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SEER AND lung cancer

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https://www.readbyqxmd.com/read/28045621/antineoplastic-treatment-of-advanced-stage-non-small-cell-lung-cancer-treatment-survival-and-spending-2000-to-2011
#1
Cathy J Bradley, K Robin Yabroff, Angela B Mariotto, Christopher Zeruto, Quyen Tran, Joan L Warren
Purpose Multiple agents for advanced non-small-cell lung cancer (NSCLC) have been approved in the past decade, but little is known about their use and associated spending and survival. Methods We used SEER-Medicare data for elderly patients with a new diagnosis of advanced-stage NSCLC and were treated with antineoplastic agents between 2000 and 2011 (N = 22,163). We estimated the adjusted percentage of patients who received each agent, days while on treatment, survival, and spending in the 12 months after diagnosis...
January 3, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28038448/the-prognosis-analysis-of-different-metastasis-pattern-in-patients-with-different-breast-cancer-subtypes-a-seer-based-study
#2
Haiyong Wang, Chenyue Zhang, Jingze Zhang, Li Kong, Hui Zhu, Jinming Yu
Studies on prognosis of different metastasis patterns in patients with different breast cancer subtypes (BCS) are limited. Therefore, we identified 7862 breast cancer patients with distant metastasis from 2010 to 2013 using Surveillance, Epidemiology, wand End Results (SEER) population-based data. The results showed that bone was the most common metastatic site and brain was the least common metastatic site, and the patients with HR+/HER2- occupied the highest metastasis proportion, the lowest metastasis proportion were found in HR-/HER2+ patients...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029318/impact-of-examined-lymph-node-count-on-precise-staging-and-long-term-survival-of-resected-non-small-cell-lung-cancer-a-population-study-of-the-us-seer-database-and-a-chinese-multi-institutional-registry
#3
Wenhua Liang, Jiaxi He, Yaxing Shen, Jianfei Shen, Qihua He, Jianrong Zhang, Gening Jiang, Qun Wang, Lunxu Liu, Shugeng Gao, Deruo Liu, Zheng Wang, Zhihua Zhu, Calvin S H Ng, Chia-Chuan Liu, René Horsleben Petersen, Gaetano Rocco, Thomas D'Amico, Alessandro Brunelli, Haiquan Chen, Xiuyi Zhi, Bo Liu, Yixin Yang, Wensen Chen, Qian Zhou, Jianxing He
Purpose We investigated the correlation between the number of examined lymph nodes (ELNs) and correct staging and long-term survival in non-small-cell lung cancer (NSCLC) by using large databases and determined the minimal threshold for the ELN count. Methods Data from a Chinese multi-institutional registry and the US SEER database on stage I to IIIA resected NSCLC (2001 to 2008) were analyzed for the relationship between the ELN count and stage migration and overall survival (OS) by using multivariable models...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28024699/temporal-patterns-of-care-and-outcomes-of-non-small-cell-lung-cancer-patients-in-the-united-states-diagnosed-in-1996-2005-and-2010
#4
Filip Kaniski, Lindsey Enewold, Anish Thomas, Shakuntala Malik, Jennifer L Stevens, Linda C Harlan
INTRODUCTION: Lung cancer remains a common and deadly cancer in the United States. This study evaluated factors associated with stage-specific cancer therapy and survival focusing on temporal trends and sociodemographic disparities. METHODS: A random sample (n=3,318) of non-small cell lung cancer (NSCLC) patients diagnosed in 1996, 2005 and 2010, and reported to the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program was analyzed...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27999144/long-term-follow-up-of-patients-having-false-positive-multi-target-stool-dna-tests-after-negative-screening-colonoscopy-the-long-haul-cohort-study
#5
Thomas G Cotter, Kelli N Burger, Mary E Devens, Julie A Simonson, Kari L Lowrie, Russell I Heigh, Douglas W Mahoney, David H Johnson, David A Ahlquist, John B Kisiel
BACKGROUND: Studies of colorectal cancer (CRC) screening by multi-target stool DNA (MT-sDNA) show false positive (FP) rates of 7-13%. It is unclear whether FP patients are at increased long-term risk of adverse outcomes. METHODS: We compared subsequent clinical events among patients with apparent FP MT-sDNA to those in patients reported as true negative (TN). This was a retrospective cohort study of participants in pre-FDA approval MT-sDNA studies having non-advanced or negative baseline colonoscopy findings from a single referral-center...
