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SEER AND lung cancer

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https://www.readbyqxmd.com/read/29221275/patterns-of-distant-organ-metastases-in-esophageal-cancer-a-population-based-study
#1
Dashan Ai, Hanting Zhu, Wenjia Ren, Yun Chen, Qi Liu, Jiaying Deng, Jinjun Ye, Jianhong Fan, Kuaile Zhao
Background: Esophageal cancer is the eighth most common cancer worldwide. The prognosis of esophageal cancer patients is dismal, especially those with distant organ metastasis. However, there are few studies describing the patterns of distant metastasis in esophageal cancer systematically. Methods: We gathered the data from Surveillance Epidemiology and End Results (SEER) database between 2010 and 2013. Categorical variables were analyzed by the Pearson Chi square test, and continuous variables were analyzed by the two-sample t test...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29211313/comparative-study-of-lung-and-extrapulmonary-poorly-differentiated-neuroendocrine-carcinomas-a-seer-database-analysis-of-162-983-cases
#2
Arvind Dasari, Kathan Mehta, Lauren A Byers, Halfdan Sorbye, James C Yao
BACKGROUND: Extrapulmonary neuroendocrine carcinomas (NECs) are poorly studied and are managed similar to lung NECs, which may not account for differences between the 2 groups of tumors as well as the heterogeneity within extrapulmonary NEC. METHODS: Data from the Surveillance, Epidemiology, and End Results program between 1973 and 2012 were used to estimate the relative percentages of lung NECs and subgroups of extrapulmonary NECs, epidemiological patterns at these sites, and the median and 5-year overall survival rates...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29208356/practice-patterns-and-outcomes-in-elderly-stage-i-non-small-cell-lung-cancer-a-2004-to-2012-seer-analysis
#3
Shraddha M Dalwadi, Sean S Szeja, Eric H Bernicker, E Brian Butler, Bin S Teh, Andrew M Farach
BACKGROUND: We reviewed the population-based treatment patterns and outcomes for elderly patients with stage I non-small-cell lung cancer (NSCLC) treated from 2004 to 2012. PATIENTS AND METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified biopsy-proven stage I NSCLC cases diagnosed from 2004 to 2012. The patients were divided into 5-year age subsets (60-64, 65-69, 70-74, 75-79, 80-84, 85-89, and ≥ 90 years). The demographic data, therapy, and survival were compared by year...
November 21, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29188724/dissecting-the-heterogeneity-of-stage-iii-non-small-cell-lung-cancer-through-incorporation-of-grade-and-histology
#4
Omar Abdel-Rahman
AIM: This study evaluated a grade-integrated American Joint Committee on Cancer (AJCC) staging system for non-small-cell lung cancer. PATIENTS & METHODS: Surveillance, Epidemiology and End Results database was queried through SEER*Stat program. Through recursive partitioning analysis and subsequent decision-tree formation, suggested grade-modified stages were formulated. RESULTS: All pairwise hazard ratio comparisons among AJCC eighth stages were significant (p < 0...
November 30, 2017: Future Oncology
https://www.readbyqxmd.com/read/29170864/risk-of-malignancy-in-a-nationwide-cohort-of-elderly-inflammatory-bowel-disease-patients
#5
Nabeel Khan, Carlos Vallarino, Trevor Lissoos, Umar Darr, Michelle Luo
BACKGROUND: Management of elderly inflammatory bowel disease (IBD) patients (≥ 65 years of age) is complicated due to many factors, including a higher risk of cancer, which may impact therapeutic decisions. OBJECTIVE: The aim of this study was to determine the risk of cancer among elderly IBD patients compared with younger IBD patients. Additionally, the absolute risk of malignancy and factors contributing to it were evaluated, and therapeutic patterns among the elderly were assessed...
