fabrication, have recently been applied to the development of silicon nanopore membranes (SNM). In contrast to membranes fabricated from polymeric materials, SNM exhibit slit-shaped pores, monodisperse pore size, constant surface porosity, zero pore overlap, and sub-micron thickness. This development in membrane fabrication is applied herein for the validation of the XDLVO (extended Derjaguin, Landau, Verwey, and Overbeek) theory of membrane transport within the context of hemofiltration...
August 15, 2017: Journal of Membrane Science
https://www.readbyqxmd.com/read/28935816/forces-to-pierce-cuticle-of-tarsi-and-material-properties-determined-by-nanoindentation-the-achilles-heel-of-bed-bugs
#13
Jorge Bustamante, Jason F Panzarino, Timothy J Rupert, Catherine Loudon
The mechanical properties of bed bug (Cimex lectularius L.) tarsi and pretarsi were investigated in order to evaluate their vulnerability to piercing by plant trichomes (sharp microscopic hairs). Nanoindentation was used to measure the force required to insert a sharp probe into the cuticle of these different regions, as well as to determine creep and reduced elastic moduli for the cuticle. Scanning electron microscopy was used to visualize the indents that had been generated by nanoindentation. The force required to insert a cube corner nanoindenter probe into the cuticle was determined for a range of displacements (1 to 9 µm) and strain rates (0...
September 21, 2017: Biology Open
https://www.readbyqxmd.com/read/28933148/frequency-selective-photobleaching-as-a-route-to-chromatic-control-in-supramolecular-oled-devices
#14
Yu-Tang Tsai, Hsiang-Fang Liu, Bo-Ji Peng, Kuo-Pi Tseng, Ming-Cheng Kuo, Ken-Tsung Wong, Guillaume Wantz, Lionel Hirsch, Guillaume Raffy, André Del Guerzo, Dario M Bassani
We report a series of molecules that spontaneously self-organize into small electroluminescent domains of sub-micrometer dimensions when dissolved in tetrahydrofuran. The self-assembled spherical aggregates have an average size of 300 nm in diameter and exhibit effient energy transfer from the blue to the green or red component. The aggregates can be chromatically addressed or patterned by selective bleaching the energy acceptor component using a laser source. This allows the fabrication of electroluminescence devices by directly photopatterning the active layer without the need of additional steps...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28932168/the-structural-coloration-of-textile-materials-using-self-assembled-silica-nanoparticles
#15
Weihong Gao, Muriel Rigout, Huw Owens
The work presented investigates how to produce structural colours on textile materials by applying a surface coating of silica nanoparticles (SNPs). Uniform SNPs with particle diameters in a controlled micron size range (207-350 nm) were synthesized using a Stöber-based solvent varying (SV) method which has been reported previously. Photonic crystals (PCs) were formed on the surface of a piece of textile fabric through a process of natural sedimentation self-assembly of the colloidal suspension containing uniform SNPs...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28931866/ion-channel-aligned-gas-blocking-membrane-for-lithium-air-batteries
#16
Wonsung Choi, Mokwon Kim, Jung Ock Park, Joon-Hee Kim, Kyunghwan Choi, Yong Su Kim, Tae Young Kim, Ken Ogata, Dongmin Im, Seok-Gwang Doo, Yunil Hwang
Lithium-metal-based batteries, owing to the extremely high specific energy, have been attracting intense interests as post-Li-ion batteries. However, their main drawback is that consumption/de-activation of lithium metal can be accelerated when O2 or S used in the cathode crosses over to the metal, reducing the lifetime of the batteries. In use of ceramic solid state electrolyte (SSE) separator, despite the capability of gas blocking, thick and heavy plates (~0.3 mm) are necessitated to compensate its mechanical fragility, which ruin the high specific energy of the batteries...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931814/optical-trapping-of-otoliths-drives-vestibular-behaviours-in-larval-zebrafish
#17
Itia A Favre-Bulle, Alexander B Stilgoe, Halina Rubinsztein-Dunlop, Ethan K Scott
The vestibular system, which detects gravity and motion, is crucial to survival, but the neural circuits processing vestibular information remain incompletely characterised. In part, this is because the movement needed to stimulate the vestibular system hampers traditional neuroscientific methods. Optical trapping uses focussed light to apply forces to targeted objects, typically ranging from nanometres to a few microns across. In principle, optical trapping of the otoliths (ear stones) could produce fictive vestibular stimuli in a stationary animal...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28931809/automatic-and-adaptive-heterogeneous-refractive-index-compensation-for-light-sheet-microscopy
#18
Duncan P Ryan, Elizabeth A Gould, Gregory J Seedorf, Omid Masihzadeh, Steven H Abman, Sukumar Vijayaraghavan, Wendy B Macklin, Diego Restrepo, Douglas P Shepherd
Optical tissue clearing has revolutionized researchers' ability to perform fluorescent measurements of molecules, cells, and structures within intact tissue. One common complication to all optically cleared tissue is a spatially heterogeneous refractive index, leading to light scattering and first-order defocus. We designed C-DSLM (cleared tissue digital scanned light-sheet microscopy) as a low-cost method intended to automatically generate in-focus images of cleared tissue. We demonstrate the flexibility and power of C-DSLM by quantifying fluorescent features in tissue from multiple animal models using refractive index matched and mismatched microscope objectives...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28928274/the-ubiquitin-ligase-e3-psh1p-is-required-for-proper-segregation-of-both-centromeric-and-two-micron-plasmids-in-saccharomyces-cerevisiae
#19
Meredith B Metzger, Jessica L Scales, Mitchell F Dunklebarger, Allan M Weissman
Protein degradation by the ubiquitin-proteasome system is essential to many processes. We sought to assess its involvement in the turnover of mitochondrial proteins in Saccharomyces cerevisiae We find that deletion of a specific ubiquitin ligase (E3), Psh1p, increases the abundance of a temperature-sensitive mitochondrial protein, mia40-4pHA, when it is expressed from a centromeric plasmid. Deletion of Psh1p unexpectedly elevates the levels of other proteins expressed from centromeric plasmids. Loss of Psh1p does not increase the rate of turn-over of mia40-4pHA, affect total protein synthesis, or increase the protein levels of chromosomal genes...
September 19, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28927590/advanced-technology-for-nanostarches-preparation-by-high-speed-jet-and-its-mechanism-analysis
#20
Wen Xia, Dong-Ning He, Yun-Fei Fu, Xiao-Yi Wei, Hong-Chao Liu, Jiang-Ping Ye, Yun-Fei Liu, Ji-Hua Li
Nanostarches were successfully prepared by high speed jet (HSJ) after pretreatment of micronization. The nanostarches were obtained at the conditions of micronization treatment for 60min, and then one cycle at 240MPa of HSJ (188.1nm). Moreover, after HSJ treated for three cycles, the particle size could reach the level of nanometer materials (66.94nm). The physicochemical properties of nanostarches had been characterized. Rapid Visco-Analysis (RVA) showed that the viscosity of nanostarches significantly decreased compared with native tapioca starch and slightly decreased with increasing processing cycles of HSJ...
November 15, 2017: Carbohydrate Polymers
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