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https://www.readbyqxmd.com/read/28821935/age-related-t2-relaxation-times-at-3-tesla-as-a-biomarker-of-infratentorial-brain-maturation
#1
Eva Bültmann, Loukia M Spineli, Friederike Göhner, Hans Hartmann, Heinrich Lanfermann
PURPOSE: The purpose of this study was to examine age-related, infratentorial changes in T2 relaxation times during infancy and childhood using routine MRI data at 3 Tesla. METHODS: One hundred patients (0-199 months) without signal abnormalities on conventional MRI were retrospectively selected from our pool of pediatric MRI examinations. T2 maps based on our routinely acquired triple-echo turbo spin-echo (TSE) sequence were created. Based on their clinical symptoms, the children were divided into 43 controls and 57 diseased children with different clinical diseases...
August 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28820255/discovery-of-a-potent-inhibitor-class-with-high-selectivity-towards-clostridial-collagenases
#2
Esther Schönauer, Andreas Martin Kany, Jörg Haupenthal, Kristina Hüsecken, Isabel Josephin Hoppe, Katrin Voos, Samir Yahiaoui, Brigitta Elsässer, Christian Ducho, Hans Brandstetter, Rolf W Hartmann
Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human metalloproteases such as MMPs. Using an SPR-based screening complemented with enzyme inhibition assays, we discovered an N-aryl mercaptoacetamide-based inhibitor scaffold that showed submicromolar affinities towards collagenase H (ColH) from the human pathogen Clostridium histolyticum...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28819694/thoracic-corpectomy-for-neoplastic-vertebral-bodies-using-a-navigated-lateral-extracavitary-approach-a-single-center-consecutive-case-series-technique-and-analysis
#3
Sebastian Hartmann, Christoph Wipplinger, Anja Tschugg, Pujan Kavakebi, Alexander Örley, Pierre Pascal Girod, Claudius Thomé
Thoracic myelopathy is often caused by vertebral body fractures resulting from neoplastic conditions, traumatic events, or infectious diseases. One of the preferred procedures for treating it is the lateral extracavitary approach (LECA) with single-level or multilevel decompressive corpectomy and reconstruction. The aim of this retrospective study was to analyze the thoracic lateral extracavitary approach with corpectomy using vertebral body replacement systems (VBR-S) and dorsal reconstruction. Twenty-four patients with metastatic or primary lesions of thoracic vertebrae T2-T12 underwent spinal decompression and ventral column reconstruction with correction of spinal deformity via a LECA...
August 17, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28818518/seladelpar-mbx-8025-a-selective-ppar-%C3%AE-agonist-in-patients-with-primary-biliary-cholangitis-with-an-inadequate-response-to-ursodeoxycholic-acid-a-double-blind-randomised-placebo-controlled-phase-2-proof-of-concept-study
#4
David Jones, Pol F Boudes, Mark G Swain, Christopher L Bowlus, Michael R Galambos, Bruce R Bacon, Yvonne Doerffel, Norman Gitlin, Stuart C Gordon, Joseph A Odin, David Sheridan, Markus-Alexander Wörns, Virginia Clark, Linsey Corless, Heinz Hartmann, Mark E Jonas, Andreas E Kremer, George F Mells, Peter Buggisch, Bradley L Freilich, Cynthia Levy, John M Vierling, David E Bernstein, Marek Hartleb, Ewa Janczewska, Fedja Rochling, Hemant Shah, Mitchell L Shiffman, John H Smith, Yun-Jung Choi, Alexandra Steinberg, Monika Varga, Harinder Chera, Robert Martin, Charles A McWherter, Gideon M Hirschfield
BACKGROUND: Many patients with primary biliary cholangitis have an inadequate response to first-line therapy with ursodeoxycholic acid. Seladelpar is a potent, selective agonist for the peroxisome proliferator-activated receptor-delta (PPAR-δ), which is implicated in bile acid homoeostasis. This first-in-class study evaluated the anti-cholestatic effects and safety of seladelpar in patients with an inadequate response to ursodeoxycholic acid. METHODS: The study was a 12-week, double-blind, placebo-controlled, phase 2 trial of patients with alkaline phosphatase of at least 1·67 times the upper limit of normal (ULN) despite treatment with ursodeoxycholic acid...