November 23, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29153966/nomogram-to-predict-cause-specific-mortality-in-patients-with-surgically-resected-stage-i-non-small-cell-lung-cancer-a-competing-risk-analysis
#6
Huaqiang Zhou, Yaxiong Zhang, Zeting Qiu, Gang Chen, Shaodong Hong, Xi Chen, Zhonghan Zhang, Yan Huang, Li Zhang
BACKGROUND: The objective of this study was to evaluate the probability of cause-specific death and other causes of death in patients with stage I non-small-cell lung cancer (NSCLC) who underwent surgery. We also built competing risk nomograms to predict the prognosis of patients with NSCLC. PATIENTS AND METHODS: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We identified patients who underwent surgery with stage I NSCLC between 2004 and 2013...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29139055/downstream-breast-imaging-following-screening-mammography-in-medicare-patients-with-advanced-cancer-a-population-based-study
#7
Gelareh Sadigh, Richard Duszak, Kevin C Ward, Renjian Jiang, Jeffrey M Switchenko, Kimberly E Applegate, Ruth C Carlos
BACKGROUND: Screening tests are generally not recommended in patients with advanced cancer and limited life expectancy. Nonetheless, screening mammography still occurs and may lead to follow-up testing. OBJECTIVE: We assessed the frequency of downstream breast imaging following screening mammography in patients with advanced colorectal or lung cancer. DESIGN: Population-based study. PARTICIPANTS: The study included continuously enrolled female fee-for-service Medicare beneficiaries ≥65 years of age with advanced colorectal (stage IV) or lung (stage IIIB-IV) cancer reported to a Surveillance, Epidemiology, and End Results (SEER) registry between 2000 and 2011...
November 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29132615/prediction-of-lung-cancer-patient-survival-via-supervised-machine-learning-classification-techniques
#8
Chip M Lynch, Behnaz Abdollahi, Joshua D Fuqua, Alexandra R de Carlo, James A Bartholomai, Rayeanne N Balgemann, Victor H van Berkel, Hermann B Frieboes
Outcomes for cancer patients have been previously estimated by applying various machine learning techniques to large datasets such as the Surveillance, Epidemiology, and End Results (SEER) program database. In particular for lung cancer, it is not well understood which types of techniques would yield more predictive information, and which data attributes should be used in order to determine this information. In this study, a number of supervised learning techniques is applied to the SEER database to classify lung cancer patients in terms of survival, including linear regression, Decision Trees, Gradient Boosting Machines (GBM), Support Vector Machines (SVM), and a custom ensemble...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29125868/local-thoracic-therapy-improve-prognosis-for-stage-iv-non-small-cell-lung-cancer-patients-combined-with-chemotherapy-a-surveillance-epidemiology-and-end-results-database-analysis
#9
Kaitai Liu, Dawei Zheng, GuoDong Xu, Zhennan Du, Shibo Wu
Patients with stage IV non-small cell lung cancer (NSCLC) comprise a heterogeneous group, and the optimal treatment for this group of patients is complex and debatable. We aimed to assess the effect of local thoracic therapy combined with chemotherapy on cancer specific survival (CSS). To evaluate the CSS of four subgroups of patients with stage IV NSCLC according to four different treatment modalities: combined modality of Chemotherapy, Surgery, and Radiation (Chem+Sur+RT), Chemotherapy and Radiation (Chem+RT), Chemotherapy and Surgery (Chem+Sur), and Chemotherapy only (Chem Only) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database...
2017: PloS One
https://www.readbyqxmd.com/read/29099678/representation-of-minorities-and-women-in-oncology-clinical-trials-review-of-the-past-14-years
#10
Narjust Duma, Jesus Vera Aguilera, Jonas Paludo, Candace L Haddox, Miguel Gonzalez Velez, Yucai Wang, Konstantinos Leventakos, Joleen M Hubbard, Aaron S Mansfield, Ronald S Go, Alex A Adjei
PURPOSE: Many cancer clinical trials lack appropriate representation of specific patient populations, limiting their generalizability. Therefore, we determined the representation of ethnic minorities and women in cancer clinical trials. METHODS: Enrollment data from all therapeutic trials reported as completed in ClinicalTrials.gov from 2003 to 2016 were analyzed. We calculated enrollment fractions (EFs) for each group, defined as the number of enrollees divided by the 2013 Surveillance, Epidemiology, and End Results (SEER) database cancer prevalence...
