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ERP and cognition in animals

Bettina Laursen, Cecilie H Bundgaard, Carina Graversen, Morten Grupe, Connie Sanchez, Steven C Leiser, Helge B D Sorensen, Asbjørn M Drewes, Jesper F Bastlund
Studies of the antidepressant vortioxetine have demonstrated beneficial effects on cognitive dysfunction associated with depression. To elucidate how vortioxetine modulates neuronal activity during cognitive processing we investigated the effects of vortioxetine (3 and 10 mg/kg) in rats performing an auditory oddball (deviant target) task. We investigated neuronal activity in target vs non-target tone responses in vehicle-treated animals using electroencephalographic (EEG) recordings. Furthermore, we characterized task performance and EEG changes in target tone responses of vortioxetine vs controls...
March 30, 2017: Brain Research
Simon Rigoulot, Inga S Knoth, Marc-Philippe Lafontaine, Phetsamone Vannasing, Philippe Major, Sébastien Jacquemont, Jacques L Michaud, Karim Jerbi, Sarah Lippé
Fragile X Syndrome (FXS) is a neurodevelopmental genetic disorder associated with cognitive and behavioural deficits. In particular, neuronal habituation processes have been shown to be altered in FXS patients. Yet, while such deficits have been primarily explored using auditory stimuli, less is known in the visual modality. Here, we investigated the putative alteration of repetition suppression using faces in FXS patients compared to controls that had the same age distribution. Electroencephalographic (EEG) signals were acquired while participants were presented with 18 different faces, each repeated ten times successively...
March 19, 2017: International Journal of Developmental Neuroscience
Meera E Modi, Mustafa Sahin
Deficits in social cognition are the defining characteristic of autism spectrum disorder (ASD). Social cognition requires the integration of several neural circuits in a time-sensitive fashion, so impairments in social interactions could arise as a result of alterations in network connectivity. Electroencephalography (EEG) has revealed abnormalities in event related potentials (ERPs) evoked by auditory and visual sensory stimuli in humans with ASD, indicating disruption of neural connectivity. Similar abnormalities in sensory-evoked ERPs have been observed in animal models of ASD, suggesting that ERPs have the potential to provide a translational biomarker of the disorder...
March 2017: Nature Reviews. Neurology
Qingguo Ma, Linfeng Hu, Can Xiao, Jun Bian, Jia Jin, Qiuzhen Wang
The present study examined the event-related potential (ERP) and time-frequency components correlates with the comprehension process of multimodal metaphors that were represented by the combination of "a vehicle picture+a written word of an animal". Electroencephalogram data were recorded when participants decided whether the metaphor using an animal word for the vehicle rendered by a picture was appropriate or not. There were two conditions: appropriateness (e.g., sport utility vehicles+tiger) vs. inappropriateness (e...
November 2016: International Journal of Psychophysiology
Ł Okruszek, A Wichniak, M Jarkiewicz, A Schudy, M Gola, K Jednoróg, A Marchewka, E Łojek
BACKGROUND: Despite social cognitive dysfunction that may be observed in patients with schizophrenia, the knowledge about social and nonsocial affective processing in schizophrenia is scant. The aim of this study was to examine neurophysiological and behavioural responses to neutral and negative stimuli with (faces, people) and without (animals, objects) social content in schizophrenia. METHODS: Twenty-six patients with schizophrenia (SCZ) and 21 healthy controls (HC) completed a visual oddball paradigm with either negative or neutral pictures from the Nencki Affective Picture System (NAPS) as targets while EEG was recorded...
September 2016: International Journal of Psychophysiology
Martyna Galazka, Marta Bakker, Gustaf Gredebäck, Pär Nyström
We investigated the neural correlates of chasing perception in infancy to determine whether animated interactions are processed as social events. By using EEG and an ERP design with animations of simple geometric shapes, we examined whether the positive posterior (P400) component, previously found in response to social stimuli, as well as the attention related negative fronto-central component (Nc), differs when infants observed a chaser versus a non-chaser. In Study 1, the chaser was compared to an inanimate object...
