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SEER AND lung cancer

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https://www.readbyqxmd.com/read/29051600/prediction-of-treatment-response-for-combined-chemo-and-radiation-therapy-for-non-small-cell-lung-cancer-patients-using-a-bio-mathematical-model
#1
Changran Geng, Harald Paganetti, Clemens Grassberger
The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadratic model with an α/β-ratio of 10, and chemotherapy effect was based on the log-cell kill model. To account for repopulation during treatment, we considered two independent methods: 1) kickoff-repopulation using exponential growth with a decreased volume doubling time, or 2) Gompertz-repopulation using the gradually accelerating growth rate with tumor shrinkage...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29026165/appropriate-surgical-modalities-for-stages-t2a-and-t2b-in-the-eighth-tnm-classification-of-lung-cancer
#2
Fenglong Bie, Xiao Qu, Xudong Yang, Zhaofei Pang, Yufan Yang, Shaorui Liu, Wei Dong, Jiajun Du
Patients with tumors of 3 to 5 cm were divided into stages T2a (3 to 4 cm) and T2b (4 to 5 cm) based on the 8(th) tumor-node-metastasis staging system for lung cancer. The objective of our study was to explore appropriate surgical modalities for the new stages, T2a and T2b. We selected 6,996 node-negative non-small-cell lung cancer patients with tumor sizes of 3 to 5 cm, diagnosed between 2009 and 2013, from the Surveillance, Epidemiology, and End Results (SEER) program. The Pearson [Formula: see text]...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025156/risk-factors-associated-with-mortality-from-vascular-thromboembolic-events-in-patients-diagnosed-with-non-small-cell-lung-cancer-a-population-based-analysis
#3
Xian-Jun He, Ying-Ying Wu, Ming-Rong Xia, Zhi-Qiang Li, Ming Zhao, Quan-De Dai, Jian-Ping Zhang, Jian-Hua Xia, Jie-Wen Zhang
Background: Lung cancer patients are at increased risk for vascular events possibly due to cancer induced hypercoagulation. Aim: The purpose of this study was to evaluate risk factors associated with the mortality from vascular thromboembolic events in patients diagnosed with non-small cell lung cancer (NSCLC). Design: Retrospective population-based analysis. Methods: We used Surveillance, Epidemiology, and End Results Program for 2004 - 2013 and evaluated 199,337 patients with NSCLC...
August 24, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29022170/modified-staging-system-for-pulmonary-carcinoids-on-the-basis-of-lung-cancer-tnm-system
#4
O Abdel-Rahman
BACKGROUND: Pulmonary carcinoids are being staged along the lines of lung cancer American Joint Committee on Cancer (AJCC) staging system. The current study evaluated the prognostic value of a modified staging system for patients with pulmonary carcinoid. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (2004-2014) was searched through SEER*Stat program. Through recursive partitioning analysis and subsequent decision tree formation, suggested stages were constructed...
October 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28989038/risk-of-second-lung-cancer-in-patients-with-previously-treated-lung-cancer-analysis-of-surveillance-epidemiology-and-end-results-seer-data
#5
Manish K Thakur, Julie J Ruterbusch, Ann G Schwartz, Shirish M Gadgeel, Jennifer L Beebe-Dimmer, Antoinette J Wozniak
BACKGROUND: The risk of developing a second primary lung cancer (SPLC) after the treatment of an initial primary lung cancer (IPLC) is around 1-2 % per patient per year. Present screening/surveillance guidelines do not adequately address this particular patient population. PATIENTS AND METHODS: We retrospectively reviewed patients in the Surveillance, Epidemiology, and End Results (SEER) data base from 1992 to 2007 to assess the frequency of occurrence of SPLC with regard to multiple patient demographics and calculated Standardized Incidence Ratios (SIRs)...
October 5, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28982749/a-population-based-assessment-of-emergency-department-observation-status-for-older-adults-with-cancer
#6
Allison Lipitz-Snyderman, Adam Klotz, Renee L Gennarelli, Jeffrey Groeger
Background: Hospitals' use of observation status for patients with cancer presenting to the emergency department (ED) is not well understood. This model of care delivery may be a viable alternative to inpatient admission for patients with cancer presenting with certain conditions. Our objective was to assess the use of observation status among Medicare beneficiaries with and without cancer. Methods: Population-based SEER-Medicare data were used to assess differences in the use of observation status between Medicare beneficiaries aged ≥66 years with and without cancer using a matched analysis (n=151,183 per cohort)...
October 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28980067/causes-of-death-and-competing-risk-analysis-of-the-associated-factors-for-non-small-cell-lung-cancer-using-the-surveillance-epidemiology-and-end-results-database
#7
Shenhai Wei, Jintao Tian, Xiaoping Song, Bingqun Wu, Limin Liu
PURPOSE: To investigate the probability of death (POD) from any causes by time after diagnosis of non-small cell lung cancer (NSCLC) and the factors associated with survival for NSCLC patients. METHODS: A total of 202,914 patients with NSCLC from 2004 to 2013 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The overall survival (OS) and lung cancer-specific survival (LCSS) were calculated and POD from any causes at different time periods after diagnosis was explored...
