keyword
MENU ▼
Read by QxMD icon Read
search

Liconic

keyword
https://www.readbyqxmd.com/read/27626102/diphenylether-modified-1-2-diamines-with-improved-drug-properties-for-development-against-mycobacterium-tuberculosis
#1
Marie H Foss, Sovitj Pou, Patrick M Davidson, Jennifer L Dunaj, Rolf W Winter, Sovijja Pou, Meredith H Licon, Julia K Doh, Yuexin Li, Jane X Kelly, Rozalia A Dodean, Dennis R Koop, Michael K Riscoe, Georgiana E Purdy
New treatments for tuberculosis infection are critical to combat the emergence of multidrug- and extensively drug-resistant Mycobacterium tuberculosis (Mtb). We report the characterization of a diphenylether-modified adamantyl 1,2-diamine that we refer to as TBL-140, which has a minimal inhibitory concentration (MIC99) of 1.2 μg/mL. TBL-140 is effective against drug-resistant Mtb and nonreplicating bacteria. In addition, TBL-140 eliminates expansion of Mtb in cell culture infection assays at its MIC. To define the mechanism of action of this compound, we performed a spontaneous mutant screen and biochemical assays...
July 8, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27453043/a-network-of-conserved-synthetic-lethal-interactions-for-exploration-of-precision-cancer-therapy
#2
Rohith Srivas, John Paul Shen, Chih Cheng Yang, Su Ming Sun, Jianfeng Li, Andrew M Gross, James Jensen, Katherine Licon, Ana Bojorquez-Gomez, Kristin Klepper, Justin Huang, Daniel Pekin, Jia L Xu, Huwate Yeerna, Vignesh Sivaganesh, Leonie Kollenstart, Haico van Attikum, Pedro Aza-Blanc, Robert W Sobol, Trey Ideker
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and genes encoding drug targets across multiple genotoxic environments. Guided by the strongest signal, we evaluate thousands of TSG-drug combinations in HeLa cells, resulting in networks of conserved synthetic lethal interactions...
August 4, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27254649/notes-from-the-field-increase-in-neisseria-meningitidis-associated-urethritis-among-men-at-two-sentinel-clinics-columbus-ohio-and-oakland-county-michigan-2015
#3
Jose A Bazan, Amy S Peterson, Robert D Kirkcaldy, Elizabeth C Briere, Courtney Maierhofer, Abigail Norris Turner, Denisse B Licon, Nicole Parker, Amanda Dennison, Melissa Ervin, Laura Johnson, Barbara Weberman, Pamela Hackert, Xin Wang, Cecilia B Kretz, A Jeanine Abrams, David L Trees, Carlos Del Rio, David S Stephens, Yih-Ling Tzeng, Mary DiOrio, Mysheika Williams Roberts
Neisseria meningitidis (Nm) urogenital infections, although less common than infections caused by Neisseria gonorrhoeae (Ng), have been associated with urethritis, cervicitis, proctitis, and pelvic inflammatory disease. Nm can appear similar to Ng on Gram stain analysis (gram-negative intracellular diplococci) (1-5). Because Nm colonizes the nasopharynx, men who receive oral sex (fellatio) can acquire urethral Nm infections (1,3,5). This report describes an increase in Nm-associated urethritis in men attending sexual health clinics in Columbus, Ohio, and Oakland County, Michigan...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27105112/methylome-wide-analysis-of-chronic-hiv-infection-reveals-five-year-increase-in-biological-age-and-epigenetic-targeting-of-hla
#4
Andrew M Gross, Philipp A Jaeger, Jason F Kreisberg, Katherine Licon, Kristen L Jepsen, Mahdieh Khosroheidari, Brenda M Morsey, Susan Swindells, Hui Shen, Cherie T Ng, Ken Flagg, Daniel Chen, Kang Zhang, Howard S Fox, Trey Ideker
HIV-infected individuals are living longer on antiretroviral therapy, but many patients display signs that in some ways resemble premature aging. To investigate and quantify the impact of chronic HIV infection on aging, we report a global analysis of the whole-blood DNA methylomes of 137 HIV+ individuals under sustained therapy along with 44 matched HIV- individuals. First, we develop and validate epigenetic models of aging that are independent of blood cell composition. Using these models, we find that both chronic and recent HIV infection lead to an average aging advancement of 4...
