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https://www.readbyqxmd.com/read/29144182/plasma-lyte-148-vs-hartmann-s-solution-for-cardiopulmonary-bypass-pump-prime-a-prospective-double-blind-randomized-trial
#1
Laurence Weinberg, Elizabeth Chiam, James Hooper, Frank Liskaser, Angela Kim Hawkins, Denise Massie, Andrew Ellis, Chong O Tan, David Story, Rinaldo Bellomo
BACKGROUND: The mechanisms of acid-base changes during cardiopulmonary bypass (CPB) remain unclear. We tested the hypothesis that, when used as CPB pump prime solutions, Plasma-Lyte 148 (PL) and Hartmann's solution (HS) have differential mechanisms of action in their contribution to acid-base changes. METHODS: We performed a prospective, double-blind, randomized trial in adult patients undergoing elective cardiac surgery with CPB. Participants received a CPB prime solution of 2000 mL, with either PL or HS...
November 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29143066/-thoracolumbar-spinal-fractures-in-the-elderly-classification-and-treatment
#2
K J Schnake, P Bula, U J Spiegl, M Müller, F Hartmann, B W Ullrich, T R Blattert
Thoracolumbar fractures in the elderly are frequently associated with osteoporosis. Osteoporosis can cause fractures or be a significant comorbidity in traumatic fractures. The OF classification is based on conventional X‑ray, computed tomography (CT) scan and magnetic resonance imaging (MRI). It is easy to use and provides a clinically relevant classification of the fractures. Therapeutic decisions are made based on the clinical and radiological situation by using the OF score. The score takes the current clinical situation including patient-specific comorbidities into consideration...
November 15, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29141638/diffusion-weighted-imaging-of-the-brains-of-dogs-with-idiopathic-epilepsy
#3
Antje Hartmann, Steffen Sager, Klaus Failing, Marion Sparenberg, Martin J Schmidt
BACKGROUND: Idiopathic epilepsy is one of the most common neurological disorders in dogs. Unfortunately, up to 30% of dogs with idiopathic epilepsy show no improvement under antiepileptic drug treatment. Diffusion-weighted imaging is used in human medicine to identify epileptogenic foci in the brain to allow for more invasive treatments such as deep brain stimulation or surgical removal. The aim of this study was to ass the feasibility of interictal diffusion-weighted MRI in dogs and to evaluate the distribution of diffusion in the brains of dogs with idiopathic epilepsy (IE) and to compare these values to previously published values from healthy beagle dogs...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29141439/double-cross-polarization-for-the-indirect-detection-of-nitrogen-14-nuclei-in-magic-angle-spinning-nmr-spectroscopy
#4
Diego Carnevale, Xiao Ji, Geoffrey Bodenhausen
Nitrogen-14 NMR spectra at fast magic-angle spinning rates can be acquired indirectly by means of two-dimensional techniques based on double cross polarization transfer (1)H → (14)N →(1)H. Experimental evidence is given for polycrystalline samples of glycine, l-histidine, and the dipeptide Ala-Gly. Either one-bond or long-range correlations can be favored by choosing the length of the cross polarization contact pulses. Longer contact pulses allow the detection of unprotonated nitrogen sites. In contrast to earlier methods that exploited second-order quadrupolar/dipolar cross-terms, cross polarization operates in the manner of the method of Hartmann and Hahn, even for (14)N quadrupolar couplings up to 4 MHz...
November 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29141050/differential-immunomodulation-in-human-monocytes-versus-macrophages-by-filarial-cystatin
#5
Gopinath Venugopal, Marion Mueller, Susanne Hartmann, Svenja Steinfelder
Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and minimizing pathological processes. One filarial molecule known to counteract host immune responses by inducing IL-10 and regulatory macrophages in mice is filarial cystatin. During a patent filarial infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive...
2017: PloS One
https://www.readbyqxmd.com/read/29138343/a-phase-i-clinical-trial-of-the-poly-adp-ribose-polymerase-inhibitor-veliparib-and-weekly-topotecan-in-patients-with-solid-tumors
#6
Andrea E Wahner Hendrickson, Michael E Menefee, Lynn C Hartmann, Harry J Long, Donald W Northfelt, Joel M Reid, Felix Boakye-Agyeman, Olumide Kayode, Karen S Flatten, Maria I Harrell, Elizabeth M Swisher, Guy G Poirer, Daniel Satele, Jacob B Allred, Janet L Lensing, Alice Chen, Jiuping Jay Ji, Yiping Zhang, Charles Erlichman, Paul Haluska, Scott H Kaufmann
PURPOSE: To determine the dose limiting toxicities (DLTs), maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of veliparib in combination with weekly topotecan in patients with solid tumors. Correlative studies were included to assess the impact of topotecan and veliparib on poly(ADP-ribose) levels in peripheral blood mononuclear cells, serum pharmacokinetics of both agents, and potential association of germline repair gene mutations with outcome. EXPERIMENTAL DESIGN: Eligible patients had metastatic nonhematological malignancies with measurable disease...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29137125/new-2-methoxy-acetylenic-acids-and-pyrazole-alkaloids-from-the-marine-sponge-cinachyrella-sp
#7
Amin Mokhlesi, Rudolf Hartmann, Tibor Kurtán, Horst Weber, Wenhan Lin, Chaidir Chaidir, Werner E G Müller, Georgios Daletos, Peter Proksch
Three new 2-methoxy acetylenic acids (1-3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5-7) were isolated from an Indonesian marine sponge of the genus Cinachyrella. Compounds 5 and 6 have previously been reported as synthetic compounds. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopy as well as by mass spectrometric data. The absolute configuration of the new acetylenic acid derivatives (1-3) was established by ECD spectroscopy...
