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Orthopaedic implant

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https://www.readbyqxmd.com/read/29445961/application-of-combined-porous-tantalum-scaffolds-loaded-with-bone-morphogenetic-protein-7-to-repair-of-osteochondral-defect-in-rabbits
#1
Qian Wang, Hui Zhang, Hongquan Gan, Hui Wang, Qijia Li, Zhiqiang Wang
PURPOSE: Porous tantalum (PT) has been widely used in orthopaedic applications for low modulus of elasticity, excellent biocompatibility, and the microstructures similar to cancellous bone. In order to improve the biological activity of PT, biologically active factors can be combined with the material. The purpose of this study was to investigate if bone morphogenetic protein 7 (BMP-7) modifications could enhance the repairing of cartilage of PT in osteochondral defect in medial femoral condyle of rabbits...
February 14, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29443852/chlorhexidine-antiseptic-irrigation-eradicates-staphylococcus-epidermidis-from-biofilm-an-in-vitro-study
#2
Kenneth Schmidt, Chris Estes, Alex McLaren, Mark J Spangehl
BACKGROUND: Antiseptic and antibacterial solutions used for intraoperative irrigation are intended to kill bacteria and thereby decrease the incidence of surgical site infections. It is unknown if the concentrations and exposure times of irrigation solutions commonly used for prophylaxis in clean cases (povidone-iodine 0.35% for 3 minutes) are effective against bacteria in biofilm that are present in implant infections. Currently, povidone-iodine (0.35%), chlorhexidine (0.05%), sodium hypochlorite (0...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29427750/is-dynamic-locking-plate-targon-fn-a-better-choice-for-treating-of-intracapsular-hip-fracture-a-meta-analysis
#3
REVIEW
Hao Yin, Zhengjun Pan, Hua Jiang
PURPOSE: The aim of this study was to assess the outcomes of dynamic locking plate (Targon FN) and other alternative implant (cannulated cancellous screws or sliding hip screw) for treating of intracapsular hip fracture. METHODS: Relevant clinical trials on the dynamic locking plate and alternative implant treatment for intracapsular hip fracture were retrieved through searching the databases, PubMed, Embase and the Cochrane Central Register of Controlled Trials up to August 2017...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29423867/uncemented-thompson-s-hemiarthroplasty-safe-palliative-and-cost-effective-surgery-in-the-infirm-patient-a-consecutive-series-of-1445-cases
#4
G Manoharan, B D Chatterton, T S Moores, P J Roberts
BACKGROUND: Guidelines on the management of displaced intracapsular fractures recommend using an Orthopaedic Data Evaluation Panel-rated cemented implant. Prior to the National Institute for Health and Care Excellence guidelines, uncemented implants were commonly used in the UK. METHODS: We retrospectively examined the outcomes of patients with uncemented Thompson's hemiarthroplasties at our unit, between April 2005 and December 2010. Patients who underwent revision surgery before December 2011 were identified...
February 8, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29417348/perioperative-management-of-external-fixation-in-staged-protocols-an-international-survey
#5
Sandro Hodel, Björn-Christian Link, Reto Babst, W H Mallee, Philippe Posso, Frank J P Beeres
INTRODUCTION: Despite the frequent use of external fixation, various regimes of antibiotic prophylaxis, surgical technique and postoperative pin care exist and underline the lack of current evidence. The aim of the study was to assess the variability or consensus in perioperative protocols to prevent implant-associated infections for temporary external fixation in closed fractures of the extremities. MATERIALS AND METHODS: A 26-question survey was sent to 170 members of the Traumaplatform...
