Lucia Francesca Lucca, Danilo Lofaro, Elio Leto, Maria Ursino, Stefania Rogano, Antonio Pileggi, Serafino Vulcano, Domenico Conforti, Paolo Tonin, Antonio Cerasa
In this study, we sought to assess the predictors of outcome in patients with disorders of consciousness (DOC) after severe traumatic brain injury (TBI) during neurorehabilitation stay. In total, 96 patients with DOC (vegetative state, minimally conscious state, or emergence from minimally conscious state) were enrolled (69 males; mean age 43.6 ± 20.8 years) and the improvement of the degree of disability, as assessed by the Disability Rating Scale, was considered the main outcome measure. To define the best predictor, a series of demographical and clinical factors were modeled using a twofold approach: (1) logistic regression to evaluate a possible causal effect among variables; and (2) machine learning algorithms (ML), to define the best predictive model...
2020: Frontiers in Human Neuroscience