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https://www.readbyqxmd.com/read/29241206/a-multicenter-experience-with-long-acting-somatostatin-analogues-in-patients-with-congenital-hyperinsulinism
#1
Ivo van der Steen, Mirjam E van Albada, Klaus Mohnike, Henrik Thybo Christesen, Susann Empting, Maria Salomon-Estebanez, Amalie Greve Rasmussen, Annemarie Verrijn Stuart, Annelieke A A van der Linde, Indraneel Banerjee, Annemieke M Boot
BACKGROUND/AIMS: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment. Long-acting somatostatin analogues have been used in children as off-label medication. However, the efficacy, outcomes, and adverse effect profiles of long-acting somatostatin analogues have not been described in multicentered studies. The aim of this retrospective study is to summarize the experience with long-acting somatostatin analogues in a large group of children with CHI...
December 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29241148/obesity-exacerbates-the-acute-metabolic-side-effects-of-olanzapine
#2
Logan K Townsend, Willem T Peppler, Natasha D Bush, David C Wright
Olanzapine is a second-generation antipsychotic used in the management of schizophrenia and various off-label conditions. The acute metabolic responses of olanzapine recapitulate many of the side effects associated with obesity. Obesity rates are high in the schizophrenic population, but it is unknown whether pre-existing obesity-associated metabolic dysfunction augments the acute side effects of olanzapine. To address this question, we compared the responses to olanzapine in lean and high-fat diet-induced (HFD) obese mice...
December 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29239621/a-qualitative-analysis-of-gabapentin-misuse-and-diversion-among-people-who-use-drugs-in-appalachian-kentucky
#3
Rachel Vickers Smith, Elaine M Boland, April M Young, Michelle R Lofwall, Alexa Quiroz, Michele Staton, Jennifer R Havens
Gabapentin, an anticonvulsant and analgesic for postherpetic neuralgia, has been thought to have no abuse potential despite numerous published reports to the contrary. Gabapentin has been linked with impaired driving and opioid use, highlighting the need to more fully understand its risk profile. Thirty-three individuals reporting recent nonmedical use of gabapentin were recruited from two ongoing longitudinal studies of drug users in Appalachian Kentucky to participate in focus groups. Four sessions were held (two in the community and two in jail settings), during which participants responded to questions regarding their personal experiences with gabapentin misuse...
December 14, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29238641/complication-rates-in-posterior-lumbar-interbody-fusion-plif-surgery-with-human-bone-morphogenetic-protein-2-medicare-population
#4
Raed Alobaidaan, Jeremiah R Cohen, Elizabeth L Lord, Zorica Buser, S Tim Yoon, Jim A Youssef, Jong-Beom Park, Darrel S Brodke, Jeffrey C Wang, Hans-Joerg Meisel
Study Design: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. Objective: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the "off-label" manner for various types of spine fusion procedures, including PLIF. However, recent studies have reported potential complications associated with the recombinant human BMP2 (rhBMP2) use in the posterior approach...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29237228/methotrexate-and-azathioprine-in-severe-atopic-dermatitis-a-5-year-follow-up-study-of-a-randomised-controlled-trial
#5
L A A Gerbens, S A S Hamann, M W D Brouwer, E Roekevisch, M M G Leeflang, Ph I Spuls
BACKGROUND: Systemic treatment is indicated for moderate-to-severe atopic dermatitis (AD), refractory to topical treatment. Long-term evidence, up to 5 years, of off-label prescribed methotrexate (MTX) and azathioprine (AZA) is lacking. OBJECTIVES: To investigate long-term effectiveness, safety and drug survival of MTX and AZA. METHODS: In an open-label follow up phase of a clinical trial patients were seen every 3 months for 5 years. MTX and AZA doses could be in- or decreased concurrent with daily clinical practice...
December 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29234617/transcatheter-mitral-valve-implantation-in-open-heart-surgery-an-off-label-technique
#6
Jacopo Alfonsi, Giacomo Murana, Anna Corsini, Carlo Savini, Roberto Di Bartolomeo, Davide Pacini
Extensive mitral annulus calcifications are considered a contraindication for valve surgery. We describe the case of a 76-year-old female with severe mitral and aortic stenosis associated with extensive calcifications of the heart. The patient underwent an open mitroaortic valve replacement using transcatheter aortic valve implantation with an Edwards SAPIEN XT valve (Edwards Lifesciences Corp., Irvine, CA, USA) in the mitral position. The aortic valve was replaced using a stentless valve prosthesis (LivaNova SOLO; LivaNova PLC, London, UK)...