October 4, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28919778/improvement-of-survival-for-non-small-cell-lung-cancer-over-time
#8
Wenjie Xia, Xinnian Yu, Qixing Mao, Wenying Xia, Anpeng Wang, Gaochao Dong, Bing Chen, Weidong Ma, Lin Xu, Feng Jiang
Non-small cell lung cancer (NSCLC) is the main histological subtype of lung cancer, which is the leading cause of cancer death. It is unclear whether the improved survival seen at high-volume centers applies to the general population and, more importantly, whether the improvement in lung cancer survival was just a consequence of improved screening work. Data from the Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 405,580 patients with NSCLC diagnosed from 1988 to 2008. The patients were divided into four groups according to the year of diagnosis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28910336/application-of-unsupervised-analysis-techniques-to-lung-cancer-patient-data
#9
Chip M Lynch, Victor H van Berkel, Hermann B Frieboes
This study applies unsupervised machine learning techniques for classification and clustering to a collection of descriptive variables from 10,442 lung cancer patient records in the Surveillance, Epidemiology, and End Results (SEER) program database. The goal is to automatically classify lung cancer patients into groups based on clinically measurable disease-specific variables in order to estimate survival. Variables selected as inputs for machine learning include Number of Primaries, Age, Grade, Tumor Size, Stage, and TNM, which are numeric or can readily be converted to numeric type...
2017: PloS One
https://www.readbyqxmd.com/read/28900786/the-pattern-of-secondary-cancers-in-patients-with-kaposi-sarcoma-in-the-united-states
#10
Vivek Kumar, Mohit Garg, Neha Chaudhary, Parita Soni, Charalampos S Floudas, Chiemeziem Nwanyanwu, Abhinav Chandra
PURPOSE: In the U.S., Kaposi sarcoma (KS) occurs mostly in HIV-infected patients, who are also at increased risk of developing secondary cancers. The trends in secondary cancer risk are unclear in the HAART era. METHODS: We extracted data from the SEER database on patients diagnosed with KS between 1981 and 2013, stratified into the pre-HAART (1981-1995) and HAART (1996-2013) eras. We compared the risk of secondary cancer in KS patients and the general population, and estimated the absolute risk...
September 12, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28839988/prognostic-significance-of-sites-of-extrathoracic-metastasis-in-patients-with-non-small-cell-lung-cancer
#11
James E Bates, Michael T Milano
BACKGROUND: Metastatic non-small cell lung cancer (NSCLC) continues to have a poor prognosis despite recent advances in both targeted radiotherapy methodologies such as stereotactic body radiotherapy (SBRT) and immunotherapies. The impact of location of metastatic disease in patients with NSCLC has not been investigated; we aimed to investigate this using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: We included 39,910 patients from the SEER database treated for M1b NSCLC from 2010-2013...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28836445/clinical-correlates-and-prognostic-value-of-different-metastatic-sites-in-metastatic-renal-cell-carcinoma
#12
Omar Abdel-Rahman
AIM: Real life data on the clinical correlates and prognostic value of metastatic sites in metastatic renal cell carcinoma (RCC) are needed. This parameter was assessed in RCC patients registered within the surveillance, epidemiology and end results (SEER) database. METHODS: Data were obtained from the National Cancer Institute-SEER database spanning 2010-2013; and it has been accessed through SEER*Stat program to determine the clinical correlates and prognosis of RCC patients with distant metastases according to the site of metastasis...
August 24, 2017: Future Oncology
https://www.readbyqxmd.com/read/28835702/comparison-of-patterns-and-prognosis-among-distant-metastatic-breast-cancer-patients-by-age-groups-a-seer-population-based-analysis
#13
Meng-Ting Chen, He-Fen Sun, Yang Zhao, Wen-Yan Fu, Li-Peng Yang, Shui-Ping Gao, Liang-Dong Li, Hong-Lin Jiang, Wei Jin
To investigate the effects of age at diagnosis on metastatic breast cancer and patients' prognosis, we collected patient data from the Surveillance, Epidemiology, and End Results (SEER) database. We finally identified 4932 eligible metastatic breast cancer patients diagnosed between 2010-2013, including 850 younger patients (<50 years), 2,540 middle-aged patients (50-69 years) and 1,542 elder patients (>69 years). The results revealed that in stage IV patients, elder patients were more likely to have lung metastasis (P < 0...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820513/predictors-of-unplanned-hospitalizations-in-patients-with-nonmetastatic-lung-cancer-during-chemotherapy
#14
Kristen L Fessele, Matthew J Hayat, Robert L Atkins
PURPOSE/OBJECTIVES: To determine predictors of unplanned hospitalizations in patients with lung cancer to receive chemotherapy in the outpatient setting and examine the potential financial burden of these events.
. DESIGN: Retrospective, longitudinal cohort study.