April 21, 2016: Molecular Cell
https://www.readbyqxmd.com/read/26949740/translation-of-genotype-to-phenotype-by-a-hierarchy-of-cell-subsystems
#5
Michael Ku Yu, Michael Kramer, Janusz Dutkowski, Rohith Srivas, Katherine Licon, Jason Kreisberg, Cherie T Ng, Nevan Krogan, Roded Sharan, Trey Ideker
Accurately translating genotype to phenotype requires accounting for the functional impact of genetic variation at many biological scales. Here we present a strategy for genotype-phenotype reasoning based on existing knowledge of cellular subsystems. These subsystems and their hierarchical organization are defined by the Gene Ontology or a complementary ontology inferred directly from previously published datasets. Guided by the ontology's hierarchical structure, we organize genotype data into an "ontotype," that is, a hierarchy of perturbations representing the effects of genetic variation at multiple cellular scales...
February 24, 2016: Cell Systems
https://www.readbyqxmd.com/read/26775035/-diabetes-and-type-of-diet-as-determinant-factor-in-the-progression-of-atherosclerosis
#6
Adriana Leticia Perales-Torres, Octelina Castillo-Ruíz, María Teresa Castañeda Licón, Sanjuana E Alemán-Castillo, Juan Miguel Jiménez Andrade
The purpose of this review is to analyze the biochemical progression of atherosclerotic plaque and its association with diet and diabetes. This study shows the scientific evidence of demonstrating that diabetic patients present high levels of fatty acids like palmitic acid and linoleic acid in their atheroma plaques in comparison with non-diabetic patients. This study also establishes how patients with diabetes mellitus have a higher prevalence of atherosclerotic heart diseases in the form of Coronary Thrombosis and have different anatomopathological appearance like higher necrotic core and thin fibrotic layer than the general population...
October 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/26437225/chemogenetic-profiling-identifies-rad17-as-synthetically-lethal-with-checkpoint-kinase-inhibition
#7
John Paul Shen, Rohith Srivas, Andrew Gross, Jianfeng Li, Eric J Jaehnig, Su Ming Sun, Ana Bojorquez-Gomez, Katherine Licon, Vignesh Sivaganesh, Jia L Xu, Kristin Klepper, Huwate Yeerna, Daniel Pekin, Chu Ping Qiu, Haico van Attikum, Robert W Sobol, Trey Ideker
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synthetic lethal interactions with inhibitors of the CHEK1 and CHEK2 checkpoint kinases. We identified eight interactions, including the Replication Factor C (RFC)-related protein RAD17. Clonogenic assays in RAD17 knockdown cell lines identified a substantial shift in sensitivity to checkpoint kinase inhibition (3...
November 3, 2015: Oncotarget
https://www.readbyqxmd.com/read/26404172/predictors-of-hypomania-during-ventral-capsule-ventral-striatum-deep-brain-stimulation
#8
Alik S Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R Arulpragasam, Joan A Camprodon, Cristina Cusin, Emad N Eskandar, Thilo Deckersbach, Darin D Dougherty
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact...
2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/26362239/crystal-structure-of-the-mycobacterium-tuberculosis-transcriptional-regulator-rv0302
#9
Tsung-Han Chou, Jared A Delmar, Catherine C Wright, Nitin Kumar, Abhijith Radhakrishnan, Julia K Doh, Meredith H Licon, Jani Reddy Bolla, Hsiang-Ting Lei, Kanagalaghatta R Rajashankar, Chih-Chia Su, Georgiana E Purdy, Edward W Yu
Mycobacterium tuberculosis is a pathogenic bacterial species, which is neither Gram positive nor Gram negative. It has a unique cell wall, making it difficult to kill and conferring resistance to antibiotics that disrupt cell wall biosynthesis. Thus, the mycobacterial cell wall is critical to the virulence of these pathogens. Recent work shows that the mycobacterial membrane protein large (MmpL) family of transporters contributes to cell wall biosynthesis by exporting fatty acids and lipidic elements of the cell wall...
