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https://www.readbyqxmd.com/read/29220866/neural-correlates-of-fatigue-in-multiple-sclerosis-a-combined-neurophysiological-and-neuroimaging-approach-r1
#1
M Russo, A Calamuneri, A Cacciola, L Bonanno, A Naro, V Dattola, E Sessa, M Buccafusca, D Milardi, P Bramanti, R S Calabrò, A Quartarone
The present study is aimed at further exploring structural and functional correlates of fatigue in Relapsing- Remitting Multiple Sclerosis (RRMS) patients by using a combined approach by means of transcranial magnetic stimulation (TMS) and a Diffusion Tensor Imaging (DTI). The physiopathology of fatigue in MS is still poorly understood, although a variety of pathogenic mechanisms has been proposed. Our working hypothesis is that diffuse microstructural white matter damage may subtend the cortico-subcortical functional disconnection described in patients with MS and fatigue...
September 30, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29220808/metabolic-engineering-of-carbon-overflow-metabolism-of-bacillus-subtilis-for-improved-n-acetyl-glucosamine-production
#2
Wenlong Ma, Yanfeng Liu, Hyun-Dong Shin, Jianghua Li, Jian Chen, Guocheng Du, Long Liu
Bacillus subtilis is widely used as cell factories for the production of important industrial biochemicals. Although many studies have demonstrated the effects of organic acidic byproducts, such as acetate, on microbial fermentation, little is known about the effects of blocking the neutral byproduct overflow, such as acetoin, on bioproduction. In this study, we focused on the influences of modulating overflow metabolism on the production of N-acetyl-d-glucosamine (GlcNAc) in engineered B. subtilis. We found that acetoin overflow competes with GlcNAc production, and blocking acetoin overflow increased GlcNAc titer and yield by 1...
October 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29220795/novel-vanillin-derivatives-synthesis-anti-oxidant-dna-and-cellular-protection-properties
#3
Matteo Scipioni, Graeme Kay, Ian Megson, Paul Kong Thoo Lin
Antioxidants have been the subject of intense research interest mainly due to their beneficial properties associated with human health and wellbeing. Phenolic molecules, such as naturally occurring Resveratrol and Vanillin, are well known for their anti-oxidant properties, providing a starting point for the development of new antioxidants. Here we report, for the first time, the synthesis of a number of new vanillin through the reductive amination reaction between vanillin and a selection of amines. All the compounds synthesised, exhibited strong antioxidant properties in DPPH, FRAP and ORAC assays, with compounds 1b and 2c being the most active...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220775/sio2-nanomaterial-as-a-tool-to-improve-hordeum-vulgare-l-tolerance-to-nano-nio-stress
#4
Cristiano Soares, Simão Branco-Neves, Alexandra de Sousa, Manuel Azenha, Ana Cunha, Ruth Pereira, Fernanda Fidalgo
This work was designed to assess the potential role of silicon dioxide nanomaterial (nano-SiO2) in enhancing barley's tolerance to nickel oxide nanomaterial (nano-NiO). For this purpose, plants were grown for 14days under nano-NiO (120mgkg-1) single and co-exposure with nano-SiO2 (3mgkg-1). The exposure of barley to nano-NiO caused a significant decrease in growth-related parameters and induced a negative response on the photosynthetic apparatus. However, upon nano-SiO2 co-exposure, the inhibitory effects of nano-NiO were partially reduced, with lower reductions in fresh and dry biomass, and with the recovery of the photosynthesis-related parameters...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220761/climate-change-potential-effects-on-the-hydrological-regime-of-freshwater-springs-in-the-italian-northern-apennines
#5
Federico Cervi, Francesca Petronici, Attilio Castellarin, Marco Marcaccio, Andrea Bertolini, Lisa Borgatti