December 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29229348/bone-morphogenetic-proteins-usage-in-anterior-lumbar-inter-body-fusion-what-else-can-go-wrong
#7
Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis
BACKGROUND: Bone Morphogenetic Protein (BMP) graft showed promising outcome during early phases of its use. However unreported adverse events and off label use shattered its safe profile and raised concerns regarding its indication. In 2008, the Food and Drug Administration (FDA) prohibited its use in anterior cervical spine procedures due to possibility of edema, hematoma and need of intubation. At the molecular level, BMP act as multifactorial growth factors playing a role in cartilage, heart, and bone formation...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29221713/effect-of-grass-sublingual-tablet-immunotherapy-is-similar-in-children-and-adults-a-bayesian-approach-to-design-pediatric-sublingual-immunotherapy-trials
#8
Amarjot Kaur, David Skoner, Joseph Ibrahim, Qing Li, Richard F Lockey, Michael Blaiss, Albrecht Bufe, Jens Strodl Andersen, Giorgio Walter Canonica, Hendrik Nolte
BACKGROUND: Large sample sizes are needed for sublingual immunotherapy (SLIT) trials due to inherent data variability secondary to inconsistent allergen exposure. Obtaining large sample sizes for pediatric SLIT trials is challenging, but a Bayesian approach using prior adult data can reduce the necessary sample size. OBJECTIVE: To describe how a Bayesian framework utilizing prior information from adult trials can be used to improve pediatric SLIT clinical development...
December 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29215762/risk-of-amphetamine-use-disorder-and-mortality-among-incident-users-of-prescribed-stimulant-medications-in-the-veterans-administration
#9
Arthur N Westover, Paul A Nakonezny, Ethan A Halm, Bryon Adinoff
BACKGROUND AND AIMS: Nonmedical use of prescribed stimulant medications is a growing concern. This study's aims were to ascertain the demographics of stimulant medication users compared with nonusers, examine temporal trends of stimulant medication use, and estimate risk factors for development of amphetamine use disorder (AUD) and mortality among new users of stimulant medications. DESIGN: Cox proportion hazards regression in a retrospective cohort adjusted by baseline covariates...
December 7, 2017: Addiction
https://www.readbyqxmd.com/read/29215401/relaxivity-of-ferumoxytol-at-1-5-t-and-3-0-t
#10
Gesine Knobloch, Timothy Colgan, Curtis N Wiens, Xiaoke Wang, Tilman Schubert, Diego Hernando, Samir D Sharma, Scott Reeder
OBJECTIVES: The aim of this study was to determine the relaxation properties of ferumoxytol, an off-label alternative to gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T. MATERIALS AND METHODS: Ferumoxytol was diluted in gradually increasing concentrations (0.26-4.2 mM) in saline, human plasma, and human whole blood. Magnetic resonance relaxometry was performed at 37°C at 1.5 T and 3.0 T. Longitudinal and transverse relaxation rate constants (R1, R2, R2*) were measured as a function of ferumoxytol concentration, and relaxivities (r1, r2, r2*) were calculated...
December 5, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29215383/mood-stabilizing-anticonvulsants-spina-bifida-and-folate-supplementation-commentary
#11
Neil Patel, Adele C Viguera, Ross J Baldessarini
PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. METHODS/PROCEDURES: Based on a semistructured review of recent literature, we summarized findings pertaining to this topic. FINDINGS/RESULTS: Valproate and carbamazepine are commonly used empirically (off-label) for putative long-term mood-stabilizing effects...
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210973/manuka-honey-a-case-study-of-severe-atopic-eczematous-dermatitis-reaction-to-henna-tattoo
#12
Jeanine Harrison
Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived. However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options...
October 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/29210952/survey-of-the-american-neurotology-society-on-cochlear-implantation-part-1-candidacy-assessment-and-expanding-indications
#13
Matthew L Carlson, Douglas P Sladen, Richard K Gurgel, Nicole M Tombers, Christine M Lohse, Colin L Driscoll
OBJECTIVE: To examine practice variance of cochlear implant candidacy assessment and off-label indications across centers in the United States. METHODS: Cross-sectional survey of the American Neurotology Society (ANS). RESULTS: A total of 81 surveys were returned from ANS members who report regular involvement in cochlear implant care. Overall there was a broad distribution in age and clinical experience, with most respondents reporting ACGME accreditation in neurotology and employment at an academic center...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29205757/enhancing-metabolic-monitoring-for-children-and-adolescents-using-second-generation-antipsychotics
#14
Mary Coughlin, Catherine L Goldie, Deborah Tregunno, Joan Tranmer, Marina Kanellos-Sutton, Sarosh Khalid-Khan
The prevalence of children and adolescents using second-generation antipsychotics (SGAs) has increased significantly in recent years. In this population, SGAs are used to treat mood and behavioural disorders although considered 'off-label' or not approved for these indications. Metabolic monitoring is the systematic physical health assessment of antipsychotic users utilized to detect cardiovascular and endocrine side effects and prevent adverse events such as weight gain, hyperglycaemia, hyperlipidemia, and arrhythmias...