December 2015: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/26047191/biological-aspects-of-crosses-between-triatoma-recurva-st%C3%A3-l-1868-hemiptera-reduviidae-triatominae-and-other-members-of-the-phyllosoma-complex
#10
José Alejandro Martínez-Ibarra, Benjamín Nogueda-Torres, Ángel Licón-Trillo, Ricardo Alejandre-Aguilar, Paz María Salazar-Schettino, Mauro Omar Vences-Blanco
The degree of reproductive isolation between Triatoma recurva (Stål) (Hemiptera: Reduviidae: Triatominae) and the six species of the genus Meccus plus T. mexicana (Herrich-Schaeffer) (Hemiptera: Reduviidae) was examined. Fertility and the segregation of morphological characteristics were examined in two generations of hybrids from crosses between these species. The percentage of couples with offspring (fertile) was low in the vast majority of sets of crosses, with the exception of that between T. recurva female and M...
June 2015: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/25890064/genotype-diversity-of-trypanosoma-cruzi-in-small-rodents-and-triatoma-sanguisuga-from-a-rural-area-in-new-orleans-louisiana
#11
Claudia P Herrera, Meredith H Licon, Catherine S Nation, Samuel B Jameson, Dawn M Wesson
BACKGROUND: Chagas disease is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi that represents a major public health problem in Latin America. Although the United States is defined as non-endemic for Chagas disease due to the rarity of human cases, the presence of T. cruzi has now been amply demonstrated as enzootic in different regions of the south of the country from Georgia to California. In southeastern Louisiana, a high T. cruzi infection rate has been demonstrated in Triatoma sanguisuga, the local vector in this area...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25779267/genotype-diversity-of-trypanosoma-cruzi-in-small-rodents-and-triatoma-sanguisuga-from-a-rural-area-in-new-orleans-louisiana
#12
Claudia P Herrera, Meredith H Licon, Catherine S Nation, Samuel B Jameson, Dawn M Wesson
BACKGROUND: Chagas disease is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi that represents a major public health problem in Latin America. Although the United States is defined as non-endemic for Chagas disease due to the rarity of human cases, the presence of T. cruzi has now been amply demonstrated as enzootic in different regions of the south of the country from Georgia to California. In southeastern Louisiana, a high T. cruzi infection rate has been demonstrated in Triatoma sanguisuga, the local vector in this area...
December 2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25777298/the-power-decoder-simulator-for-the-evaluation-of-pooled-shrna-screen-performance
#13
Jesse Stombaugh, Abel Licon, Žaklina Strezoska, Joshua Stahl, Sarah Bael Anderson, Michael Banos, Anja van Brabant Smith, Amanda Birmingham, Annaleen Vermeulen
RNA interference screening using pooled, short hairpin RNA (shRNA) is a powerful, high-throughput tool for determining the biological relevance of genes for a phenotype. Assessing an shRNA pooled screen's performance is difficult in practice; one can estimate the performance only by using reproducibility as a proxy for power or by employing a large number of validated positive and negative controls. Here, we develop an open-source software tool, the Power Decoder simulator, for generating shRNA pooled screening experiments in silico that can be used to estimate a screen's statistical power...
September 2015: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/25715771/sec31a-alk-fusion-gene-in-lung-adenocarcinoma
#14
Ryong Nam Kim, Yoon-La Choi, Mi-Sook Lee, Maruja E Lira, Mao Mao, Derrick Mann, Joshua Stahl, Abel Licon, So Jung Choi, Michael Van Vrancken, Joungho Han, Iwona Wlodarska, Jhingook Kim
Anaplastic lymphoma kinase (ALK) fusion is a common mechanism underlying pathogenesis of non-small cell lung carcinoma (NSCLC) where these rearrangements represent important diagnostic and therapeutic targets. In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. The conjoined region in the fusion transcript was generated by the fusion of SEC31A exon 21 and ALK exon 20 by genomic rearrangement, which contributed to generation of an intact, in-frame open reading frame...
January 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/25705724/a-dynamic-programming-algorithm-for-finding-the-optimal-segmentation-of-an-rna-sequence-in-secondary-structure-predictions
#15
Abel Licon, Michela Taufer, Ming-Ying Leung, Kyle L Johnson
In this paper, we present a dynamic programming algorithm that runs in polynomial time and allows us to achieve the optimal, non-overlapping segmentation of a long RNA sequence into segments (chunks). The secondary structure of each chunk is predicted independently, then combined with the structures predicted for the other chunks, to generate a complete secondary structure prediction that is thus a combination of local energy minima. The proposed approach not only is more efficient and accurate than other traditionally used methods that are based on global energy minimizations, but it also allows scientists to overcome computing and storage constraints when trying to predict the secondary structure of long RNA sequences...
