keyword
https://read.qxmd.com/read/38534207/platform-specific-fc-n-glycan-profiles-of-an-antisperm-antibody
#21
JOURNAL ARTICLE
Ellena Nador, Chaoshuang Xia, Philip J Santangelo, Kevin J Whaley, Catherine E Costello, Deborah J Anderson
IgG Fc N -glycosylation is necessary for effector functions and is an important component of quality control. The choice of antibody manufacturing platform has the potential to significantly influence the Fc glycans of an antibody and consequently alter their activity and clinical profile. The Human Contraception Antibody (HCA) is an IgG1 antisperm monoclonal antibody (mAb) currently in clinical development as a novel, non-hormonal contraceptive. Part of its development is selecting a suitable expression platform to manufacture HCA for use in the female reproductive tract...
March 6, 2024: Antibodies
https://read.qxmd.com/read/38534138/the-functional-small-rna-interactome-reveals-targets-for-the-vancomycin-responsive-srna-rsaoi-in-vancomycin-tolerant-staphylococcus-aureus
#22
JOURNAL ARTICLE
Winton Wu, Chi Nam Ignatius Pang, Daniel G Mediati, Jai Justin Tree
UNLABELLED: Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge...
March 27, 2024: MSystems
https://read.qxmd.com/read/38533721/new-developments-in-cosmetic-applications-of-electromagnetic-fields-client-and-occupational-hazard-assessment
#23
REVIEW
Rianne Stam
Energy-based devices are used to improve features of appearance for aesthetic reasons while avoiding more invasive methods. Examples of treatment targets are the reduction of wrinkles, sagging, unwanted skin lesions, body hair and excess fatty tissue, and the enhancement of muscle tissue. One treatment modality is the use of electromagnetic fields (EMF, 0‒300 GHz). The present work aims to give an up-to-date survey of cosmetic applications of EMF for professional use with an assessment of client and worker exposure and possible adverse effects...
March 27, 2024: Bioelectromagnetics
https://read.qxmd.com/read/38533716/role-of-opioid-use-in-gastrointestinal-obstruction-and-perforation-a-retrospective-review
#24
JOURNAL ARTICLE
Divya Bishnoi, Priyanka Sharma, Anant Kumar Rathi
INTRODUCTION: Pain is one of the most common complaints that brings a patient to a hospital. For this, usually, the patient might have already consumed various types of pain killer combinations, either prescribed or over-the-counter. In some of these cases, a patient consumes these medicines unmonitored for a long time and then comes with complications, among which gastrointestinal tract obstruction and perforation are the most life threatening. MATERIALS AND METHODS: Case files from the Department of Surgery were retrieved and studied...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533704/compliance-to-personal-hygiene-habits-in-response-to-covid-19-pandemic
#25
JOURNAL ARTICLE
Mohammad Y Alzaatreh, Huthaifah Khrais, Mohammad R Alsadi, Obay A Al-Maraira
OBJECTIVE: This study aimed to evaluate the Jordanians' compliance rates in terms of personal hygiene habits in response to the coronavirus disease 2019 (COVID-19) pandemic. METHODS: A descriptive cross-sectional design was utilized to collect data from 651 Jordanians via an electronic self-report questionnaire. Data was analyzed using Statistical Package for Social Sciences software Results: The overall compliance rate for personal hygiene habits among Jordanians was 79 percent (11...
2024: Journal of Emergency Management: JEM
https://read.qxmd.com/read/38533591/healthcare-personnel-with-laboratory-confirmed-mpox-in-california-during-the-2022-outbreak
#26
JOURNAL ARTICLE
Allison E Bailey, Shua J Chai, Robert E Snyder, David P Bui, Linda S Lewis, Kayla Saadeh, J Bradford Bertumen, Erin Epson, Jane D Siegel
The California Department of Public Health (CDPH) reviewed 109 cases of healthcare personnel (HCP) with laboratory-confirmed mpox to understand transmission risk in healthcare settings. Overall, 90% of HCP with mpox had nonoccupational exposure risk factors. One occupationally acquired case was associated with sharps injury while unroofing a patient's lesion for diagnostic testing.
March 27, 2024: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/38533585/the-effects-of-shoulder-stabilization-exercises-on-muscle-strength-proprioceptive-sensory-ability-and-performance-in-office-workers-with-shoulder-protraction
#27
JOURNAL ARTICLE
O Depreli, Z Erden
Objectives . Shoulder protraction is frequently seen in office workers because of working with excessive trunk flexion for a long time. This study aimed to compare the effectiveness of stabilization exercises (SE) given in addition to office exercises (OE). Methods . Sixty office workers with shoulder protraction were divided into SE + OE ( n =  30) and OE ( n =  30) groups by stratified random sampling for 8 weeks and followed up for 4 weeks. Shoulder protraction was assessed with a caliper, muscle strength with a hand-held dynamometer, proprioception with an isokinetic dynamometer, vibration sense with a vibrometer and upper extremity functional performance with the closed kinetic chain upper extremity stability test...
