keyword
MENU ▼
Read by QxMD icon Read
search

defensin

keyword
https://www.readbyqxmd.com/read/28430679/cervicovaginal-levels-of-human-%C3%AE-defensin-1-2-3-and-4-of-reproductive-aged-women-with-chlamydia-trachomatis-infection
#1
Nathália Mayumi Noda-Nicolau, Larissa Brito Bastos, Aline Nascimento Bolpetti, Gabriel Vitor Silva Pinto, Larissa Doddi Marcolino, Camila Marconi, Carolina Sanitá Tafner Ferreira, Jossimara Polettini, Eliane Passarelli Vieira, Márcia Guimarães da Silva
OBJECTIVE: This study included women attending primary health care units in Botucatu, São Paulo, Brazil, to assess the cervicovaginal levels of human β-defensin (hBD) 1, 2, 3, and 4 during Chlamydia trachomatis infection. PATIENTS AND METHODS: Cervicovaginal samples were collected for Pap testing and assessing the presence of infection by C. trachomatis, human papillomavirus, Neisseria gonorrhoeae, and Trichomonas vaginalis. Vaginal smears were taken to evaluate local microbiota...
April 21, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28429578/soy-isoflavones-enhance-%C3%AE-defensin-synthesis-and-secretion-in-endometrial-epithelial-cells-with-exposure-to-tlr3-agonist-polyinosinic-polycytidylic-acid
#2
Yotesawee Srisomboon, Sutthasinee Poonyachoti, Chatsri Deachapunya
PROBLEM: β-defensins are important innate chemical barriers that protect the endometrium from pathogen invasion. The effects of soy isoflavones, genistein and daidzein, on the expression and secretion of porcine β-defensins (PBD) in endometrial epithelial cells were investigated under normal or poly I:C-stimulated conditions. METHOD OF STUDY: Primary cultured porcine endometrial epithelial (PE) cells were pretreated with genistein or daidzein followed by poly I:C inoculation...
April 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28428776/mapping-and-identification-of-antifungal-peptides-in-the-putative-antifungal-protein-afpb-from-the-filamentous-fungus-penicillium-digitatum
#3
Sandra Garrigues, Mónica Gandía, Attila Borics, Florentine Marx, Paloma Manzanares, Jose F Marcos
Antifungal proteins (AFPs) from Ascomycetes are small cysteine-rich proteins that are abundantly secreted and show antifungal activity against non-producer fungi. A gene coding for a class B AFP (AfpB) was previously identified in the genome of the plant pathogen Penicillium digitatum. However, previous attempts to detect the AfpB protein were not successful despite the high expression of the corresponding afpB gene. In this work, the structure of the putative AfpB was modeled. Based on this model, four synthetic cysteine-containing peptides, PAF109, PAF112, PAF118, and PAF119, were designed and their antimicrobial activity was tested and characterized...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28427438/canine-%C3%AE-defensin-1-cbd1-gene-as-a-possible-marker-for-leishmania-infantum-infection-in-dogs
#4
Lidiane Gomes da Silva, César Raimundo Lima Costa-Júnior, Carlos Alberto Santiago Figueiredo-Júnior, Tereza Cristina Leal-Balbino, Sergio Crovella, Domenico Otranto, Valdir de Queiroz Balbino, Filipe Dantas-Torres
BACKGROUND: Canine leishmaniasis caused by Leishmania infantum is a parasitic disease of great veterinary significance. Some dogs infected by L. infantum may mount a strong cellular immune response and clear the infection, while others may respond with exaggerated antibody production against the parasite and develop an overt disease, which may be fatal, if left untreated. The initial factors triggering the polarization of the immune response towards a predominantly T-helper 1 or T-helper 2 cytokines, as well as the markers of resistance and susceptibility to L...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28424690/bacillus-subtilis-improves-immunity-and-disease-resistance-in-rabbits
#5
Mengjiao Guo, Fahao Wu, Guangen Hao, Qin Qi, Rong Li, Ning Li, Liangmeng Wei, Tongjie Chai
Probiotics such as Lactobacillus and Bifidobacterium have been successfully used to promote growth and prevent diseases. Previous reports have demonstrated that Bacillus subtilis (B. subtilis) was a potential probiotic for animals. In this research, 180 B. subtilis were isolated from the soil, identified, and investigated in vitro. Furthermore, five B. subtilis were selected and mixed to investigate their effect on growth performance, immune response, intestine microbiota, and disease resistance in rabbits...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28423004/variations-in-the-interaction-of-human-defensins-with-escherichia-coli-possible-implications-in-bacterial-killing
#6
Basil Mathew, Ramakrishnan Nagaraj
Human α and β-defensins are cationic antimicrobial peptides characterized by three disulfide bonds with a triple stranded β-sheet motif. It is presumed that interaction with the bacterial cell surface and membrane permeabilization by defensins is an important step in the killing process. In this study, we have compared interactions of three human α-defensins HNP3, HNP4, HD5 and human β-defensins HBD1-4 that are active against Escherichia coli, with its cell surface and inner membrane as well as negatively charged model membranes...