December 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27997301/treatment-burden-of-medicare-beneficiaries-with-stage-i-non-small-cell-lung-cancer
#6
Carolyn J Presley, Pamela R Soulos, Mary Tinetti, Victor M Montori, James B Yu, Cary P Gross
PURPOSE: To quantify the burden and complexity associated with treatment of Medicare beneficiaries with stage I non-small-cell lung cancer (NSCLC). METHODS: Using the SEER-Medicare database, we conducted a retrospective cohort study of Medicare beneficiaries who were diagnosed with stage I NSCLC from 2007 to 2011 and who were treated with surgery, stereotactic body radiation therapy, or external beam radiation therapy. Main outcome measures were the number of days a patient was in contact with the health care system (encounter days), the number of physicians involved in a patient's care, and the number of medications prescribed...
December 20, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27969457/mini01-08-disparities-in-the-management-of-patients-with-stage-i-small-cell-lung-cancer-sclc-a-surveillance-epidemiology-and-end-results-seer-analysis-topic-surgery
#7
Zaheer Ahmed, Lara Kujtan, Sashidhar Manthravadi, Kevin F Kennedy, John R Davis, Janakiraman Subramanian
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27956436/cancer-incidence-and-survival-trends-by-subtype-using-data-from-the-surveillance-epidemiology-and-end-results-program-1992-2013
#8
Anne-Michelle Noone, Kathleen A Cronin, Sean F Altekruse, Nadia Howlader, Denise R Lewis, Valentina I Petkov, Lynne Penberthy
BACKGROUND: Cancers are heterogeneous comprising of distinct tumor subtypes. Therefore, presenting the burden of cancer in the population and trends over time by these tumor subtypes is important to identify patterns and differences in the occurrence of these subtypes, especially to generalize findings to the US general population. METHODS: Using SEER cancer registry data, we present incidence rates according to subtypes for diagnosis years (1992-2013) among men and women for five major cancer sites: breast (female only), esophagus, kidney and renal pelvis, lung and bronchus, and thyroid...
December 12, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27925181/estimation-of-the-tumor-size-at-cure-threshold-among-aggressive-non-small-cell-lung-cancers-nsclcs-evidence-from-the-surveillance-epidemiology-and-end-results-program-seer-and-the-national-lung-screening-trial-nlst
#9
Deborah L Goldwasser
The National Lung Screening Trial (NLST) demonstrated that non-small cell lung cancer (NSCLC) mortality can be reduced by a program of annual CT screening in high-risk individuals. However, CT screening regimens and adherence vary, potentially impacting the lung cancer mortality benefit. We defined the NSCLC cure threshold as the maximum tumor size at which a given NSCLC would be curable due to early detection. We obtained data from 518,234 NSCLCs documented in the U.S. SEER cancer registry between 1988 and 2012 and 1,769 NSCLCs detected in the NLST...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27882054/risk-of-cancer-among-commercially-insured-hiv-infected-adults-on-antiretroviral-therapy
#10
Jeannette Y Lee, Ishwori Dhakal, Corey Casper, Ariela Noy, Joel M Palefsky, Missak Haigentz, Susan E Krown, Richard F Ambinder, Ronald T Mitsuyasu
The objective of this study was to explore the cancer incidence rates among HIV-infected persons with commercial insurance who were on antiretroviral therapy and compare them with those rates in the general population. Paid health insurance claims for 63,221 individuals 18 years or older, with at least one claim with a diagnostic code for HIV and at least one filled prescription for an antiretroviral medication between January 1, 2006, and September 30, 2012, were obtained from the LifeLink® Health Plan Claims Database...