March 27, 2024: International Journal of Occupational Safety and Ergonomics: JOSE
https://read.qxmd.com/read/38533203/clients-knowledge-and-satisfaction-with-outpatient-pharmacy-services-and-associated-factors-at-felege-hiwot-comprehensive-specialized-hospital-ethiopia-a-cross-sectional-study
#28
JOURNAL ARTICLE
Firdawek Shenkute Ergetie, Abebe Tarekegn Kassaw, Eyayaw Ashete Belachew
OBJECTIVE: This study aimed to assess patient knowledge and satisfaction and associated factors with outpatient pharmacy service at Felege Hiwot comprehensive specialized hospital. DESIGN SETTING AND PARTICIPANTS: An institution-based cross-sectional study was conducted at Felege Hiwot comprehensive specialized hospital on patients getting outpatient Pharmacy service from 01 March 2022 to 30 May 2022. The study participants were selected by simple random sampling method...
2024: SAGE Open Medicine
https://read.qxmd.com/read/38532919/effects-of-stress-management-and-relationship-enrichment-counseling-on-sexual-and-marital-satisfaction-of-working-women-with-high-occupational-stress
#29
JOURNAL ARTICLE
Leily Kazemi, Mojgan Mirghafourvand, Khalil Esmaeilpour, Mahin Kamalifard
BACKGROUND: Industrialization of societies has placed considerable stress on employees influencing marital and sexual satisfaction. This study investigated the effects of stress management (SM) and relationship enrichment (RE) counseling on marital and sexual satisfaction in stressed women working at Tabriz University of Medical Sciences hospitals, Iran. MATERIALS AND METHODS: In this quasi-experimental study, 75 nurses and midwives experiencing moderate-to-severe occupational stress after obtaining written informed consent were assigned to SM and RE counseling and control groups randomly...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38532918/analysis-of-risk-factor-for-pneumonia-in-children-less-than-five-years-in-makassar
#30
JOURNAL ARTICLE
Evalina Sidabutar, Ansariadi, Wahiduddin, Nadjib Bustan, Stang, Agus Bintara Birawida
BACKGROUND: Pneumonia is one of the main causes of mortality in children less than five years worldwide and in Makassar City. The aim of this study was to investigate the risk factors for pneumonia in children less than five years in Makassar City. MATERIALS AND METHODS: A case-control study design was used in this research. A total of 210 children with consent from the parents were included in this study, which consisted of 70 children's cases, and the data of the control group were taken by the random sampling method...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38532913/the-effectiveness-of-behavioral-activation-therapy-on-the-symptoms-of-depression-rumination-and-social-occupational-functioning-impairment-among-women-with-postpartum-depression
#31
JOURNAL ARTICLE
Zahra Nikandish, Ilnaz Sajjadian
BACKGROUND: Postpartum depression is caused by a wide range of factors, and women in their postpartum period are highly vulnerable, either physically or emotionally. The present study aimed to investigate the effects of behavioral activation therapy on the symptoms of depression, rumination, and social-occupational functioning impairment among women with postpartum depression (PPD). MATERIALS AND METHODS: This quasi-experimental research included a pre-test, a post-test, and a one-month follow-up, as well as experimental and control groups...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38532909/aluminosis-pneumoconiosis-presenting-as-hyperdense-lung-nodules
#32
Sara E Mantz, Matthew J DeVries
We present the case of a 66-year-old man who presented with new incidentally found hyperdense pulmonary nodules. Further workup with a PET/CT revealed that the nodules were FDG-avid and that there was associated hypermetabolic lymphadenopathy. Due to his history of aluminum toxicity from welding, aluminosis pneumoconiosis was suspected. Biopsy of one of the nodules was done which reinforced this diagnosis. Aluminosis pneumoconiosis is a rare occupational lung disease mostly associated with industrial workers with prolonged unprotected exposure to fine aluminum dust...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38532506/sonographic-characteristics-of-diffuse-sclerosing-variant-of-papillary-thyroid-carcinoma-with-histopathological-correlation-a-preliminary-study
#33
JOURNAL ARTICLE
Wanying Li, Ying Wang, Luying Gao, Ruie Feng, Ke Lv, Xining Wu, Xiao Yang, Sheng Cai, Hongyan Wang, Jianchu Li
BACKGROUND: Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is a rare but high invasive subtype of papillary thyroid carcinoma, which mandates an aggressive clinical strategy. Few studies have focused on the sonographic characteristics of DSVPTC and the role of ultrasound in diagnosis and treatment of this variant remains unknown. This study aimed to identify and understand DSVPTC more accurately under ultrasound in correlation with pathology. METHODS: The ultrasound characteristics and histopathologic sections of 10 lesions in 10 DSVPTC patients who underwent thyroid surgery at our center between 2014 and 2020 were reviewed and compared with 184 lesions in 168 classic variant of papillary thyroid carcinoma (cPTC) patients...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38532400/knowledge-attitudes-and-practices-towards-kawasaki-disease-from-caregivers-of-children-with-kawasaki-disease-a-cross-sectional-study
#34
JOURNAL ARTICLE
Miaomiao Zhao, Jiaxin Ye, Luping Chen, Yitong Yang, Meng Zhao, Mingzhu Yang, Zhaoling Shi
PURPOSE: To examine the knowledge, attitudes, and practices (KAP) of caregivers of children with Kawasaki disease toward Kawasaki disease. METHODS: This cross-sectional study was conducted at four hospitals in China from March 2023 to June 2023. The KAP scores were evaluated using a self-designed questionnaire (Cronbach's α = 0.840; KMO = 0.7381). Correlations between dimension scores were evaluated by Pearson correlation analysis...