August 14, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28816865/liquid-crystal-spatial-light-modulators-for-simulating-zonal-multifocal-lenses
#5
Yiyu Li, Arthur Bradley, Renfeng Xu, Pete S Kollbaum
SIGNIFICANCE: To maximize efficiency of the normally lengthy and costly multizone lens design and testing process, it is advantageous to evaluate the potential efficacy of a design as thoroughly as possible prior to lens fabrication and on-eye testing. The current work describes an ex vivo approach of optical design testing. PURPOSE: The aim of this study was to describe a system capable of examining the optical characteristics of multizone bifocal and multifocal optics by subaperture stitching using liquid crystal technologies...
August 14, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28815923/biophysical-screening-of-a-focused-library-for-the-discovery-of-cyp121-inhibitors-as-novel-antimycobacterials
#6
Christian Brengel, Andreas Thomann, Alexander Schifrin, Giuseppe Allegretta, Ahmed A M Kamal, Joerg Haupenthal, Isabell Schnorr, Sang Hyun Cho, Scott Gary Franzblau, Martin Empting, Jens Eberhard, Rolf W Hartmann
The development of novel antimycobacterial agents against Mycobacterium tuberculosis (Mtb) is urgently required due to the appearance of multi-drug resistance (MDR) combined with a complicated long-term treatment. CYP121 was shown to be a promising novel target for inhibition of mycobacterial growth. In this study, we describe the rational discovery of new CYP121 inhibitors by a systematic screening based on biophysical and microbiological methods. Best hits originating from only one structural class gave first information about molecular motifs required for binding and activity...
August 16, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28812998/a-framework-based-on-reference-data-with-superordinate-accuracy-for-the-quality-analysis-of-terrestrial-laser-scanning-based-multi-sensor-systems
#7
Ulrich Stenz, Jens Hartmann, Jens-André Paffenholz, Ingo Neumann
Terrestrial laser scanning (TLS) is an efficient solution to collect large-scale data. The efficiency can be increased by combining TLS with additional sensors in a TLS-based multi-sensor-system (MSS). The uncertainty of scanned points is not homogenous and depends on many different influencing factors. These include the sensor properties, referencing, scan geometry (e.g., distance and angle of incidence), environmental conditions (e.g., atmospheric conditions) and the scanned object (e.g., material, color and reflectance, etc...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28811992/analysis-of-the-literature-on-cervical-spine-fractures-in-ankylosing-spinal-disorders
#8
REVIEW
Sebastian Hartmann, Anja Tschugg, Christoph Wipplinger, Claudius Thomé
STUDY DESIGN: Narrative literature review. OBJECTIVE: The numbers of low-energy cervical fractures seen in patients suffering from ankylosing spondylitis (also known as Bechterew disease) or diffuse idiopathic skeletal hyperostosis (also known as Forestier disease) have greatly increased over recent decades. These fractures tend to be particularly overlooked, leading to delayed diagnosis and secondary neurological deterioration. The aim of the present evaluation was to summarize current knowledge on cervical fractures in patients with ankylosing spinal disorders (ASDs)...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28810907/schr%C3%A3-dinger-s-microbes-tools-for-distinguishing-the-living-from-the-dead-in-microbial-ecosystems
#9
REVIEW
Joanne B Emerson, Rachel I Adams, Clarisse M Betancourt Román, Brandon Brooks, David A Coil, Katherine Dahlhausen, Holly H Ganz, Erica M Hartmann, Tiffany Hsu, Nicholas B Justice, Ivan G Paulino-Lima, Julia C Luongo, Despoina S Lymperopoulou, Cinta Gomez-Silvan, Brooke Rothschild-Mancinelli, Melike Balk, Curtis Huttenhower, Andreas Nocker, Parag Vaishampayan, Lynn J Rothschild
While often obvious for macroscopic organisms, determining whether a microbe is dead or alive is fraught with complications. Fields such as microbial ecology, environmental health, and medical microbiology each determine how best to assess which members of the microbial community are alive, according to their respective scientific and/or regulatory needs. Many of these fields have gone from studying communities on a bulk level to the fine-scale resolution of microbial populations within consortia. For example, advances in nucleic acid sequencing technologies and downstream bioinformatic analyses have allowed for high-resolution insight into microbial community composition and metabolic potential, yet we know very little about whether such community DNA sequences represent viable microorganisms...