December 4, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29204800/hospital-pharmacists-perceived-beliefs-and-responsibilities-in-indication-based-off-label-prescribing
#15
Ramsankar Basak, David J McCaffrey
Background Off-label prescribing is prevalent in healthcare. There is a lack of understanding of pharmacists' attitudes toward the practice of off-label prescribing, especially those that are prescribed for other indications than approved ones (termed as indication-based off-label prescribing). Objective Explore hospital pharmacists' attitudes toward and perceived responsibility in off-label and indication-based off-label prescribing in hospital pharmacy practice. Setting Pharmacists practicing in hospitals in the United States were investigated...
December 4, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29200376/anesthetic-considerations-for-patients-on-antidepressant-therapy-part-i
#16
Mana Saraghi, Leonard R Golden, Elliot V Hersh
Millions of patients take antidepressant medications in the United States for the treatment of depression or anxiety disorders. Some antidepressants are prescribed off-label to treat problems such as chronic pain, low energy, and menstrual symptoms. Antidepressants are a broad and expansive group of medications, but the more common drug classes include tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and monoamine oxidase inhibitors. A miscellaneous or "atypical" category covers other agents...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/29198659/incidence-of-infectious-disease-and-malignancies-after-rituximab-therapy-in-kidney-transplant-recipients-results-from-a-cohort-in-germany
#17
E Schrezenmeier, K Budde, O Staeck, L Lehner, M Duerr, D Khadzhynov, T Dörner, F Halleck
BACKGROUND: Rituximab is frequently used in solid organ transplantation off-label, especially in patients with renal allografts. Few data are available on the safety aspects of solid organ transplant recipients receiving rituximab. There is a knowledge gap on long-term follow-up data, in particular on infectious complications. PATIENTS AND METHODS: A retrospective observational registry study (German Registry on Autoimmune Diseases) comprising a total of 681 patients was conducted...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29197213/-sudden-crisis-in-dementia
#18
Elmar J Kainz
If we're thinking about Dementia, we normally don't think about a sudden crisis. Dementia is a slowly creeping illness, which causes a loss of memory. In addition to this loss of cognitive functions, there is also the death of neural cells, which in turn leads to completely different symptoms. This leads to the appearance of BPSD (Behavioural and psychotic symptoms of dementia). There are guides to the therapy of cognitive deficits of dementia in existence, to use them within the EbM criteria. There exists only a little bit of information on the therapy of BPSD...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29197104/the-effect-of-dronabinol-in-a-male-patient-with-anorexia-nervosa-suffering-from-severe-acute-urge-to-be-physically-active
#19
Holmer Graap, Yesim Erim, Georgios Paslakis
OBJECTIVE: A 27-year-old male suffering from chronic anorexia nervosa was admitted for inpatient psychotherapy suffering from severe urge to be physically active. METHODS: An off-label treatment with dronabinol was initiated, to reduce his symptoms related to that urge. Several attempts to reduce symptoms including intensive psychotherapy and several psychopharmacological agents had failed in the past. RESULTS: Following treatment with 7.5 mg dronabinol twice a day, the patient reported a significant reduction in his acute urge to be physically active...
December 1, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29193136/clinical-indications-for-intravenous-immunoglobulin-utilization-in-a-tertiary-medical-center-a-9-year-retrospective-study
#20
Asaf Shemer, Shaye Kivity, Yehuda Shoenfeld
BACKGROUND: Intravenous immunoglobulins (IVIG) are a biologic product originally developed to treat immunocompromised patients. In the past decades, there has been increased utilization of IVIG in autoimmune conditions. The objectives were to evaluate the clinical use of IVIG in the largest tertiary medical center in Israel and to determine top uses, estimate off-label usage, and assess consumption of this blood product. STUDY DESIGN AND METHODS: We conducted an observational, retrospective study involving all patients who received IVIG from 2007 through 2015...
November 27, 2017: Transfusion
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