March 26, 2024: BMC Public Health
https://read.qxmd.com/read/38532343/phenome-wide-causal-associations-between-osteoarthritis-and-other-complex-traits-through-the-latent-causal-variable-analysis
#35
JOURNAL ARTICLE
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhihong Li
BACKGROUND: Individuals with osteoarthritis present with comorbidities, and the potential causal associations remain incompletely elucidated. The present study undertook a large-scale investigation about the causality between osteoarthritis and variable traits, using the summary-level data of genome-wide association studies (GWAS). METHODS: The present study included the summary-level GWS data of knee osteoarthritis, hip osteoarthritis, hip or knee osteoarthritis, hand osteoarthritis, and other 1355 traits...
March 26, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38532238/pharmacological-basis-of-differences-in-dose-response-dose-equivalence-and-duration-of-action-of-inhaled-corticosteroids
#36
JOURNAL ARTICLE
Peter T Daley-Yates, Bhumika Aggarwal, Maximilian Plank
INTRODUCTION: Asthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are not independently assessed accordingly. Moreover, differences in ICS duration of action are not considered when a dose regimen is selected. We investigated the efficacy and safety implications of these limitations for available ICS molecules. METHODS: Published pharmacodynamic and pharmacokinetic parameters were used, alongside physiological and pharmacological principles, to estimate the efficacy and safety of available ICS molecules...
March 27, 2024: Advances in Therapy
https://read.qxmd.com/read/38532179/lung-fibre-burden-and-risk-of-malignant-mesothelioma-in-shipyard-workers-a-necropsy-based-case-control-study
#37
JOURNAL ARTICLE
Dario Mirabelli, Anna Benedetta Somigliana, Danila Azzolina, Dario Consonni, Pietro Gino Barbieri
OBJECTIVES: In Italy, the highest pleural cancer mortality and incidence have been observed among Italian regions where the 2 largest Italian shipyards were (and are) located. The objective of this study was to assess the exposure-response relationship for mesothelioma among male workers employed in the Monfalcone, Italy, shipyard. METHODS: We conducted a necropsy-based case-control study. Cases (N = 102) were mesothelioma decedents and controls were those with lung cancer (N = 84)...
March 26, 2024: Annals of Work Exposures and Health
https://read.qxmd.com/read/38531827/the-association-between-social-determinants-of-health-risk-factors-job-performance-and-healthcare-costs-in-an-employed-population
#38
JOURNAL ARTICLE
Wayne N Burton, Alyssa B Schultz, Martha E Shepherd, David Hines
OBJECTIVE: To compare employees of a US school district based on their social determinants of health (SDoH). METHODS: Employees (N = 5006) were categorized into low, medium, or high need SDoH tiers. Of them, N = 2469 also participated in a health risk appraisal in 2019. Subjects' average healthcare costs, health risk factors, and self-rated job performance were compared by SDoH tier and race. RESULTS: Significant differences were observed among the SDoH comparison groups regarding age, gender, race, and marital status...
March 27, 2024: Journal of Occupational and Environmental Medicine
https://read.qxmd.com/read/38531821/the-coronovirus-19-pandemic-and-the-future-of-work
#39
JOURNAL ARTICLE
Chidimma Ogechukwu Ezeilo, Judith Green-McKenzie
INTRODUCTION: The "Future of Work" refers to workplace modifications projected to occur after pandemics, other large-scale events that affect the health and safety of broad sectors of the workforce, technological advancements, or shifts in the economy. This paper examines the influence of the COVID-19 pandemic on the Future of Work. METHODS: The electronic databases PubMed, Google Scholar and Scopus were explored using search terms such as "post-pandemic", "working force" and "future of work" for papers published between 2000 to 2023...
March 27, 2024: Journal of Occupational and Environmental Medicine
https://read.qxmd.com/read/38531813/moser-s-effective-management-of-health-and-safety-programs-a-practical-guide-fourth-edition
#40
JOURNAL ARTICLE
David Cathcart
No abstract text is available yet for this article.
March 27, 2024: Journal of Occupational and Environmental Medicine
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