In large areas of the Italian Northern Apennines, hundreds of low-yield springs provide water for drinking and industrial purposes, with short groundwater flow paths being formed within fractured sedimentary rock units. This hydrogeological setting results in spring water discharges that closely follow meteoric water recharge patterns, leading to low-flow periods concentrated in the summer/early autumn. Therefore, the springs' outflow can be very sensitive to a shortage in water recharge, as it was the case in 2003 and 2017, when a prolonged period of drought caused severe water management issues...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220760/historical-trace-element-accumulation-in-marine-sediments-from-the-tamaulipas-shelf-gulf-of-mexico-an-assessment-of-natural-vs-anthropogenic-inputs
#6
Omar Celis-Hernandez, Leticia Rosales-Hoz, Andrew B Cundy, Arturo Carranza-Edwards, Ian W Croudace, Hector Hernandez-Hernandez
The Gulf of Mexico is considered one of the world's major marine ecosystems, supporting important fisheries and habitats such as barrier islands, mangrove forests, seagrass beds, coral reefs etc. It also hosts a range of complex offshore petroleum exploration, extraction, and refining industries, which may have chronic or acute impacts on ecosystem functioning. Previous work on the marine effects of this activity is geographically incomplete, and has tended to focus on direct hydrocarbon impacts, while impacts from other related contaminants (e...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220758/interaction-of-a-digestive-protease-candida-rugosa-lipase-with-three-surfactants-investigated-by-spectroscopy-molecular-docking-and-enzyme-activity-assay
#7
Rui Zhang, Yang Liu, Xinran Huang, Mengchen Xu, Rutao Liu, Wansong Zong
The extensive use of surfactants in food, laundry products and agriculture has caused concern about their biosafety. However, few studies have been done on their potential effect on the lipase which has always been used with surfactants in food and laundry industry. Herein, we investigated the interaction of three surfactants (sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), sodium lauryl sulfonate (SLS)) with Candida rugosa lipase (CRL), which is a popular biocatalyst used regularly with surfactants...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220744/sensitive-detection-of-pyoverdine-with-an-electrochemical-sensor-based-on-electrochemically-generated-graphene-functionalized-with-gold-nanoparticles
#8
Islem Gandouzi, Mihaela Tertis, Andreea Cernat, Amina Bakhrouf, Maria Coros, Stela Pruneanu, Cecilia Cristea
The design and development of an electrochemical sensor for the sensitive and selective determination of pyoverdine, a virulence factor secreted by Pseudomonas aeruginosa, bacteria involved in nosocomial infections is presented in this work. The presence of pyoverdine in water and body fluids samples can be directly linked to the presence of the Pseudomonas bacteria, thus being a nontoxic and low cost marker for the detection of water pollution as well as for the biological contamination of other media. The sensor was elaborated using layer-by-layer technique for the deposition of a graphene‑gold nanoparticles composite film on the graphite-based screen printed electrode, from aqueous suspension...
December 5, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29220740/validity-of-health-insurance-data-to-identify-people-with-epilepsy
#9
Merel Wassenaar, Johannes A Carpay, Josemir W Sander, Roland D Thijs
BACKGROUND: Large administrative databases may prove useful to assess epilepsy-related comorbidity and mortality. Despite their increased use, their validity as data source in epilepsy is yet under-ascertained. METHODS: Achmea is a large Dutch health insurance company covering about 25% of the population. We performed a retrospective cohort study using data from the Achmea Health Insurance Database (AHID) over the period 2006-2009. To assess the validity of epilepsy codes in the AHID, we randomly invited 1000 individuals (age 18-75 years insured by Achmea), attending an epilepsy centre or a district hospital during 2006-2009, to participate...