February 7, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29414477/effect-of-porous-orthopaedic-implant-material-and-structure-on-load-sharing-with-simulated-bone-ingrowth-a-finite-element-analysis-comparing-titanium-and-peek
#6
R Dana Carpenter, Brett S Klosterhoff, F Brennan Torstrick, Kevin T Foley, J Kenneth Burkus, Christopher S D Lee, Ken Gall, Robert E Guldberg, David L Safranski
Osseointegration of load-bearing orthopaedic implants, including interbody fusion devices, is critical to long-term biomechanical functionality. Mechanical loads are a key regulator of bone tissue remodeling and maintenance, and stress-shielding due to metal orthopaedic implants being much stiffer than bone has been implicated in clinical observations of long-term bone loss in tissue adjacent to implants. Porous features that accommodate bone ingrowth have improved implant fixation in the short term, but long-term retrieval studies have sometimes demonstrated limited, superficial ingrowth into the pore layer of metal implants and aseptic loosening remains a problem for a subset of patients...
January 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29414468/a-novel-fracture-mechanics-model-explaining-the-axial-penetration-of-bone-like-porous-compressible-solids-by-various-orthopaedic-implant-tips
#7
Sloan A Kulper, K Y Sze, Christian X Fang, Xiaodan Ren, Margaret Guo, Kerstin Schneider, Frankie Leung, William Lu, Alfonso Ngan
Many features of orthopaedic implants have been previously examined regarding their influence on migration in trabecular bone under axial loading, with screw thread design being one of the most prominent examples. There has been comparatively little investigation, however, of the influence that implant tip design has on migration under axial loads. We present a novel fracture mechanics model that explains how differences in tip design affect the force required for axial penetration of porous, compressible solids similar to trabecular bone...
February 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29413102/synchrotron-analysis-of-human-organ-tissue-exposed-to-implant-material
#8
Ilona Swiatkowska, J Fred W Mosselmans, Tina Geraki, Cody C Wyles, Joseph J Maleszewski, Johann Henckel, Barry Sampson, Dominic B Potter, Ibtisam Osman, Robert T Trousdale, Alister J Hart
BACKGROUND: Orthopaedic implants made of cobalt-chromium alloy undergo wear and corrosion that can lead to deposition of cobalt and chromium in vital organs. Elevated cardiac tissue cobalt levels are associated with myocardial injury while chromium is a well-established genotoxin. Though metal composition of tissues surrounding hip implants has been established, few investigators attempted to characterize the metal deposits in systemic tissues of total joint arthroplasty patients. METHODS: We report the first use of micro-X-ray fluorescence coupled with micro-X-ray absorption spectroscopy to probe distribution and chemical form of cobalt, chromium and titanium in postmortem samples of splenic, hepatic and cardiac tissue of patients with metal-on-polyethylene hip implants (n = 5)...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29409284/reliability-of-the-phi-angle-to-assess-rotational-alignment-of-the-talar-component-in-total-ankle-replacement
#9
Luigi Manzi, Jorge Hugo Villafañe, Cristian Indino, Jacopo Tamini, Pedro Berjano, Federico Giuseppe Usuelli
BACKGROUND: The purpose of this study was to investigate the test-retest reliability of the Phi angle in patients undergoing total ankle replacement (TAR) for end stage ankle osteoarthritis (OA) to assess the rotational alignment of the talar component. METHODS: Retrospective observational cross-sectional study of prospectively collected data. Post-operative anteroposterior radiographs of the foot of 170 patients who underwent TAR for the ankle OA were evaluated...
November 8, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29405452/immunotherapy-synergizes-with-debridement-and-antibiotic-therapy-in-a-murine-1-stage-exchange-model-of-mrsa-implant-associated-osteomyelitis
#10
Noriaki Yokogawa, Masahiro Ishikawa, Kohei Nishitani, Christopher A Beck, Hiroyuki Tsuchiya, Addisu Mesfin, Stephen L Kates, John L Daiss, Chao Xie, Edward M Schwarz
Methicillin-resistant Staphylococcus aureus (MRSA) reinfection following revision surgery remains a major orthopaedic problem. Toward the development of immunotherapy with anti-glucosaminidase monoclonal antibodies (anti-Gmd), we aimed to: (i) develop a murine 1-stage exchange model of bioluminescent MRSA (USA300LAC::lux) contaminated femoral implants; and (ii) utilize this model to demonstrate the synergistic effects of combination vancomycin and anti-Gmd therapy on reinfection and bone healing. Following an infection surgery, the original plate and two screws were removed on day 7, and exchanged with sterile implants...