November 3, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29076352/ethnic-disparities-in-cancer-incidence-and-survival-among-the-oldest-old-in-the-united-states
#11
Jessica L Krok-Schoen, Ingrid K Adams, Ryan D Baltic, James L Fisher
OBJECTIVE: To examine potential ethnic disparities in cancer incidence and survival rates among the oldest old using data from the SEER Program. DESIGN: Cases diagnosed with one of the leading four cancer sites (lung and bronchus, colon and rectum, female breast, prostate) and four cancer sites (stomach, liver and intrahepatic bile duct, gallbladder, and cervical) that disproportionally affect Hispanics were reported to one of 18 SEER registries. Differences in cancer incidence were examined for cases aged ≥85 years diagnosed during the most recent 5-year time period (2009-2013) and, to examine changes over time, from 1992 to 2013...
October 27, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29057889/racial-disparities-in-patient-survival-and-tumor-mutation-burden-and-the-association-between-tumor-mutation-burden-and-cancer-incidence-rate
#12
Wensheng Zhang, Andrea Edwards, Erik K Flemington, Kun Zhang
The causes underlying racial disparities in cancer are multifactorial. In addition to socioeconomic issues, biological factors may contribute to these inequities, especially in disease incidence and patient survival. To date, there have been few studies that relate the disparities in these aspects to genetic aberrations. In this work, we studied the impacts of race on the patient survival and tumor mutation burden using the data released by the Cancer Genome Atlas (TCGA). The potential relationship between mutation burden and disease incidence is further inferred by an integrative analysis of TCGA data and the data from the Surveillance, Epidemiology, and End Results (SEER) Program...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057703/the-risk-of-second-primary-malignancy-in-patients-with-stage-ia-non-small-cell-lung-cancer-a-u-s-population-based-study
#13
Amit Khanal, Bilal Haider Lashari, Sreechandralekha Kruthiventi, Lubina Arjyal, Amir Bista, Priya Rimal, Dipesh Uprety
BACKGROUND: Lung cancer is one of the most common cancers worldwide. Patients with early stage lung cancer have improved long-term survival. With the introduction of low-dose CT scan, more patients are going to be diagnosed at an early stage. However, there is limited data on the risk of second primary malignancies (SPMs) in these subsets of patients in the United States. METHODS: We utilized SEER-13 (Surveillance, Epidemiology and End Results) registry to obtain Multiple Primary- Standardized Incidence Ratio and an Absolute Excess Risk between January 2004 and December 2010 for patients with Stage Ia non-small cell lung cancer...
October 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29051600/prediction-of-treatment-response-for-combined-chemo-and-radiation-therapy-for-non-small-cell-lung-cancer-patients-using-a-bio-mathematical-model
#14
Changran Geng, Harald Paganetti, Clemens Grassberger
The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadratic model with an α/β-ratio of 10, and chemotherapy effect was based on the log-cell kill model. To account for repopulation during treatment, we considered two independent methods: 1) kickoff-repopulation using exponential growth with a decreased volume doubling time, or 2) Gompertz-repopulation using the gradually accelerating growth rate with tumor shrinkage...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29026165/appropriate-surgical-modalities-for-stages-t2a-and-t2b-in-the-eighth-tnm-classification-of-lung-cancer
#15
Fenglong Bie, Xiao Qu, Xudong Yang, Zhaofei Pang, Yufan Yang, Shaorui Liu, Wei Dong, Jiajun Du
Patients with tumors of 3 to 5 cm were divided into stages T2a (3 to 4 cm) and T2b (4 to 5 cm) based on the 8(th) tumor-node-metastasis staging system for lung cancer. The objective of our study was to explore appropriate surgical modalities for the new stages, T2a and T2b. We selected 6,996 node-negative non-small-cell lung cancer patients with tumor sizes of 3 to 5 cm, diagnosed between 2009 and 2013, from the Surveillance, Epidemiology, and End Results (SEER) program. The Pearson [Formula: see text]...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025156/risk-factors-associated-with-mortality-from-vascular-thromboembolic-events-in-patients-diagnosed-with-non-small-cell-lung-cancer-a-population-based-analysis
#16
Xian-Jun He, Ying-Ying Wu, Ming-Rong Xia, Zhi-Qiang Li, Ming Zhao, Quan-De Dai, Jian-Ping Zhang, Jian-Hua Xia, Jie-Wen Zhang
Background: Lung cancer patients are at increased risk for vascular events possibly due to cancer induced hypercoagulation. Aim: The purpose of this study was to evaluate risk factors associated with the mortality from vascular thromboembolic events in patients diagnosed with non-small cell lung cancer (NSCLC). Design: Retrospective population-based analysis. Methods: We used Surveillance, Epidemiology, and End Results Program for 2004 - 2013 and evaluated 199,337 patients with NSCLC...