December 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29220736/arsenic-stress-effects-on-root-water-absorption-in-soybean-plants-physiological-and-morphological-aspects
#10
Mariana E Vezza, Analía Llanes, Claudia Travaglia, Elizabeth Agostini, Melina A Talano
Soybean (Glycine max L.) is often cultivated in areas contaminated with arsenic (As), which negatively affects plant growth and reduces crop yield. The deleterious effects may be due, at least in part, to disturbances in the water status, as was reported for some plants exposed to heavy metals. However, to our knowledge, these mechanisms have not been studied in depth in soybean plants exposed to As. The aim of the present work was to analyze possible changes in water relations and the responses developed in soybean plants under arsenate (AsV) and arsenite (AsIII) stress...
December 2, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29220733/a-fast-method-for-ghb-gluc-quantitation-in-whole-blood-by-gc-ms-ms-tqd-for-forensic-purposes
#11
Ana S Dias, André L Castro, Paula Melo, Sónia Tarelho, Pedro Domingues, João Miguel Franco
γ-Hydroxybutyric acid (GHB) is an endogenous compound with a historical use, both in licit and illicit terms. Importantly, the post-mortem behavior of GHB has been studied due to the possibility of using this compound as a biomarker for estimating the post-mortem interval (PMI). However, the post-mortem behavior of the recently discovered glucuronated GHB metabolite (GHB-GLUC) has not been studied. Nevertheless, GHB-GLUC may also have potential both to assist in PMI determination and also to increase the window of detection of GHB consumption...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29220727/the-health-impacts-of-weekday-traffic-a-health-risk-assessment-of-pm2-5-emissions-during-congested-periods
#12
Weeberb J Requia, Christopher D Higgins, Matthew D Adams, Moataz Mohamed, Petros Koutrakis
Little work has accounted for congestion, using data that reflects driving patterns, traffic volume, and speed, to examine the association between traffic emissions and human health. In this study, we performed a health risk assessment of PM2.5 emissions during congestion periods in the Greater Toronto and Hamilton Area (GTHA), Canada. Specifically, we used a micro-level approach that combines the Stochastic User Equilibrium Traffic Assignment Algorithm with a MOVES emission model to estimate emissions considering congestion conditions...
December 5, 2017: Environment International
https://www.readbyqxmd.com/read/29220710/life-satisfaction-and-its-associated-factors-among-money-boys-in-china
#13
A Zhang, J Yan, G Yang, X Tan, X Wang, S Tan
OBJECTIVES: Money Boy (MB) is a unique term used in China referring to a specialized population of men who sell sex to other men. Life satisfaction can influence one's health-related behaviors. The aim of our study was to find out the situation of MBs' life satisfaction and its associated factors. STUDY DESIGN: A cross-sectional study among MBs was conducted between July and December 2013 in Hunan province, China. METHODS: Respondent-driven sampling method was used for recruitment, with the initial seven 'seeds' found from a gay dating website, and 234 participants were enrolled into the study...
December 5, 2017: Public Health
https://www.readbyqxmd.com/read/29220709/self-reported-influenza-vaccination-rates-and-attitudes-towards-vaccination-among-health-care-workers-results-of-a-survey-in-a-german-university-hospital
#14
M H Hagemeister, N K Stock, T Ludwig, P Heuschmann, U Vogel
OBJECTIVES: The objective of this survey was to analyse vaccination rates and attitudes towards vaccination among health care workers (HCWs). The period prevalence of self-reported acute respiratory infections in the influenza season 2014/2015 was examined. STUDY DESIGN: A cross-sectional study was conducted among HCWs of a German university hospital using an anonymised questionnaire. Recruitment was performed by providing all medical and nursing staff a paper questionnaire with an invitation to participate...
December 5, 2017: Public Health
https://www.readbyqxmd.com/read/29220705/therapeutic-landscapes-and-longevity-wellness-tourism-in-bama
#15
Liyuan Huang, Honggang Xu
Due to the rising demand for healthcare products and concern over environmental pollution, wellness tourism has been booming in China in recent years. The therapeutic landscape theory provides a multi-scale interpretation of wellness tourism to explore how wellness tourists achieve health in healing places. By presenting the results of 83 interviews conducted in Bama, China, this study reveals that the "longevity village" Bama, endorsed by centenarians, provides a retreat that combines natural beauty and a harmonious neighbourhood for wellness tourists...