February 5, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29401094/ultra-low-dose-ct-scan-reduction-protocol-for-extremity-fracture-evaluation-is-as-safe-and-effective-as-conventional-ct-an-evaluation-of-quality-outcomes
#11
Sanjit Reddy Konda, Abraham Michael Goch, Jack Haglin, Kenneth Andrew Egol
OBJECTIVES: To assess clinical and hospital quality outcomes of patients receiving the previously reported Reduced Effective Dose Using Computed Tomography In Orthopaedic iNjury (REDUCTION) imaging protocol. DESIGN: Retrospective Chart review SETTING:: Level I Trauma Center and affiliated Tertiary Care Hospital CenterPatients/Participants: fifty patients who received this protocol for acute traumatic fracture evaluation and met inclusion criteria were compared to a cohort of fifty patients matched for age and fracture type who previously received conventional CT scanning for acute traumatic fracture evaluation...
January 30, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29399002/the-infection-rate-of-metal-on-metal-total-hip-replacement-is-higher-when-compared-to-other-bearing-surfaces-as-documented-by-the-australian-orthopaedic-association-national-joint-replacement-registry
#12
Phil Huang, Matt Lyons, Michael O'Sullivan
Background: Despite the well-documented decline in the use of metal-on-metal (MoM) implants over the last decade, there are still controversies regarding whether all MoM implants are created equally. Complications such as elevated serum metal ion levels, aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) and pseudotumours have all been well documented, but recent studies suggest increased risk of infection with MoM bearing surfaces. Most of these studies however have small patient numbers...
February 2018: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/29397920/-review-of-patient-specific-instrumentation-for-total-knee-prosthesis
#13
T Vaillant, J Steelandt, A-L Cordonnier, S Haghighat, P Anract, P Paubel, C Duhamel
OBJECTIVES: Single use patient-specific instruments (PSI) for total knee prosthesis are introduced as a new alternative to conventional ancillaries and computer assisted surgery by improving implants positioning. An exhaustive review was carried out to identify their specific characteristics, with their advantages and disadvantages. METHODS: Medical devices suppliers were consulted in 2015 for reviewing their PSI. Their technical, clinical and economic data were compared...
February 2, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29382603/sonication-of-orthopaedic-implants-a-valuable-technique-for-diagnosis-of-prosthetic-joint-infections
#14
Sujeesh Sebastian, Rajesh Malhotra, Vishnubhatla Sreenivas, Arti Kapil, Rama Chaudhry, Benu Dhawan
INTRODUCTION: Accurate and prompt microbiological diagnosis of prosthetic joint infection (PJI) is crucial for successful antimicrobial treatment. Studies have shown the diagnostic utility of sonication of explanted implants in total joint arthroplasty but all did not use consensus statements for defining PJI. We evaluated the diagnostic utility of culture of samples obtained by sonication of explanted implants compared with periprosthetic tissue cultures (PTC) for the diagnosis of PJI using Musculoskeletal Infection Society (MSIS) consensus criteria...
January 27, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29366661/long-term-results-of-hemiarthroplasty-compared-with-arthrodesis-for-osteoarthritis-of-the-first-metatarsophalangeal-joint
#15
Stefan R Beekhuizen, Timothy Voskuijl, Ron Onstenk
If operative treatment is opted for grade 3 and 4 osteoarthritis of the first metatarsophalangeal joint, arthrodesis is considered the standard of care. However, if preservation of joint mobility is preferred, implant arthroplasty could be favored. Previous studies have suggested hemiarthroplasty might result in less pain, better function, and greater patient satisfaction compared with arthrodesis. However, these studies only evaluated short-term results (range 2.2 to 6.6 years). The aim of our study was to determine whether patients treated with hemiarthroplasty would show better postoperative outcomes compared with those treated with arthrodesis after ≥5 years after surgery...