August 16, 2017: Microbiome
https://www.readbyqxmd.com/read/28808263/ising-ferromagnets-on-proximity-graphs-with-varying-disorder-of-the-node-placement
#10
Hendrik Schawe, Christoph Norrenbrock, Alexander K Hartmann
We perform Monte Carlo simulations to determine the critical temperatures of Ising Ferromagnets (IFM) on different types of two-dimensional proximity graphs, in which the distribution of their underlying node sets has been changed systematically by means of a parameter σ. This allows us to interpolate between regular grids and proximity graphs based on complete random placement of nodes. Each edge of the planar proximity graphs carries a weighted ferromagnetic coupling. The coupling strengths are determined via the Euclidean distances between coupled spins...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805747/what-is-nutritious-snack-food-a-comparison-of-expert-and-layperson-assessments
#11
Tamara Bucher, Christina Hartmann, Megan E Rollo, Clare E Collins
The term "nutritious" is being increasingly used by product manufacturers but the term is not currently regulated as a nutrition claim. It is unclear how lay consumers and experts define and interpret the term or how they evaluate the "nutritiousness" of various foods. To address this evidence gap, a mixed methods design was applied and both nutrition experts (n = 206) and lay participants (n = 269) provided definitions of the term "nutritious" and evaluated the "nutritiousness" of 20 different snack foods in a cross-sectional survey...
August 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28805418/adaptation-of-a-nursing-home-culture-change-research-instrument-for-frontline-staff-quality-improvement-use
#12
Christine W Hartmann, Jennifer A Palmer, Whitney L Mills, Camilla B Pimentel, Rebecca S Allen, Nancy J Wewiorski, Kristen R Dillon, A Lynn Snow
Enhanced interpersonal relationships and meaningful resident engagement in daily life are central to nursing home cultural transformation, yet these critical components of person-centered care may be difficult for frontline staff to measure using traditional research instruments. To address the need for easy-to-use instruments to help nursing home staff members evaluate and improve person-centered care, the psychometric method of cognitive-based interviewing was used to adapt a structured observation instrument originally developed for researchers and nursing home surveyors...
August 2017: Psychological Services
https://www.readbyqxmd.com/read/28805264/large-nested-variant-of-urothelial-carcinoma-a%C3%A2-clinicopathological-study-of-36-cases
#13
Eva Compérat, Jesse K McKenney, Arndt Hartmann, Ondrej Hes, Simone Bertz, Justine Varinot, Fadi Brimo
AIMS: The large nested variant of urothelial carcinoma (LNUC) has been added to the World Health Organization (WHO) 2016 classification. Scant data exist, and little is known about its clinical behaviour. MATERIAL AND RESULTS: Cases fulfilling the morphological criteria of LNUC were collected. Pure and mixed cases (i.e. with other patterns of invasive UC) were studied. Immunohistochemical staining with cytokeratin (CK)7, p63, GATA-3, CK20, p53 and Ki-67 was performed...
June 9, 2017: Histopathology
https://www.readbyqxmd.com/read/28803294/-barbecue-burns
#14
REVIEW
Bernd Hartmann
No abstract text is available yet for this article.
August 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28801697/low-hartmann-s-procedure-or-intersphincteric-proctectomy-for-distal-rectal-cancer-a-retrospective-comparative-cohort-study
#15
Emma Westerduin, Gijsbert D Musters, Anna A W van Geloven, Marinke Westerterp, Erwin van der Harst, Willem A Bemelman, Pieter J Tanis
PURPOSE: Two non-restorative options for low rectal cancer not invading the sphincter are the low Hartmann's procedure (LH) or intersphincteric proctectomy (IP). The aim of this study was to compare postoperative morbidity with emphasis on pelvic abscesses after LH and IP. METHODS: All patients that had LH or IP for low rectal cancer were included in three centres between 2008 and 2014 in this retrospective cohort study. Follow-up was performed for at least 12 months...