November 28, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29220659/organizing-organoids-stem-cells-branch-out
#16
Jamie A Davies
In this issue of Cell Stem Cell, Taguchi and Nishinakamura (2017) describe a carefully optimized method for making a branch-competent ureteric bud, a tissue fundamental to kidney development, from mouse embryonic stem cells and human induced pluripotent stem cells. The work illuminates embryology and has important implications for making more realistic kidney organoids.
December 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29220658/multi-omic-mitoprotease-profiling-defines-a-role-for-oct1p-in-coenzyme-q-production
#17
Mike T Veling, Andrew G Reidenbach, Elyse C Freiberger, Nicholas W Kwiecien, Paul D Hutchins, Michael J Drahnak, Adam Jochem, Arne Ulbrich, Matthew J P Rush, Jason D Russell, Joshua J Coon, David J Pagliarini
Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, although their direct substrates are often difficult to discern. Through multi-omic profiling of diverse Saccharomyces cerevisiae mitoprotease deletion strains, we predicted numerous associations between mitoproteases and distinct mitochondrial processes. These include a strong association between the mitochondrial matrix octapeptidase Oct1p and coenzyme Q (CoQ) biosynthesis-a pathway essential for mitochondrial respiration...
December 7, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29220628/autobiographical-narration-as-a-tool-for-the-empowerment-of-older-adults-subjective-and-psychological-wellbeing-in-nursing-homes
#18
Federica Biassoni, Giada Cassina, Stefania Balzarotti
OBJECTIVES: Conceiving narration as a resource to promote older people's wellbeing, the present work aimed to implement a narrative-based intervention to empower the subjective and psychological wellbeing of older adults living in nursing homes. METHODS: Twenty-one nursing-home residents took part in a narrative training experience consisting of three weekly interview sessions. During each interview, a psychologist helped the participants to construct an autobiographical narrative about their present life in the nursing home based on a Deconstruction-Reconstruction technique...
September 20, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29220609/evaluation-of-structured-assessment-and-mediating-factors-of-suicide-focused-group-therapy-for-veterans-recently-discharged-from-inpatient-psychiatry
#19
Lora L Johnson, Stephen S O'Connor, Barbara Kaminer, Peter M Gutierrez, Erin Carney, Brittany Groh, David A Jobes
OBJECTIVES: The current study investigated the impact of adding the Suicide Status Form (SSF) to a suicide-focused group therapy for veterans recently discharged from an inpatient psychiatry setting. METHODS: A sample of 141 veterans was enrolled and randomized into a Usual Assessment Group Therapy or SSF-Assessment Group Therapy. Participants completed interviews at baseline, 1, and 3 months. RESULTS: No significant differences were observed between groups regarding group attendance (IRR = 1...
December 8, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29220594/modification-of-immunological-features-in-human-platelets-during-sepsis
#20
Valle-Jiménez Xareni Raque, Sánchez-García Juan Carlos, Revilla-Rodríguez Eduardo, Baltierrez-Hoyos Rafael, Romero-Tlalolini María de Los Ángeles, Ramírez-Cosmes Adriana, Torres-Aguilar Honorio, Bustos-Arriaga José, Aguilar-Ruiz Sergio Roberto
Sepsis is an organic dysfunction that puts at risk the life of patients suffering this disorder due to an exacerbated immunological response to the infection mediated by the host. Platelets have been largely researched on sepsis owing to its role in Disseminated Intracellular Coagulation (DIC) and because thrombocytopenia is an important clinical feature of these patients. Nevertheless, a great number of evidence shows that platelets have also an important role in immunological response since they have pattern recognition receptors, chemokine receptors and granules with stored soluble mediators...
December 8, 2017: Immunological Investigations
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