2017: PloS One
https://www.readbyqxmd.com/read/28422156/anticancer-properties-of-a-defensin-like-class-iid-bacteriocin-laterosporulin10
#7
Piyush Baindara, Ankur Gautam, G P S Raghava, Suresh Korpole
Laterosporulin10 (LS10) is a defensin like peptide from Brevibacillus sp. strain SKDU10 that inhibited microbial pathogens. However, in this study, anticancer activity of LS10 was examined against different cancer cell lines and compared with normal cells. LS10 displayed cytotoxicity against cancer cells like MCF-7, HEK293T, HT1080, HeLa and H1299 at below 10 μM concentration, but not against prostate epithelium cells RWPE-1. Additionally, no hemolysis was observed at significantly higher concentration compared to IC50 values observed for different cancer cell lines...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421080/b-cell-functions-can-be-modulated-by-antimicrobial-peptides-in-rainbow-trout-oncorhynchus-mykiss-novel-insights-into-the-innate-nature-of-b-cells-in-fish
#8
Xu-Jie Zhang, Peng Wang, Nu Zhang, Dan-Dan Chen, Pin Nie, Jia-Le Li, Yong-An Zhang
B cells in fish were recently proven to have potent innate immune activities like macrophages. This inspired us to further explore the innate nature of B cells in fish. Moreover, antimicrobial peptides (AMPs) are representative molecules of innate immunity, and they can modulate the functions of macrophages. These make fish an appropriate model to study the interactions between B cells and AMPs. Interestingly, the results in this study revealed that the IgM(+) and IgT(+) B cells of rainbow trout could express multiple AMP genes, including four cathelicidin genes and one β-defensin gene...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420383/ppbp-and-defa1-defa3-genes-in-hyperlipidaemia-as-feasible-synergistic-inflammatory-biomarkers-for-coronary-heart-disease
#9
Yaowapa Maneerat, Kriengchai Prasongsukarn, Surachet Benjathummarak, Wilanee Dechkhajorn
BACKGROUND: Coronary heart disease (CHD) is an important complication of atherosclerosis. Biomarkers, which associate with CHD development, are potential to predict CHD risk. To determine whether genes showing altered expression in hyperlipidaemia (H) and coronary heart disease (CHD) patients compared with controls could be CHD risk biomarkers. METHODS: Control, H, and CHD groups represented atherosclerosis to CHD development. Gene profiling was investigated in peripheral blood mononuclear cells using DNA microarrays...
April 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28418601/to-arginine-residues-in-the-cooh-terminal-of-human-%C3%AE-defensin-3-constitute-an-essential-motif-for-antimicrobial-activity-and-il-6-production
#10
Yoko Sakagami-Yasui, Yoshinori Shirafuji, Osamu Yamasaki, Shin Morizane, Toshihisa Hamada, Hiroshi Umemura, Keiji Iwatsuki
Human β-defensin-3 (HBD-3) possesses antimicrobial activities and the potential to induce proinflammatory cytokines. HBD-3 contains a unique motif of two arginine residues (Arg. R) in the COOH-terminal region. To understand the bioactive properties of the Arg residues of HBD-3, we examined antimicrobial activities against S. aureus and P. aeruginosa using synthetic HBD-2, HBD-3, and two variant peptides of HBD-3: the Arg-truncated variant designated desR HBD-3, and NRR HBD-3, in which both Arg residues were shifted to the N-terminal region...
April 18, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28414889/proteomics-in-pediatric-cystic-craniopharyngioma
#11
Luca Massimi, Claudia Martelli, Massimo Caldarelli, Massimo Castagnola, Claudia Desiderio
Adamantinomatous craniopharyngioma (ACP) is still often burdened by a poor prognosis in children as far as the risk of recurrence and the quality of life are concerned. Therefore, many efforts are now dedicated to investigate the molecular characteristics of this tumor aiming at finding new therapeutic options. ACP is prevalently a cystic lesion so that an increasing number of researches are focused on the analysis of its cystic content. In the present article, the main results of the current proteomic analysis (PA) on the ACP fluid are summarized...