January 20, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29359259/extra-articular-distal-tibia-fractures-controversies-regarding-treatment-options-a-single-centre-prospective-comparative-study
#16
Mihail-Lazar Mioc, Radu Prejbeanu, Bogdan Deleanu, Bogdan Anglitoiu, Horia Haragus, Marius Niculescu
Distal tibia fractures are reported to have a high complication rate pre-operatively as well as post-operatively, which can include open fractures, soft tissue damage, infection, malalignment, pseudarthrosis and ankle arthrosis. The operative treatment for the extra-articular distal tibia fractures is a controversial topic in the orthopaedic literature. Some of these fractures are proximal enough to be treated with an intramedullary nail while others are too distal for that. The aim of our study was to compare the results we have had with intramedullary nail (IMN) and minimally invasive plate osteosynthesis (MIPO) in distal metaphyseal (extra-articular) tibia fractures...
January 22, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29355743/usefulness-of-sonication-for-diagnosing-infection-in-explanted-orthopaedic-implants
#17
R Erivan, G Villatte, G Eymond, A Mulliez, S Descamps, S Boisgard
BACKGROUND: Orthopaedic implant infection is a rare but serious complication whose optimal treatment requires an accurate microbiological diagnosis. The objective of this study was to determine whether culturing sonicated explants improved sensitivity compared to culturing standard sonicated soft-tissue samples. HYPOTHESIS: Cultures of explant sonication fluid are more sensitive than cultures of soft-tissue sonication fluid in patients with implant infection. METHODS: This single-centre retrospective study included all sonication fluid samples from implants explanted in orthopaedic surgery theatres for any reason...
January 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29342496/-adverse-events-in-the-treatment-of-periprosthetic-fractures-around-the-knee-a-clinical-and-radiological-outcome-analysis
#18
Anna Janine Schreiner, Christoph Gonser, Christoph Ihle, Max Konstantin Zauleck, Tim Klopfer, Fabian Stuby, Ulrich Stöckle, Björn Gunnar Ochs
BACKGROUND: The incidence of periprosthetic fractures associated with total knee arthroplasty (PpFxK) has been reported to be 0.3 - 5.5%. 40% of all cases are related to revision TKA. The most common localisation is the distal femur. Classification is performed according to Rorabeck (RB). RB I - II fractures are usually treated with locked plating and retrograde intramedullary nailing, whereas RB III fractures are an indication for revision arthroplasty using a hinged endoprosthesis...
January 17, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29341933/the-effects-of-platelet-lysate-patches-on-the-activity-of-tendon-derived-cells
#19
Raquel Costa-Almeida, Albina R Franco, Tamagno Pesqueira, Mariana B Oliveira, Pedro S Babo, Isabel B Leonor, João F Mano, Rui L Reis, Manuela E Gomes
Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeutic factors in patch augmentation strategies aiming at tendon repair. Developed PL patches exhibited a controlled release profile of PL proteins, including bFGF and PDGF-BB...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29337716/management-of-biceps-tendon-pathology-from-the-glenoid-to-the-radial-tuberosity
#20
Rachel M Frank, Eric J Cotter, Eric J Strauss, Laith M Jazrawi, Anthony A Romeo
Management of proximal and distal biceps tendon pathology is evolving. The long head of the biceps tendon, if inflamed, may be a pain-producing structure. In appropriately indicated patients, a symptomatic long head of the biceps tendon can be surgically managed via tenotomy, tenodesis, and/or superior labrum anterior to posterior repair. In some patients, primary superior labrum anterior to posterior pathology can be managed via biceps tenodesis. Determining which procedure is most appropriate and which technique and implant are preferred for a given patient with biceps tendon pathology is controversial...
February 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
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