2016: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/27864324/colorectal-cancer-is-a-leading-cause-of-cancer-incidence-and-mortality-among-adults-younger-than-50%C3%A2-years-in-the-usa-a-seer-based-analysis-with-comparison-to-other-young-onset-cancers
#11
Abhishek Bhandari, Melissa Woodhouse, Samir Gupta
Colorectal cancer (CRC) incidence and mortality are rising among young adults. Our aim was to contrast the relative incidence and mortality of CRC to other common cancers among young adults in the USA. We used Surveillance, Epidemiology, and End Results registry data to compare cancer site-specific and age-specific mortality and incident rates for adults younger than age 50. We summarized extracted data, both overall, and stratified by sex. We found CRC was the third leading cause of cancer death among adults younger than age 50, after breast and lung cancer (1...
November 18, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27831506/causes-of-death-among-cancer-patients
#12
N G Zaorsky, T M Churilla, B L Egleston, S G Fisher, J A Ridge, E M Horwitz, Je Meyer Md
BACKGROUND: The purpose of our study was to characterize the causes of death among cancer patients as a function of objectives: (I) calendar year, (II) patient age, and (III) time after diagnosis. PATIENTS AND METHODS: US death certificate data in SEER Stat 8.2.1 were used to categorize cancer patient death as being due to index-cancer, non-index-cancer, and non-cancer cause from 1973 to 2012. In addition, data were characterized with standardized mortality ratios (SMRs), which provide the relative risk of death compared to all persons...
November 9, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27743073/addition-of-surgery-after-radiation-significantly-improves-survival-in-stage-iiib-non-small-cell-lung-cancer-a-population-based-analysis
#13
Alex Herskovic, Bhargava Chitti, Paul Christos, A Gabriella Wernicke, Bhupesh Parashar
OBJECTIVES: Limited work, either retrospective or prospective, has been done to investigate whether or not there is a cause-specific mortality (CSM) or all-cause mortality (ACM) benefit to adding surgery following neoadjuvant treatment for Stage IIIB NSCLC. METHODS: We extracted patients with Stage IIIB NSCLC from the Survival, Epidemiology, and End Results Program (SEER) database treated from 2004 to 2012 with either radiation alone or radiation followed by surgery...
October 14, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27646951/enrollment-trends-and-disparity-among-patients-with-lung-cancer-in-national-clinical-trials-1990-to-2012
#14
Herbert H Pang, Xiaofei Wang, Thomas E Stinchcombe, Melisa L Wong, Perry Cheng, Apar Kishor Ganti, Daniel J Sargent, Ying Zhang, Chen Hu, Sumithra J Mandrekar, Mary W Redman, Judith B Manola, Richard L Schilsky, Harvey J Cohen, Jeffrey D Bradley, Alex A Adjei, David Gandara, Suresh S Ramalingam, Everett E Vokes
PURPOSE: Under-representation of elderly, women, and racial/ethnic minority patients with cancer in clinical trials is of national concern. The goal of this study was to characterize enrollment trends and disparities by age, sex, and race/ethnicity in lung cancer trials. METHODS: We analyzed data for 23,006 National Cancer Institute cooperative group lung cancer trial participants and 578,476 patients with lung cancer from the SEER registry from 1990 to 2012. The enrollment disparity difference (EDD) and enrollment disparity ratio (EDR) were calculated on the basis of the proportion of each subgroup in the trial population and the US lung cancer population...
September 19, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27638773/cancer-incidence-in-patients-with-hereditary-hemorrhagic-telangiectasia
#15
Christine W Duarte, Adam W Black, F Lee Lucas, Calvin P H Vary
PURPOSE: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by deficiency in endoglin, an angiogenic protein. We previously showed that HHT, in which systemic endoglin expression is reduced, was associated with better survival outcomes in cancer patients (Duarte et al. in Cancer Epidemiol Biomarkers Prev 23:117-125, 2014). Here, we evaluated whether HHT was associated with reduced cancer incidence. METHODS: A matched case-control analysis using SEER Medicare was conducted to evaluate the effect of HHT on diagnosis with breast, colorectal, lung, or prostate cancer between 2000 and 2007 (n = 633,162)...
