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https://www.readbyqxmd.com/read/23893182/sodium-selenite-induces-apoptosis-in-colon-cancer-cells-via-bax-dependent-mitochondrial-pathway
#1
Z Li, J Meng, T-J Xu, X-Y Qin, X-D Zhou
OBJECTIVES: We aimed to elucidate a possible mechanism of action by investigating the effects of selenium (Se) on cell cycle arrest and apoptosis in colorectal cancer cells (HCT116 cells and SW620 cells). MATERIALS AND METHODS: The colorectal cancer cells were treated with varying concentrations of Se (1 microM, 5 microM and 10 microM) for 24 hours. The effects of Se on cell cycle, apoptosis, mitochondrial transmembrane potential and apoptosis related proteins were examined by flow cytometry assessment and immunoblotting...
August 2013: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/1244086/tryptophan-metabolism-in-skin-diseases
#2
M Binazzi, P Calandra
In a number of skin disturbances conditioned or aggravated by sunlight and/or mainly diffused to the cutaneous connective tissue (present acquired pellagra, lupus erythematosus, porphyria cutanea tarda, actinic reticuloid, Rothmund-Thomson syndrome, lymphocytoma cutis, scleroderma, dermatomyositis, burns, linphomas, parapsoriasis, acrodermatitis enteropathica) excretive changes were found only in the "via kynurenine" metabolites. As a rule kynureniase activity was reduced and tryptophan-pyrrolase activity was increased...
1975: Acta Vitaminologica et Enzymologica
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