Caterina Michetti, Daniele Ferrante, Barbara Parisi, Lorenzo Ciano, Cosimo Prestigio, Silvia Casagrande, Sergio Martinoia, Fabio Terranova, Enrico Millo, Pierluigi Valente, Silvia Giovedi', Fabio Benfenati, Pietro Baldelli
Dietary restriction, such as low glycemic index diet (LGID), have been successfully used to treat drug-resistant epilepsy. However, if such diet could also counteract antiepileptogenesis is still unclear. Here, we investigated whether the administration of LGID during the latent pre-epileptic period, prevents or delays the appearance of the overt epileptic phenotype. To this aim, we used the Synapsin II knockout (SynIIKO) mouse, a model of temporal lobe epilepsy in which seizures manifest 2-3 months after birth, offering a temporal window in which LGID may affect epileptogenesis...
November 10, 2023: Cellular and Molecular Life Sciences: CMLS