August 24, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29022170/modified-staging-system-for-pulmonary-carcinoids-on-the-basis-of-lung-cancer-tnm-system
#17
O Abdel-Rahman
BACKGROUND: Pulmonary carcinoids are being staged along the lines of lung cancer American Joint Committee on Cancer (AJCC) staging system. The current study evaluated the prognostic value of a modified staging system for patients with pulmonary carcinoid. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (2004-2014) was searched through SEER*Stat program. Through recursive partitioning analysis and subsequent decision tree formation, suggested stages were constructed...
October 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28989038/risk-of-second-lung-cancer-in-patients-with-previously-treated-lung-cancer-analysis-of-surveillance-epidemiology-and-end-results-seer-data
#18
Manish K Thakur, Julie J Ruterbusch, Ann G Schwartz, Shirish M Gadgeel, Jennifer L Beebe-Dimmer, Antoinette J Wozniak
BACKGROUND: The risk of developing a second primary lung cancer (SPLC) after the treatment of an initial primary lung cancer (IPLC) is around 1-2 % per patient per year. Present screening/surveillance guidelines do not adequately address this particular patient population. PATIENTS AND METHODS: We retrospectively reviewed patients in the Surveillance, Epidemiology, and End Results (SEER) data base from 1992 to 2007 to assess the frequency of occurrence of SPLC with regard to multiple patient demographics and calculated Standardized Incidence Ratios (SIRs)...
October 5, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28982749/a-population-based-assessment-of-emergency-department-observation-status-for-older-adults-with-cancer
#19
Allison Lipitz-Snyderman, Adam Klotz, Renee L Gennarelli, Jeffrey Groeger
Background: Hospitals' use of observation status for patients with cancer presenting to the emergency department (ED) is not well understood. This model of care delivery may be a viable alternative to inpatient admission for patients with cancer presenting with certain conditions. Our objective was to assess the use of observation status among Medicare beneficiaries with and without cancer. Methods: Population-based SEER-Medicare data were used to assess differences in the use of observation status between Medicare beneficiaries aged ≥66 years with and without cancer using a matched analysis (n=151,183 per cohort)...
October 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28980067/causes-of-death-and-competing-risk-analysis-of-the-associated-factors-for-non-small-cell-lung-cancer-using-the-surveillance-epidemiology-and-end-results-database
#20
Shenhai Wei, Jintao Tian, Xiaoping Song, Bingqun Wu, Limin Liu
PURPOSE: To investigate the probability of death (POD) from any causes by time after diagnosis of non-small cell lung cancer (NSCLC) and the factors associated with survival for NSCLC patients. METHODS: A total of 202,914 patients with NSCLC from 2004 to 2013 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The overall survival (OS) and lung cancer-specific survival (LCSS) were calculated and POD from any causes at different time periods after diagnosis was explored...
October 4, 2017: Journal of Cancer Research and Clinical Oncology
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