November 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29135916/lactones-from-the-sponge-derived-fungus-talaromyces-rugulosus
#8
Lisa Küppers, Weaam Ebrahim, Mona El-Neketi, Ferhat C Özkaya, Attila Mándi, Tibor Kurtán, Raha S Orfali, Werner E G Müller, Rudolf Hartmann, Wenhan Lin, Weiguo Song, Zhen Liu, Peter Proksch
The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1-5), seven (3S)-resorcylide derivatives (6-12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15-17). Among them, fourteen compounds (1-3, 6-16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry)...
November 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29133385/targeted-next-generation-sequencing-of-cancer-genes-in-poorly-differentiated-thyroid-cancer
#9
Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner, Thomas J Musholt
Poorly differentiated thyroid carcinoma (PDTC) is a rare malignancy with higher mortality than well-differentiated thyroid carcinoma. The histological diagnosis can be difficult as well as the therapy. Improved diagnosis and new targeted therapies require knowledge of DNA sequence changes in cancer-relevant genes. The TruSeq Amplicon Cancer Panel was used to screen cancer genomes from 25 PDTC patients for somatic single nucleotide variants in 48 genes known to represent mutational hotspots. A total of 4490 variants were found in 23 tissue samples of PDTC...
November 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29131747/linking-challenges-in-wound-healing-key-highlights-from-the-hartmann-congress
#10
(no author information available yet)
With a special focus on advanced wound healing (wound bed preparation, epithelialisation and hydration) and negative pressure wound therapy, the Hartmann LINK for Wound Healing Congress took place in Belfast, Northern Ireland, on 19 September. The event aimed to promote the latest advances in wound care and highlight the main challenges that clinicians face when treating different types of wounds. Annabel De Coster, editor of the British Journal of Community Nursing, gives an overview of selected talks from the congress...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29131519/displaying-tetra-membrane-spanning-claudins-on-enveloped-virus-like-particles-for-cancer-immunotherapy
#11
Irene C Schneider, Jessica Hartmann, Gundula Braun, Jörn Stitz, Thorsten Klamp, Mahjoub Bihi, Ugur Sahin, Christian J Buchholz
Virus-like particles (VLPs) displaying foreign antigens have become an important tool in vaccination including the induction of immune responses against self-antigens. Claudin 6 (CLDN6) has been identified as tumor-associated antigen and is therefore a potential target for tumor vaccination strategies. However, as tetra-membrane spanning protein its incorporation into VLPs while preserving a native fold is challenging. Here, we attempted the incorporation of a panel of engineered CLDN6 variants into the membrane of retrovirus-derived VLPs...
November 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29131170/co-phasing-experiment-of-a-segmented-mirror-using-a-combined-broadband-and-two-wavelength-algorithm
#12
Bin Li, Wen-Hao Yu, Mo Chen, Jin-Long Tang, Hao Xian
In this paper, a broadband phasing algorithm is combined with a two-wavelength phasing algorithm to detect the piston error of a segmented mirror with the advantages of long range, high precision, and fast detection. Moreover, an active optics co-phasing experimental system of the segmented mirror is built to verify the algorithm's effectiveness. The segmented mirror consists of four hexagonal segments, with flat-to-flat lengths of 100 mm and radii of curvature of 2000 mm. First, a Shack-Hartmann sensor and piezoelectric actuators are used to finely co-focus the segmented mirror...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29130457/gene-dosage-reductions-of-trf1-and-or-tin2-induce-telomere-dna-damage-and-lymphoma-formation-in-aging-mice
#13
K Hartmann, A Illing, F Leithäuser, A Baisantry, L Quintanilla-Martinez, K L Rudolph
This corrects the article DOI: 10.1038/leu.2015.173.