September 16, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27625078/impact-of-sex-on-prognostic-host-factors-in-surgical-patients-with-lung-cancer
#16
Zoe Wainer, Gavin M Wright, Karla Gough, Marissa G Daniels, Peter Choong, Matthew Conron, Prudence A Russell, Naveed Z Alam, David Ball, Benjamin Solomon
BACKGROUND: Lung cancer has markedly poorer survival in men. Recognized important prognostic factors are divided into host, tumour and environmental factors. Traditional staging systems that use only tumour factors to predict prognosis are of limited accuracy. By examining sex-based patterns of disease-specific survival in non-small cell lung cancer patients, we determined the effect of sex on the prognostic value of additional host factors. METHODS: Two cohorts of patients treated surgically with curative intent between 2000 and 2009 were utilized...
September 14, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27619939/postoperative-complications-and-long-term-survival-after-complex-cancer-resection
#17
Hari Nathan, Huiying Yin, Sandra L Wong
BACKGROUND: Recent attention has focused on the ability to rescue patients from postoperative complications and prevent short-term mortality. However, it is unknown whether patients rescued from complications after complex cancer resections have long-term survival outcomes similar to those of patients without complications. METHODS: From 2005 to 2009 Surveillance, Epidemiology, and End Results (SEER)-Medicare data, the study identified elderly patients who underwent resection for cancers of the esophagus, lung, or pancreas...
September 12, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27613557/impact-of-location-of-readmission-on-outcomes-after-major-cancer-surgery
#18
Karyn B Stitzenberg, YunKyung Chang, Angela B Smith, Michael O Meyers, Matthew E Nielsen
BACKGROUND: The burden of readmissions after major cancer surgery is high. Prior work suggests that one-third of readmitted patients are readmitted to a different hospital than where the surgery was performed. The impact of this location of readmission needs to be more thoroughly understood. METHODS: This retrospective cohort study was performed on Surveillance, Epidemiology, and End Results (SEER)-Medicare patients with bladder, esophagus, lung, or pancreas cancer diagnosed from 2001 to 2007 who underwent extirpative surgery and were readmitted within 90 days...
September 9, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27605636/new-anticancer-drugs-associated-with-large-increases-in-costs-and-life-expectancy
#19
David H Howard, Michael E Chernew, Tamer Abdelgawad, Gregory L Smith, Josephine Sollano, David C Grabowski
Spending on anticancer drugs has risen rapidly over the past two decades. A key policy question is whether new anticancer drugs offer value, given their high cost. Using data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database, we assessed the value of new cancer treatments in routine clinical practice for patients with metastatic breast, lung, or kidney cancer or chronic myeloid leukemia in the periods 1996-2000 and 2007-11. We found that there were large increases in medical costs, but also large gains in life expectancy...
September 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27574722/treatment-patterns-and-cost-effectiveness-of-first-line-treatment-of-advanced-non-squamous-non-small-cell-lung-cancer-in-medicare-patients
#20
Daniel M Gilden, Joanna M Kubisiak, Gerhardt M Pohl, Daniel E Ball, David E Gilden, William J John, Stewart Wetmore, Katherine B Winfree
AIM: To assess the cost-effectiveness of first-line pemetrexed/platinum and other commonly administered regimens in a representative US elderly population with advanced non-squamous non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: This study utilized the Surveillance Epidemiology and End Results (SEER) cancer registry linked to Medicare claims records. The study population included all SEER-Medicare patients diagnosed in 2008-2009 with advanced non-squamous NSCLC (stages IIIB-IV) as their only primary cancer and who started chemotherapy within 90 days of diagnosis...
February 2017: Journal of Medical Economics
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