March 2010: International Conference on Bioinformatics and Computational Biology 2010: BICoB-2010
https://www.readbyqxmd.com/read/25204428/inhibition-of-cav2-3-channels-by-nk1-receptors-is-sensitive-to-membrane-cholesterol-but-insensitive-to-caveolin-1
#16
Yamhilette Licon, Deniss Leandro, Catalina Romero-Mendez, Aldo A Rodriguez-Menchaca, Sergio Sanchez-Armass, Ulises Meza
Voltage-gated, CaV2.3 calcium channels and neurokinin-1 (NK1) receptors are both present in nuclei of the central nervous system. When transiently coexpressed in human embryonic kidney (HEK) 293 cells, CaV2.3 is primarily inhibited during strong, agonist-dependent activation of NK1 receptors. NK1 receptors localize to plasma membrane rafts, and their modulation by Gq/11 protein-coupled signaling is sensitive to plasma membrane cholesterol. Here, we show that inhibition of CaV2.3 by NK1 receptors is attenuated following methyl-β-cyclodextrin (MBCD)-mediated depletion of membrane cholesterol...
August 2015: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/24460609/%C3%AE-alanine-suppresses-malignant-breast-epithelial-cell-aggressiveness-through-alterations-in-metabolism-and-cellular-acidity-in-vitro
#17
Roger A Vaughan, Nicholas P Gannon, Randi Garcia-Smith, Yamhilette Licon-Munoz, Miguel A Barberena, Marco Bisoffi, Kristina A Trujillo
BACKGROUND: Deregulated energetics is a property of most cancer cells. This phenomenon, known as the Warburg Effect or aerobic glycolysis, is characterized by increased glucose uptake, lactate export and extracellular acidification, even in the presence of oxygen. β-alanine is a non-essential amino acid that has previously been shown to be metabolized into carnosine, which functions as an intracellular buffer. Because of this buffering capacity, we investigated the effects of β-alanine on the metabolic cancerous phenotype...
2014: Molecular Cancer
https://www.readbyqxmd.com/read/24360959/a-uv-induced-genetic-network-links-the-rsc-complex-to-nucleotide-excision-repair-and-shows-dose-dependent-rewiring
#18
Rohith Srivas, Thomas Costelloe, Anne-Ruxandra Carvunis, Sovan Sarkar, Erik Malta, Su Ming Sun, Marijke Pool, Katherine Licon, Tibor van Welsem, Fred van Leeuwen, Peter J McHugh, Haico van Attikum, Trey Ideker
Efficient repair of UV-induced DNA damage requires the precise coordination of nucleotide excision repair (NER) with numerous other biological processes. To map this crosstalk, we generated a differential genetic interaction map centered on quantitative growth measurements of >45,000 double mutants before and after different doses of UV radiation. Integration of genetic data with physical interaction networks identified a global map of 89 UV-induced functional interactions among 62 protein complexes, including a number of links between the RSC complex and several NER factors...
December 26, 2013: Cell Reports
https://www.readbyqxmd.com/read/24034221/electrokinetics-in-undeveloped-flows
#19
Andriy Yaroshchuk, Edxon Eduardo Licón Bernal, Thomas Luxbacher
For the correct interpretation of results of tangential electrokinetic measurements with porous materials, in particular, composite/asymmetric membranes on porous supports, it is necessary to have the data available for various channel heights. In some kinds of equipment, the variation of channel height is technically possible only for a range of relatively large heights. This communication shows that under these conditions, the fluid flow can become undeveloped and the conventional approaches to the interpretation of electrokinetic measurements should be modified accordingly...
November 15, 2013: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/23902372/separation-of-ions-using-polyelectrolyte-modified-nanoporous-track-etched-membranes
#20
Jason A Armstrong, Edxon Eduardo Licón Bernal, Andriy Yaroshchuk, Merlin L Bruening
Selective ion exclusion from charged nanopores in track-etched membranes allows separation of ions with different charges or mobilities. This study examines pressure-driven transport of dissolved ions through track-etched membranes modified by adsorption of poly(styrene sulfonate) (PSS)/protonated poly(allylamine) (PAH) films. For nominal 30 nm pores modified with a single layer of PSS, Br(-)/SO4(2-) selectivities are ∼3.4 with SO4(2-) rejections around 85% due to selective electrostatic exclusion of the divalent anion from the negatively charged pore...
August 13, 2013: Langmuir: the ACS Journal of Surfaces and Colloids
keyword
keyword
68031
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"