June 2016: Developmental Cognitive Neuroscience
Raksha A Mudar, Hsueh-Sheng Chiang, Justin Eroh, Lydia T Nguyen, Mandy J Maguire, Jeffrey S Spence, Fanting Kung, Michael A Kraut, John Hart
We examined the effects of amnestic mild cognitive impairment (aMCI) on behavioral (response times and error rates) and scalp-recorded event-related potential (ERP) measures of response execution and inhibition, using Go/NoGo tasks involving basic and superordinate semantic categorization. Twenty-five aMCI (16 F; 68.5±8 years) and 25 age- and gender-matched normal control subjects (16 F; 65.4±7.1 years) completed two visual Go/NoGo tasks. In the single car task, responses were made based on single exemplars of a car (Go) and a dog (NoGo) (basic)...
2016: Journal of Alzheimer's Disease: JAD
Anushka V Goonawardena, Jaime Heiss, Courtney Glavis-Bloom, Gerhard Trube, Edilio Borroni, Daniela Alberati, Tanya L Wallace
A growing body of evidence indicates that neuronal oscillations in the gamma frequency range (30-80 Hz) are disturbed in schizophrenic patients during cognitive processes and may represent an endophenotype of the disease. N-methyl-D-aspartate (NMDA) receptor antagonists have been used experimentally to induce schizophrenia-like symptoms including cognitive deficits in animals and humans. Here we characterized neuronal oscillations and event-related potentials (ERPs) in Cynomolgus macaques fully trained to perform a continuous performance test (CPT) in the presence and absence of the NMDA antagonist phencyclidine (PCP)...
April 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Hernando Santamaría-García, Miguel Burgaleta, Nuria Sebastián-Gallés
UNLABELLED: Social hierarchy is an ubiquitous principle of social organization across animal species. Although some progress has been made in our understanding of how humans infer hierarchical identity, the neuroanatomical basis for perceiving key social dimensions of others remains unexplored. Here, we combined event-related potentials and structural MRI to reveal the neuroanatomical substrates of early status recognition. We designed a covertly simulated hierarchical setting in which participants performed a task either with a superior or with an inferior player...
July 29, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
L Giraudet, J-P Imbert, M Bérenger, S Tremblay, M Causse
The Air Traffic Control (ATC) environment is complex and safety-critical. Whilst exchanging information with pilots, controllers must also be alert to visual notifications displayed on the radar screen (e.g., warning which indicates a loss of minimum separation between aircraft). Under the assumption that attentional resources are shared between vision and hearing, the visual interface design may also impact the ability to process these auditory stimuli. Using a simulated ATC task, we compared the behavioral and neural responses to two different visual notification designs--the operational alarm that involves blinking colored "ALRT" displayed around the label of the notified plane ("Color-Blink"), and the more salient alarm involving the same blinking text plus four moving yellow chevrons ("Box-Animation")...
November 1, 2015: Behavioural Brain Research
Raksha A Mudar, Hsueh-Sheng Chiang, Mandy J Maguire, Jeffrey S Spence, Justin Eroh, Michael A Kraut, John Hart
We used event-related potentials (ERPs) to study age effects of perceptual (basic-level) vs. perceptual-semantic (superordinate-level) categorization on cognitive control using the go/nogo paradigm. Twenty-two younger (11 M; 21 ± 2.2 years) and 22 older adults (9 M; 63 ± 5.8 years) completed two visual go/nogo tasks. In the single-car task (SiC) (basic), go/nogo responses were made based on single exemplars of a car (go) and a dog (nogo). In the object animal task (ObA) (superordinate), responses were based on multiple exemplars of objects (go) and animals (nogo)...
2015: Behavioural Brain Research
Carol Jahshan, Jonathan K Wynn, Kristopher I Mathis, Michael F Green
INTRODUCTION: The ability to recognize human biological motion is a fundamental aspect of social cognition that is impaired in people with schizophrenia. However, little is known about the neural substrates of impaired biological motion perception in schizophrenia. In the current study, we assessed event-related potentials (ERPs) to human and nonhuman movement in schizophrenia. METHODS: Twenty-four subjects with schizophrenia and 18 healthy controls completed a biological motion task while their electroencephalography (EEG) was simultaneously recorded...
January 2015: Brain and Behavior
Daniel C Javitt
Schizophrenia is a major mental disorder associated with core neurocognitive impairments. The ability to recreate these deficits in animal models is limited, hampering ongoing translational drug development efforts. This paper reviews the use of electroencephalography (EEG)-based neurophysiological measures, such as event-related potentials (ERPs) or event-related spectral perturbations (ERSPs), as novel translational biomarkers for both etiological and treatment development research in neuropsychiatry. In schizophrenia, cognitive impairments manifest as deficits not only in high-level processes, such as working memory or executive processing, but also as deficits in neurophysiological responses to simple auditory and visual stimuli...