. SETTING: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database.
. SAMPLE: Of 104,388 incident cases of lung cancer diagnosed from 2005-2009, 2,457 cases of patients with lung cancer who received outpatient chemotherapy were identified...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28819775/sublobar-resection-versus-lobectomy-in-patients-aged-%C3%A2-35%C3%A2-years-with-stage-ia-non-small-cell-lung-cancer-a-seer-database-analysis
#15
Chang Gu, Rui Wang, Xufeng Pan, Qingyuan Huang, Yangyang Zhang, Jun Yang, Jianxin Shi
PURPOSE: Sublobar resection has been increasingly adopted in elderly patients with stage IA non-small cell lung cancer (NSCLC), but the equivalency of sublobar resection versus lobectomy among young patients with stage IA NSCLC is unknown. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) registry, we identified patients aged ≤35 years who were diagnosed between 2004 and 2013 with pathological stage IA NSCLC and treated with sublobar resection or lobectomy...
November 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28819435/pattern-of-distant-extrahepatic-metastases-in-primary-liver-cancer-a-seer-based-study
#16
Wenrui Wu, Xingkang He, Dewi Andayani, Liya Yang, Jianzhong Ye, Yating Li, Yanfei Chen, Lanjuan Li
Background and Aims: Primary liver cancer remains still the common cause of cancer-related deaths globally and the prognosis for patients with extrahepatic metastasis is poor. The aim of our study was to assess extrahepatic metastatic pattern of different histological subtypes and evaluate prognostic effects of extrahepatic metastasis in patients with advanced disease. Methods: Based on the Surveillance, Epidemiology and End Results (SEER) database, eligible patients diagnosed with primary liver cancer was identified between 2010 to 2012...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28808860/validation-of-the-ajcc-8th-lung-cancer-staging-system-among-patients-with-small-cell-lung-cancer
#17
O Abdel-Rahman
BACKGROUND: The current study tried to validate the prognostic significance of the 8th American Joint Committee on Cancer (AJCC) staging system among small cell lung cancer (SCLC) patients recorded within the surveillance, epidemiology, and end results (SEER) database. PATIENTS AND METHODS: SEER database (2004-2014) has been queried through SEER*Stat program, and both AJCC 7th and 8th edition stages were constructed. Cancer-specific and overall survival analyses according to both editions were performed through Kaplan-Meier analysis...
August 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28770444/benefits-of-marriage-on-relative-and-conditional-relative-cancer-survival-differ-between-males-and-females-in-the-usa
#18
Ray M Merrill, Erin Johnson
PURPOSE: The purpose of the paper is to assess the influence of marital status on conditional relative survival of cancer according to sex. METHODS: Analyses involved 779,978 males and 1,032,868 females diagnosed with 1 of 13 cancer types between 2000 and 2008, and followed through 2013. Data are from the Surveillance, Epidemiology, and End Results (SEER) Program. Regression models were adjusted for age, sex, race, and tumor stage. RESULTS: Five-year relative survival conditional on years already survived is higher among married patients with less lethal cancers (oral cavity and pharynx, colon and rectum, breast, urinary bladder, kidney and renal pelvis, melanoma of the skin, thyroid, lymphoma)...
August 2, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28743940/the-burdens-of-lung-cancer-involved-multiple-primary-cancers-and-its-occurring-patterns-seer-analysis-between-1973-and-2006
#19
Rui Mao, Tao Chen, Fangyu Zhou, Weili Jiang, Xiaorong Yang, Zisheng Ai, Mu Li, Linlin Qin, Long Wang, Ke Fei, Chang Chen
The prognosis of malignancies has improved in recent years, subsequent primary cancers (SPCs) have become more frequent. This study investigates the patterns of lung cancer involved multiple primary cancers. We enrolled 206,619 primary lung cancer patients and 2,071,922 patients with other primary malignancies from Surveillance, Epidemiology and End Results (SEER) database. Observed annual risk (OAR) and absolute numbers were used to describe the risk of SPC and observed cases of SPC per 10,000 person-years at risk...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722466/assessing-the-generalizability-of-the-national-lung-screening-trial-comparison-of-patients-with-stage-1-disease
#20
COMPARATIVE STUDY
Nichole T Tanner, Lin Dai, Brett C Bade, Mulugeta Gebregziabher, Gerard A Silvestri
RATIONALE: The findings of the NLST (National Lung Screening Trial) are the basis for screening high-risk individuals according to age and smoking history. Although screening is covered for eligible Medicare beneficiaries, the generalizability of the NLST in the elderly population has been questioned. OBJECTIVES: Compare outcomes of patients diagnosed with stage 1 non-small cell lung cancer in the NLST to a nationally representative cohort of elderly patients Methods: Analysis of Surveillance, Epidemiology, and End Results (SEER)-Medicare and NLST datasets for patients with stage 1 disease aged 65 to 74 years...
September 1, 2017: American Journal of Respiratory and Critical Care Medicine
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