August 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28801534/cgas-is-activated-by-dna-in-a-length-dependent-manner
#16
Stefanie Luecke, Andreas Holleufer, Maria H Christensen, Kasper L Jønsson, Gerardo A Boni, Lambert K Sørensen, Mogens Johannsen, Martin R Jakobsen, Rune Hartmann, Søren R Paludan
Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP-AMP synthase (cGAS) recognizes cytoplasmic DNA and signals via STING to induce IFN production. Despite the importance of DNA in innate immunity, the nature of the DNA that stimulates IFN production is not well described. Using low DNA concentrations, we show that dsDNA induces IFN in a length-dependent manner. This is observed over a wide length-span of DNA, ranging from the minimal stimulatory length to several kilobases, and is fully dependent on cGAS irrespective of DNA length...
August 10, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28801085/measuring-in-vivo-cerebral-maturation-using-age-related-t2-relaxation-times-at-3t
#17
Eva Bültmann, Loukia M Spineli, Hans Hartmann, Heinrich Lanfermann
OBJECTIVE: To examine age-related changes in T2 relaxation times during infancy and childhood in order to assess T2 values obtained from routine MRI as a biomarker. METHODS: From our pool of clinical pediatric MRI examinations at 3T all patients with normal conventional MRI scans were retrospectively selected. Depending on their clinical findings the identified 99 patients (0-199months) were divided into 43 healthy controls and 56 diseased children with various clinical abnormalities (developmental delay, epilepsy, prematurity, and deafness)...
August 8, 2017: Brain & Development
https://www.readbyqxmd.com/read/28800171/antioxidant-protection-by-%C3%AE-selenoamines-against-thioacetamide-induced-oxidative-stress-and-hepatotoxicity-in-mice
#18
Sílvio Terra Stefanello, Diane Duarte Hartmann, Guilherme Pires Amaral, Aline Alves Courtes, Martim T B Leite, Thayanara Cruz da Silva, Débora Farina Gonçalves, Micaela B Souza, Pâmela Carvalho da Rosa, Luciano Dornelles, Félix Alexandre Antunes Soares
Thioacetamide (TAA) is a hepatotoxin that rapidly triggers the necrotic process and oxidative stress in the liver. Nevertheless, organic selenium compounds, such as β-selenoamines, can be used as pharmacological agents to diminish the oxidative damage. Thus, the aim of this study was to investigate the protective effect of the antioxidant β-selenoamines on TAA-induced oxidative stress in mice. Here, we observed that a single intraperitoneal injection of TAA (200 mg/kg) dramatically elevated some parameters of oxidative stress, such as lipid peroxidation and reactive oxygen species (ROS) production, as well as depleted cellular antioxidant defenses...
August 11, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28799513/ketogenic-diets-in-the-treatment-of-epilepsy
#19
Maurizio Elia, Joerg Klepper, Baerbel Leiendecker, Hans Hartmann
BACKGROUND: Although a larger number of antiepileptic drugs became available in the last decades, epilepsy remains drug-resistant in approximately a third of patients. Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not completely understood. Over the last decades, different types of ketogenic diets (KDs) have been developed, namely classical KD and modified Atkins diet (MAD). They offer an effective alternative for children and adults with drug-resistant epilepsies...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28798985/nanostring-based-breast-cancer-risk-prediction-for-women-with-sclerosing-adenosis
#20
Stacey J Winham, Christine Mehner, Ethan P Heinzen, Brendan T Broderick, Melody Stallings-Mann, Aziza Nassar, Robert A Vierkant, Tanya L Hoskin, Ryan D Frank, Chen Wang, Lori A Denison, Celine M Vachon, Marlene H Frost, Lynn C Hartmann, E Aubrey Thompson, Mark E Sherman, Daniel W Visscher, Amy C Degnim, Derek C Radisky
PURPOSE: Sclerosing adenosis (SA), found in ¼ of benign breast disease (BBD) biopsies, is a histological feature characterized by lobulocentric proliferation of acini and stromal fibrosis and confers a two-fold increase in breast cancer risk compared to women in the general population. We evaluated a NanoString-based gene expression assay to model breast cancer risk using RNA derived from formalin-fixed, paraffin-embedded (FFPE) biopsies with SA. METHODS: The study group consisted of 151 women diagnosed with SA between 1967 and 2001 within the Mayo BBD cohort, of which 37 subsequently developed cancer within 10 years (cases) and 114 did not (controls)...
August 10, 2017: Breast Cancer Research and Treatment
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