May 2015: Annals of the New York Academy of Sciences
S A Kalinin, N Iu Gerasimenko, A V Slavutskaia, E S Mihaĭlova
In psychophysical (n = 55) and neurophysiological (n = 25) experiments subjects recognized the images from two categories--"animals" and "non-living objects" under forward masking. Subjects recognized images in two experimental conditions: the target and masking stimuli (SOA = 50 ms) belonged to same category and the stimuli belonged to different categories ("compatible" or "incompatible" pairs). It was found that an efficiency of forward masking depends on the categorical proximity the mask and the target stimuli...
July 2014: Fiziologiia Cheloveka
Henkjan Honing, Fleur L Bouwer, Gábor P Háden
The aim of this chapter is to give an overview of how the perception of a regular beat in music can be studied in humans adults, human newborns, and nonhuman primates using event-related brain potentials (ERPs). Next to a review of the recent literature on the perception of temporal regularity in music, we will discuss in how far ERPs, and especially the component called mismatch negativity (MMN), can be instrumental in probing beat perception. We conclude with a discussion on the pitfalls and prospects of using ERPs to probe the perception of a regular beat, in which we present possible constraints on stimulus design and discuss future perspectives...
2014: Advances in Experimental Medicine and Biology
Kwun Kei Ng, Trevor B Penney
Humans, and other animals, are able to easily learn the durations of events and the temporal relationships among them in spite of the absence of a dedicated sensory organ for time. This chapter summarizes the investigation of timing and time perception using scalp-recorded electroencephalography (EEG), a non-invasive technique that measures brain electrical potentials on a millisecond time scale. Over the past several decades, much has been learned about interval timing through the examination of the characteristic features of averaged EEG signals (i...
2014: Advances in Experimental Medicine and Biology
Yawei Cheng, Chenyi Chen, Jean Decety
Empathic arousal is the first ontogenetic building block of empathy to appear during infancy and early childhood. As development progresses, empathic arousal becomes associated with an increasing ability to differentiate between self and other, which is a critical aspect of mature empathetic ability (Decety and Jackson, 2004). This allows for better regulation of contagious distress and understanding others mental states. In the current study, we recorded electroencephalographic event-related potentials and mu suppression induced by short visual animations that depicted painful situations in 57 typically developing children aged between 3 and 9 years as well as 15 young adults...
October 2014: Developmental Cognitive Neuroscience
Jochen Kaiser, Christoph Bledowski, Jörg Dietrich
Cancer survivors frequently experience cognitive deficits following chemotherapy. The most commonly affected functions include memory, attention and executive control. The present paper reviews animal research and clinical studies including event-related potential (ERP) and neuroimaging investigations of chemotherapy-related changes of brain structure and function. In rodents, chemotherapeutic substances have been shown to damage neural precursor cells and white matter tracts and are associated with impairments of learning and memory...
May 2014: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Morten Grupe, Morten Grunnet, Bettina Laursen, Jesper Frank Bastlund
The P300 (P3) event-related potential (ERP) is a neurophysiological signal believed to reflect cognitive processing of salient cues, and is thus used as a measure of attention and working memory. Additionally, P3 amplitude and latency is altered in neurological diseases and can be pharmacologically modulated. As P3-like ERPs can be recorded in rodents, it may serve as a potential translational biomarker of value for drug discovery. Here we investigated whether a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors, NS9283, and the psychostimulant modafinil could modulate P3-like ERPs in healthy adult rats performing an auditory oddball discrimination task...
April 2014: Neuropharmacology
R E Featherstone, L R Nagy, C G Hahn, S J Siegel
BACKGROUND: Increased susceptibility to cognitive impairment or psychosis in adulthood is associated with adolescent drug abuse. Studies in adults have identified impairments in attention and memory, and changes in EEG, as common consequences of ketamine abuse. In contrast, the effects of ketamine on the juvenile brain have not been extensively tested. This is a significant omission, since abuse of ketamine is often observed within this age group. OBJECTIVES: Juvenile mice (4-6 weeks of age) were administered ketamine (20mg/kg) for 14 days...
January 1, 2014: Drug and Alcohol Dependence
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