Joséphine Muller, Elodie Duray, Margaux Lejeune, Sophie Dubois, Erwan Plougonven, Angélique Léonard, Paola Storti, Nicola Giuliani, Martine Cohen-Solal, Ute Hempel, Victor L Thijssen, Yves Beguin, Roy Heusschen, Jo Caers
Multiple myeloma osteolytic disease is caused by an uncoupled bone-remodelling process with an increased osteoclast activity. Disease development relies on interactions between myeloma cells and bone marrow stromal cells. Recent findings suggest a role for glycan-binding proteins in myeloma microenvironment. Here, we investigated lectins involved in osteoclastogenesis and their role in myeloma bone disease. Microarray data analysis showed a lower expression of galectin-1 (gal-1) in mature osteoclasts compared to monocytic progenitor cells, confirmed at the RNA and protein levels in osteoclast cultures...
February 23, 2019: Cancers