November 10, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29130164/detection-of-the-bacterial-quorum-sensing-signaling-molecules-n-acyl-homoserine-lactones-hsl-and-n-acyl-homoserine-hs-with-an-enzyme-linked-immunosorbent-assay-elisa-and-via-ultrahigh-performance-liquid-chromatography-coupled-to-mass-spectrometry-uhplc-ms
#14
Michael Rothballer, Jenny Uhl, Josie Kunze, Philippe Schmitt-Kopplin, Anton Hartmann
Quick and reliable quantitative methods requiring low amounts of sample volume are needed for the detection of N-acyl-homoserine lactones (HSL) and their degradation products N-acyl-homoserines (HS) in order to elucidate the occurrence and dynamics of these prevalent quorum-sensing molecules of Gram-negative bacteria in natural samples and laboratory model experiments. A combination of ELISA and UHPLC-MS is presented here which has proven to meet these requirements. Both methods can not only precisely detect and quantify HSLs but also their degradation products HS and thereby enable studying signaling dynamics in quorum sensing, which have been identified to play an essential role in bacterial communication...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29129450/resident-choice-a-nursing-home-staff-perspective-on-tensions-and-resolutions
#15
Jennifer A Palmer, Victoria A Parker, Dan Berlowitz, A Lynn Snow, Christine W Hartmann
A central component of person-centered care, resident choice in daily life, has received little research attention in the U.S. CONTEXT: This study investigated nursing home staff experiences in realizing resident choice. Twenty-six qualitative staff interviews were conducted in an opportunistic sample from two Veterans Health Administration (VHA) Community Living Centers (CLCs, i.e., nursing homes) implementing the Green House Model. Thematic content analysis surfaced several key tensions at the intra-personal, inter-personal, and organizational levels...
November 9, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29128976/neurons-in-the-crow-nidopallium-caudolaterale-encode-varying-durations-of-visual-working-memory-periods
#16
Konstantin Hartmann, Lena Veit, Andreas Nieder
Adaptive sequential behaviors rely on the bridging and integration of temporally separate information for the realization of prospective goals. Corvids' remarkable behavioral flexibility is thought to depend on the workings of the nidopallium caudolaterale (NCL), a high-level avian associative forebrain area. We trained carrion crows to remember visual items for three alternating delay durations in a delayed match-to-sample task and recorded single-unit activity from the NCL. Sample-selective delay activity, a correlate of visual working memory, was maintained throughout different working memory durations...
November 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29128595/ultrafast-protein-folding-in-membrane-mimetic-environments
#17
Georg Krainer, Andreas Hartmann, Abhinaya Anandamurugan, Pablo Gracia, Sandro Keller, Michael Schlierf
Proteins fold on timescales from hours to microseconds. In addition to protein size, sequence, and topology, the environment represents an equally important factor in determining folding speed. This is particularly relevant for proteins that require a lipid membrane or a membrane mimic to fold. However, only little is known about how properties of such a hydrophilic/hydrophobic interface modulate the folding landscape of membrane-interacting proteins. Here, we studied the influence of different membrane-mimetic micellar environments on the folding and unfolding kinetics of the helical-bundle protein Mistic...
November 8, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29127336/intermediate-levels-of-network-heterogeneity-provide-the-best-evolutionary-outcomes
#18
Flávio L Pinheiro, Dominik Hartmann
Complex networks impact the diffusion of ideas and innovations, the formation of opinions, and the evolution of cooperative behavior. In this context, heterogeneous structures have been shown to generate a coordination-like dynamics that drives a population towards a monomorphic state. In contrast, homogeneous networks tend to result in a stable co-existence of multiple traits in the population. These conclusions have been reached through the analysis of networks with either very high or very low levels of degree heterogeneity...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29124458/pitfalls-of-cannulation-for-extracorporeal-life-support-review-of-the-literature-and-illustrative-case-presentation
#19
REVIEW
Martin Geyer, Bernhard Gohrbandt, Ingo Sagoschen, Thomas Hartmann, Felix Post, Christian-Friedrich Vahl, Thomas Münzel
Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS) are an increasingly established advanced therapy for emerging severe lung and/or cardiocirculatory dysfunction or failure. Several reports have provided evidence for a potential benefit in prognosis by ECLS in cases of cardiogenic shock including cardiopulmonary resuscitation. Routine use in specialized centers reduces the incidence of negative side effects (e.g., vascular/ischemic, embolic, hemorrhagic, hemolytic and, furthermore, septic)...
November 9, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29124274/-psycho-oncology-care-in-rural-areas-results-from-a%C3%A2-cross-sectional-survey-on-the-utilisation-of-community-based-psychosocial-support-services
#20
Markus W Haun, Halina Sklenarova, Verena Zimmermann-Schlegel, Wolfgang Herzog, Mechthild Hartmann
BACKGROUND: Clinically relevant distress and unmet psychosocial needs frequently occur in the course of cancer diseases. Particularly for thinly populated rural areas in Germany rates of distressed patients and uptake of community-based psycho-oncology services are unknown. OBJECTIVES: Determination of a) the proportion of cancer patients with psychosocial distress and unmet needs and b) the utilisation of community-based psycho-oncology services in thinly populated rural areas...
November 9, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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