May 2017: Brain Pathology
https://www.readbyqxmd.com/read/28413476/the-mechanism-of-human-%C3%AE-defensin-3-in-mrsa-induced-infection-of-implant-drug-resistant-bacteria-biofilm-in-the-mouse-tibial-bone-marrow
#12
Chen Zhu, Ni-Rong Bao, Shuo Chen, Jian-Ning Zhao
The mechanism of human β-defensin 3 (HBD-3) in methicillin-resistant Staphylococcus aureus (MRSA-induced infection of implant drug-resistant bacteria biofilm in the mouse tibial bone marrow was studied. Healthy adult male Sprague-Dawley rats with average weight of 230 g were selected to construct the infection model of MRSA-induced implant drug-resistant bacteria biofilm in the mouse left tibial bone marrow. The drugs were intraperitoneally injected after 24 h medullary cavity infection, and the experimental groups included the model group, HBD-3 group, and vancomycin group (20 rats in each group)...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28413475/evaluation-of-the-role-of-human-%C3%AE-defensin-3-in-modulation-of-immunity-and-inflammatory-response-after-knee-replacement
#13
Jiguang Jia, Hao Peng, Sen Chen
The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28413046/heat-stress-decreases-expression-of-the-cytokines-avian-%C3%AE-defensins-4-and-6-and-toll-like-receptor-2-in-broiler-chickens-infected-with-salmonella-enteritidis
#14
W M Quinteiro-Filho, A S Calefi, D S G Cruz, T P A Aloia, A Zager, C S Astolfi-Ferreira, J A Piantino Ferreira, S Sharif, J Palermo-Neto
A high ambient temperature is a highly relevant stressor in poultry production. Heat stress (HS) has been reported to reduce animal welfare, performance indices and increase Salmonella susceptibility. Salmonella spp. are major zoonotic pathogen that cause over 1 billion of human infections worldwide annually. Therefore, the current study was designed to analyze the effect of heat stress on Salmonella infection in chickens through modulation of the immune responses. Salmonella Enteritidis was inoculated via gavage at one day of age (10(6)cfu/mL)...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28400780/overexpression-of-a-new-osmotin-like-protein-gene-sindolp-confers-tolerance-against-biotic-and-abiotic-stresses-in-sesame
#15
Supriyo Chowdhury, Arpita Basu, Surekha Kundu
Osmotin-like proteins (OLPs), of PR-5 family, mediate defense against abiotic, and biotic stresses in plants. Overexpression in sesame of an OLP gene (SindOLP), enhanced tolerance against drought, salinity, oxidative stress, and the charcoal rot pathogen. SindOLP was expressed in all parts and localized to the cytosol. The transgenic plants recovered after prolonged drought and salinity stress, showing less electrolyte leakage, more water content, longer roots, and smaller stomatal aperture compared to control plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28384529/vitamin-d-reduces-the-inflammatory-response-by-porphyromonas-gingivalis-infection-by-modulating-human-%C3%AE-defensin-3-in-human-gingival-epithelium-and-periodontal-ligament-cells
#16
Anna De Filippis, Margherita Fiorentino, Luigi Guida, Marco Annunziata, Livia Nastri, Antonietta Rizzo
Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process. Porphyromonas gingivalis, a Gram-negative black-pigmented anaerobe, is a major pathogen in the initiation and progression of periodontitis; it produces several virulence factors that stimulate human gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators. A variety of substances, such as vitamin D, have growth-inhibitory effects on some bacterial pathogens and have shown chemo-preventive and anti-inflammatory activity...
April 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28378952/haplotype-structure-and-copy-number-polymorphism-of-the-beta-defensin-7-genes-in-diverse-chicken-breeds
#17
M O Lee, M N Romanov, K V Plemyashov, N V Dementieva, O V Mitrofanova, O Y Barkova, J E Womack
Beta-defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta-defensin 7 gene (AvBD7) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated AvBD7 allele. We also found haplotypes upstream of the AvBD6 regions that are strongly linked to the AvBD7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the AvBD6 gene, with two SNPs being flanking markers to detect duplication of the AvBD7...
April 5, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28378902/molecular-displaying-of-differential-immunoresponse-to-various-infections-of-amniotic-epithelia
#18
Waleed Nemr, Monem Bashandy, Eman Araby, Omaima Khamiss
PROBLEM: Molecular displaying for the interaction of innate immune cells against pathogen is important for knowing their defense mechanism. This study aimed to visualize the differential gene expression profiles of amniotic epithelium, in response to various infections, using simple reverse transcription polymerase chain reaction (RT-PCR) techniques. METHOD OF STUDY: Antimicrobial activity of human amniotic epithelial cells (HAECs) was verified against three different models of pathogenic microorganisms...
April 5, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28376793/comparative-genomic-identification-and-validation-of-%C3%AE-defensin-genes-in-the-ovis-aries-genome
#19
T J Hall, C McQuillan, E K Finlay, C O'Farrelly, S Fair, K G Meade
BACKGROUND: β-defensins are small, cationic, antimicrobial peptides found in species across the plant and animal kingdoms. In addition to microbiocidal activity, roles in immunity as well as reproduction have more recently been documented. β-defensin genes in Ovis aries (domestic sheep) have been poorly annotated, having been identified only by automatic gene prediction algorithms. The objective of this study was to use a comparative genomics approach to identify and characterise the β-defensin gene repertoire in sheep using the bovine genome as the primary reference...
April 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28373699/oral-administration-of-lactobacillus-gasseri-sbt2055-is-effective-in-preventing-porphyromonas-gingivalis-accelerated-periodontal-disease
#20
R Kobayashi, T Kobayashi, F Sakai, T Hosoya, M Yamamoto, T Kurita-Ochiai
Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatment significantly reduced alveolar bone loss, detachment and disorganization of the periodontal ligament, and bacterial colonization by subsequent P. gingivalis challenge. Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection...
April 3, 2017: Scientific Reports
keyword
keyword
68026
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"